Clinical trials: Obstetric; Injury
Intraventricular Hemorrhage, Premature Birth
Intranasal Fresh Mother's Own Milk to Prevent Intraventricular Hemorrhage in Extremely Preterm Infants
Babies born very prematurely are at risk of intraventricular hemorrhage (IVH), which is bleeding in or around the fluid-filled spaces of the brain. Most IVH occurs during the first week after birth.
- Trial name
- iF-MOM-IVH (NCT07812922)
- Testing
- Intranasal Fresh Mother's Own Milk (iF-MOM)
- Volunteers
- 67 people
- Sponsor
- University of Manitoba
Prematurity, Transfer Injury
Minimising the Adverse Physiological Effects of Transportation on the Premature Infant
Centralisation of neonatal intensive care has led to an increase in postnatal inter-hospital transfers within the first 72 hours of life.
- Conditions
- Prematurity, Transfer Injury, Brain Injuries, Intraventricular Hemorrhage
- Trial name
- TRiPs (NCT03754439)
- Testing
- Physiological changes to noise and vibration exposure
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Nottingham
Premature Birth, Brain Injury
Melatonin As A Novel Neuroprotectant In Preterm Infants- Dosage Study
Preterm babies are at risk of brain injury. Melatonin, a naturally occurring hormone, may reduce this risk. The unborn baby receives melatonin from the mother but following premature delivery there maybe a period of prolonged…
- Trial name
- MIND (NCT00649961)
- Testing
- Melatonin injection
- Where
- 2 sites in United Kingdom
- Volunteers
- 18 people
- Sponsor
- Imperial College London
BPD - Bronchopulmonary Dysplasia
Safety and Efficacy of Umbilical Cord-derived Mesenchymal Stem Cell(MSC) Transplantation in the Treatment of Bronchopulmonary Dysplasia(BPD) in Premature Infants
Bronchopulmonary dysplasia (BPD) is a chronic lung disease, which is a major complication of very low and ultra-low preterm infants.
- Trial name
- MSC，BPD (NCT06788470)
- Testing
- MSC
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Perineal Trauma, Hands-on Technique
Hands-on vs Hands-off Techniques in Perineal Protection
Perineal tears are frequent during vaginal delivery. This study evaluates the impact of hands-on versus hands-off techniques on perineal and neonatal outcomes to determine the most effective protective strategy.
- Conditions
- Perineal Trauma, Hands-on Technique, Hands-of Technique, Manual Perineal Protection
- Trial name
- MPP (NCT07492940)
- Where
- Italy
- Volunteers
- 737 people
- Sponsor
- Azienda ULSS 8 Berica
Obstetric Anal Sphincter Injury
Reproducibility of External Anal Sphincter Elastic Properties Assessment Using Elastography During Pregnancy
The risk prediction of obstetric anal sphincter injury couyl be optimized by considering pregnant women's anal sphincter intrinsic viscoelastic properties.
- Trial name
- SEA ELASTO 1 (NCT04350632)
- Testing
- Shear wave elastography assessment of the external anal sphincter
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Preterm, General Movements
Fidgety Movements of Preterm Neonates Included in COSGOD III
The evidence on the effects of clinical care with cerebral NIRS (Near-infrared spectroscopy) monitoring on short term neurological outcome, displayed by fidgety movements between six to 20 weeks post term, are still uncertain.
- Conditions
- Preterm, General Movements, Fidgety Movements, Near Infrared Spectroscopy
- Trial name
- Figdety_Ms (NCT06105333)
- Testing
- standard care plus cerebral oxygen saturation monitoring with a dedicated treatment guideline
- Where
- 2 sites in Austria
- Volunteers
- 183 people
- Sponsor
- Medical University of Graz
Bronchopulmonary Dysplasia (BPD), Premature Births
PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysplasia
The purpose of the study is to learn how safe montelukast may be in premature infants at significant risk for Bronchopulmonary Dysplasia (BPD) and to determine how much and how quickly montelukast moves from the stomach into the…
- Conditions
- Bronchopulmonary Dysplasia (BPD), Premature Births, Critical Illness
- Trial name
- PRISM (NCT07101640)
- Testing
- montelukast 4 mg granule
- Where
- 5 sites in United States
- Volunteers
- 28 people
- Sponsor
- Duke University
Bronchopulmonary Dysplasia, Right Ventricular Dysfunction
Right vEntricular Function Prediction mOdel to Identify pReterm infanTs With Early BronchoPulmonary Dysplasia.
