Clinical trials: Obstetrics
Hypertension in Pregnancy, Obstetrical Complications
Gestational Hypertension and Preeclampsia Blood Pressure (BP) Treatment Goals Less Than 140/90 vs. Less Than 160/110 mmHg: The GOALPOST Trial
This is a phase-III multi-center open-label randomized clinical trial of 4,120 individuals between 23 weeks, 0 days and 35 weeks, 6 days gestation with gestational hypertension or preeclampsia without severe features randomized…
- Trial name
- GOALPOST (NCT07746271)
- Testing
- Anti-hypertensive medication titrated to a BP goal of <140/90 mmHg, Usual Care: Anti-hypertensive medication for BP ≥160/110 mmHg titrated to a goal of < 160/110 mmHg
- Where
- 14 sites in United States
- Volunteers
- 4,120 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Labor Pain
A Novel Approach to Optimize Programmed Intermittent Epidural Bolus (PIEB) Delivery for Labour Analgesia
Programmed intermittent epidural bolus (PIEB) for labour analgesia allows an epidural pump to be programmed to deliver small amounts of the local anesthetic and opioid solution at regularly timed intervals.
- Trial name
- NCT03871530
- Testing
- Coordinate A, Coordinate B, Coordinate C
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- IWK Health Centre
Vacuum Extraction, Obstetrical, Randomized Controlled Trials
a Randomized Multicenter Trial Comparing Vacuum Assisted Delivery With the New Device "iCUP" Versus the Reference Cup.
The hypothesis is that the new vacuum assisted delivery device iCup is more effective than the reference cup, in terms of maternal and newborn morbidities and functioning
- Conditions
- Vacuum Extraction, Obstetrical, Randomized Controlled Trials, Failures, Medical Device, Maternal Lesions
- Trial name
- ICUP (NCT01058200)
- Testing
- iCup, reference cup
- Where
- 6 sites in France
- Volunteers
- 668 people
- Sponsor
- University Hospital, Grenoble
Gestational Diabetes Mellitus (GDM)
Implementation and Evaluation of Bump2Baby and Me+ Programme for Gestational Diabetes Mellitus in Routine Maternity Care Setting.
Gestational diabetes mellitus (GDM) affects approximately 1 in 7 pregnancies globally and is associated with significant short and long-term health consequences for both mothers and infants.
- Trial name
- B2B&ME+ (NCT07189221)
- Testing
- Life Style Intervention
- Volunteers
- 3,600 people
- Sponsor
- University College Dublin
Analgesia, Analgesics, Opioid
Dexmedetomine as Adjuvant for Spinal Anesthesia in Elective Cesarian Sections : a Pilot Study
The proposed pilot study is a prospective, randomized, controlled, double-blind, single-center pilot study.The aim of this pilot project is to evaluate the feasibility of a phase III study on the use of dexmedetomidine in…
- Conditions
- Analgesia, Analgesics, Opioid, Anesthesia, Obstetrical, Anesthesia, Spinal
- Trial name
- NCT05099055
- Testing
- Dexmedetomidine 0.004 MG/ML [Precedex], Opioids
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- St. Justine's Hospital
Bacterial Vaginosis
A Prospective, Randomized Controlled Study of the Probiotics as Adjuvant Treatment for Bacterial Vaginosis
The investigators are trying to determine if oral Probiotics(Umeta-mimi,30 days) with Metronidazole vaginal suppositories (7 days) is better than using Metronidazole vaginal suppositories(7 days) only in preventing the recurrence…
- Trial name
- NCT04771728
- Testing
- Metronidazole vaginal suppositories, Metronidazole vaginal suppositories and Probiotics(Umeta-mimi)
- Where
- China
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Peking University Shenzhen Hospital
Pregnancy
BIOmetric MEasurements in Diagnostics: Comparison of EXperts and IA-assisted Residents
Obstetric ultrasound is the cornerstone of fetal growth assessment. It provides essential biometric measurements for estimating fetal weight, monitoring growth and identifying conditions such as intrauterine growth retardation…
- Trial name
- BIOMEDEXIA (NCT06892327)
- Testing
- standard biometric ultrasound
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Pregnancy Related, Cardiac Disease
The Heart Outcomes in Pregnancy Expectations (H.O.P.E) Registry
Prospective US registry of pregnant women with cardiac disease to address the substantial gaps in knowledge surrounding these patients, in order to improve future care.
- Trial name
- NCT04828070
- Testing
- Observation
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Saint Luke's Health System
Maternal Sepsis, Intensive Care Units
Epidemiological Investigation of Sepsis in Obstetrics Admitted to ICU
Sepsis is still the main cause of maternal death, accounting for 11% of maternal deaths. Early identification of high risk factors of sepsis and early intervention can improve the prognosis of pregnant women with sepsis.
