Clinical trials: Obstructive Airway Diseases
Bronchiolitis Obliterans, Bone Marrow Transplantation
Forced Oscillations for Diagnosis Help in Bronchiolitis Obliterans Syndrome in Post Bone Marrow Transplantation
A study to evaluate the role of forced oscillations in diagnosis of bronchiolitis obliterans syndrome in patients after bone marrow transplantation. The force oscillations technique will be compared with classical spirometry.
- Trial name
- OSCILLOMOELL (NCT02902471)
- Testing
- Forced oscillations measure
- Where
- 2 sites in France
- Volunteers
- 110 people
- Sponsor
- Hopital Foch
COPD
Diagnostic and Therapeutic Approaches to Hyperinflation and Small Airway Disease in COPD
Current guideline-based criteria defining COPD do not meet the challenges set by the complex pathophysiology of the disease. Hyperinflation and affection of the small airways are two components that are not represented in current…
- Trial name
- NCT03287921
- Testing
- mono bronchodilatation, dual bronchodilatation
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- Universitätsmedizin Mannheim
Reactive Airways Disease (RAD)
Study of Levalbuterol and Racemic Albuterol in Pediatric Subjects With Reactive Airways Disease (RAD)
The purpose of this study is to compare the efficacy of two dose levels of levalbuterol compared with one dose level of racemic albuterol in pediatric subjects aged birth to 48 months old.
- Trial name
- NCT00685126
- Testing
- Levalbuterol HCl Inhalation Solution, Albuterol HCl Inhalation Solution
- Where
- 34 sites in United States, Canada
- Volunteers
- 117 people
- Sponsor
- Sumitomo Pharma America, Inc.
Chronic Obstructive Pulmonary Disease (COPD)
Evaluation of the Effect of PUR118 on Ozone Induced Airway Inflammation in Healthy Normal Volunteers
This trial in healthy subjects will assess PUR118's effect on attenuating ozone induced airway inflammation. This trial will establish the tolerability of PUR118 in healthy normal volunteers.
- Trial name
- NCT01690949
- Testing
- PUR118
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pulmatrix Inc.
Asthma
Anti-histamines and Methacholine Challenges.
The asthmatic airway is identified and studied using inhaled agents such as histamine and methacholine. The use of antihistamines prior to the test will inhibit the test result if histamine is used to cause airway constriction.
- Trial name
- NCT01985789
- Testing
- Diphenhydramine, cetirizine, desloratadine
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Don Cockcroft
Asthma, Recurrent Cough
Spirometry and Methacholine Challenge Test in Asthmatic Children Age 3-6years
Rational: The possible contribution of methacholine challenge test via spirometry to the clinical diagnosis of young children with various respiratory symptoms, the most appropriate spirometry index, and the proper cutoff point…
- Trial name
- MCH-preschool (NCT00550758)
- Testing
- Methachoine, spirometry
- Volunteers
- 84 people
- Sponsor
- Rambam Health Care Campus
Asthma
Effect of an Inhaled Corticosteroid on Airway Gene Expression in Asthma
The purpose of this study is to determine whether an inhaled corticosteroid (fluticasone) alters the expression of any gene expressed in the lining of the airways of asthmatics.
- Trial name
- NCT00187499
- Testing
- Inhaled fluticasone 500 ug BID for 8 weeks
- Where
- United States
- Sponsor
- University of California, San Francisco
Uncontrolled Asthma
A Phase 3 Study to Evaluate the Efficacy and Safety of Tralokinumab in Adults and Adolescents With Uncontrolled Asthma
A 52-Week, Multicentre, Randomized, Double-Blind, Parallel Group, Placebo Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Tralokinumab in Adults and Adolescents with Asthma Inadequately Controlled on Inhaled…
- Trial name
- STRATOS1 (NCT02161757)
- Testing
- Tralokinumab
- Where
- 243 sites in United States, Argentina and 13 more
- Volunteers
- 1,207 people
- Sponsor
- AstraZeneca
Asthma, Reactive Airway Disease
Comparison of Oral Dexamethasone Doses in Asthma Exacerbation
Hypothesis: A 2-day course of oral dexamethasone is the superior option for the resolution of symptoms and prevention of relapse in the emergency department (ED) management of mild-moderate asthma exacerbations.
- Trial name
- NCT00942201
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Rady Children's Hospital, San Diego
Chronic Obstructive Pulmonary Disease (COPD), Chronic Obstructive Lung Disease
Make Every Step Count: Personalised Music Feedback to Walking for People Living With COPD
Pulmonary Rehabilitation (PR) is an evidence-based intervention to effectively manage the physiological and psychological effects of Chronic Obstructive Pulmonary Disease (COPD).
