Clinical trials: Obstructive Airway Diseases
Sleep Apnea, Obstructive
Dexmedetomidine and Propofol in Children With History of Obstructive Sleep Apnea
The purpose of this research study is to examine the effects of two commonly used anesthetic drugs, dexmedetomidine and propofol, have on the shape and muscle tone of the upper airway in children, adolescents, and young adults…
- Trial name
- NCT01344759
- Testing
- Dexmedetomidine, Propofol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Chronic Obstructive Pulmonary Disease, COPD
A Safety, Tolerability and Efficacy Study With QBW251 in COPD Patients With QBW251
To evaluate the efficacy, safety and tolerability of multiple doses of QBW251 vs placebo administered orally, on airway function, lung volume, and quality of life in patients with chronic obstructive pulmonary disease (COPD)
- Trial name
- NCT02449018
- Testing
- QBW251
- Where
- 16 sites in United States, Poland
- Volunteers
- 92 people
- Sponsor
- Novartis Pharmaceuticals
Metabolic Syndrome, Insulin Resistance
Impact of Obstructive Sleep Apnea Syndrome on Metabolic Syndrome in Severe Obesity
The aim of this project is to study the relationship between obstructive sleep apnea (OSA) and metabolic syndrome (MS) in a population of obese patients who are candidates for bariatric surgery.
- Conditions
- Metabolic Syndrome, Insulin Resistance, Adipokines, Cytokines
- Trial name
- SYBILA (NCT01029561)
- Testing
- CPAP, Diet
- Where
- Spain
- Volunteers
- 126 people
- Sponsor
- Hospital Universitari de Bellvitge
Asthma, Healthy
Factors Involved in Asthma and Airway Inflammation
Asthma is the third leading cause of preventable admissions to the hospital in the United States. Deaths and diseases associated with asthma increase every year. Asthma is a disorder of airway inflammation.
- Trial name
- NCT00001887
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Asthma
Modulation Of Airway Reactivity With Chronic Mechanical Strain
The purpose of this study is to see if the use of a machine called CPAP will help children with asthma breathe better. CPAP is a machine that produces airflow to help people with breathing problems.
- Trial name
- NCT02396849
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Indiana University
Community Acquired Pneumonia, Bronchiolitis
HVNI vs CPAP in Children With Acute Respiratory Distress
Acute breathing problems are a common reason for children to be admitted to the pediatric intensive care unit, and many of these children need breathing support without a breathing tube.
- Trial name
- P-HVNI-CPAP (NCT07336121)
- Testing
- High Velocity Nasal Insufflation (HVNI), Nasal Continuous Positive Airway Pressure (Nasal CPAP)
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Obstructive Sleep Apnea
Diurnal Evaluation of OSA Upper Airway Collapsibility and Muscle Responsiveness
In the framework of pathophysiological trait in obstructive sleep apnea (OSA) patients, a simplified method is proposed to measure upper airway (UA) collapsibility and muscle responsiveness during wakefulness.
- Trial name
- Muscle-OSA (NCT06334601)
- Testing
- Tests of upper airway collapsibility and muscle responsiveness.
- Where
- Italy
- Volunteers
- 66 people
- Sponsor
- Istituto Auxologico Italiano
Atrial Fibrillation (AF), OSA - Obstructive Sleep Apnea
Impact of Atrial Fibrillation Ablation on Sleep Parameters.
Assessment of Sleep Parameters Using Polygraphy in Patients with Paroxysmal Atrial Fibrillation Qualified for Pulmonary Vein Isolation - A Prospective Observational Study: Afib Ablation and Hypopnea Index - The "AAHI" Study…
- Conditions
- Atrial Fibrillation (AF), OSA - Obstructive Sleep Apnea, Pulmonary Vein Isolation
- Trial name
- AAHI (NCT07259200)
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Primula Clinics
Obstructive Sleep Apnea
Effect of CPAP Treatment in Women With Moderate-to-severe OSA.
The purpose of this study is to determine whether Continuous Positive Airways Pressure (CPAP) improves quality of life, cardiovascular (blood pressure) and metabolic profile (glucose and lipid metabolism) in females with…
- Trial name
- NCT02047071
- Testing
- Continuous positive airways pressure
- Where
- Spain
- Volunteers
- 307 people
- Sponsor
- Francisco Campos-Rodriguez
Obesity, Bariatric Surgery
Obesity: Prospective Evaluation of Upper Airway Obstruction and Compliance in Obese Patients in Pre and Post Bariatric Surgery
This clinical trial is a monocentric, prospective, observational and controlled trial (historical cohort control group of healthy non-obese subjects who had Nasal functional exploration for Snoring) as part of current care.
