Clinical trials: Obstructive Airway Diseases
BIPAP Biphasic Intermittent Positive Airway Pressure, Diaphragm Issues
The Effect of BIPAP on Diaphragmatic Function
This research is designed to evaluate how long-term treatment with Bilevel Positive Airway Pressure (BiPAP) influences diaphragm function in patients with Chronic Obstructive Pulmonary Disease (COPD) who suffer from chronic…
- Conditions
- BIPAP Biphasic Intermittent Positive Airway Pressure, Diaphragm Issues, Ultrasound Diagnostics, COPD (Chronic Obstructive Pulmonary Disease)
- Trial name
- NCT07193017
- Testing
- BIPAP
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul Demiroglu Bilim University
Obstructive Sleep Apnea Syndrome
Cost-utility Study of Continuous Positive Airway Pressure Treatment in Obstructive Sleep Apnea Syndrome Patients
The purpose of this study is to estimate the cost-utility of continuous positive airway pressure (CPAP) therapy in obstructive sleep apnea (OSA) patients in Sao Paulo city, Brazil, after 3 years of treatment and to estimate the…
- Trial name
- NCT01590420
- Testing
- CPAP S8- Scape / Resmed
- Where
- Brazil
- Volunteers
- 1,000 people
- Sponsor
- Associação Fundo de Incentivo à Pesquisa
Asthma, Allergic
Lung-Resident Memory Th2 Cells in Asthma
Determining how memory T helper type 2 (Th2) initiate recall responses to aeroallergens has the potential to change the therapeutic approach to allergic asthma, the most common asthma subtype.
- Trial name
- NCT03455959
- Testing
- Bronchoscopy/BAL, Airway Brushing
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Andrew D. Luster, M.D.,Ph.D.
Asthma, Chronic Rhinosinusitis With Nasal Polyps
Moving Towards Precision Medicine in United Airways Disease: Unraveling Inflammatory Patterns in Asthmatic Patients With or Without Nasal Polyps
Asthma and chronic rhinosinusitis (CRS) are inflammatory diseases of the respiratory tract, asthma from the lower part, and CRS, from the upper part.
- Conditions
- Asthma, Chronic Rhinosinusitis With Nasal Polyps, Chronic Rhinosinusitis (Diagnosis), Nasal Polyps
- Trial name
- PREMIUM (NCT05009758)
- Testing
- Blood sampling, Nasosorption, Oral sampling
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Chronic Obstructive Pulmonary Disease
Effects of Inhaled Corticosteroids in Chronic Obstructive Pulmonary Disease (COPD)
Human and animal studies have shown that inhaled corticosteroids (ICS) decrease airway blood flow . This effect is immediate (within 30 minutes), transient (lasting 90 minutes), and in animal studies independent of gene…
- Trial name
- NCT00202189
- Testing
- Budesonide
- Where
- Canada
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Queen's University
Obstructive Sleep Apnea, OSA
Predictability of OSA With a Subjective Screening Scale (OSASSS1)
the study aims to evaluate the accuracy correlation between subjective perception of the air flow through airways from patients and survey and/or polysomnography they spent, using a brief clinical protocol they answered with a…
- Trial name
- OSASSS1 (NCT06092710)
- Testing
- neuro-sensorial subjective evaluation of the airways collapsibility
- Where
- Belgium
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Center for Sleep Medicine - Clinique André Renard
Obstructive Sleep Apnea of Adult
Effect of Continuous Positive Airway Pressure on Chronotype, Dietary Intake, and Cardiovascular Risk Markers
In this study the investigators will evaluate chronotype, food intake pattern, and cardiovascular risk markers of elder individuals with OSA, in use of CPAP, when submitted to two weeks of CPAP withdrawal.
- Trial name
- NCT04262960
- Testing
- Device: active CPAP
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Asthma
Phase II Study to Evaluate the Effect of AZD4604 on Airway Inflammation and Biomarkers in Adults With Asthma
The purpose of this study is to investigate the effect on airway inflammation and JAK1-associated signalling pathways of AZD4604 compared with placebo in participants with moderate-to-severe asthma.
- Trial name
- ARTEMISIA (NCT06435273)
- Testing
- AZD4604
- Where
- 18 sites in Canada, Denmark and 3 more
- Volunteers
- 36 people
- Sponsor
- AstraZeneca
Bronchiolitis, Respiratory Syncytial Virus Infections
Assessment of Airway Obstruction in Infants With Lower Respiratory Infections
The purpose of this study is to evaluate how two different aerosol medications may improve airway function in infants with respiratory illness.
- Trial name
- NCT00435994
- Testing
- Inhaled primatene will be given as a breathing treatment, Nasal Washing
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Indiana University
Asthma
Pilot Study to Identify the Mediators and Inflammatory Cell Surface Receptors Involved in Allergic Airway Inflammation
Asthma is a heterogeneous disorder in which multiple potential inflammatory pathways contribute to airway obstruction. The biological basis for airway inflammation is the subject of intensive investigation.
