Clinical trials: Obstructive Airway Diseases
Smoking, COPD
Canadian Cohort on the Origin and Progression of Airway Disease: Physiology Platform
The Canadian Respiratory Research Network (CRRN) has recently been established to study the origins and evolution of airways disease in the population.
- Trial name
- NCT02153684
- Where
- 3 sites in Canada
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Dr. Denis O'Donnell
COPD, Chronic Obstructive Pulmonary Disease
A Study to Assess the Effects of PT001 and PT005 MDI on Specific Image Based Parameters in Subjects With Moderate to Severe COPD
To assess the effect of treatment with Glycopyronnium (GP) MDI administered twice daily (BID) and Formoterol Fumarate (FF) MDI administered BID on specific image-based airway volumes and resistance in subjects with moderate to…
- Trial name
- NCT02937584
- Testing
- GP MDI (PT001) 14.4 μg, FF MDI (PT005) 9.6 μg
- Where
- 2 sites in Belgium
- Volunteers
- 23 people
- Sponsor
- Pearl Therapeutics, Inc.
Obstructive Sleep Apnea Syndrome, Hypertension
Russian Study of the Effect of Continuous Positive Airway Pressure (CPAP) in Hypertension
The purpose of this study is to determine whether CPAP is effective in the treatment of systemic hypertension.
- Trial name
- NCT00801671
- Testing
- cPAP
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Russian Cardiology Research and Production Center
Sleep Apnea, Obstructive
Effectiveness of Auto-adjusted Continuous Positive Airway Pressure for Long-term Treatment of Sleep Apnea
Hypothesis: Computer controlled continuous positive airway pressure (autoCPAP) is equally effective in improving obstructive sleep apnea syndrome symptoms, breathing disturbances, objective vigilance, and it is cost-effective…
- Trial name
- NCT00280800
- Testing
- constant CPAP devices, automatic CPAP devices
- Where
- Switzerland
- Volunteers
- 208 people
- Sponsor
- Konrad E. Bloch
Pulmonary Disease, Chronic Obstructive, Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome
Differences of Small Airways Function Between Chronic Obstructive Pulmonary Disease(COPD) and Asthma-copd Overlap(ACO)
The purpose of this study is to research the differences of small airways function between subjects with diagnosis of chronic obstructive pulmonary disease(COPD) and asthma-COPD overlap(ACO).The assessment of quality of life is…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome, Small Airway Disease, Quality of Life
- Trial name
- NCT03563001
- Testing
- Budesonide(160ug) and Formoterol(4.5ug) bid
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhujiang Hospital
Asthma, Allergic Rhinitis
Viral Mucosal Reprogramming
This is a mechanistic, controlled, open-label, single-site study to evaluate the effects of RG-RV16 inoculation on airway mucosal gene expression and airway remodeling in 25 healthy controls (HC), in 25 allergic rhinitis subjects…
- Conditions
- Asthma, Allergic Rhinitis, Cat Allergy, Healthy
- Trial name
- VMR (NCT05331170)
- Testing
- Research Grade RG-RV
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
ASTHMA
Breathing Training for Asthma
For the proposed randomized controlled treatment study, the investigators plan to compare the effects of this hypoventilation-based breathing training with a control intervention that will focus on breathing regularity and…
- Trial name
- NCT00975273
- Testing
- Capnometry Assisted Respiration Training, Breathing Awareness
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Southern Methodist University
Obstructive Sleep Apnea, Muscle Disorder
Effects of Newly-created Individualized Upper Airway Muscle Functional Training on Patients With OSA
Objectives: To observe the effect of newly-created individualized upper airway muscle functional training on the condition and intraday symptoms of OSA patients; to study the effect of this training method on the excitability of…
- Trial name
- NCT05346705
- Testing
- New individualized upper airway muscle functional training
- Where
- China
- Volunteers
- 300 people
- Sponsor
- First Hospital of China Medical University
Obstructive Sleep Apnea
Upper Airway Stimulation Versus Continuous Positive Airway Pressure
Standard therapy in patients with obstructive sleep apnea (OSA) is continuous positive airway pressure (CPAP). 30% to 50% are not adherent to this therapy and need an alternative treatment.
- Trial name
- NCT03756805
- Testing
- upper airway stimulation, continuous positive airway pressure
- Where
- Germany
- Volunteers
- 227 people
- Sponsor
- Technical University of Munich
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
HR-lowering Efficacy and Respiratory Safety of Ivabradine in Patients With Obstructive Airway Disease
The purpose of this study is to investigate heart rate lowering efficacy and respiratory safety of ivabradine in patients with asthma and COPD.
