Clinical trials: Observation, open to volunteers
Prostate Cancer Patients on Active Surveillance
Intratumoral and Systemic Hiltonol® (Poly-ICLC) in Prostate Cancer Patients on Active Surveillance
This is a partially blinded randomized controlled phase II pilot study comparing Poly-ICLC (Hiltonol®) treatment vs no treatment, for prostate cancer participants on active surveillance.
- Trial name
- NCT06343077
- Testing
- Poly-ICLC intramuscular (IM) injection, Poly-ICLC, Intertumoral (IT) injection
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Ashutosh Kumar Tewari
Non-Tuberculous Mycobacteria Pulmonary Disease, Bronchiectasis
Health Impact of Non-Tuberculous Mycobacteria Pulmonary Disease (NTM-PD)
Nontuberculous mycobacteria (NTM) are environmental organisms found in soil and water. The majority do not cause human disease. When they do, this is mostly as a chronic lung infection in people with long-term lung problems such…
- Trial name
- NCT07192705
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University College, London
Endometriosis
Salivary microRNA in Endometriosis: Correlation With Response to Progestin Therapy
This study aims to analyze the salivary miRNA specific for patients diagnosed with endometriosis, specifically evaluating the miRNA profile of patients who respond versus those who do not respond to progestin therapy.
- Trial name
- ENDOmiRNA (NCT06414720)
- Testing
- Dienogest 2 MG
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- University of Udine
NSCLC (Advanced Non-small Cell Lung Cancer), Brain Metastasases
AI-guided Prognostication and Cranial Radiotherapy Optimization in EGFR-TKI-treated Non-small Cell Lung Cancer Patients With Baseline Brain Metastases
The goal of this observational study is to extract the imaging features of brain lesions and primary lung lesions in NSCLC patients with brain metastases by deep learning, as well as common clinicopathological parameters, which…
- Trial name
- NCT06604689
- Testing
- third-generation EGFR TKIs (Almonertinib/Furmonertinib/Osimertinib)
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Fudan University
Isometric Muscle Strength, Jumping Performance
Neuromuscular Variables and Performance in Mexican Weightlifters
This study aims to determine whether, within each weight and sex category, higher isometric pull force or greater vertical jump impulse is associated with better final placement in the competition.
- Conditions
- Isometric Muscle Strength, Jumping Performance, Weightlifting, Performance Measures
- Trial name
- KRAFT (NCT07277335)
- Testing
- Isometric start position pull (ISPP), Vertical impulse, Performance
- Where
- Mexico
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ángel Rodríguez
Mild Cognitive Impairment
Navigating the Clinical Research Process for Mild Cognitive Impairment
Participation in medical research usually favors a particular demographic group. But there is limited research available to explain what trial attributes affect the completion of these specific demographic groups.
- Trial name
- NCT06207903
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Power Life Sciences Inc.
Myotonic Dystrophy Type 1 (DM1)
A Registered Observational Cohort Study of Myotonic Dystrophy Type 1
Myotonic dystrophy type 1 (DM1) is the most common form of muscular dystrophy.There is little phenotype and genetic data for Chinese DM1 patients.
- Trial name
- NCT06979024
- Testing
- Triplet-primed PCR or Long-read sequencing
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Tracheal Intubation, Postoperative Complications (Cardiopulmonary)
Tracheal Cuff Pressure and Postoperative Complications
This prospective observational study aims to identify risk factors for tracheal mucosal injuries caused by orotracheal tube use during the intraoperative period in patients undergoing elective surgeries at the Hospital de…
- Trial name
- TCP-POC (NCT07264179)
- Where
- Brazil
- Volunteers
- 362 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Open-angle Glaucoma (OAG)
5-Year Postoperative Outcomes of Patients Who Completed the CREST Study
This study is designed to collect clinical data at 3, 4, and 5 years postoperatively for participants who completed the CREST Study without having secondary IOP-lowering surgery in the study eye(s).
- Trial name
- CREST-XT (NCT07480343)
- Testing
- CycloPen Micro-Interventional Cyclodialysis System, CycloPen Micro-Interventional Cyclodialysis System Post Cataract
- Where
- 10 sites in United States
- Volunteers
- 250 people
- Sponsor
- Iantrek, Inc.
Cardiac Surgery Requiring Cardiopulmonary Bypass
Oxygen Consumption, Hypoperfusion and Organ Injury After Cardio-pulmonary Bypass
The goal of this observational study is to understand how oxygen consumption after heart surgery relates to blood flow problems and organ injury.