- Trial name
- OBANEZ (NCT03360565)
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sleep Apnea
Non-Inferiority Study of the FRESCA Airbox Positive Airway Pressure System
Prospective, open-label, randomized crossover assignment, multi-center non-inferiority study conducted in the United States
- Trial name
- NCT03999944
- Testing
- positive airway pressure system
- Where
- 6 sites in United States
- Volunteers
- 52 people
- Sponsor
- FRESCA Medical
Chronic Obstructive Pulmonary Disease, Pulmonary Emphysema
Volumetric HRCT in Stable COPD Patients.
This study evaluates the role of volumetric high-resolution computed tomography (HRCT) of the chest in assessing patients with stable chronic obstructive pulmonary disease (COPD).
- Conditions
- Chronic Obstructive Pulmonary Disease, Pulmonary Emphysema, Airway Obstruction
- Trial name
- NCT07809399
- Testing
- Volumetric HRCT chest, Spirometry and Body Plethysmography
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Mansoura University
Pulmonary Disease, Chronic Obstructive, Airway Disease
Innate Immunity in Ozone-induced Airway Inflammation in COPD
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States. Patients with COPD are routinely exposed to indoor and outdoor air pollution, which appears to cause escalation of their…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Airway Disease, COPD Exacerbation, Pollution; Exposure
- Trial name
- CO3PD (NCT04669743)
- Testing
- Ozone exposure
- Where
- 3 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Obstructive Sleep Apnea
Improving 24-hour Blood Pressure in Obstructive Sleep Apnea
This study examines the combined effects of an angiotensin receptor blocker (ARB), antioxidant supplementation, and continuous positive airway pressure (CPAP) therapy on the lowering of 24-hour blood pressure in persons with…
- Trial name
- NCT04021550
- Testing
- Continuous Positive Airway Pressure CPAP, Telmisartan 80mg, Alpha-Lipoic Acid 600mg
- Sponsor
- University of British Columbia
Chronic Obstructive Airway Disease, Asthma
Cough Responses to Tussive Agents in Health and Disease
The sensitivity of a persons cough reflex can be measured by getting them to breath in (inhale) irritant chemicals. The purpose of this clinical research study is to test the sensitivity of the cough reflex to a variety of…
- Conditions
- Chronic Obstructive Airway Disease, Asthma, Chronic Cough
- Trial name
- NCT01297790
- Testing
- Cough Challenge Tests, ambulatory cough recording, Cough questionnaires
- Where
- United Kingdom
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Manchester University NHS Foundation Trust
Sedative Effect During Drug-induced Sleep Endoscopy, Obstructive Sleep Apnea (OSA)
Combination of Remimazolam and Propofol During Drug-induced Sleep Endoscopy
This study helps patients find the optimal sedation regimen in drug-induced sleep endoscopy
- Trial name
- NCT06784479
- Testing
- Remimazolam and Propofol, Propofol, Midazolam and propofol
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Dan Liu
Airway Inflammation, Chronic Obstructive Pulmonary Disease (COPD)
Immune Status and Disease Control of Inflammatory Airway Diseases
The goal of this study is to learn how the body's immune system affects disease control in people with different airway inflammatory diseases.We want to understand: 1.Whether specific immune cell patterns in the blood are linked…
- Conditions
- Airway Inflammation, Chronic Obstructive Pulmonary Disease (COPD), Asthma (Diagnosis), Bronchiectasis
- Trial name
- ISDC-IAD (NCT07493629)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Ningbo University
Sleep Apnea, Obstructive, Sleep Apnea Syndromes
Continuous Positive Airway Pressure (CPAP) After Adenotonsillectomy in Children
Obstructive sleep-disordered breathing (SDB) affects 2-3% of children and may lead to problems with nighttime sleep and daytime behavior, learning, sleepiness, and mood.
- Conditions
- Sleep Apnea, Obstructive, Sleep Apnea Syndromes, Child Behavior Disorders, Attention Deficit Disorder With Hyperactivity
- Trial name
- NCT01554527
- Testing
- CPAP treatment, No CPAP treatment
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Michigan
Asthma
Therapeutic Relevance of Abnormal Airway Morphology in Asthma
Most individuals with asthma can effectively manage their symptoms and maintain normal lung function using inhaled medications, unfortunately, there is a subset of asthma sufferers whose symptoms, lung function, and risk of…
- Trial name
- AirPATH (NCT06970080)
- Testing
- Inhaled corticosteroid (ICS), Oral Corticosteroid (OCS)
- Where
- 2 sites in Canada
- Volunteers
- 242 people
- Sponsor
- McMaster University
Asthma
Development of a Breath Analyzer for Asthma Screening
Annually, asthma is responsible for 1 million emergency room visits, 400,000 hospitalizations, and 5000 deaths according to the NHLBI.
- Trial name
- NCT00386737
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Ekips Technologies
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