- Trial name
- NCT00595491
- Testing
- Bronchoscopy, Segmental Allergen Challenge, and Broncheoalveolar Lavage
- Where
- United States
- Volunteers
- 313 people, healthy volunteers welcome
- Sponsor
- Benjamin Medoff
Asthma
Effect of Medical Food on Reducing Asthma Symptoms in Asthmatic Children
To determine the effect of medical food on reducing asthma symptoms in asthmatic children.
- Trial name
- NCT01087710
- Testing
- medical food with EPA and GLA, vitamins and minerals, medical food minus EPA and GLA, antioxidant vitamins/minerals
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Abbott Nutrition
Allergic Rhinitis, Asthma
Effects of Whole Sprouts on Airway Allergic Inflammation
The primary objective of this study is to determine if broccoli sprouts (BS) improves airway inflammatory, oxidative stress (OS), and symptoms among asthmatic adults with aeroallergen sensitization.
- Conditions
- Allergic Rhinitis, Asthma, Allergy
- Trial name
- NCT01522703
- Testing
- Broccoli Sprouts
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Johns Hopkins University
Chronic Airway Disease
Impulse Oscillation to Evaluate Diagnostic Efficacy in Patients With Chronic Airway Disease
The aim of the research is to explore the diagnostic efficacy of impulse oscillation (IOS) before and after bronchial provocation test (BPT) and bronchial dilation test (BDT) in chronic airway disease.
- Trial name
- NCT04668027
- Testing
- impulse oscillation（IOS）, bronchial provocation test(BPT), bronchial dilation test(BDT)
- Where
- China
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Asthma
Airway Smooth Muscle and Asthma Severity
Our hypothesis is that the severity of asthma is determined by the way in which airway smooth muscle cells grow and release inflammatory mediators.
- Trial name
- NCT00779870
- Testing
- bronchoscopy
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Pulmonary Disease, Chronic Obstructive
Study To Assess Efficacy and Safety of Oglemilast in Patients With Chronic Obstructive Pulmonary Disease (COPD)
This study will assess the safety and efficacy of a range of oglemilast doses. The study will be 14 weeks in duration. All patients meeting the eligibility criteria will be randomized to one of three doses of oglemilast or…
- Trial name
- NCT00671073
- Testing
- Oglemilast
- Where
- 47 sites in United States
- Volunteers
- 427 people
- Sponsor
- Forest Laboratories
Chronic Obstructive Pulmonary Disease, Emphysema
BROnchoalveolar Investigations of Never-smokers With Chronic Obstruction From the Swedish CardioPulmonary bioImage Study
Obstructive lung disease is an increasing global health problem of pandemic proportions, with COPD alone affecting >10% of the population. Smoking is the main and most well studies risk factor for developing COPD.
- Conditions
- Chronic Obstructive Pulmonary Disease, Emphysema, Chronic Bronchitis, Airway Obstruction
- Trial name
- BRONCOSCAPIS (NCT03049202)
- Where
- 6 sites in Sweden
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Asthma, Small Airway Disease
The Prevalence Of Small Airways Dysfunction In Asthma Patients And The Impact On The Asthma Control
Asthma, which are one of the most important causes of morbidity and mortality both in the world and in our country, constitute a very serious social and economic burden.
- Trial name
- NCT04375995
- Testing
- Impulse oscillometry, Spirometric pulmonary function test, Fractional exhaled nitric oxide (FENO) test
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Sibel Naycı
Asthma
Mechanistic Insights From Bronchoscopy Airway Samples
The purpose of this study is to examine the mechanisms of asthma. The investigators are comparing the cells of individuals with and without asthma and looking at the roles various parts of the cell play in the production and…
- Trial name
- MIBAS (NCT06105710)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Sleep Apnea Syndromes, High Cardiovascular Risk
Blood Pressure Reduction Induced by CPAP in Sleep Apnea Patients at High Cardiovascular Risk : OPTISAS 2 Study
Targeted population: Sleep apnea patients at high cardiovascular risk newly treated by CPAP Hypothesis: Improvement in blood pressure after 6 months of CPAP treatment might be greater in the telemonitoring arm compared to usual…
- Trial name
- NCT01505959
- Testing
- CPAP treatment
- Where
- 32 sites in France
- Volunteers
- 936 people
- Sponsor
- Fédération Française de Pneumologie
Obstructive Sleep Apnea
A Study of Myofunctional Therapy After Sleep Apnea Surgery
Obstructive sleep apnea (OSA) is a common disorder characterized by recurrent upper airway collapse. While surgery is a common treatment, its success rates are variable.
- Trial name
- MFT-OSA (NCT07231224)
- Testing
- myofunctional therapy
- Where
- Taiwan
- Volunteers
- 51 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.