- Trial name
- VO2-EPOC (NCT06930443)
- Testing
- Oxygen consumption measurement
- Where
- Sweden
- Volunteers
- 65 people
- Sponsor
- Uppsala University Hospital
Pancreatic Cancer
CtDNA-guided Maintenance Therapy in Pancreatic Cancer
This study aims to conduct a large-scale prospective clinical trial to evaluate the efficacy and safety of capecitabine monotherapy as maintenance treatment following standard adjuvant chemotherapy (gemcitabine plus capecitabine)…
- Trial name
- NCT07054879
- Where
- China
- Volunteers
- 70 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Drug-eluting Stent, Coronary Artery Disease
Efficacy of OSFIT Drug-Eluting Stent in Coronary Ostial Artery Stenosis
The purpose of this observational study is to evaluate the long-term effectiveness and safety of the OSFIT drug-eluting stent designed to facilitate procedures in coronary artery lesions.
- Trial name
- NCT06066450
- Testing
- Genoss® DES system, Genoss® Osfit system
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Genoss Co., Ltd.
Mid-Rectal Cancer, Rectal Cancer Stage II
Can Neoadjuvant Chemoradiotherapy be Ommited in Mid-rectal Cancer
This project aims to compare the oncological and functional outcomes of patients with mid-rectal cancer who have a low risk of local recurrence (without MRF involvement) and who either receive or do not receive neoadjuvant…
- Conditions
- Mid-Rectal Cancer, Rectal Cancer Stage II, Rectal Cancer Stage III
- Trial name
- CANO (NCT06823297)
- Testing
- Total mesorectal excision, Neoadjuvant Chemotherapy followed by total mesorectal excision
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 436 people
- Sponsor
- Turkish Society of Colon and Rectal Surgery
Vaginal Neoplasms
Image-guided Brachytherapy for Vaginal Cancer (EMBRAVE)
The goal of this clinical study is to improve clinical outcomes of patients with vaginal cancer including vaginal recurrences who are treated with curative intent by primary radio(chemo)therapy and image-guided adaptive…
- Trial name
- EMBRAVE (NCT06514235)
- Testing
- Observational study (Non-interventional study)
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- Erasmus Medical Center
Hypertension, Fracture
Immediate Fracture Risk After Antihypertensive Drug Initiation
This retrospective observational study aims to evaluate the short-term fracture risk associated with anti-hypertensive medication initiation using a self-controlled case series (SCCS) design and investigate temporal trends of…
- Trial name
- FADI (NCT06964217)
- Testing
- Monotherapy, Combination therapy
- Volunteers
- 10,000,000 people
- Sponsor
- Ajou University School of Medicine
Consciousness Disorders, Persistent Vegetative State
Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)
After a severe brain injury some patients survive but cannot communicate, and deciding early which of them are likely to recover consciousness remains one of the hardest problems in neurocritical care.
- Conditions
- Consciousness Disorders, Persistent Vegetative State, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- CyDoC-MAP (NCT07736820)
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Nicosia General Hospital
Neuropathic Pain, Neuropathic Pain Diagnostic Questionnaire (DN4) ≥ 4
Hematological Indices and Sympathetic Block Response in Neuropathic Pain
This prospective observational study aims to evaluate the relationship between hematological inflammatory indices and clinical treatment response in patients with neuropathic pain undergoing sympathetic nerve block procedures as…
- Trial name
- HINSPAIN (NCT07596823)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara City Hospital Bilkent
Musculoskeletal Diseases
Digital Care Programs for Musculoskeletal Health
The purpose of this study is to create a research repository, composed of data collected in the course of digital care programs for musculoskeletal conditions and musculoskeletal health delivered by SWORD Health to individuals…
- Trial name
- NCT05417685
- Testing
- Acute and post-acute, Chronic, Post-surgical
- Where
- United States
- Volunteers
- 300,000 people, healthy volunteers welcome
- Sponsor
- Sword Health, SA
Restless Leg Syndrome (RLS), Variant Restless Legs Syndrome
Novel Calcium Channel Modulators in RLS and Variants: Efficacy & Safety
The goal of this [study type: clinical trial] is to [primary purpose: evaluate the efficacy and safety of a novel calcium channel modulator in treating Restless Legs Syndrome (RLS) and its variant subtypes] in [describe…
- Trial name
- NCT07453862
- Testing
- Crisugabalin
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Friendship Hospital
Hearing Loss, Hearing Loss, Sensorineural
Cochlear Implant Recipients: Comprehensive Longitudinal Evaluation
This study aims to assess hearing and speech perception, as well as quality of life, in deaf patients of all ages before and after cochlear implantation, and to explore differences across age groups and treatment subtypes…
- Conditions
- Hearing Loss, Hearing Loss, Sensorineural, Deafness, Cochlear Implantation
- Trial name
- CIRCLE (NCT07380269)
- Testing
- Cochlear Implantation
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Eye & ENT Hospital of Fudan University
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