Clinical trials: Obstruction of Biliary Tree, open to volunteers
Non-invasive Diffusion-weighted Imaging, Magnetic Resonance Cholangiopancreatography
Non-invasive Diffusion-weighted Imaging With MRCP in the Diagnosis of Neoplastic Biliary Obstruction
This study aims to evaluate the diagnostic value of non-invasive diffusion-weighted magnetic resonance imaging (DW-MRI) in detecting neoplastic biliary obstruction.
- Conditions
- Non-invasive Diffusion-weighted Imaging, Magnetic Resonance Cholangiopancreatography, Diagnosis, Neoplastic Biliary Obstruction
- Trial name
- NCT07108725
- Testing
- Magnetic Resonance Cholangiopancreatography
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- The General Authority for Teaching Hospitals and Institutes
Biliary Obstruction, Acute Cholecystitis
Prevention of Acute Cholecystitis With ETGBD
The goal of this clinical trial is to learn about Efficacy of the ETGBD parallel insertion with fully covered self-expandable metal stent for preventing acute cholecystitis in patients with low cystic duct insertion.
- Trial name
- NCT06287112
- Testing
- Endoscopic transpapillary gallbladder drainage (ETGBD)
- Where
- South Korea
- Volunteers
- 35 people
- Sponsor
- Seoul National University Hospital
Fragility, Biliary Obstruction
Sedation Methods in Percutaneous Transhepatic Biliary Drainage: Procedure Quality and Recovery
This prospective, randomized, single-center study aims to evaluate and compare two different sedation and analgesia regimens used during percutaneous transhepatic biliary drainage (PTBD) procedures.
- Conditions
- Fragility, Biliary Obstruction, Cholangitis, Malignancy
- Trial name
- NCT07640243
- Testing
- Remifentanil, Ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Ankara City Hospital Bilkent
Incarcerated Hernia, Appendicitis Acute
Prevention of Postoperative Hernias in Emergency Surgery
The aim of this observational study is to understand the risk factors and incidence of postoperative hernias among patients undergoing emergency surgery.
- Conditions
- Incarcerated Hernia, Appendicitis Acute, Cholecystitis, Acute, Ileus
- Trial name
- PROPHECY (NCT06815822)
- Where
- Poland
- Volunteers
- 500 people
- Sponsor
- Jan Kochanowski University
Malignant Biliary Obstruction, Advanced Pancreatic Cancer and Cholangiocarcinoma
Improving a Bile Duct Drainage Procedure in Patients With Inoperable Cancer Blocking the Bile Ducts: Comparing Two Types of Endoscopically Placed Internal Stents to Prevent Blockage of a Lumen Apposing Metal Stent
This study looks at the best way to treat bile duct blockage in people with advanced cancer that cannot be removed by surgery. A blocked bile duct can cause serious symptoms like yellowing of the skin (jaundice), infection, and…
- Conditions
- Malignant Biliary Obstruction, Advanced Pancreatic Cancer and Cholangiocarcinoma, Inoperable Malignant Biliary Obstruction, Lumen Apposing Metal Stents
- Trial name
- Opti-LAMS (NCT07115420)
- Testing
- Fully covered self expanding metal stent (FCSEMS) within LAMS, Double pigtail stent (DPS) within LAMS
- Where
- New Zealand
- Volunteers
- 100 people
- Sponsor
- Waikato Hospital
Choledocholithiasis With Cholecystitis With Obstruction, Obstructive Jaundice
Supraglottic Oxygenation Via Oral Transtracheal Catheter for Reducing the Incidence of Hypoxemia During ERCP Under Sedation
Endoscopic retrograde cholangiopancreatography (ERCP) is commonly used for the diagnosis and treatment of pancreatobiliary diseases.
- Conditions
- Choledocholithiasis With Cholecystitis With Obstruction, Obstructive Jaundice, Pancreatitis, Cholelithiasis
- Trial name
- NCT07637721
- Testing
- The Supraglottic Oxygenation Via Oral Transtracheal Catheter Group, The Regular Nasal Cannula
- Where
- 3 sites in China
- Volunteers
- 410 people
- Sponsor
- Zhejiang University
Cholelithiasis
Effect of Erector Spinae Plane Block on Postoperative Respiratory Function After Laparoscopic Cholecystectomy
Postoperative pulmonary dysfunction is frequently observed after laparoscopic abdominal surgery due to the combined effects of general anesthesia, pneumoperitoneum, diaphragmatic dysfunction, and postoperative pain.