Short title REPORT-BPD feasibility study Design A mixed methods observational cohort feasibility study Study Setting Neonatal Intensive Care Unit at University Hospitals Plymouth NHS Trust Aim To explore the feasibility of…
- Conditions
- Bronchopulmonary Dysplasia, Right Ventricular Dysfunction, In the Perinatal Period
- Trial name
- REPORT-BPD (NCT05235399)
- Testing
- Echo scans
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University Hospital Plymouth NHS Trust
Prematurity, Respiratory Disease
Caffeine as an Adjuvant Therapy for Late Preterm Infants With Respiratory Distress
Use of caffeine citrate in late-preterm infants with respiratory distress is questionable. Oliphant and colleagues found in a recently published study that caffeine therapy use in late-preterm infants at a loading dose of 20 and…
- Conditions
- Prematurity, Respiratory Disease, Ventilator Lung; Newborn
- Trial name
- CAT/LPT (NCT06026163)
- Testing
- Caffeine citrate
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 134 people
- Sponsor
- Ministry of Health, Saudi Arabia
Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
Duration of Continuous Positive Airway Pressure and Pulmonary Function Testing in Preterm Infants
The primary aim of this study is to quantify and compare changes in lung volumes (as measured by functional residual capacity) in premature infants stable on continuous positive airway pressure (CPAP), and then randomized to two…
- Trial name
- NCT02249143
- Testing
- CPAP and room air
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Oregon Health and Science University
Obstetric Anal Sphincter Injury
Pelvic Floor Exercises for Suboptimal Anorectal Manometry
Currently, guidelines from the Royal College of Obstetricians and Gynaecologists stipulate that all women who have sustained an obstetric anal sphincter injury in a previous pregnancy and who are symptomatic or have abnormal…
- Trial name
- NCT07062731
- Testing
- Supervised pelvic floor muscle exercises
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- King's College Hospital NHS Trust
Premature Infant
Bonding Quality and Gene Expression in Fullterm Infants Compared to Late Preterm Infants and Preterm Infants With Early Skin to Skin or Visual Contact
Recent research has identified differences in the quality of mother-child interaction and gene expression of six key molecules involved in stress response and neurobehavioral development in preterm infants (born <32 weeks of…
- Trial name
- NCT03366285
- Testing
- Attachment story completion taks (ASCT)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- University of Cologne
Neonatal Oxygen Desaturation, Premature
Non-Invasive Neurally Adjusted Ventilatory Assist (NAVA) Prone vs Supine in Premature Infants
This research study is being done to investigate the effect of changing an infant's body position on how hard the baby works to breathe, the baby's oxygen level, the baby's carbon dioxide level, the baby's lung volume, the baby's…
- Conditions
- Neonatal Oxygen Desaturation, Premature, Ventilator Lung; Newborn, Apnea of Prematurity
- Trial name
- NCT05968586
- Testing
- Body positioning
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Milton S. Hershey Medical Center
Premature Birth
Therapeutic Effects of Maternal Melatonin Administration on Brain Injury and White Matter Disease
Neurocognitive sequelae observed in preterm represent a major health problem for which there is no preventive treatment approved to date.
- Trial name
- PREMELIP (NCT02395783)
- Testing
- Melatonin 10 µg, Melatonin 20 µg
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prematurity; Extreme
High Flow Nasal Cannula in Preterm Infants
The HIFLO study evaluates the impact of HFNC oxygen therapy on duration of nCPAP therapy, oxygen therapy and hospitalization. The cost of use of CPAP and two HFNC devices are also evaluated.
- Trial name
- HIFLO (NCT03007056)
- Testing
- High flow nasal cannula
- Where
- France
- Volunteers
- 207 people
- Sponsor
- Hôpital de la Croix-Rousse
Pelvic Floor Disorders, Ultrasound Therapy; Complications
Role of Rehabilitation for the Repair of Pelvic Floor Injuries Associated to Vaginal Delivery Identified by 3/4D Transperineal Ultrasound
SUMMARY: (Objective, design, scope of the study, subjects of study, instrumentation, results, conclusions) Objectives: To evaluate if the physiotherapy treatment in pelvic floor dysfunctions, identified by transperineal…
- Conditions
- Pelvic Floor Disorders, Ultrasound Therapy; Complications, Physical Disorder, Obstetric Labor Complications
- Trial name
- NCT03592160
- Testing
- Physiotherapy treatment
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Hospital Universitario de Valme
Anomaly Uterus
Retrospective Study of 110 Cases of Uterine Rupture to Determine Obstetric and Neonatal Complications
This study has for objective to collect medical data from patients with uterine rupture at the childbirth.
- Trial name
- RUVO (NCT03052686)
- Testing
- Childbirth with uterine rupture
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Hôpital NOVO
Pregnancy, High Risk, Parturition Complication as Antepartum Condition
The Periviable Birth Plan
Pregnant women who are at risk of delivering their infants in the periviable period can suffer a large amount of stress and anxiety. Moreover, many women feel a loss of control over their own pregnancy.
- Conditions
- Pregnancy, High Risk, Parturition Complication as Antepartum Condition, Anxiety, PTSD
- Trial name
- NCT03061864
- Testing
- Periviable Birth Plan
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Albany Medical College
Infant, Premature, Bronchopulmonary Dysplasia
Assessment of the Pulmonary Diffusion Capacity in Healthy Infants and Infants With Chronic Lung Disease
The purpose of this study is to evaluate how easily gas can be taken up by the lung. We are comparing infants born premature <32 weeks gestation to infants born full term >37 weeks.
- Conditions
- Infant, Premature, Bronchopulmonary Dysplasia, Asthma
- Trial name
- NCT00428038
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Indiana University