- Trial name
- NCT01365286
- Testing
- Ivabradine (Procoralan)
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Lodz
Chronic Obstructive Pulmonary Disease (COPD)
Microbiology & Immunology of the Chronically-inflamed Airway
Chronic obstructive pulmonary disease (COPD) is the fourth most common cause of death and the only one of the common causes that is still rising.
- Trial name
- MICA (NCT01701869)
- Where
- United Kingdom
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Asthma
Sorting and Expression Profiling of Airway Cells From Humans (The SEARCH Study)
This will be a single site, mechanistic study of asthmatic subjects and healthy, non-asthmatic controls involving a baseline characterization visit and a research bronchoscopy visit.
- Trial name
- SEARCH (NCT02791542)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Obstructive Sleep Apnea
Improving 24-hour Blood Pressure in Obstructive Sleep Apnea
This study examines the combined effects of an angiotensin receptor blocker (ARB), antioxidant supplementation, and continuous positive airway pressure (CPAP) therapy on the lowering of 24-hour blood pressure in persons with…
- Trial name
- NCT04021550
- Testing
- Continuous Positive Airway Pressure CPAP, Telmisartan 80mg, Alpha-Lipoic Acid 600mg
- Sponsor
- University of British Columbia
Emphysema or COPD
Airway Bypass - Safety and Feasibility Study
The objective of this study is to evaluate its safety and feasibility of the Airway Bypass Stent System in patients with severe emphysema.
- Trial name
- AIRWAY (NCT06249529)
- Testing
- Airway Bypass
- Where
- Georgia
- Volunteers
- 10 people
- Sponsor
- Zoar Engelman
Controlled Asthma
Modelling of the Upper Airway in Children With Controlled Asthma
Asthma in children is recognized as a disease area with a high medical need. As the investigators move into this field it is necessary to improve the investigators knowledge of upper airway anatomical structure in paediatric…
- Trial name
- NCT01594151
- Testing
- Cone Beam Computed Tomography
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- FLUIDDA nv
Obstructive Sleep Apnea Syndrome, Brain Infarction
Consequences of Obstructive Sleep Apnea Syndrome (OSAS) After Ischemic Subtentorial Stroke.
Obstructive Sleep Apnea Syndrome (OSAS) is associated with stroke as a risk factor but little is known about the consequences of OSAS on the outcome and the survival after stroke.
- Trial name
- NCT01561677
- Testing
- Continuous Positive Airway pressure-RESPIRONICS
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Montpellier
Obstructive Sleep Apnea
Association Between Treatment Adherence and Treatment Adherence in Sleep Apnea (SEMSAS)
The objective of the study is to define an optimal threshold of the SEMSA-15 scale for obstructive sleep apnea (OSA) perception in patients with OSA to predict 3-month and 1-year continuous positive airway pressure adherence.
- Trial name
- SEMSAS (NCT04894175)
- Where
- France
- Volunteers
- 302 people
- Sponsor
- Thibaut Gentina
Chronic Obstructive Pulmonary Disease, Lung Disease
To Evaluate the Effect of AZD3199 on the Electrical Activity in the Heart
The purpose of this research study is to evaluate the effect of AZD3199 on the electrical activity of the heart. The effect of AZD3199 will be compared to a licensed antibiotic (moxifloxacin).
- Trial name
- NCT01222442
- Testing
- AZD3199, Moxifloxacin
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Obstructive Sleep Apnea
TPAP for Comfort in OSA
TheraPAP is a prototype device (with full documented electrical and isolation safety) being developed by SleepRes for the treatment of obstructive sleep apnea (OSA) that can deliver either standard CPAP at a set pressure or what…
- Trial name
- NCT06264128
- Testing
- TPAP, CPAP
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- SleepRes Inc.
Obstructive Sleep Apnea
Impact of Interface With/Without Oral Appliance of Sleep Apnea Treatment
CPAP is the most effective treatment of obstructive sleep apnea. Oro-nasal masks may be used in case of mouth leaks but these are associated with higher positive pressure needs and lower compliance to treatment.
- Trial name
- NCT01889472
- Testing
- Nasal mask and oral appliance vs oro-nasal mask during autoCPAP therapy
- Where
- 3 sites in Canada, France
- Volunteers
- 15 people
- Sponsor
- Laval University
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