- Trial name
- ESP-LC (NCT07478601)
- Testing
- Erector Spinae Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Uludag University
Biliary Tract Neoplasms, Biliary Drainage
Suprapapillary Versus Transpapillary Plastic Stents for Unresectable Malignant Hilar Biliary Obstruction
Bile duct blockage caused by cancer near the liver hilum (where the bile ducts join) leads to jaundice and infection. The standard treatment is to place a plastic stent (a small tube) through an endoscope to drain the bile.
- Conditions
- Biliary Tract Neoplasms, Biliary Drainage, Malignant Biliary Obstruction, Obstructive Jaundice
- Trial name
- NCT07811791
- Testing
- Suprapapillary plastic stent placement, Transpapillary plastic stent placement
- Where
- 8 sites in Taiwan
- Volunteers
- 70 people
- Sponsor
- National Taiwan University Hospital
Gallbladder Diseases, Cholelithiasis
Impact of Pringle Maneuver on Postoperative Gallbladder Diseases After Hepatectomy
The liver is an organ with a rich blood supply. During liver surgery (hepatectomy), surgeons often temporarily clamp the blood vessels supplying the liver to maintain a clear surgical field and reduce bleeding.
- Trial name
- NCT07452848
- Testing
- Pringle maneuver
- Where
- 8 sites in China
- Volunteers
- 2,000 people
- Sponsor
- West China Hospital
Malignant Biliary Obstruction, Malignant Biliary Stricture
Endoscopic Ultrasound Guided Hepaticogastrostomy With or Without Antegrade Stenting for Palliation of Malignant Distal Biliary Obstruction: Randomized Controlled Trial
The purpose of this study is to compare the efficacy and safety between EUS-HGAS and EUS-HGS. We hypothesized that EUS-HGAS provides lower recurrent biliary obstruction (RBO) rate but with a comparable safety profile to EUS-HGS.
- Trial name
- EASE-MBO (NCT07832045)
- Testing
- HGAS, HGS
- Where
- Taiwan
- Volunteers
- 88 people
- Sponsor
- National Taiwan University Hospital
Acute Appendicitis, Acute Cholecystitis
Web-based International Register of Emergency Surgery and Trauma
The WIRES-T project (Web-based International Registry of Emergency General Surgery and Trauma) has been set up to allow to all the EGS (Emergency General Surgery) and Trauma surgeons to register their activity and to obtain a…
- Conditions
- Acute Appendicitis, Acute Cholecystitis, Acute Diverticulitis, Post-operative Complications
- Trial name
- WIRES-T (NCT03643718)
- Testing
- Emergency General Surgery
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Common Bile Duct Calculi, Acute; Cholecystitis, Choledocholithiasis
Modified Laparoscopic Transcystic Biliary Drainage in the Management of Cholecystocholedocholithiasis
The modified laparoscopic transcystic biliary drainage which we developed in the treatment of cholecystocholedocholithiasis has some advantages over conventional techniques.
