Clinical trials: Obstructive Airway Diseases
Obstructive Sleep Apnea, Upper Airway Resistance Syndrome
Minimally Invasive Tongue Suture For Obstructive Sleep Apnea
This is a pilot study to determine the usefulness of a newly developed, minimally invasive tongue suture procedure for people with obstructive sleep apnea.
- Trial name
- NCT00515580
- Testing
- Tongue Sutures for Obstructive Sleep Apnea
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- West Side ENT
Sleep Apnea, Obstructive
Comparison of Breathing Events Detected by the SleepStyle 200 Auto Continuous Positive Airway Pressure (CPAP) Device to Attended Polysomnography
Obstructive Sleep Apnoea (OSA) is a common sleep-breathing disorder affecting around 2-4% of the population and is characterised by loud snoring, periodic collapse of the upper airway particular to sleep, sleep fragmentation, and…
- Trial name
- NCT00697424
- Testing
- SleepStyle 200 Auto Series CPAP Humidifier
- Where
- New Zealand
- Volunteers
- 20 people
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea, Excessive Daytime Sleepiness
BF2.649 in Patients With OSA and Treated by CPAP But Still Complaining of EDS
Multicenter randomized double blind study versus placebo during 12 weeks with at first, an escalating dose period followed by stable dose period at the selected dose.
- Trial name
- HAROSA1 (NCT01071876)
- Testing
- BF2.649
- Where
- France
- Volunteers
- 244 people
- Sponsor
- Bioprojet
COPD, LUNG DISEASES, OBSTRUCTIVE
Airway Effects of Tiotropium in Patients With COPD
The aim of the study is to investigate the effect of tiotropium from different devices on a panel of small (IOS, MBNW, DLCO, FVC) and large airway (FEV1, PEF) responses in patients with mild-moderate COPD.
- Trial name
- NCT02683668
- Testing
- Handihaler-Tiotropium 18 mcg untrained, Handihaler-Tiotropium 18 mcg trained, Respimat-Tiotropium 5 mcg trained
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- Imperial College London
Sleep Apnea, Obstructive
Titration Pressures in Sleep Apnea Patients Using ThermoSmart® Versus Conventional Humidification
Patients who have Obstructive Sleep Apnea (OSA) may have different Continuous Positive Airway Pressure (CPAP)when titrated with different levels of humidification.
- Trial name
- NCT00681083
- Testing
- Heated breathing tube (CPAP with ThermoSmart), Non heated breathing tube (CPAP with conventional humidification)
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Fisher and Paykel Healthcare
COPD (Chronic Obstructive Pulmonary Disease)
Airway Dysfunction, Occlusions and Remodeling: COPD Patients and Mepolizumab
The goal of this study is to evaluate the effect of mepolizumab on patients with COPD using MRI and CT imaging as well as breathing tests.
- Trial name
- ADORE (NCT07749001)
- Testing
- Mepolizumab 100 MG Injection
- Volunteers
- 36 people
- Sponsor
- Western University, Canada
COPD
The Assessment of Airway Resistance and Airtrapping in Elderly COPD Patients by Forced Oscillation Technique (FOT)
The study hypothesize that parameters of new function machine---'forced oscillation technique' (FOT) can correlate well with the conventional lung function data for measurement of airway resistance and airtrapping in elderly COPD…
- Trial name
- NCT01553812
- Volunteers
- 158 people
- Sponsor
- Kwong Wah Hospital
Sleep Apnea, Obstructive
The Changes of Patterns of Microarray in Patients With Obstructive Sleep Apnea
The aim of this study are (1) To genome-wide profile the gene expression patterns of peripheral blood mononuclear cell (PBMC) in patients with obstructive sleep apnea (OSA) (2) To profile the gene expression patterns change…
- Trial name
- NCT00498849
- Testing
- CPAP
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Sleep Apnea, Obstructive
Reboxetine for Sleep Apnoea After ENT Surgery
This pilot study will establish the feasibility of a larger trial to investigate whether reboxetine, a medication used to treat depression, can reduce the severity of obstructive sleep apnea (OSA) including increased blood…
- Trial name
- RENTOSA (NCT05978505)
- Testing
- Reboxetine 4 MG Oral Tablet
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Flinders University
Asthma
Development of Small Airway Disease Questionnaire
The aim of this study is to develop a patient reported outcome tool specific to small airways disease, which assesses symptoms and signs of small airways disease and may help in addition to FEF50% to discriminate between…
- Trial name
- SADQ (NCT01360294)
- Where
- Netherlands
- Volunteers
- 65 people
- Sponsor
- University Medical Center Groningen
Obstructive Sleep Apnea
Effects of PAP Treatment of OSA in Patients With Heart Failure
The purpose of this study is to see if treatment of OSA with the CPAP device makes a difference to insulin resistance and heart disease.
