Clinical trials: Observational Study, open to volunteers
Liver Cirrhosis, HCC - Hepatocellular Carcinoma
Effect of Laparoscopic Hepatectomy Combined With Splenectomy on Hepatic Functional Reserve and Immune Function
Splenectomy may relieve hypersplenism, reverse liver fibrosis, improve hepatic functional reserve, and reshape the systemic antitumor immune milieu by removing the source of negative immunomodulation.
- Conditions
- Liver Cirrhosis, HCC - Hepatocellular Carcinoma, Hypersplenism
- Trial name
- LHCS-HFRI (NCT07811687)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Northern Jiangsu People's Hospital
Locally Advanced Head and Neck Squamous Cell Carcinoma
A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy
The main purpose of this study is to assess the efficacy and safety of volrustomig compared to observation in participants with unresected locally advanced head and neck squamous cell carcinoma (LA-HNSCC) who have not progressed…
- Trial name
- eVOLVE-HNSCC (NCT06129864)
- Testing
- volrustomig
- Where
- 306 sites in United States, Austria and 21 more
- Volunteers
- 1,145 people
- Sponsor
- AstraZeneca
Asthma
Efficacy of a Smart add-on Device in Combination With a Triple Treatment in Asthma Patients on Inhaler Technique and Adherence
The goal of this observational study is to determine if using the SiA® (Systematic Intervention Agent) system can improve inhaler technique and medication adherence in adults with asthma who are already using Trimbow pMDI…
- Trial name
- SiASMARTer (NCT06908421)
- Where
- 2 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- Chiesi Pharma AB, Nordic
Erection; Incomplete
Pornography Abstinence and Nocturnal Erections in Adult Men
The effects of pornography use on male sexual health remain uncertain, with mixed findings across existing literature and substantial variability at the individual level.
- Trial name
- NCT07618104
- Testing
- Pornography Abstinence
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Efforia, Inc
Neonates From Birth up to 5 Days Postpartum
Observational Study Exploring the Timing of Postnatal Neonate Weight Measurements
This study will help us address the national question of when is the best day to weigh neonates to ensure we give neonates the best possible chance within the first week of their life, maximizing breastmilk without giving formula…
- Trial name
- WEIGHT (NCT07599332)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- East Suffolk and North Essex NHS Foundation Trust
Mortality, Extra Corporeal Membrane Oxygenation
Outcomes of Veno Arterial ECMO
veno arterial (VA) extra corporeal membrane oxygenation (ECMO) is a rescue therapy with various indications including refractory cardiac arrest and refractory cardiogenic shock.
- Trial name
- ECMOCARD (NCT05155904)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Subarachnoid Hemorrhage, Spontaneous, Subarachnoid Hemorrhage, Aneurysmal
Determining the Clinical Impact and Prevalence of Hemorrhagic Subtypes in Perimesencephalic Subarachnoid Hemorrhage
Background: Perimesencephalic subarachnoid hemorrhage (pmSAH) is a distinct subtype of traumatic subarachnoid hemorrhage (SAH) characterized by a localized bleeding pattern around the midbrain not resulting from a ruptured…
- Conditions
- Subarachnoid Hemorrhage, Spontaneous, Subarachnoid Hemorrhage, Aneurysmal, Perimesencephalic Subarachnoid Hemorrhage, Basilar Artery Perforator Aneurysm
- Trial name
- DECIPHER-pmSAH (NCT07923084)
- Testing
- Completion of a patient-reported outcome measure (PROM) in the form of a EQ-5D questionnaire
- Where
- Switzerland
- Volunteers
- 264 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Skin Diseases, Photoaging
Driving Time and Facial Skin Hydration Asymmetry in Florida Drivers
his observational study examines whether time spent driving is associated with differences in skin hydration between the left and right cheeks in female drivers residing in Florida.
- Conditions
- Skin Diseases, Photoaging, Skin Hydration
- Trial name
- DCHA-FL-25-65 (NCT07764809)
- Testing
- BT-Analyze bioimpedance skin hydration measurement
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IAS Skin Care
Lower Limb Deformity
Clinical-MRI Evaluation in Patients Undergoing Subtalar Arthrorisis With Reabsorbable Endorthesis Implant in PLLA
From the archives of the IRCCS Rizzoli Orthopedic Institute, all cases of arthrorrhesis of the subtalar joint with a reabsorbable endorthotic implant in PLLA will be retrieved.
- Trial name
- CS-RM (NCT06525532)
- Testing
- follow up
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Istituto Ortopedico Rizzoli
Varicose Veins of Lower Limb, Chronic Venous Insufficiency, CVI
Efficacy and Safety of Endovenous Ablation for Relief of Knee Pain in Elderly Patients With Lower Extremity Varicose Veins: A Prospective Observational Study
Lower extremity varicose veins (LEVV) are common among elderly patients and can cause leg heaviness, pain, and swelling. In some older adults, venous congestion may contribute to knee or peri-knee pain, which is often…
- Conditions
- Varicose Veins of Lower Limb, Chronic Venous Insufficiency, CVI, Knee Pain, Knee Osteoarthritis
- Trial name
- EVA-Knee-Elder (NCT07239284)
- Testing
- Endovenous Ablation for Varicose Veins
- Volunteers
- 50 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Gastric Cancer, Liver Metastases
Prospective Observational Cohort Study
The goal of this observational study is to learn about the overall disease status, diagnostic and therapeutic modalities, and prognosis of patients with gastric cancer liver metastasis(GCLM) in China.
