Clinical trials: Obsessive-compulsive Disorder (OCD)
Obsessive-Compulsive Disorder, Trichotillomania (Hair-Pulling Disorder)
Epidiolex in Obsessive Compulsive Disorder and Related Disorders
The primary objective of the proposed study is to evaluate the safety and efficacy of Epidiolex (cannabidiol) in adults with obsessive compulsive and related disorders (OCRDs).
- Conditions
- Obsessive-Compulsive Disorder, Trichotillomania (Hair-Pulling Disorder), Tourette Syndrome, Hoarding Disorder
- Trial name
- NCT04978428
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Chicago
Obsessive-compulsive Disorder
D-cycloserine Augmentation of Cognitive Behavioral Therapy (CBT) for Pediatric Obsessive-compulsive Disorder (OCD)
The investigators are conducting a randomized double-blind placebo-controlled study to assess the efficacy of d-cycloserine augmentation of cognitive-behavioral therapy for the treatment of pediatric obsessive compulsive…
- Trial name
- NCT01411774
- Testing
- Cognitive-behavioral therapy, d-cycloserine
- Where
- 2 sites in United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Trichotillomania
Feasibility Study for Treating Trichotillomania With Wearable Device and App System
Trichotillomania is characterized by recurrent hair pulling resulting in hair loss causing significant distress and impairment which persists despite repeated attempts to stop.
- Trial name
- NCT04241120
- Testing
- Device and app system designed for participant to self-administer Habit Reversal Training, Reminder bracelet control condition
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- HabitAware Inc.
Hoarding Disorder, Hoarding
Enhancing Treatment of Hoarding Disorder With Personalized In-Home Sorting and Decluttering Practice
The proposed study aims to investigate the efficacy of adding in-home decluttering practice to Buried in Treasures Workshop (BIT) facilitated group treatment for hoarding disorder.
- Conditions
- Hoarding Disorder, Hoarding, Clutter
- Trial name
- BITS (NCT02843308)
- Testing
- Facilitated group therapy with behavioral practice; 18 weeks
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Stanford University
Obsessive-Compulsive Disorder
Transcranial Magnetic Stimulation (TMS) and Obsessive Compulsive Disorder (OCD)
This study will evaluate the clinical efficacy of functional Magnetic Resonance Imaging (fMRI) guided 1 Hz repetitive Transcranial Magnetic Stimulation (rTMS) applied to the Supplementary Motor Area (SMA) in OCD patients who have…
- Trial name
- NCT00106249
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- New York State Psychiatric Institute
Obsessive-Compulsive Disorder
Tolcapone in Obsessive Compulsive Disorder
The proposed study will consist of a 5-week double-blind cross-over study trial of tolcapone in 20 people (ages 18-65). The study will be divided into an initial 2 week phase and a second 2 week phase, with one of the 2 week…
- Trial name
- NCT03348930
- Testing
- Tolcapone 200 MG
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Obsessive-Compulsive Disorder
Pilot Study of Ketamine in Adults With Obsessive-Compulsive Disorder (OCD)
In this study investigators are studying the effects of a drug called ketamine on the symptoms of Obsessive-compulsive disorder (OCD).
- Trial name
- NCT01100255
- Testing
- Ketamine infusion, Saline
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- New York State Psychiatric Institute
Obsessive-Compulsive Disorder, Autism Spectrum Disorder
Riluzole to Treat Child and Adolescent Obsessive-Compulsive Disorder With or Without Autism Spectrum Disorders
This study will examine the effectiveness of riluzole for treating Obsessive-Compulsive Disorder in Youth, Including those with Autism Spectrum Disorders.
- Conditions
- Obsessive-Compulsive Disorder, Autism Spectrum Disorder, Autism, Asperger Disorder
- Trial name
- NCT00251303
- Testing
- Riluzole
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- National Institute of Mental Health (NIMH)
Hoarding Disorder, Hoarding
Hoarding Disorder Treatment With Virtual Reality
This study explores whether a facilitated peer support group called Buried in Treasures (BIT) and a virtual reality decluttering practice can help individuals with clutter challenges.
- Conditions
- Hoarding Disorder, Hoarding, Clutter
- Trial name
- HDVR (NCT03828461)
- Testing
- Facilitated group therapy with behavioral practice; 16 weeks
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Stanford University
Obsessive-Compulsive Disorder
2/2 D-Cycloserine Augmentation of CBT for Pediatric OCD
The purpose of this study is to find out if D-Cycloserine (DCS), taken at the same time as a child gets cognitive behavioral therapy (CBT) can help children with pediatric obsessive-compulsive disorder.
- Trial name
- NCT01404208
- Testing
- D-Cycloserine
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- Massachusetts General Hospital
Obsessive Compulsive Disorder
Overlapping Neural Circuits in Pediatric OCD
The purpose of this study is to examine the brain functioning of children and adolescent with OCD before and after treatment with Exposure and Response Prevention (EXRP) therapy.
- Trial name
- NCT02421315
- Testing
- CBT treatment for OCD based on Exposure & Response Prevention (EX/RP) and when indicated medication treatment
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Obsessive Compulsive Disorder
Pilot Study of Minocycline (NPL-2003) in Adults With Obsessive-Compulsive Disorder (OCD)
Obsessive-compulsive disorder (OCD) is a common psychiatric illness that affects up to 2-3% of the population. People with OCD experience anxiety-provoking, intrusive thoughts, known as obsessions, and feel compelled to perform…
- Trial name
- NCT00728923
- Testing
- NPL-2003
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- New York State Psychiatric Institute
Obsessive-Compulsive Disorder
Memantine Augmentation in Obsessive-Compulsive Disorder
The purpose of this study is to determine whether memantine is safe and effective when used as an augmentation to standard treatment for Obsessive-Compulsive Disorder (OCD).
- Trial name
- NCT00264238
- Testing
- Memantine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stanford University
Obsessive-Compulsive Disorder, Pediatric Psychiatric Disorder
Transcranial Direct Current Stimulation (tDCS) in Pediatric Obsessive Compulsive Disorder (OCD)
In this study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in modulating aberrant neurocognitive processes implicated in pediatric patients with obsessive compulsive disorder…
- Trial name
- NCT04548609
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Massachusetts General Hospital
Trichotillomania
Awareness Enhancement and Monitoring Device for Treatment of Trichotillomania
The goals of the study are to further design, develop, and test an awareness enhancement and monitoring device, which will be used in the self-awareness training and general treatment of patients with compulsive hair-pulling…
- Trial name
- NCT01654523
- Testing
- Awareness Enhancement and Monitoring Device for Treatment of Trichotillomania
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Michigan
Autism, Asperger's Syndrome
Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders
Autism spectrum disorders affect as many as 1 out of 150 children and are related to significant impairment in social, adaptive, and school functioning.
- Conditions
- Autism, Asperger's Syndrome, Generalized Anxiety Disorder, Social Phobia
- Trial name
- NCT01178385
- Testing
- Cognitive-behavioral therapy, Treatment as Usual
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Obsessive-Compulsive Disorder
Dextro-Amphetamine Versus Caffeine in Treatment-resistant OCD
The study hypothesis is that dextro-amphetamine (d-amphetamine) will be safe and effective when used to augment treatment for Obsessive-Compulsive Disorder (OCD), and that tolerance (loss of therapeutic effect) to the medication…
- Trial name
- NCT00363298
- Testing
- dextro-amphetamine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Stanford University
Anxiety Disorders, Generalized Anxiety Disorder
Computerized Intervention Targeting the Error-Related Negativity and Balance N1 in Anxious Children
Anxiety disorders are the most common form of psychopathology, and frequently begin in childhood, resulting in lifelong impairment.
- Conditions
- Anxiety Disorders, Generalized Anxiety Disorder, Social Anxiety Disorder, Obsessive-Compulsive Disorder
- Trial name
- NCT05503017
- Testing
- Psycho-social, computerized intervention targeting error sensitivity, Psycho-social, computerized intervention on healthy lifestyle choices
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- Florida State University
Obsessive-Compulsive Disorder
Ketamine Treatment for Pediatric-Refractory Obsessive-Compulsive Disorder (OCD)
This pilot study is proposed to determine the acceptability, feasibility and potential efficacy of ketamine, a medication that modulates glutamate in the brain, as a rapid treatment for obsessive-compulsive disorder (OCD)…
- Trial name
- NCT02422290
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- New York State Psychiatric Institute
Obsessive Compulsive Disorder
Transcranial Magnetic Stimulation (TMS) in Obsessive Compulsive Disorder (OCD): Mechanisms and Biomarkers
The purpose of this study is to test the efficacy of 1-Hz repetitive transcranial magnetic stimulation (TMS) over the pre-supplementary motor area as a treatment for obsessive compulsive disorder.
- Trial name
- TMSOCD (NCT02355002)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Massachusetts General Hospital