Clinical trials: Obstetric Bleeding
Postpartum Hemorrhage, Uterine Atony
Oxytocin Bolus Versus Infusion in High-Risk Patients Undergoing Elective Cesarean Section (INBOX-HR)
The goal of this randomized, double-blind clinical trial is to learn if Oxytocin is most effective at achieving adequate uterine tone (important for preventing postpartum hemorrhage) when administered as a bolus or an infusion in…
- Conditions
- Postpartum Hemorrhage, Uterine Atony, Uterine Atony With Hemorrhage, Elective Cesarean Section
- Trial name
- INBOX-HR (NCT07688512)
- Testing
- Oxytocin Bolus or Oxytocin Infusion
- Volunteers
- 180 people
- Sponsor
- Stony Brook University
Postpartum Hemorrhage
Carbetocin vs. Oxytocin: In-vitro Myometrial Contractions With and Without Oxytocin Pre-treatment
The purpose of this study is to compare the ability of an isolated sample of uterine muscle tissue (in a tissue bath) to contract in the presence of various drugs.
- Trial name
- NCT01689298
- Testing
- Oxytocin, Carbetocin
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Infant, Newborn, Infant, Low Birth Weight
In Utero Magnesium Sulfate Exposure: Effects on Extremely-Low-Birth-Weight Infants
This study examined the effect of magnesium sulfate (MgSO4) exposure on adverse outcome in extremely low birth weight (ELBW) infants.
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- MgSO4 (NCT01203501)
- Where
- 15 sites in United States
- Volunteers
- 1,339 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Postpartum Haemorrhage
Towards Better Prognostic and Diagnostic Strategies for Haemostatic Changes During Major Obstetric Haemorrhage
Major obstetric haemorrhage (MOH) remains a cause of significant maternal morbidity and mortality worldwide. By identifying women with a higher a priori risk of major haemorrhage during their pregnancy or early during postpartum…
- Trial name
- TeMpOH-2 (NCT02149472)
- Where
- Netherlands
- Volunteers
- 1,649 people, healthy volunteers welcome
- Sponsor
- Sanquin-LUMC J.J van Rood Center for Clinical Transfusion Research
Postpartum Period, Depression
Relationship Between Postpartum Mood Disorders and Delivery Experience
The purpose of this study is to evaluate potential risk factors for developing postpartum depression or posttraumatic stress disorder during the first year postpartum in patients who have no preexisting history of PTSD or PPD.
- Conditions
- Postpartum Period, Depression, Stress Disorders, Post-Traumatic
- Trial name
- NCT03004872
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- University of Michigan
Postpartum Hemorrhage
Temporary Aortic Compression With the Abdominal Tourniquet for Refractory Postpartum Hemorrhage
This multicenter study aims to evaluate effectiveness and safety of using the AAJT-S device as a temporary intervention for severe, atony-related PPH that is refractory to standard therapies
- Trial name
- ACT-PPH (NCT07034924)
- Testing
- Abdominal Aortic and Junctional Tourniquet - Stabilized (AAJT-S)
- Where
- Ukraine
- Volunteers
- 20 people
- Sponsor
- LLC UkrMedGroup
Gestational Diabetes, Pregnancy Complications
Gestational Diabetes Monitoring and Management
The primary goal is to predict the clinical outcomes of mother and baby using blood glucose and other routinely collected clinical data in pregnancy to predict adverse outcomes at birth in women with GDM.
- Conditions
- Gestational Diabetes, Pregnancy Complications, Pregnancy in Diabetic, Pregnancy, High Risk
- Trial name
- NCT06963528
- Where
- United Kingdom
- Volunteers
- 1,800 people
- Sponsor
- University of Oxford
Post Partum Hemorrhage
Bilateral Uterine Artery Ligation in Reducing Incidence of Postpartum Hemorrhage in Cesarean Section
The patients were recruited from women attending labor ward to undergo cesarean section.
- Trial name
- NCT03591679
- Testing
- Oxytocin, bilateral uterine artery ligation
- Where
- Egypt
- Volunteers
- 1,070 people
- Sponsor
- Assiut University
Postpartum Haemorrhage
Topical Tranexamic Acid in Caesarean Section
The objective of this study is to investigate whether topical application of tranexamic acid into the uterine cavity and the surgical site intra-operatively can reduce blood loss and provide better surgical haemostasis in…
- Trial name
- TXACS (NCT02492087)
- Testing
- Topical tranexamic acid, Normal saline 0.9%
- Where
- Malaysia
- Volunteers
- 84 people
- Sponsor
- Dr Meng-Li Lee
Post Partum Hemorrhage, Anemia
Single Dose Intravenous Iron Isomaltoside in Combination With Oral Iron vs Oral Iron Monotherapy in Patients With Anemia After Postpartum Haemorrhage
The investigator's study is going to compare effectiveness of single dose intravenous iron in combination with oral iron versus oral iron monotherapy in correcting haemoglobin deficit, replenishing iron stores and improving…
- Trial name
- IVIronPPH (NCT04505514)
- Testing
- Iron Isomaltoside 1000, Iberet-Folic-500
- Where
- Malaysia
- Volunteers
- 60 people
- Sponsor
- University of Malaya
PreTerm Birth, Intraventricular Hemorrhage
Deferred Cord Clamping Compared to Umbilical Cord Milking in Preterm Infants
For preterm infants, deferred cord clamping has been shown to improve both short term and long-term neonatal outcomes without an established harm for both the mother and her infant.The interference with resuscitative measures for…
- Trial name
- NCT02996799
- Testing
- Umbilical cord milking
- Where
- Saudi Arabia
- Volunteers
- 180 people
- Sponsor
- King Abdulaziz University
Healthy Participants
Rate of Tranexamic Acid Administration on Blood Pressure (RateTXA) Study.
Tranexamic acid is a well-established treatment for post-partum hemorrhage. This study aims to examine the effect of tranexamic acid administration rates on blood pressure changes over 1 minute compared to 10 minutes in healthy…
- Trial name
- RateTXA (NCT06356948)
- Testing
- Tranexamic Acid (TXA)
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Maternal Death, Neonatal Death
Evaluating the Effects of SMS Text Messaging Support System Among Frontline Health Workers in Ghana
Introduction Maternal and neonatal mortality continue to be to be prominent public health issues in sub Saharan Africa including Ghana, with slow progress made towards attainment of Millennium Development Goals (MDG) 4 \& 5.
- Conditions
- Maternal Death, Neonatal Death, Postpartum Haemorrhage, Pre-eclampsia
- Trial name
- Accelerate (NCT02468310)
- Testing
- Maternal and neonatal emergency protocols
- Where
- Ghana
- Volunteers
- 65,831 people, healthy volunteers welcome
- Sponsor
- Hannah Brown Amoakoh
Preterm Birth
Preterm Infant Transport Stress (PremiTranS) Study
This is an observational pilot study to quantify the amount of vibration, noise, physiological and biochemical instability that premature babies are exposed to during inter-hospital transport.
- Trial name
- PremiTranS (NCT01851668)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Nottingham
Postpartum Hemorrhage
Safety, Tolerability and Pharmacokinetics (PK) Study of Oxytocin (GR121619) Administered Via an Inhaled Route in Healthy Female Volunteers
Intramuscular (IM) oxytocin is the gold standard prophylactic therapy for post partum haemorrhage (PPH). However, in resource-poor settings within the developing world, the stability and therefore effectiveness of prophylactic IM…
- Trial name
- NCT02542813
- Testing
- IM oxytocin 10 IU, IH oxytocin 50 mcg, IH oxytocin 200 mcg
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cesarean Section Complications
Tranexamic Acid in Pregnant Women Undergoing Cesarean Section.
Purpose to evaluate the effects of topical tranexamic acid (TA) on reducing post-partum hemorrhage in pregnant women with hemorrhagic cesarean section
- Trial name
- NCT03778242
- Testing
- Topical tranexamic acid, normal saline
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Aswan University Hospital
Blood Loss Massive, Trauma
Evaluation of the Clinical Performance of the Quantra System With the QStat Cartridge
This pilot study will evaluate the performance of the Quantra System comprised of the Quantra Hemostasis Analyzer with the QStat Cartridge in trauma patients or patients with OB hemorrhage.
- Conditions
- Blood Loss Massive, Trauma, Hemorrhage, Postpartum
- Trial name
- NCT03912545
- Testing
- Quantra System
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- HemoSonics LLC
Postpartum Hemorrhage
The Effect Of Sımulatıon-Based Postpartum Bleedıng Management On Mıdwıfery Students
This study was planned to determine the effect of simulation-based postpartum hemorrhage management on the application skills, satisfaction, self-confidence and self-efficacy-competences of Health Sciences University Hamidiye…
- Trial name
- NCT05928481
- Testing
- Simulation-based postpartum bleeding management training
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Placenta Accreta, Postpartum Hemorrhage
Perioperative Administration of Tranexamic Acid for Placenta Previa and Accreta Study
The purpose of this pilot study is to determine if intravenous tranexamic acid (TXA) is effective for reducing blood loss during high risk surgical procedures related to placenta previa and placenta accreta.
- Conditions
- Placenta Accreta, Postpartum Hemorrhage, Cesarean Section, Tranexamic Acid
- Trial name
- TAPPAS (NCT02806024)
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of California, San Francisco
Anemia
Well Being of Obstetric Patients on Minimal Blood Transfusions
Postpartum haemorrhage (PPH) is one of the top five causes of maternal mortality in developed and developing countries. The most important treatment of PPH is red blood cell (RBC) transfusion.
- Trial name
- WOMB (NCT00335023)
- Testing
- Red blood cell transfusion
- Where
- Netherlands
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Sanquin Research & Blood Bank Divisions