- Trial name
- OSA-MRI (NCT01136122)
- Testing
- CPAP Treatment
- Where
- United States
- Sponsor
- Ulysses Magalang MD
Chronic Obstructive Airway Disease
The Effect of Twice Daily vs. Once Daily Bronchodilation on Hyperinflation in COPD Patients During 24 Hours.
To study the effect of twice daily dual bronchodilation versus once daily single bronchodilation in patients with chronic obstructive pulmonary disease on 24-hour static and dynamic hyperinflation.
- Trial name
- BOTH (NCT03275116)
- Testing
- Tiotropium 'Respimat' 5 mcg, Aclidinium Bromide/Formoterol Fumarate 340/12 mcg
- Where
- Netherlands
- Volunteers
- 49 people
- Sponsor
- Maastricht University Medical Center
Asthma, Copd
Effects of Smoking on Bronchial Epithelium
Asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory airway diseases affecting millions of people worldwide.
- Trial name
- NCT00849433
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- University Medical Center Groningen
Asthma, Obesity
Oxidative Stress in Asthma
40% of all asthma patients in the US are obese. Obese asthmatics have more severe disease than lean asthmatics and do not respond as well to conventional anti-inflammatory therapies.
- Trial name
- NCT04512547
- Testing
- Hyperpolarized 129XeMRI
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Bastiaan Driehuys
Asthma, Vitamin D Deficiency
The Effect of Vitamin D Replacement on Airway Reactivity, Allergy and Inflammatory Mediators in Exhaled Breath Condensate in Vitamin D Deficient Asthmatic Children
Research Title: The effect of vitamin D replacement on airway reactivity, allergy and inflammatory mediators in exhaled breath condensate in vitamin D deficient asthmatic children.
- Trial name
- NCT01287455
- Testing
- Vitamin D3 as "BABY D3"
- Where
- Israel
- Volunteers
- 83 people
- Sponsor
- Rambam Health Care Campus
Asthma, Airway Hyperresponsiveness
Airway Dysfunction and Remodelling in Athletes Following Swimming Training in Chlorinated Pools
Swimmers show the highest prevalence of asthma among elite athletes, certainly due to chlorine exposure. The consequences of a chronic exposure to chlorine compounds by swimmers and the mechanisms of asthme in this population are…
- Trial name
- proto nage (NCT00686452)
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Laval University
Resistant Hypertension, Obstructive Sleep Apnea
Effect of Continuous Positive Airway Pressure for Treatment of Obstructive Sleep Apnea on Resistant Hypertension
The objectives of this study are to investigate the effect of continuous positive airway pressure (CPAP) treatment on blood pressure control and vascular inflammation in subjects with resistant hypertension and moderate…
- Trial name
- NCT00881985
- Testing
- continuous positive airway pressure
- Where
- China
- Volunteers
- 92 people
- Sponsor
- The University of Hong Kong
Asthma
Study to Evaluate the Effects of Weight Loss on Airway Inflammation and Mechanics in Subjects With Asthma (Asthma-Bariatric Surgery Study)
Current research shows that obesity greatly increases the risk of developing asthma. Although the two conditions are clearly related, experts do not fully understand why they are linked.
- Trial name
- NCT00615498
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Emory University
Hypertension
Long-term Cardiovascular Outcomes in Patients With RH and OSA With or Without Treatment With CPAP
Objectives: Main objective: To assess the impact of obstructive sleep apnea (OSA) and its treatment on cardiovascular outcomes (morbidity and mortality) in patients with resistant hypertension (RH).
- Trial name
- SARAH (NCT03002558)
- Where
- Spain
- Volunteers
- 591 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Asthma; Eosinophilic, Asthma Chronic
Characteristics of Type 2- High Inflammatory Endotype of Asthma Using New Biomarkers From Peripheral Blood and Exhaled Air and Its Effect on the Outcome of Therapy
The goal of this study is to identify reliable, valid, easily measurable, interpretable, and useful biomarkers in peripheral blood and exhaled air by people with severe asthma for a more accurate description of the pathogenetic…
- Conditions
- Asthma; Eosinophilic, Asthma Chronic, Bronchial Asthma, Asthma, Bronchial
- Trial name
- NCT05270278
- Where
- Czechia
- Volunteers
- 89 people
- Sponsor
- Value Outcomes Ltd.
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