Clinical trials: Obstetric Labor Complications
Postpartum Hemorrhage
The Effect Of Sımulatıon-Based Postpartum Bleedıng Management On Mıdwıfery Students
This study was planned to determine the effect of simulation-based postpartum hemorrhage management on the application skills, satisfaction, self-confidence and self-efficacy-competences of Health Sciences University Hamidiye…
- Trial name
- NCT05928481
- Testing
- Simulation-based postpartum bleeding management training
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Late-Onset Neonatal Sepsis, Necrotising Enterocolitis
Markers of Platelet Activation foR Identification of Late Onset Sepsis in Preterm Infants
The PARENT study will examine platelet and endothelial associated proteins in preterm infants being investigated for late onset sepsis (LOS) to see if infants with fulminant sepsis can be prospectively identified using these…
- Conditions
- Late-Onset Neonatal Sepsis, Necrotising Enterocolitis, Culture Negative Neonatal Sepsis
- Trial name
- PARENT (NCT05530330)
- Testing
- Platelet/Endothelial proteomics
- Where
- 2 sites in Ireland
- Volunteers
- 268 people
- Sponsor
- University College Dublin
Preterm, Pain, Acute
Peripheral Intravenous Central Catheter Intervention in Preterm Infants
This study will be conducted to evaluate the effect of grasping reflex stimulation applied during peripheral intravenous central catheter (PIC) intervention on pain and stress in preterm infants receiving treatment and care in…
- Conditions
- Preterm, Pain, Acute, Stress, Nursing Caries
- Trial name
- NCT05359809
- Testing
- Graspin Palmar Reflex Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Hypertriglyceridemia
Fat Tolerance From Lipid Emulsion Infusion Packaged in Glass or Plastic
This will be a prospective, randomized trial to determine if differences exist in the tolerance of lipid injectable emulsions in the neonatal intensive care unit (NICU).
- Trial name
- NCT00278928
- Testing
- Liposyn III 20% (lipid infusion), Intralipid 20% (lipid infusion)
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Beth Israel Deaconess Medical Center
Postpartum Hemorrhage, Systemic Autoimmune Diseases
Prophylactic Tranexamic Acid Reduces Postpartum Hemorrhage
Postpartum hemorrhage (PPH) is the most significant leading cause of pregnancy-related mortality in high-risk cesarean delivery women.
- Trial name
- NCT06754371
- Testing
- tranexamic acid, normal saline
- Where
- China
- Volunteers
- 276 people
- Sponsor
- RenJi Hospital
Preterm Birth
A Multicenter Assessment of a Spontaneous Preterm Birth Risk Predictor
Prospective multicenter observational study to further develop and validate a preterm birth risk predictor, using a preterm cutoff at 37 0/7 weeks gestation and at 35 0/7 weeks gestation.
- Trial name
- TREETOP (NCT02787213)
- Where
- 18 sites in United States
- Volunteers
- 5,011 people
- Sponsor
- Sera Prognostics, Inc.
Bronchopulmonary Dysplasia
Safety and Efficacy Evaluation of PNEUMOSTEM® Treatment in Premature Infants With Bronchopulmonary Dysplasia
PNEUMOSTEM® is human umbilical cord blood derived mesenchymal stem cells and it is intended to treat premature infants with bronchopulmonary dysplasia. This study is to assess the safety and the efficacy of this study drug.
- Trial name
- NCT01297205
- Testing
- Human Umbilical Cord Blood Derived-Mesenchymal Stem Cells
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- Medipost Co Ltd.
Obstetric Labor, Premature
Indomethacin Versus Nifedipine for Preterm Labor Tocolysis
Indomethacin and Nifedipine are commonly used medications for treatment of pre term labor. This study will compare the efficacy and adverse outcomes of oral nifedipine versus oral indomethacin for preterm labor tocolysis in an…
- Trial name
- NCT00486824
- Testing
- Indomethacin, Nifedipine
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Stanford University
Preterm Birth, Inflammation
Stress Phenotypes and Preterm Birth
Pregnancy ends in preterm birth (PTB) for approximately 1 in 10 women, though more often for Non-Hispanic Black women, 14.12% PTB rate, compared to 9.09% for Non-Hispanic White women.
- Conditions
- Preterm Birth, Inflammation, Stress, Mental Health Issue
- Trial name
- PTB (NCT05229666)
- Testing
- Cognitive Challenge
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Columbia University
Preterm Birth, Preterm Labor
To Optimize Antenatal Management of Women With Pre Term Labor Using Amniocentesis
Implementation of prediction models of risk of spontaneous delivery within 7 days or of intra-amniotic infection in women with preterm labor and intact membranes
- Conditions
- Preterm Birth, Preterm Labor, Intra-amniotic Infection, Amniocentesis Affecting Fetus or Newborn
- Trial name
- OPTIM-PTL (NCT04831086)
- Testing
- Steroid Drug, Tocolytic Agents
- Where
- Spain
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Pre Eclampsia, Eclampsia, Antepartum
BH4 Blood Levels Variations in Pre Eclamptic Women
tetrahydrobiopterin (BH4) is degraded by several enzymes, including BH4 oxidase and peroxidases. Several factors can affect its synthesis and degradation.