- Conditions
- Common Bile Duct Calculi, Acute; Cholecystitis, Choledocholithiasis, Acute Cholecystitis With Obstruction, Acute Cholangitis
- Trial name
- NCT06011941
- Testing
- Modified laparoscopic transcystic biliary drainage
- Where
- China
- Volunteers
- 310 people
- Sponsor
- Peking University Third Hospital
Malignant Distal Biliary Obstruction, Malignant Biliary Obstruction
12-mm Partial Covered Versus Bare Self-Expandable Metallic Stents for Malignant Distal Biliary Obstruction
Metallic stents are commonly used for biliary drainage in patients with unresectable malignant distal biliary obstruction. However, it is unclear whether a 12-mm partially covered self-expandable metallic stent or a 12-mm bare…
- Conditions
- Malignant Distal Biliary Obstruction, Malignant Biliary Obstruction, Biliary Obstruction
- Trial name
- PCSEMS-12 (NCT07559968)
- Testing
- 12-mm partially covered self-expandable metallic stent, 12-mm bare self-expandable metallic stent
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Chung-Ang University Hospital
Pancreatic Cancer
Preoperative Biliary Drainage in Malignant Biliary Obstruction
The first alarming symptom of a malignancy of the pancreas or periampullary tumor can be obstructive jaundice (OJ). Pancreato-duodenectomy (PD) combined with oncological treatment can provide long disease-free survival in…
- Trial name
- PEAR (NCT04847297)
- Testing
- Preoperative drainage and pancreatoduodenectomy, Pancreatoduodenectomy
- Volunteers
- 353 people
- Sponsor
- University of Pecs
Pancreatic Cancer, Hepatocellular Cancer
Durvalumab and Tremelimumab in Combination With Propranolol and Chemotherapy for Treatment of Advanced Hepatopancreabiliary Tumors (BLOCKED)
A single-arm, interventional study combining Immunotherapy and propranolol with/without chemotherapy and propranolol 1. Pancreatic Cancer Durvalumab will be administered once every 4 weeks, in combination with gemcitabine +…
- Conditions
- Pancreatic Cancer, Hepatocellular Cancer, Biliary Tract Cancer, Cholangiocarcinoma
- Trial name
- NCT05451043
- Testing
- Durvalumab, Gemcitabine, Nab paclitaxel
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- AHS Cancer Control Alberta
Pancreatic Cancer, Malignant Biliary Obstruction
Comparison of a Short Modified Metal Stent Versus Plastic Stent as a Bridge to Surgery in Pancreatic Cancer With Malignant Biliary Obstruction
This study is a multicenter, randomized clinical trial designed to compare the effectiveness and safety of a modified 8-mm fully covered self-expandable metal stent (FCSEMS) with a conventional plastic stent for preoperative…
- Trial name
- BRIDGE-8 (NCT07606430)
- Testing
- Modified 8-mm Fully Covered Self-Expandable Metal Stent, Plastic stent
- Volunteers
- 116 people
- Sponsor
- Soonchunhyang University Hospital
Biliary Obstruction, Acute Cholecystitis
Gallbladder Stenting in FC-SEMS
The goal of this randomized controlled trial is to determine whether primary prophylaxis with transpapillary gallbladder drainage prevents acute cholecystitis after fully-covered self-expandable metal stents placement during…
- Trial name
- NCT06820541
- Testing
- Double plastic pigtail stent plus fully covered self-expandable metal stent, Fully covered self-expandable metal stent
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Malignant Biliary Obstruction
EUS-guided Hepatico-gastrostomy Using a Novel Lumen Apposing Metal Stent
EUS-guided biliary drainage is gaining popularity as a means of achieving endoscopic drainage in patients with failed endoscopic retrograde cholangiopancreatography (ERCP) 1.
- Trial name
- NCT05169398
- Testing
- EUS-guided hepaticogastrostomy
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
Acute Cholangitis, Biliary Tract Infection
Comparative Efficacy Of Intraductal Antibiotic During ERCP In Acute Cholangitis
Does intraductal administration of antibiotics during endoscopic retrograde cholangiopancreatography (ERCP), in addition to standard systemic antibiotic therapy, improve clinical outcomes in patients with acute cholangitis…
- Conditions
- Acute Cholangitis, Biliary Tract Infection, Biliary Obstruction, Choledocholithiasis
- Trial name
- NCT07407491
- Testing
- Gentamicin - single dose, Distilled water
- Where
- Malaysia
- Volunteers
- 172 people
- Sponsor
- National University of Malaysia
Biliary Obstruction
Safety and Efficacy of Mechanical Versus Electrocautery Dilator for EUS-guided Biliary Drainage (MED-BD)
The purpose of this study is to investigate the likelihood of post-dilation bleeding using mechanical or electrocautery dilation. We hypothesized that the risk of bleeding is lower in the mechanical group.
- Trial name
- MED-BD (NCT06620328)
- Testing
- endoscopic ultrasonography-guided biliary drainage
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- National Taiwan University Hospital