Clinical trials: Obstetrics
Antiphospholipid Syndrome
Comparative Prevalence of Psychiatric Manifestations in Purely Obstetrical Antiphospholipid Syndrome
The main objective of this study is to estimate the lifetime prevalence of major psychiatric disorders (axis I DSM-IV; Diagnostic and Statistical Manual of Mental Disorders, version IV) in a large sample of patients with…
- Trial name
- MENT-APL-O (NCT01649479)
- Testing
- Antiphospholipid antibody tests, Thrombophilia bloodwork, Psychiatric evaluation
- Where
- 5 sites in France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Preeclampsia
Preeclampsia Ratio (sFlt-1/PlGF)
The aim of the PRECOG study is to determine in a prospective interventional randomized study whether the implementation of a predictive test based on the sFLT-1/PlGF ratio improves perinatal care and reduces costs, in patients…
- Trial name
- PRECOG (NCT03289611)
- Testing
- sFlt-1 / PlGF ratio
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Labor Pain, Analgesia, Epidural
Comparing PIEB and CEI for Labor Pain Relief
The purpose of this randomized controlled trial is to compare the efficacy and safety of two epidural analgesia maintenance methods for labor pain relief: Programmed Intermittent Epidural Bolus (PIEB) and Continuous Epidural…
- Conditions
- Labor Pain, Analgesia, Epidural, Analgesia, Obstetrical, Labor, Obstetric
- Trial name
- COPILOT (NCT07395934)
- Testing
- PIEB + PCEA, CEI + PCEA
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Da Nang Family General Hospital
High Risk Pregnancy, Cesarean Wound Disruption With Postnatal Complication
Negative Pressure Wound Therapy to Prevent Wound Complications Following Cesarean Section in High Risk Patients
This is a randomized controlled trial. Patients with a condition that increases their risk of a wound complication will be approached for inclusion in the trial.
- Trial name
- NCT03082664
- Testing
- PICO Single Use Negative Pressure Wound Therapy
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- University of Arizona
Analgesia, Obstetrical, Coagulation Defect; Postpartum
IV Ketorolac on Platelet Function Post-Cesarean Delivery
Cesarean delivery has become the most common surgical procedure in the US. Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to improve the quality of post-cesarean analgesia and markedly reduce opioid consumption.
- Conditions
- Analgesia, Obstetrical, Coagulation Defect; Postpartum, Nonsteroidals (NSAIDs)Toxicity, Postpartum Hemorrhage
- Trial name
- KetoPltAgg (NCT03805607)
- Testing
- Ketorolac Tromethamine 30 MG/ML
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Birth
Management of Obstetrical Pain: " 7 Days Survey of Obstetric Analgesia/Anesthesia in France"
Obstetric analgesia is a requirement of our times. The different applicable methods vary in effectiveness. The essential part is represented by epidural analgesia which remains one of the most effective methods.
- Trial name
- Epidol (NCT02853890)
- Testing
- Questionnaires during hospitalization for delivery
- Where
- France
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Endometrial Carcinoma Stage I, Atypical Endometrial Hyperplasia
Patient-derived Tumor-like Cell Clusters Predict Progesterone Sensitivity in Patients With Early Endometrial Cancer
To construct a prediction model of progesterone sensitivity in patients with endometrial cancer treated with fertility preservation
- Trial name
- NCT05647109
- Testing
- No intervention
- Where
- China
- Volunteers
- 244 people
- Sponsor
- Peking University People's Hospital
Obesity, Inflammation
Inflammasome Activation and Cortisol Metabolism in Obese Women With Recurrent Miscarriage
The prevalence of obesity among women of reproductive age is increasing. Obesity represents a chronic low-grade inflammatory state and NLRP3 inflammasome plays a pivotal role in obesity-induced inflammation.
- Trial name
- NCT04275674
- Where
- Taiwan
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
How Pregnant and Postnatal Women With Two or More Long-term Health Conditions Experience Midwifery Care as Part of Multi-disciplinary Maternity Care
MultIple Long-term Conditions in Pregnancy and Experiences of Midwifery Care
This is a qualitative study using in-depth semi-structured interviews. This study will explore pregnant women with two or more long-term health condition's (MLTC) experience of midwifery care and midwives and health professionals…
- Trial name
- MILLENIA (NCT07207759)
- Volunteers
- 80 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Refugee, Asylum-seeking Women
Maternity Care Experiences of Asylum-seeking and Refugee Women in Scotland
The International Organisation of Migration reports that over half (52.4%) of international migrants in Europe are women. Evidence suggests that women with immigrant backgrounds often struggle to access healthcare across the…
- Conditions
- Refugee, Asylum-seeking Women, Maternity
- Trial name
- MACAWS (NCT06354751)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Aberdeen
Weight Stigma, Pregnancy Outcomes
EMBodied psychOsocial Impacts of Weight Stigma During Pregnancy (EMBODY): A Prospective Cohort Study
The goal of this prospective cohort study is to investigate the contribution of stigma and discrimination due to body size to adverse pregnancy outcomes.