- Conditions
- Pre Eclampsia, Eclampsia, Antepartum, HELLP Syndrome (HELLP), Unspecified Trimester, Acute Renal Failure
- Trial name
- BH4P (NCT05847361)
- Testing
- BH4 blood level
- Where
- Tunisia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Premature Birth
Decision Making in Neonatology : a Qualitative Study
This study aimed to describe and understand the decision making process in neonatology in situations of limiting of withdraw life sustaining treatments, by conducting interviews with physicians from one neonatology unit.
- Trial name
- PRODA (NCT03323970)
- Testing
- semi-structured interviews
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Gastric Tube Placement
Correct Gastric Tube Placement in Very Low Birth Weight Neonates
Gastric tube (GT) placement is a recurrent procedure in VLBW infants due to feeding impairment correlated with low birth weight.
- Trial name
- NCT04127773
- Testing
- oro gastric tube
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Gestational Diabetes Mellitus in Pregnancy, Macrosomia, Fetal
Late Gestational Diabetes Mellitus Diagnosis in Obese Women
In the current work, we aim to perform a prospective study that will investigate the relationship between maternal obesity (BMI >30 kg/m2) and morbid obesity (BMI >35 kg/m2) with a late GDM diagnosis (>32 weeks), with an emphasis…
- Conditions
- Gestational Diabetes Mellitus in Pregnancy, Macrosomia, Fetal, Dystocia, Shoulder, Neonatal Jaundice
- Trial name
- NCT05510518
- Testing
- oral glucose tolerance test (OGTT)
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Western Galilee Hospital-Nahariya
Neonatal Death, Preterm Birth
SURVIVAL PLUSS: Increasing Capacity for Mama-baby Survival in Post-conflict Uganda and South Sudan
Universal coverage of good quality facility based care globally could prevent nearly 113,000 maternal deaths, 531,000 stillbirths and 1.3 million neonatal deaths annually by 2020.
- Conditions
- Neonatal Death, Preterm Birth, Low Birthweight, Neonatal Hypoglycemia
- Trial name
- NCT02605369
- Testing
- Intervention arm: An integrated package
- Where
- Uganda
- Volunteers
- 1,877 people, healthy volunteers welcome
- Sponsor
- Makerere University
Preterm Birth, Breastfeeding
Phone Breastfeeding Support for Premature Babies
It was observed that premature babies had the risk of insufficient milk intake and a lower rate of breastfeeding compared to term babies.
- Trial name
- NCT04883866
- Testing
- Telephone Breastfeeding Support Program, Sending a breastfeeding guide for premature babies to the phone of mothers in addition to the routine discharge procedure
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Post Partum Hemorrhage, Fibrinogenolysis; Hemorrhage
Patient Blood Management for Massive Obstetric Hemorrhage
Obstetric Hemorrhage continues to be the first cause of maternal morbidity and mortality around the world especially in middle to low income countriesThe blood components are high value resources; however, its use has been shown…
- Conditions
- Post Partum Hemorrhage, Fibrinogenolysis; Hemorrhage, Fibrinogen; Deficiency, Acquired, Massive Hemorrhage
- Trial name
- NCT03784794
- Testing
- Thromboelastometry, Standard Coagulation Test, Fibrinogen Concentrate Human
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Angel Augusto Perez Calatayud
Small for Gestational Age at Delivery, Low Birth Weight
Effect of a Fortified Balanced Energy-Protein Supplement on Birth Outcome and Child Growth in Houndé District, Burkina Faso.
The 2016 WHO antenatal care guidelines stated that pregnant women in undernourished populations should receive fortified balanced energy-protein (BEP) supplements to reduce the risk of stillbirth and small-for-gestational-age…
- Conditions
- Small for Gestational Age at Delivery, Low Birth Weight, Prematurity, Infant Malnutrition
- Trial name
- MISAME-3 (NCT03533712)
- Testing
- Fortified balanced energy-protein (BEP) supplement, Fe and folic acid supplement
- Where
- Burkina Faso
- Volunteers
- 1,788 people, healthy volunteers welcome
- Sponsor
- University Ghent
Placenta Accreta, Third Trimester
A Serum Galectin-3 Levels in Placenta Accreta Spectrum Pregnancies
Placenta Accreta Spectrum (PAS) represents a significant cause of maternal morbidity and mortality, causing complications that surpass those posed by most routine obstetric issues.
- Trial name
- NCT05945446
- Testing
- Galectin 3
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Hemorrhage; Complicating Delivery
Combined Use of Oxytocin and Misoprostol in the Prevention of Post Partum Haemorrhage
To demonstrate that the combined used of oxytocin and misoprostol prevent from post partum haemorrhage better than oxytocin alone, following vaginal birth at 36 to 42 weeks.
- Trial name
- CYTOCINON (NCT01113229)
- Testing
- Misoprostol
- Where
- France
- Volunteers
- 1,721 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris