Clinical trials: Observation of Neuromuscular Block
Incomplete Reversal of Neuromuscular Block
Quality of Recovery After Reversal With Neostigmine or Sugammadex.
This study will compare patient recovery measures after reversal of neuromuscular blockade with neostigmine or sugammadex after surgery.
- Trial name
- NCT02909439
- Testing
- Sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Stony Brook University
Colorectal Cancer
RADOX' Reduced Abdominal Distension and Oxygen Delivery
The use of laparoscopic surgery is continuing to increase in colorectal resection and expected reach 80% in the next 10 years. Although laparoscopic (keyhole) or minimally invasive surgery can lead to faster recovery it can also…
- Trial name
- RADOX (NCT02045680)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Dr Michael Scott
Minimally Invasive Cardiac Surgery
Postoperative Respiratory Complications According to Neuromuscular Block Reversal After MICS
Postoperative respiratory complications according to the type of drug (sugammadex, pyridostigmine) used for reversible neuromuscular block when extubating an endotracheal tube in the operating room after minimally invasive…
- Trial name
- NCT04957836
- Testing
- reversal with sugammadex
- Where
- South Korea
- Volunteers
- 1,216 people
- Sponsor
- Pusan National University Yangsan Hospital
Pneumoperitoneum, Neuromuscular Blockade
The Effect of Low Pressure Pneumoperitoneum During Laparoscopic Colorectal Surgery on Early Quality of Recovery
Randomised controlled trial comparing the effect of low pressure pneumoperitoneum with deep neuromuscular block versus normal pressure pneumoperitoneum with moderate neuromuscular block during laparoscopic colorectal surgery on…
- Conditions
- Pneumoperitoneum, Neuromuscular Blockade, Surgery
- Trial name
- RECOVER (NCT03608436)
- Testing
- Low pressure pneumoperitoneum, Rocuronium Bromide
- Where
- 3 sites in Netherlands
- Volunteers
- 178 people
- Sponsor
- Radboud University Medical Center
Myasthenia Gravis
Univent Tube for Thoracoscopic Thymectomy in Myasthenic Patients
This observational study included consecutive MG patients who underwent thoracoscopic thymectomy with Univent tube intubation under general anesthesia without NMBAs and combined with airway topical anesthesia between January 2016…
- Trial name
- NCT06101407
- Volunteers
- 83 people
- Sponsor
- Nguyen Dang Thu
Quality of Life, Postoperative Complications
Low Pressure Pneumoperitoneum and Deep Neuromuscular Block vs. Standard During RARP to Improve Quality of Recovery; a Randomized Controlled Study.
Intra-abdominal pressure (IAP) needed to create sufficient workspace during laparoscopic surgery affects the surrounding organs with ischemia-reperfusion injury and a systemic immune response.
- Conditions
- Quality of Life, Postoperative Complications, Acute Pain, Immune System Tolerance
- Trial name
- RECOVER-2 (NCT04250883)
- Testing
- Low intra-abdominal pressure, Deep neuromuscular blockade (NMB), Standard intra-abdominal pressure
- Where
- Netherlands
- Volunteers
- 97 people
- Sponsor
- Radboud University Medical Center
Elective Surgery
Neuromuscular Blocking Agents in the Elderly
The number of elderly patients (>80 years) is increasing and a large proportion of these patients will require surgery and anaestheasia within the next decades.
- Trial name
- NCT03857750
- Testing
- Rocuronium
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Postoperative Residual Curarisation, Postoperative Hypoxemia
Postoperative Residual Curarisation at Arrival in the Post-anesthesia Care Unit
Several studies have documented that neuromuscular block often persists in the postanesthesia care unit (PACU). Residual paralysis is associated with postoperative complications such as hypoxia, weakness, and respiratory failure.
- Conditions
- Postoperative Residual Curarisation, Postoperative Hypoxemia, Postoperative Airway Obstruction
- Trial name
- NCT01362647
- Testing
- neuromuscular transmission monitoring, Pulse oximetry measurement
- Where
- Belgium
- Volunteers
- 625 people
- Sponsor
- Onze Lieve Vrouw Hospital
Gastrointestinal Cancer, Sarcopenia
Sarcopenia and Neuromuscular Block in Gastrointestinal Cancer Surgery
This prospective observational study aims to evaluate the effects of sarcopenia on intraoperative neuromuscular block (NMB) in patients undergoing gastrointestinal cancer surgery.
- Conditions
- Gastrointestinal Cancer, Sarcopenia, Neuromuscular Blockade
- Trial name
- NCT07003061
- Testing
- Standard Anesthesia Management
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Neuromuscular Blockade, Pulmonary Complication
Incidence of Residual Neuromuscular Blockade in Intra-abdominal Surgery: A Prospective, Observational Study
The aim of this prospective, observational study is to determine the incidence of post-operative residual neuromuscular blockade (PRNB) in patients undergoing intra-abdominal procedures compared to patients undergoing other…
- Trial name
- NCT02984839
- Testing
- Stimpod NMS450® Nerve Stimulator, by Xavant™ Technology
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- OhioHealth
Neuromuscular Blockade
Interaction Between Magnesium and Neostigmine or Sugammadex for the Reversal of a Rocuronium-induced Neuromuscular Block
Magnesium sulphate is regularly used in perioperative medicine. During and after general anesthesia, it enhances the effect of muscle relaxants because it reduces the liberation of acetylcholine at the neuromuscular junction.