- Trial name
- NCT06493448
- Testing
- observation
- Where
- China
- Volunteers
- 1,326 people
- Sponsor
- Lin Chen
Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, Primary Mediastinal Large B-Cell Lymphoma
Epcoritamab Compared to Observation for Treating B-cell Lymphoma Patients Not in Complete Remission After CD19-directed CAR-T Therapy
This phase II trial compares epcoritamab to standard practice (observation) for the treatment of patients with B-cell lymphomas who are not in complete remission after treatment with CD19-directed chimeric antigen receptor T-cell…
- Conditions
- Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, Primary Mediastinal Large B-Cell Lymphoma, Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma
- Trial name
- NCT06238648
- Testing
- Biopsy, Biospecimen Collection, Computed Tomography
- Where
- 6 sites in United States
- Volunteers
- 120 people
- Sponsor
- Academic and Community Cancer Research United
Multiple Myeloma (MM), Hematologic Neoplasm
Factors Associated With Health-related Quality of Life and Social Participation of Patients With Multiple Myeloma and Their Caregivers
Individuals with multiple myeloma (MM) are vulnerable because of the effects of systemic organ damage and the side effects of treatment.
- Trial name
- MMYLIFE (NCT07014865)
- Where
- Italy
- Volunteers
- 190 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Osteochondral Defect
Study Protocol to Evaluate Clinical and Imaging Results of Knee Fresh Osteochondral Allografts
The main objective of this study is to assess the clinical and radiological results after carrying out a transplant of fresh osteochondral allograft in the knee.
- Trial name
- NCT04236492
- Testing
- Fresh osteochondral allografting
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
ESR1 Gene Mutation, Breast Cancer (Locally Advanced or Metastatic)
ESR1 Mutations in Metastatic Hormone Receptor-Positive Breast Cancer in the Greek Population
The goal of this observational study is to assess the prevalence of ESR1 mutations in patients with metastatic hormone receptor-positive/HER2-negative breast cancer in Greece and evaluate the associations of these mutations with…
- Conditions
- ESR1 Gene Mutation, Breast Cancer (Locally Advanced or Metastatic), Hormon Receptor Positive Breast Cancer
- Trial name
- ΗΕ 11ESR1/24 (NCT07899463)
- Where
- Greece
- Volunteers
- 500 people
- Sponsor
- Hellenic Cooperative Oncology Group
Trauma, Multiple
Mortality Prediction Using Trauma Scores
The goal of this prospective cohort study is to compare the predictive utility of the Injury Severity Score (ISS), New Injury Severity Score (NISS), Revised Trauma Score (RTS), and Trauma and Injury Severity Score (TRISS) in…
- Trial name
- NCT06709547
- Where
- Iraq
- Volunteers
- 150 people
- Sponsor
- Al-Nahrain University
Sepsis
A Study on How the Immune System Responds to Sepsis and Its Long-term Effects
Sepsis occurs when an infection, caused by bacteria, a virus, or a fungus, enters the body and throws the immune system out of balance.
- Trial name
- HEAL-SEPSIS (NCT07273344)
- Testing
- blood sampling
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Radboud University Medical Center
Hemoptysis
Chinese Hemoptysis Registry Study
This is a prospective, multicenter, observational registry study of hemoptysis in China. Hospitalized patients with active hemoptysis who undergo vascular interventional diagnosis and therapy will be consecutively enrolled from…
- Trial name
- CHORE (NCT07833878)
- Testing
- Not applicable. This is an observational patient registry. All clinical procedures (including bronchial artery embolization) are part of routine medical care and are not assigned as study intervention
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Qiu Jipeng
Non-Hodgkin Lymphoma, B-cell
A Prospective, Observational Cohort Study on the Clinical Impact of Novel Monoclonal Antibodies in B-cell Non-Hodgkin Lymphoma in Italian Clinical Practice
This is a prospective, observational cohort study to evaluate the clinical impact of novel Monoclonal AntiBodies (MAB) in B-cell Non-Hodgkin Lymphoma (NHL) in Italian clinical practice.
- Trial name
- FIL_MAB (NCT06008691)
- Testing
- "novel" MAB (alone or in combination)
- Where
- 61 sites in Italy
- Volunteers
- 1,500 people
- Sponsor
- Fondazione Italiana Linfomi - ETS
Subarachnoid; Hemorrhage, Nontraumatic, Headache
Lidocaine Infusion Treatment for Subarachnoid Hemorrhage Headaches
The goal of this observational study is to evaluate intravenous lidocaine efficacy and safety in treating headache following non-traumatic subarachnoid hemorrhage. Through this prospective analysis, the investigators hope to: 1.
- Trial name
- NCT06582810
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Kansas Medical Center
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