Clinical trials: Obstructive Airway Diseases
Asthma
Elite Sport and Development of Asthma
International studies have shown that elite athletes have a high prevalence of respiratory symptoms and asthma as compared to normal subjects.
- Trial name
- NCT00262587
- Testing
- Seretide
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Obstructive Sleep Apnea
The Effects of Provent® on Obstructive Sleep Apnea During Continuous Positive Airway Pressure Therapy Withdrawal
Randomised, placebo-controlled trial of continuous positive airway pressure therapy (CPAP) versus Provent® and Placebo-Provent® to define the effects of Provent® on the severity of obstructive sleep apnea, daytime symptoms as…
- Trial name
- NCT01332175
- Testing
- Provent®, CPAP
- Where
- 3 sites in Switzerland, United Kingdom
- Volunteers
- 67 people
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease (COPD)
Nitric Oxyde Concentration in Chronic Obstructive Pulmonary Disease Patients - SANOB Study
Among many other causes, Bronchial obstruction in Chronic Obstructive Pulmonary Disease (COPD) is also caused by inflammation of peripheral airways walls.
- Trial name
- SANOB (NCT01853787)
- Testing
- Formoterol Fumarate, Salmeterol
- Where
- 2 sites in Italy
- Volunteers
- 49 people
- Sponsor
- University of Milan
Obstructive Sleep Apnea, Metabolic Syndrome
Prevalence of Metabolic Syndrome in Obstructive Sleep Apnea (OSA) and Effect of Treatment With Continuous Positive Airway Pressure (Auto-CPAP) on Metabolic Syndrome
Metabolic syndrome is a constellation of risk factors for cardiovascular disease. The prevalence of metabolic syndrome in persons with obstructive sleep apnea syndrome (OSAS) is known to be very high, about 70%.
- Trial name
- NCT00694616
- Testing
- AutoSet Spirit, Modified-AutoSet Spirit
- Where
- India
- Volunteers
- 90 people
- Sponsor
- All India Institute of Medical Sciences
Sleep Apnea, Obstructive
Effect of CPAP vs Control on Nocturnal Dipping in Normotensive Patients With Obstructive Sleep Apnea
This is an open-label, parallel, prospective, randomised control trial evaluating the effect of Continuous Positive airway pressure (CPAP), the standard treatment for obstructive sleep apnea (OSA) versus control (diet and…
- Trial name
- NCT04938128
- Testing
- CPAP
- Where
- Ireland
- Sponsor
- St Vincent's University Hospital, Ireland
Bronchiolitis, Pneumonia
Airway Pressure During Humidified High Flow Nasal Cannula Therapy in Children
Humidified High Flow Nasal Cannula (HHFNC) is a new modality of respiratory support for children with respiratory failure. Despite its extensive use in pediatric and adult population, the exact mechanism of work of HHFNC is not…
- Conditions
- Bronchiolitis, Pneumonia, Bronchial Asthma
- Trial name
- NCT02387632
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McMaster University
Obstructive Sleep Apnea/Hypopnea Syndrome
Comparison of Vascular Risk in Patients Treated for Obstructive Sleep Apnea/Hypopnea Syndrome
a monocentric,non interventional, prospective study to compare cardiovascular risk in patients with Obstructive Sleep Apnea/Hypopnea Syndrome treated with Continuous Positive Airway Pressure (CPAP) and Mandibular Advancement…
- Trial name
- SAHOSVAS (NCT05491967)
- Where
- France
- Volunteers
- 172 people
- Sponsor
- Centre Hospitalier de Valence
Chronic Obstructive Pulmonary Disease, Emphysema
Clinical & Systems Medicine Investigations of Smoking-related Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) is an increasing global health problem, which primarily increases among the female population.
- Conditions
- Chronic Obstructive Pulmonary Disease, Emphysema, Chronic Bronchitis, Chronic Airways Obstruction
- Trial name
- COSMIC (NCT02627872)
- Where
- Sweden
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Pulmonary Disease, Chronic Obstructive
A Pilot Study of the Mechanism of Synergism Between FP and Salmeterol in Preventing COPD Exacerbations
The purpose of this study is to evaluate the blood and airway of subjects with mild to moderate COPD while undergoing standard treatment.
- Trial name
- NCT00116402
- Testing
- fluticasone and salmeterol
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Chicago
Chronic Obstructive Pulmonary Disease
Effect of Acetazolamide on Exercise Performance in Patients With Respiratory Disease at Altitude
In this trial, the investigators will evaluate the effect of acetazolamide (375 mg per day) vs. placebo on exercise performance at altitude in patients with COPD.
- Trial name
- NCT03177837
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 176 people
- Sponsor
- University of Zurich
Asthma
Determining the Optimal Adenosine Provocation Test
Asthma is a frequently occurring inflammatory lung disease that affects the whole bronchial tree including the small airways (<2mm).