- Trial name
- MagNeoSug (NCT03497923)
- Testing
- Magnesium Sulfate
- Where
- 2 sites in Switzerland
- Volunteers
- 48 people
- Sponsor
- Christoph Czarnetzki
Neuromuscular Blocking Agents, Residual Neuromuscular Block
Measuring of the Duration of Action of Different Doses of Rocuronium-induced Neuromuscular Block in Infants During Surgical Treatment of Craniosynostosis
The use of intravenous muscle relaxants during anaesthesia can significantly facilitate endotracheal intubation and reduce the chance of possible airway complications during intubation.
- Conditions
- Neuromuscular Blocking Agents, Residual Neuromuscular Block, Neuromuscular Blockade Monitoring
- Trial name
- NCT07080528
- Testing
- Sevofluorane, Propofol
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- Tamas Vegh, MD
Incidence of Postoperative Residual Curarization
Combined Use of Low-dose Sugammadex Plus Neostigmine Administered for Reversal of Rocuronium
Reversal of rocuronium-induced neuromuscular block by the combination of low-doses of neostigmine plus sugammadex decreases the cost of anesthetic medications, while maintaining efficacy of reversal in obese patients.
- Trial name
- NCT03328312
- Testing
- Sugammadex, neostigmine+atropine, neostigmine+atropine+sugammadex
- Volunteers
- 90 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Postoperative Residual Curarization
Comparison of Train of Four, Tetanus 50 and 100 Hz Recovery After Rocuronium Block Reversed by Sugammadex
Despite neuromuscular transmission monitoring and pharmacological reversal allowing a train of four ratio recovery higher than 0.9, patients receiving neuromuscular blocking agent during general anesthesia have a high risk of…
- Trial name
- NCT05003024
- Testing
- TOF SCAN, ITF
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Poitiers University Hospital
Brain Tumors
Effect of Sugammadex for Reversal of Rocuronium-induced Neuromuscular Block on Perioperative Management of Awake Craniotomy
Effect of sugammadex for reversal of rocuronium-induced neuromuscular block on Perioperative Management of awake Craniotomy
- Trial name
- NCT05202899
- Testing
- sugammadex
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Muscle Relaxation
Effect of Magnesium Sulphate Pretreatment in Pediatric Abdominal Surgery
In this study, the investigators will compare the effect of magnesium sulphate pretreatment on the onset and duration of intense and deep neuromuscular Block of rocuronium versus Cis-Atracurium and on the period of no response to…
- Trial name
- MgSO4/MR (NCT05736744)
- Testing
- MgSO4, Cis-Atracurium
- Where
- 2 sites in Egypt
- Volunteers
- 58 people
- Sponsor
- Assiut University
Neuromuscular Monitoring After Administration of Neuromuscular Blocking Agents in Different Types of Surgery
Observational Study to Evaluate the Current Neuromuscular Monitoring Practice Used After Different Types of Surgery, for Which Neuromuscular Blocking Agents Were Used, With or Without Blocking Reversal (P06556)
The intent of this observational study is to collect prospective data regarding neuromuscular monitoring practices and extubation standards (Train-Of-Four [TOF] value) during surgery, in countries of Central and Eastern Europe…
- Trial name
- NCT01213264
- Testing
- No neuromuscular blockade (NMB)-reversal agent used, Sugammadex, Other NMB-Reversal Agents Used in Routine Anesthesiology Practice
- Volunteers
- 659 people
- Sponsor
- Merck Sharp & Dohme LLC
Airway Reflexes, Protective, Recovery After Neuromuscular Block
Impact of Anesthetic Choice (Sevoflurane Versus Desflurane) on Airway Reflex Recovery in the Context of Antagonized Neuromuscular Block
Protective airway reflexes may be impaired in the postoperative period, creating the potential for aspiration of gastric contents, even after a patient exhibits appropriate response to command.
- Conditions
- Airway Reflexes, Protective, Recovery After Neuromuscular Block, Anesthetic Recovery
- Trial name
- NCT01199237
- Testing
- Sevoflurane, Desflurane, Rocuronium
- Where
- 2 sites in United States
- Volunteers
- 107 people
- Sponsor
- University of California, San Francisco
Incomplete Reversal of Neuromuscular Block
Sugammadex ED90 Dose in the Obese Patients
The purpose of this study is to determine the minimum effective dose of sugammadex, an antagonist of neuromuscular blockade used during anesthesia practice, in obese patients, considering that sugammadex is indicated in adults…
- Trial name
- NCT02568345
- Testing
- sugammadex ED90
- Volunteers
- 31 people
- Sponsor
- Faculdade de Ciências Médicas da Santa Casa de São Paulo
Anesthesia,General, Neuromuscular Blockade
MONITORING NEUROMUSCULAR BLOCK IN PAEDIATRIC ANAESTHESIA
To date there is still little scientific evidence regarding neuromuscular block monitoring in pediatric anesthesia and indications for safe reversal.
- Conditions
- Anesthesia,General, Neuromuscular Blockade, Tracheal Intubation
- Trial name
- MOTOR (NCT06331611)
- Testing
- TOF monitoring
- Volunteers
- 200 people
- Sponsor
- Istituto Giannina Gaslini