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Chronic Obstructive Lung Disease, Chronic Obstructive Airway Disease
- Trial name
- MuSiC (NCT06629675)
- Testing
- Music walking application BeatClearWalker (BCW)
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Leicester
Chronic Obstructive Airways Disease Exacerbated, Critical Care
Survival After Failed First-line Non-invasive Ventilation in Acute on Chronic Obstructive Pulmonary Disease
Observational cohort study of mid-to-long term survival of patients with acute on chronic obstructive pulmonary disease, analyzed per type of ventilation support provided during first 24 hours in intensive care.
- Trial name
- NCT03011853
- Testing
- Non-invasive and/or invasive mechanical ventilation
- Where
- Sweden
- Volunteers
- 7,900 people
- Sponsor
- Swedish Intensive Care Registry
Asthma
Effect of Dietary Supplements With Fish Oil on Mannitol-induced Airway Sensitivity & Inflammation in Persons With Asthma
We wish to investigate the effects of 3 weeks of orally administered fish oil supplements on the airway sensitivity (provoking dose to cause a 15% fall in FEV1, PD15) to inhaled mannitol (AridolTM).
- Trial name
- NCT00526357
- Testing
- omega-3 fatty acid
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Firestone Institute for Respiratory Health
Asthma
Unrefined Salmon Oil as Dietary Supplement in Adult Asthmatics
Research has over decades showed that marine food carries nutritional characteristics that promote human health. As seen in epidemiological studies and based on in vitro and in vivo studies, it is hypothesized that unrefined…
- Trial name
- NCT05137132
- Testing
- CARDIO®
- Where
- Norway
- Volunteers
- 70 people
- Sponsor
- Hofseth Biocare ASA
Asthma, Eosinophilic Asthma
Intense Airway Eosinophilia in Asthma
In asthma, the type and importance of the inflammatory response in the airways has allows identification of different phenotypes.
- Trial name
- NCT03696914
- Where
- Canada
- Volunteers
- 918 people
- Sponsor
- Laval University
Resistant Hypertension, Obstructive Sleep Apnea
Effect of Continuous Positive Airway Pressure (CPAP) Versus Auto-titrating Continuous Positive Airway Pressure (APAP) on Resistant Hypertension (HTN) and Arterial Stiffness
The primary objective is to evaluate the relative effectiveness of fixed CPAP in comparison to APAP in reducing arterial blood pressure in patients with resistant hypertension and obstructive sleep apnea (OSA).
- Trial name
- NCT01044355
- Testing
- CPAP, APAP
- Where
- 2 sites in Canada
- Volunteers
- 34 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Pulmonary Disease, Chronic Obstructive
Comparison of Aclidinium Bromide and Formoterol Fumarate in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
This exploratory study will compare the efficacy of the fixed-dose combination (FDC) of aclidinium bromide and formoterol fumarate once daily in the morning and placebo once in the evening vs.
- Trial name
- NCT00706914
- Testing
- Once-daily aclidinium/formoterol, Twice-daily formoterol fumarate, Once-daily formoterol fumarate
- Where
- 40 sites in United States
- Volunteers
- 156 people
- Sponsor
- AstraZeneca
Obstructive Sleep Apnea, Central Sleep Apnea (Diagnosis)
Effectiveness of Adaptive Servoventilation (ASV) in Patients With Central Sleep Apnea Due to Chronic Opioid Use
Prospective, randomized, blinded, cross-over study assessing the effectiveness of adaptive servo-ventilation (ASV) in treating patients who have obstructive sleep apnea (OSA) complicated by central sleep apnea (CSA) due to the…
- Conditions
- Obstructive Sleep Apnea, Central Sleep Apnea (Diagnosis), Chronic Opioid Use
- Trial name
- NCT01462084
- Testing
- Adaptive servo-ventilation (ASV), Bi-Level PAP
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- ResMed
Obstructive Sleep Apnea
Benefits of Telemedicine in CPAP Treatment
Continuous positive airway pressure (CPAP) is the first choice of treatment for moderate to severe obstructive sleep apnea syndrome (OSAS).
- Trial name
- NCT03202602
- Testing
- Telemonitoring of CPAP treatment, Standard care
- Where
- Sweden
- Volunteers
- 216 people
- Sponsor
- Uppsala University
Obstructive Sleep Apnea Syndrome
Obstructive Sleep Apnea Therapy by Stimulation of the Hypoglossal Nerve
Continuous positive airway pressure (CPAP) is the gold standard to normalize breathing during sleep in patients with obstructive sleep apnea syndrom (OSA). Many patients will not tolerate or will not accept CPAP.
- Trial name
- AIRSTIM (NCT03844295)
- Testing
- Activated Inspire® Upper Airway Stimulation System, Inactivated Inspire® Upper Airway Stimulation System
- Where
- France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Grenoble
COPD, Emphysema
Evaluate the Effects of Formoterol and Beclomethasone Dipropionate Combination Therapy on Small Airways Function
Inuvair® is a novel fixed combination product used in the treatment of asthma and under clinical development for the treatment of COPD.
- Conditions
- COPD, Emphysema, Small Airway Disease
- Trial name
- NCT01466712
- Testing
- Tiotropium + formoterol/beclometasone
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- KU Leuven