- Trial name
- impact (NCT01610921)
- Testing
- Bronchial provocation test
- Where
- 2 sites in Netherlands
- Volunteers
- 11 people
- Sponsor
- University Medical Center Groningen
Pulmonary Disease, Chronic Obstructive, Interstitial Pulmonary Fibrosis
An Atlas of Airways at a Single Cell Level in Chronic Obstructive Pulmonary Disease, Idiopathic Pulmonary Fibrosis and Controls
The increasing incidence of chronic respiratory disease is a public health problem that affects hundreds of thousands of people worldwide at all ages.
- Trial name
- DISCOVAIR (NCT04529993)
- Testing
- Bronchoscopy
- Where
- France
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Breathing, Lung Function Decreased
Body Composition Related Evaluation of Airway Tone and Hyper-rEactivity Using Oscillometry
This study will determine if airway resistance to airflow and pressure, measured by Oscillometry, is associated with abnormal findings on methacholine challenge testing and whether these findings are associated with body habitus,
- Conditions
- Breathing, Lung Function Decreased, Asthma (Diagnosis), Obesity
- Trial name
- BREATH-OSC (NCT07356310)
- Testing
- Oscillometer
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Rochester
Early Onset Alzheimer Disease, Alzheimer Disease
Sleep Apnea in Early to Mid-Stage Alzheimer's Disease
Obstructive sleep apnea (OSA) is much more common in the elderly than in the young; the latest studies show prevalence between 45% and 62% in individuals over 60.
- Conditions
- Early Onset Alzheimer Disease, Alzheimer Disease, Obstructive Sleep Apnea Syndromes
- Trial name
- AZAP (NCT01400542)
- Testing
- CPAP Treatment, No treatment
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Pulmonary Disease, Chronic Obstructive, Pulmonary Emphysema
PROCHYMAL™ (Human Adult Stem Cells) for the Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
The objective of the present study is to establish the safety and efficacy of multiple administrations of Prochymal™(ex-vivo cultured human adult mesenchymal stem cells) in participants with moderate to severe chronic obstructive…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Pulmonary Emphysema, Chronic Bronchitis
- Trial name
- NCT00683722
- Testing
- Prochymal™
- Where
- 6 sites in United States
- Volunteers
- 62 people
- Sponsor
- Mesoblast, Inc.
COPD, AECOPD
Home Oscillatory Positive Expiratory Pressure - Aerobic Exercise Rehabilitation Study
The goal of this clinical trial is to evaluate the feasibility and effectiveness of home OPEP therapy and aerobic exercise training in patients with moderate to severe Chronic Obstructive Pulmonary Disease (COPD) who are at high…
- Trial name
- HOPE-AERO (NCT06970054)
- Testing
- OPEP, Aerobic Exercise
- Where
- China
- Volunteers
- 312 people
- Sponsor
- Sir Run Run Shaw Hospital
Heart Failure, Obstructive Sleep Apnea
CPAP Therapy in Patients With Heart Failure and Obstructive Sleep Apnea.
Heart failure affects approximately 5-6 million North Americans and is increasing in prevalence. Sleep-related disorders, such as obstructive sleep apnea (OSA) often coexist (11-37% incidence) with heart failure.
- Trial name
- PET-OSA (NCT00756366)
- Testing
- Positron Emission Tomography
- Where
- Canada
- Volunteers
- 67 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Sleep Apnea, COPD Exacerbation
Impact of Continuous Positive Airway Pressure on the Occurrence of Acute Exacerbations of COPD in Patients With COPD-OSA Overlap Syndrome (CO-OS)
Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA) are both frequent respiratory diseases with estimated prevalences between 8 and 15% of the adult population.
- Conditions
- Sleep Apnea, COPD Exacerbation, Overlap Syndrome
- Trial name
- SLEEPOVEA (NCT05958563)
- Testing
- continuous positive airway pressure treatment
- Where
- 15 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Angers
Obstructive Sleep Apnea Syndrome, Continuous Positive Airway Pressure
Observance of Continuous Positive Pressure for the Treatment of Obstructive Sleep Apnea Syndrome
Moderate to severe obstructive sleep apnea syndrome (OSAS) (HAI hypopnea apnea index ≥ 15) is a common pathology, which affects 6 to 17% of the general population.
- Conditions
- Obstructive Sleep Apnea Syndrome, Continuous Positive Airway Pressure, Adherence, Perception and Beliefs
- Trial name
- EvOPPC (NCT05369845)
- Testing
- questionary
- Where
- France
- Volunteers
- 132 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Obstructive Sleep Apnoea
Antioxidant Carbocysteine Treatment in Obstructive Sleep Apnoea Syndrome
Obstructive sleep apnoea syndrome (OSAS) is characterised by repeated episodes of upper airway occlusion during sleep.It can cause cycles of hypoxia reoxygenation.
- Trial name
- NCT02015598
- Testing
- Carbocysteine, Continuous Positive Airway Pressure
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
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