Clinical trials: Obstructive Airway Diseases
Asthma in Children, Asthma
Dynamics of the Upper and Lower Airway Respiratory Microbiomes Associated With Severe Infant Asthma
Nature of potential dysbiosis, interrelation of the different microbiomes of the respiratory tract, and potential role of the immune system in the pathogenesis of severe asthma in infants, and its evolution under treatment.
- Trial name
- Microbiosthme (NCT06044051)
- Testing
- Blood sample, Expectoration, Nasopharyngeal swab
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Rouen
Asthma, Airway Obstruction
Role of Parasympathetic Activity in Mild to Severe Asthma With Fixed Airway Obstruction (PARASMA Study)
In asthma, the significant role of pathogenesis is chronic airway inflammation, bronchial hyperresponsiveness, and variable airflow obstruction.
- Conditions
- Asthma, Airway Obstruction, Airway Remodeling, Parasympathetic Nervous System Diseases
- Trial name
- PARASMA (NCT05550402)
- Testing
- Salbutamol, Ipratropium Bromide, Salbutamol plus Ipratropium Bromide
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Hat Yai Medical Education Center
Wheezy Bronchitis, Asthmatic Bronchitis
Efficacy of Intermittent Tiotropium in Early Childhood Wheezing
This study evaluates the effect of intermittent tiotropium bromide and salbutamol as needed versus intermittent fluticasone propionate and salbutamol as needed, or solely, salbutamol as needed on episode-free days in infants and…
- Conditions
- Wheezy Bronchitis, Asthmatic Bronchitis, Wheezing, Obstruction Airway
- Trial name
- NCT03199976
- Testing
- Tiotropium Bromide, Fluticasone Propionate, Salbutamol
- Where
- Finland
- Volunteers
- 80 people
- Sponsor
- Helsinki University Central Hospital
Hypertension, OSA - Obstructive Sleep Apnea
Primary Prevention Long-term Registry Study in OSA and Hypertension. Survival Analysis 2010-2022
Hypertension and obstructive sleep apnea (OSA) are both common conditions that independently increase the risk cardiovascular disease including atrial fibrillation, ischemic heart disease, heart failure and stroke.
- Conditions
- Hypertension, OSA - Obstructive Sleep Apnea, MACE, Survival Analysis
- Trial name
- DISCOVERY-HT (NCT06930989)
- Testing
- Positive airway pressure (PAP)
- Where
- Sweden
- Volunteers
- 148,467 people
- Sponsor
- Vastra Gotaland Region
Obstructive Sleep Apnea
The Effects of Nasal Airflow on Upper Airway Dilator Muscles During Sleep
Obstructive sleep apnea (OSA) is an increasingly prevalent disorder characterized by repeated upper airway collapse during sleep, resulting in oxygen desaturation and frequent arousals. The etiology of OSA remains unclear.
- Trial name
- NCT03506178
- Testing
- Oxymetazoline Nasal Spray, Menthol Nasal Spray, Normal saline Nasal Spray
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Airway Inflammation, Chronic Obstructive Pulmonary Disease (COPD)
Immune Status and Disease Control of Inflammatory Airway Diseases
The goal of this study is to learn how the body's immune system affects disease control in people with different airway inflammatory diseases.We want to understand: 1.Whether specific immune cell patterns in the blood are linked…
- Conditions
- Airway Inflammation, Chronic Obstructive Pulmonary Disease (COPD), Asthma (Diagnosis), Bronchiectasis
- Trial name
- ISDC-IAD (NCT07493629)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Ningbo University
COPD (Chronic Obstructive Pulmonary Disease)
A Clinical Study of REGEND001 for the Treatment of Chronic Obstructive Pulmonary Disease (COPD)
Chronic obstructive pulmonary disease (COPD) is a common, progressive, and heterogeneous respiratory disorder. It is associated with substantial morbidity and mortality worldwide, leading to progressive decline in lung function…
- Trial name
- NCT07828353
- Testing
- REGEND001
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Regend Therapeutics
Asthma
Acute Airway Vascular Smooth Muscle Effects of Inhaled Budesonide
Glucocorticosteroids recently have been shown to have non-genomic actions that are plasma membrane-mediated and do not require gene transcription and translation.
- Trial name
- NCT01219738
- Testing
- Budesonide 360ug, Budesonide 720ug, Budesonide 1440ug
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Miami
Nasal Obstruction, Nasopharyngeal Obstruction
Administration of Dexamethasone in PONV Prophylaxis in Children Undergoing Adenotomy
Adenotomy, together with tonsillectomy, belongs among the most frequently performed surgical procedures in paediatric patients. These surgical procedures are associated with the second highest incidence of post-operative nausea…
- Conditions
- Nasal Obstruction, Nasopharyngeal Obstruction, Snoring, Apnea, Obstructive
- Trial name
- NCT03398044
- Testing
- Dexamethasone
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- University Hospital Ostrava
Obstructive Sleep Apnea
Correlation Between CPAP Compliance and Food Intake Timing
Despite widespread agreement that continuous positive airway pressure is effective therapy for obstructive sleep apnea, it is estimated that 50% of patients recommended for therapy are noncompliant 1 year later.
