Clinical trials: Obstetric Bleeding
Postpartum Hemorrhage
Carbetocin Versus Oxytocin Plus Sublingual Misoprostol in the Management of Atonic Postpartum Hemorrhage
The objective of this study is to compare the effectiveness and safety of carbetocin vs. oxytocin plus sublingual misoprostol in the management of atonic postpartum hemorrhage (PPH)after vaginal delivery.
- Trial name
- NCT03870503
- Testing
- oxytocin, oxytocin plus misoprostol, Carbetocin
- Where
- Egypt
- Volunteers
- 135 people
- Sponsor
- Aswan University Hospital
Cesarean Delivery
The Effectiveness of a Care Bundle to Prevent Postpartum Hemorrhage After Cesarean Delivery
Delays in the detection or inconsistent use of effective interventions of postpartum hemorrhage can result in complications or death.
- Trial name
- RE-TEAM (NCT06684080)
- Testing
- A care bundle
- Volunteers
- 52,000 people
- Sponsor
- Dunjin Chen
Postpartum Hemorrhage
Double Simultaneous Uterotonic Agents Versus Single Agent Regimen to Prevent Early Postpartum Hemorrhage
To determine the effectiveness of using two medications simultaneously versus one medication, as is standard of care, in preventing early postpartum hemorrhage.
- Trial name
- NCT05245227
- Testing
- Sublingual Misoprostol, IV Oxytocin
- Where
- United States
- Volunteers
- 1,358 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Postpartum Hemorrhage
The Impact of "Natural" Cesarean Delivery on Peripartum Maternal Blood Loss.
Throughout the history, the neonate was dependent on maternal touch and care for survival. In modern obstetrics, with hospital care the neonates are seldom separated from their mothers after delivery.
- Trial name
- NCT02768142
- Testing
- Natural cesarean delivery, Standard cesarean delivery
- Where
- Israel
- Volunteers
- 214 people
- Sponsor
- Raed Salim
Primary Postpartum Hemorrhage, Misoprostol
A Trial of Sublingual Misoprostol to Reduce Primary Postpartum Haemorrhage After Vaginal Delivery
The objective of the randomized controlled study is to compare combination of sublingual misoprostol and routine uterotonics versus routine uterotonics alone on PPH in low risk women after vaginal delivery.
- Conditions
- Primary Postpartum Hemorrhage, Misoprostol, Delivery Complication
- Trial name
- NCT05079061
- Testing
- Misoprostol
- Volunteers
- 1,300 people
- Sponsor
- The University of Hong Kong
Placenta Previa Complete Centralis
the Treatment of Postpartum Hemorrhage Due to Placenta Previa Complete Centralis
Objective: To assess the efficacy of lower uterine compression sutures (involved bilateral uterine artery ligation and compression of the lower uterine segment at the same time with one circular stitch) as a conservative…
- Trial name
- PPH (NCT02157441)
- Testing
- lower uterine compression sutures
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Benha University
Postpartum Hemorrhage, Postpartum Depression
Postpartum Video Education in High Risk Populations
This is a prospective, single-center, randomized control study to determine if video education at the time of postpartum discharge improves patient knowledge on the warning signs for the top three causes of severe maternal…
- Conditions
- Postpartum Hemorrhage, Postpartum Depression, Postpartum Sepsis, Postpartum Preeclampsia
- Trial name
- NCT06310720
- Testing
- Video Education
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Placenta Accreta, Placenta Previa
Topical Adrenaline Versus Warm Saline Solution for Minimizing Intraperitoneal Bleeding During Caesarian Delivery for Placenta Previa / Accreta Spectrum ( PAS)
Placenta accreta spectrum (PAS), encompassing the terms placenta accreta, increta, and percreta; abnormally invasive placenta; morbidly adherent placenta; and invasive placentation, is a leading cause of life-threatening…
- Trial name
- NCT06030479
- Testing
- Topical adrenaline, Warm saline
- Where
- Egypt
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Cairo University
Premature Birth, Mortality
Trial to Evaluate a Specified Type of Apgar (TEST-APGAR) Follow Up Study
A specified version of the Apgar-Score, that can be used in newborns under resuscitation, was developed and its value to predict chronic damage in preterm infants will be tested.
- Conditions
- Premature Birth, Mortality, Apgar Score
- Trial name
- NCT01186627
- Where
- Germany
- Volunteers
- 1,500 people
- Sponsor
- Technische Universität Dresden
Postpartum Hemorrhage
Comparison Between Preoperative Vaginal and Postoperative Sublingual Misoprostol for Prevention of Postpartum Hemorrhage During Cesarean Section
Cesarean section (CS) is one of the most frequently performed operative interventions worldwide [1]. Cesarean section rates increase each year throughout the world.