- Conditions
- Weight Stigma, Pregnancy Outcomes, Overweight and Obesity
- Trial name
- EMBODY (NCT06531694)
- Where
- 2 sites in Australia
- Volunteers
- 800 people
- Sponsor
- Monash University
Critical Illness, Difficult; Intubation, Postpartum, During Puerperium
Ultrasound Airway Assessment of Critically Ill Preeclamptic; Comparison Between Two Technique
Unexpected difficult airway exposes the patient to serious morbidity and even mortality. The changes in pregnancy and preeclampsia increase the risk of difficult intubation.
- Conditions
- Critical Illness, Difficult; Intubation, Postpartum, During Puerperium, Pre-Eclampsia
- Trial name
- NCT06651879
- Testing
- techniques of ultrasound examination of the airway
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Labor Pain
Development and Validation of Metrics Lumbar Labor Epidural Catheter Placement
Procedural skills play an important role in anaesthetic expertise. More focused training and assessment of procedural skills will be needed in the future as training moves from an apprenticeship based training system to…
- Trial name
- NCT02179879
- Testing
- Video validation
- Where
- Ireland
- Volunteers
- 20 people
- Sponsor
- Cork University Hospital
Hysteroscopy Surgery, Informed Consent
Assessing the Impact of a Patient Education Platform to Augment the Informed Consent Process for Obstetrics and Gynecology Procedures
Over the past few decades, there has been a shift in the informed consent process, whereby the focus is centered on patient comprehension, preparedness and satisfaction.
- Trial name
- NCT04614688
- Testing
- Patient Education Platform
- Volunteers
- 78 people
- Sponsor
- Unity Health Toronto
Normal Fetal Brain Morphology
Evaluation of Brain Volume and Dimensions in Healthy Fetuses Using Obstetrics Ultrasound Examination at 14-34 Weeks of Pregnancy.
The aim of this study is to evaluate the "normal" development of cerebral cortex with quantitative measurement in low risk pregnant women
- Trial name
- NCT03186807
- Testing
- ultrasonographic scan of fetal brain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Postpartum Care, Maternal Health Care
Effect of a Respectful Maternity Care-Based Action Plan in Postpartum Care on Maternal and Neonatal Outcomes
This study will examine whether a Respectful Maternity Care-based action plan can improve the quality of postpartum care and maternal and newborn outcomes.
- Conditions
- Postpartum Care, Maternal Health Care, Newborn Health, Postpartum Depression (PPD)
- Trial name
- NCT07280000
- Testing
- Respectful Maternity Care Training and Action Plan
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- ilayda sel
Polycystic Ovary Syndrome
Effects of Oral Inositol Supplementation on Obstetrics Outcomes in PCOS Women
Polycystic ovarian syndrome (PCOS) is a heterogeneous, multifaceted and complex disorder characterized by insulin resistance (IR), hyperinsulinemia, and hyperandrogenism leading ovarian disfunction and infertility.
- Trial name
- IPOSI-1 (NCT03585738)
- Testing
- Inositol + Folic acid, Folic acid
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Università degli Studi dell'Insubria
Chronic Diseases in Pregnancy
Pregnancy and Chronic Disease: The Effect of a Midwife-coordinated Maternity Care Intervention
The number of pregnant women affected by chronic diseases such as epilepsy, hypertension and thyroid disease is rising, and in the Danish population 15 % of all pregnant women had a chronic disease in 2016.
- Trial name
- ChroPreg (NCT03511508)
- Testing
- ChroPreg + standard care
- Where
- Denmark
- Volunteers
- 262 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Duration of Labor
Obstetrical Gel and Its Impact in Shortening the Duration of Labor in Women Undergoing a Vaginal Birth After Cesarean (VBAC)
The objective of our study is to investigate whether the use of obstetric gel shortens the first and second stage of labor and exerts a protective effect on the lower genital tract in women undergoing a Vaginal Birth After…
- Trial name
- NCT03751553
- Testing
- obsteric gel(k-Y jelly)
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pregnancy, Labor Pain
Does Ultrasound of the Spine Improve Labor Epidurals/Spinal Anesthesia in Obstetric Patients?
The investigators are interested in determining the utility of ultrasound of the spine for labor epidurals or spinal anesthesia for women in labor or having a cesarean delivery.
- Trial name
- NCT01243216
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia