Clinical trials: Obstructive Airway Diseases
Asthma, COPD
The Effects of Positive Airway Pressure on the Mucolytic Effects of NAC (TEAM)
The goal of this clinical trial is to determine if positive pressure during inspiration will improve penetration of aerosolized N-Acetylcysteine (NAC) into airway mucus plugs in the lungs of patients with asthma or Chronic…
- Trial name
- TEAM (NCT06152653)
- Testing
- n-acetylcystine (NAC)+ albuterol, AeroEclipse-VersaPAP System
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Asthma, Obesity
Obesity, Metabolic Dysregulation and the Airway Epithelium in Asthmatics
The objective of this pilot study is to determine whether obesity and metabolic syndrome are in fact synergistic in relation to airway nitric oxide (NO) biology.
- Conditions
- Asthma, Obesity, Metabolic Syndrome
- Trial name
- NCT03215836
- Testing
- Bronchoscopy and Nasal Epithelium Brush Sampling
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Obstructive Sleep Apnea
Inspire® Upper Airway Stimulation (UAS) System German Post-Market Study
The purpose of this study is to obtain additional safety and efficacy data on the use of Inspire® therapy for the treatment of subjects with moderate to severe Obstructive Sleep Apnea.
- Trial name
- NCT02293746
- Testing
- Inspire® Upper Airway Stimulation (UAS) System
- Where
- 3 sites in Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Inspire Medical Systems, Inc.
COPD, Healthy Controls
Supramaximal High-Intensity Interval Training in People With and Without Chronic Obstructive Pulmonary Disease
Beyond pulmonary complications, COPD presents with extrapulmonary manifestations including reduced cognitive, cardiovascular, and muscle function.
- Trial name
- COPD-HIIT (NCT06068322)
- Testing
- Exercise training on a stationary bicycle
- Where
- 2 sites in Belgium, Sweden
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Umeå University
Sleep Apnea, Obstructive
NPA-OSA Device Tolerability, Usability and Acclimation Clinical Study in Adult Obstructive Sleep Apnea (OSA) Patients
This pilot study is being done to determine if the nasopharyngeal airway obstructive sleep apnea (NPA-OSA) device can be used in the treatment of OSA in adults.
- Trial name
- NCT06677151
- Testing
- nasopharyngeal airway obstructive sleep apnea (NPA-OSA) device
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan
COPD
Predictive Questionnaires for Risk of Acute COPD (Chronic Obstructive Pulmonary Disease) Exacerbations
COPD patients frequently suffer intermittent exacerbations of their disease characterised by acute deterioration of symptoms. Acute exacerbations of COPD (AECOPD) are associated with significant impairment of health status, use…
- Trial name
- NCT01248507
- Where
- Spain
- Volunteers
- 634 people
- Sponsor
- AstraZeneca
Asthma
Comparison of Combination Therapy: Montelukast and Inhaled Steroid on Exercise Induced Bronchoconstriction
The purpose of this study is to compare the effects of 2 weeks therapy of montelukast, budesonide, their combination on exercise induced bronchoconstriction (EIB) and airway inflammation in children and young adults, not on…
- Trial name
- NCT00462592
- Testing
- budesonide, montelukast
- Where
- 2 sites in Canada
- Volunteers
- 18 people
- Sponsor
- Hamilton Health Sciences Corporation
Asthma
Poly-unsaturated Fats for Improving Nasal Polyps and Asthma
Asthma is a syndrome compromising many phenotypes including N-ERD (caused by increased 4-series leukotriene (LT) production). n-3 PUFA supplementation modulates 4-series LT and has anti-inflammatory effects.
- Trial name
- PUFFIN (NCT05613803)
- Testing
- Fish oil
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Pulmonary Disease, Chronic Obstructive
Analyzing Lung Tissue in People With and Without Chronic Obstructive Pulmonary Disease Who Are Undergoing Lung Transplantation
Chronic obstructive pulmonary disease (COPD) is a long-term lung disease. People with COPD have difficulty breathing because of lung damage.
- Trial name
- NCT00756522
- Testing
- There is no intervention. Study is observational.
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Washington University School of Medicine
Chronic Obstructive Airway Disease
Czech Multicentre Research Database of Chronic Obstructive Pulmonary Disease (COPD)
The chronic obstructive pulmonary disease (COPD) is the occurrence of chronic bronchitis or emphysema, a pair of commonly co-existing diseases of the lungs in which the airways narrow over time.
- Trial name
- NCT01923051
- Where
- 14 sites in Czechia
- Volunteers
- 813 people
- Sponsor
- Zuzana Zbožínková, M.Sc.
Obstructive Sleep Apnea
Endotype-Targeted Therapy to Rescue OSA Patients Struggling With CPAP Adherence (TOP-CPAP)
More than 10% of the US population have obstructive sleep apnea (OSA). Standard of care is therapy with CPAP (continuous positive airway pressure) which virtually eliminates OSA.
- Trial name
- TOP-CPAP (NCT05951023)
- Testing
- Eszopiclone 2 mg
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of California, San Diego
Cystic Fibrosis, Pulmonary Disease, Chronic Obstructive
Comparison of Two Treatment Regimens to Reduce PA Infection in Children With Cystic Fibrosis
Cystic fibrosis (CF) is a chronic disease that significantly affects an individual's lung function. Antibiotic medications have been proven effective at reducing Pseudomonas aeruginosa (PA) infection, which is one of the main…
- Trial name
- EPIC (NCT00097773)
- Testing
- Tobramycin solution for inhalation (TOBI), Oral ciprofloxacin
- Where
- 54 sites in United States
- Volunteers
- 304 people
- Sponsor
- Seattle Children's Hospital
Asthma Chronic
Azithromycin Treatment for the Airway Microbiome in Asthma
The purpose of this study to determine whether the bacteria inside the lungs of people with asthma can be modified (changed) if they are given an antibiotic and if this change is associated with an improvement in asthma symptoms.
- Trial name
- NCT03736629
- Testing
- Azithromycin
- Where
- 2 sites in United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Chronic Obstructive Airway Disease
Effect of Prolonged Decubitus on Nitric Oxide Concentration in Chronic Obstructive Pulmonary Disease
Bronchial obstruction in Chronic Obstructive Pulmonary Disease (COPD) is caused by inflammation of peripheral airways walls. Neutrophils and other inflammatory mediators Interleukin-6 (IL6), Interleukin-8 (IL8), Interleukin-1…
- Trial name
- NCT01555593
- Testing
- Cardioline Exp'air by Medi-soft - Sorinnes (B)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Milan
Sleep Apnea, Obstructive
Evaluation of an Algorithm to Detect Sleep and Wake in Continuous Positive Airway Pressure (CPAP)
The purpose of this engineering trial is to develop and validate an algorithm that will deliver Paced Breathing as a ramp feature to obstructive sleep apnea (OSA) subjects using Continuous Positive Airway Pressure (CPAP) therapy.
- Trial name
- PBSW (NCT01031914)
- Testing
- Paced Breathing
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Philips Respironics
Pediatric Respiratory Diseases
Structured Light Plethysmography in Obstructive Airways Disease
Obstructive airways disease is the most common group of acute illnesses leading to hospital treatment in children. This group consists of different age-related diagnoses, such as bronchiolitis in infants or wheezing and asthma in…
- Trial name
- NCT03499938
- Testing
- Structured Light Plethysmography
- Where
- United Kingdom
- Volunteers
- 57 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Asthma
In Vitro Evaluation of a Novel Drug on Airway Epithelial Cells Obtained From Participants With Severe Asthma
Asthma is a long term disease of the lungs. In asthma patients the sensitive airway tubes narrow in reaction to something that irritates the airways such as allergens or environmental pollutants.
- Trial name
- NCT02740049
- Testing
- VR588
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- Imperial College London
Sleep Apnea, Obstructive
Characterizing Upper Airway Collapse to Guide Patient Selection for Oral Appliance Therapy for Obstructive Sleep Apnea
Obstructive Sleep Apnea (OSA) is characterized by collapse of one or more pharyngeal structures during sleep (velum, tongue base, lateral walls, epiglottis).
- Trial name
- NCT02489591
- Testing
- Oral appliance, BluePro oral appliance
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea
Mechanisms of Upper Airway Obstruction
The current study is designed to examine underlying mechanisms of action of lingual muscles in the maintenance of airway patency during sleep.
- Trial name
- DISE-CAD (NCT04322097)
- Testing
- Hypoglossal Nerve Stimulation
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Obstructive Sleep Apnea, Atrial Fibrillation
Effects of PAP on Afib Recurrence Risk After Catheter Ablation in OSA Patients
With this pilot study, we are hoping to test the feasibility of a larger study in the future and to learn whether positive airway pressure therapy reduces the recurrence risk of atrial fibrillation after successful catheter…
- Trial name
- OSA-AFIB (NCT03242720)
- Testing
- Cardiac Ablation for Atrial Fibrillation
- Where
- United States
- Sponsor
- Stanford University
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