- Conditions
- Maternal Sepsis, Intensive Care Units, Drug Resistance, Multiple
- Trial name
- NCT05055388
- Testing
- Multidrug-resistant bacteria
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Peking University Third Hospital
Pregnancy
The Effect of Birth Plans on Obstetrical Outcomes
The study design is a prospective, single institution, randomized control trial in which the introduction of a birth plan is the intervention and a comparison of the rate of Caesarean sections between participants in the control…
- Trial name
- NCT02526459
- Testing
- Birth plan
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Saskatchewan Health Authority - Regina Area
Anesthesia,Obstetrical
Palpation and ACCURO for Placing Spinal in C-section
The Accuro is a three dimensional handheld ultrasound device. This device uses sound waves to create pictures of the spine in three dimensions.
- Trial name
- NCT03090295
- Testing
- Palpation and Accuro
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Virginia
Severe Infection
Validation of the Quick Sequential [Sepsis-related] Organ Failure Assessment (qSOFA) in Obstetric Patients
Research problem: In 1991, the terms Systemic Inflammatory Response Syndrome (SIRS), severe sepsis, and septic shock were introduced, based on the pro-inflammatory theory, conforming to a list of classification criteria for each…
- Trial name
- COLOSSAL (NCT04621539)
- Where
- Colombia
- Volunteers
- 2,125 people
- Sponsor
- Fundación Grupo de Investigación en Cuidados Intensivos y Obstetricia
Unexpected Delivery Outside Maternity
Observatory of Unintentional Births Hospital Extras
In France, pre-hospital unexpected birth is a rare situation, but over the last ten years, the investigators have seen an increase in the number of these.
- Trial name
- AIEH34 (NCT03820505)
- Where
- France
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Spermatozoa, Fertility
Dissect Assembly Rules of SPET12 Complex in the Mammalian Sperm
The sperm of the KO mouse shothe investigatorsd severe defects of all found compartments: acrosome, nucleus, midpiece and tail. The investigators also found SEPT12 co-localizes and interact with SEPT1, 2, 4, 6, 7, 10, 11, and 14…
- Trial name
- NCT04159402
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Obstetrics, Maternal Morbidity
Activity and Quality of Care Indicators' for a Sentinel Network Creation
There is no large-scale data in France or internationally, on the quality of care in gynecological emergencies, or the consequences of delay or misdiagnosis of women's health or on determinants of these delays or misdiagnosis.
- Conditions
- Obstetrics, Maternal Morbidity, Gynecology, Quality
- Trial name
- URGO (NCT02274441)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertensive Disorder of Pregnancy
Thriving Hearts: Healing-Centered, Integrated, Community Maternity Care
The overarching goal of Thriving Hearts is to implement a multi-level program through Local Health Departments (LHDs) that cultivates conditions for mothers and birthing people to not only survive pregnancy, but to thrive.
- Trial name
- NCT06744231
- Testing
- Usual Care, Thriving Hearts
- Where
- United States
- Volunteers
- 17,500 people
- Sponsor
- University of North Carolina, Chapel Hill
Analgesia, Obstetrical, Obstetric Surgical Procedures
Spinal Morphine vs. Hydromorphone for Pain Control After Cesarean Delivery
Intrathecal (IT) opioids are commonly administered with local anesthetic during spinal anesthesia for post-Cesarean delivery analgesia. Traditionally, IT morphine has been used but the use of IT hydromorphone is growing.
- Trial name
- NCT02789410
- Testing
- Morphine, Hydromorphone
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Mayo Clinic
Monochorionic Diamniotic Placenta, Monochorial Monoamniotic Placenta
MoDi Twin Placental Imaging
Twin-twin transfusion syndrome (TTTS) can arise in monochorionic, diamniotic (MoDi), those identical twins arising from division of a single fertilized ovum at 4-8 days gestational age (GA) or monochorionic, monoamniotic (MoMo or…
- Conditions
- Monochorionic Diamniotic Placenta, Monochorial Monoamniotic Placenta, Monochorionic Twins, Ultrasound Doppler
- Trial name
- NCT07667647
- Testing
- Verasonics Vantage 256 Ultrasound
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Carilion Clinic
Blood Donors, Anti-HLA Antibody
Obstetrical History and Anti-HLA Antibodies Level
Chronic histiocytic intervillositis (CHI) is associated with severe and recurrent obstetrical complications. A link between anti-HLA Antibodies (Ab) and CHI has recently been established.
- Trial name
- OBS-HLA (NCT06021925)
- Testing
- Obstetrical history, Anti-HLA Antibody tests
- Where
- France
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Labor Pain
The Effect of a Culturally Sensitive Educational Intervention on Acceptance of Neuraxial Anesthesia
The purpose of this study is to see if an educational intervention provided to pregnant women in early labor has an effect on their decision to use epidural anesthesia for relief of labor pain.
- Trial name
- NCT02672397
- Testing
- Additional Epidural Education
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Oregon Health and Science University