- Trial name
- NCT06765473
- Testing
- Misoprostol
- Volunteers
- 400 people
- Sponsor
- Assiut University
Postpartum Hemorrhage
Efficacy of Four Different Treatment Regimes on Postpartum Hemorrhage
Postpartum hemorrhage is the most important cause of maternal morbidity and mortality worldwide and accounts for approximately 25% of deaths worldwide.
- Trial name
- NCT05467462
- Testing
- I.V carbetocin administration, I.V Oxytocin administration, I.V carbetocin and tranexamic acid administration
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Cesarean Section
Misoprostol+Oxytocin vs. Carbetocin in CS
This prospective randomized double-blind clinical trial will be conducted at Ain-Shams University Maternity Hospital, Cairo, Egypt. Patients eligible for elective lower segment cesarean section will be randomized to 2 groups.
- Trial name
- CS (NCT02786992)
- Testing
- Misoprostol, Oxytocin, Carbetocin
- Where
- Egypt
- Volunteers
- 600 people
- Sponsor
- Ain Shams University
Postpartum Hemorrhage Prevention by Using Oxytocin Verses Misoprostol
Comparison of Sublingual Misoprostol and Intravenous Oxytocin in Active Management of the Third Stage of Labor
Sublingual misoprostol is superior to oxytocin in reduction of blood loss during the third and fourth stages of labor
- Trial name
- NCT01612390
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Rasha Mohammed Mohammed Badawi
Cesarean Section, Hypotension
Effect of Oxytocin Bolus Versus Slow Infusion on Haemodynamic Stability During Caesarean Section Under Spinal Anaesthesia
This study compares two standard ways of giving oxytocin (a medicine that helps the uterus contract) after the baby is born during a planned caesarean section performed under spinal anaesthesia.
- Conditions
- Cesarean Section, Hypotension, Postpartum Hemorrhage, Spinal Anesthesia
- Trial name
- NCT07784478
- Testing
- Oxytocin
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Khyber Girls Medical College
Oxytocin
The Effect of Labor Induction With Oxytocin on Early Postpartum Hemorrhage, Perineal Integrity and Breastfeeding
Aim: This study has been planned as an observational study. The aim of this study is to determine the effect of labor induction with oxytocin on early postpartum hemorrhage, perineal integrity and breastfeeding.
- Trial name
- NCT04441125
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Saglik Bilimleri Universitesi
Postpartum Hemorrhage
Tampostat for Management of Postpartum Hemorrhage
The purpose of the study is to evaluate the safety, feasibility and applicability of a new device 'Tampostat' in the management of primary postpartum hemorrhage and compare the efficacy of 'Tampostat' in terms of arresting…
- Trial name
- NCT02416089
- Testing
- Tampostat, Condom catheter tamponade
- Where
- Bangladesh
- Volunteers
- 344 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Postpartum Hemorrhage
Active Management of the Third Stage of Labour: Uterine Tonus Assessment by Midwife vs. Patient Self-administration
To determine whether there is a difference in effectiveness of routine uterine tonus assessment (every 15 minutes, for 2 hours) when performed by a midwife or self-administered by a patient on the incidence of postpartum…
- Trial name
- UTAMP (NCT02223806)
- Testing
- Uterine Tonus Assessment by Midwife, Patient self-assessment of uterine tonus
- Where
- Ghana
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Post Partum Hemorrhage
Misoprostol Versus Oxytocin for Prevention of Post Partum Hemorrhage
Post partum Hemorrhage (PPH) is one of three main causes of death in pregnant women. Oxytocin is widely used for prevention of PPH. Some studies suggested misoprostol as an alternative treatment when Oxytocin isn't available.
- Trial name
- NCT01863706
- Testing
- Misoprostol, Oxytocin
- Where
- Iran
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hormozgan University of Medical Sciences
Postpartum Hemorrhage
IV Versus IM Administration of Oxytocin for Postpartum Bleeding
This double-blind, randomized controlled trial will evaluate the effect of the route of administration of 10 IU of oxytocin on the average blood loss postpartum.
- Trial name
- NCT02954068
- Where
- Argentina
- Volunteers
- 543 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Postpartum Hemorrhage
Misoprostol in the Treatment of Postpartum Hemorrhage
Postpartum haemorrhage (PPH) remains a leading cause of maternal mortality, despite treatment with conventional methods. Uncontrolled reports and three small randomised controlled trials have suggested that misoprostol may have…
- Trial name
- NCT00116480
- Testing
- Misoprostol
- Where
- 2 sites in Pakistan
- Volunteers
- 61 people
- Sponsor
- Gynuity Health Projects