- Trial name
- TLMECC (NCT01851811)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Hackensack Meridian Health
Asthma, Allergies and Obesity
The Relation Between Obesity, Adipose Tissue Content of Fatty Acids and Systemic and Airway Inflammation
Obesity has been recognized as a risk factors for developing asthma. In a cohort of 5384 children aged 15-17, we aim to: 1. To investigate the association of asthma prevalence at age 15-17 with body mass index (BMI) at age 15-17…
- Trial name
- NCT01229787
- Where
- Cyprus
- Volunteers
- 5,384 people, healthy volunteers welcome
- Sponsor
- Cyprus International Institute for Environment and Public Health
Obstructive Sleep Apnea, Nasal Obstruction
Assessment of Adenoidal Obstruction in Children : Clinical Signs Versus Flexible Nasal Endoscopy and Roentgenographic Findings
The term adenoids describes lymphoid tissue on the superior and posterior walls of the nasopharynx, and their hypertrophy is a common condition of childhood.
- Trial name
- NCT01965457
- Where
- Israel
- Volunteers
- 36 people
- Sponsor
- Carmel Medical Center
Sleep Apnea, Obstructive, Stroke
Stroke and CPAP Outcome Study 2
Obstructive sleep apnea (OSA) is associated with impaired stroke recovery. Treatment with continuous positive airway pressure (CPAP) may prevent this but is limited by poor adherence.
- Conditions
- Sleep Apnea, Obstructive, Stroke, Patient Adherence
- Trial name
- SCOUTS2 (NCT02809430)
- Testing
- Continuous Positive Airway Pressure
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Washington
Fatigue, Multiple Sclerosis
Continuous Positive Airway Pressure (CPAP) for Fatigue in Patients With Multiple Sclerosis (MS) and Obstructive Sleep Apnea (OSA)
Fatigue is a symptom present in 76 to 92% of people with multiple sclerosis (MS). Fatigue is usually described as an overwhelming sense of tiredness, lack of energy, and feeling of exhaustion which is different from sleepiness.
- Conditions
- Fatigue, Multiple Sclerosis, Sleep Apnea
- Trial name
- NCT01563900
- Testing
- Auto-titration CPAP
- Where
- United States
- Sponsor
- Northwestern University
COPD
Mucin Concentration in Sputum From COPD Patients During a Pulmonary Exacerbation
chronic obstructive pulmonary disease (COPD) is typically associated with mucus hypersecretion in the airways. In health, mucin is the major macromolecular component and is responsible for the protective and clearance properties…
- Trial name
- mucinCOPDex (NCT01848093)
- Testing
- sputum collection
- Where
- 2 sites in Germany
- Sponsor
- Philipps University Marburg
Refractory Chronic Cough
Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic Cough
This research study is evaluating the effectiveness of escalating doses of Amitriptyline and Duloxetine in reducing cough frequency in patients with refractory chronic cough (RCC)
- Trial name
- MACS-1 (NCT05110144)
- Testing
- Duloxetine 30 MG, Duloxetine 60 MG, Amitriptyline 25 MG
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Emphysema, Pulmonary Disease, Chronic Obstructive
Biomarkers and Genetic Factors Related to Emphysema
Emphysema, a common type of chronic obstructive pulmonary disease (COPD), is a long-term lung disease that is usually caused by cigarette smoking.
- Trial name
- NCT00757120
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- Washington University School of Medicine
Obstructive Sleep Apnea, Obesity
UBT251 Injection Phase Ⅲ Study (OSA-NPAP)
The objective of this clinical trial is to evaluate the efficacy of investigational drug UBT251 in the treatment of moderate-to-severe obstructive sleep apnea (OSA) with obesity, as well as to assess its safety.
- Trial name
- UNISHAPE-OSA-1 (NCT07767942)
- Testing
- UBT251
- Volunteers
- 150 people
- Sponsor
- The United Bio-Technology (Hengqin) Co., Ltd.
Smoking, COPD
Smoking-induced EGF-dependent Reprogramming of Airway Basal Cell Function
Early changes associated with the development of smoking-induced diseases, e.g., COPD and lung cancer (the two commonest causes of death in U.S.) are often characterized by abnormal airway epithelial differentiation.
- Conditions
- Smoking, COPD, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT01974180
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Hyperventilation, Larynx
Vocal Cord Responses During Hyperventilation in Normal Individuals and in Mild and Severe Asthmatics.
The Investigators aim to: 1. Study the effect of hyperventilation on the development of paradoxical vocal cord movement (PVCM) in healthy individuals and in patients with mild and severe asthma, 2.
- Conditions
- Hyperventilation, Larynx, Asthma
- Trial name
- NCT05565430
- Testing
- Acute Hyperventilation, Chronic hyperventilation, Effects of anticholinergic medication
- Where
- Australia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Monash Medical Centre
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