Clinical trials: Obstructive Airway Diseases
Chronic Obstructive Airway Disease
Continuous Versus Interval Walking Training in Patients With COPD - a Pilot Study
This study will investigate the effects of interval walking training versus continuous walking training in patients with chronic obstructive pulmonary disease.
- Trial name
- NCT02209207
- Testing
- Treadmill, walking training
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Primary Snore, Obstructive Sleep Apnea (Mild and Moderate).
Effects of Oropharyngeal Exercises on Patients With Primary Snore, Mild and Moderate Obstructive
Randomized study of patients with primary snore, mild and moderate obstructive sleep apnea. Protocol include 40 patients randomized to oropharyngeal exercise or use of nasal dilator, breathing exercise and nasal lavage.
- Trial name
- EOE (NCT01636856)
- Testing
- Oropharyngeal exercises, Respiratory exercises, nasal dilator, nasal lavage
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Obstructive Sleep Apnea
The TELEAP1 CPAP-telemonitoring Study
TELEAP1 is a multicenter cohort pilot-study designed to evaluate the impact of a published SFRMS/SPLF CPAP-telemonitoring diagnosis/therapeutic algorithm on the CPAP-compliance of newly treated patients with obstructive sleep…
- Trial name
- TELEAP1 (NCT04897646)
- Testing
- SFRMS/SPLF CPAP-telemonitoring diagnosis/therapeutic algorithm.
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Montpellier
Obstructive Sleep Apnea
The Effect of Eszopiclone on the Arousal Threshold in Sleep Apnea Syndrome
The purpose of this study is to find out whether taking eszopiclone (Lunesta) changes the breathing effort required to briefly wake people with obstructive sleep apnea from sleep (respiratory arousal threshold).
- Trial name
- NCT01102270
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Brigham and Women's Hospital
Snoring, Obstructive Sleep Apnea
NO Measurements in Screening for Asthma and OSA, in Patients With Severe Snoring
In Denmark an estimated 200.000 patients suffer from obstructive sleep apnoea (OSA). The breathing pauses during sleep result in varying degrees of symptoms ranging from none over disturbed sleep to severe daytime sleepiness and…
- Conditions
- Snoring, Obstructive Sleep Apnea, Asthma, Airway Disease
- Trial name
- NCT03964324
- Testing
- Fractioned Exhaled Nitrogen Oxide measurements
- Where
- Denmark
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Christian von Buchwald
Asthma, Chronic Obstructive Pulmonary Disease
Inhaled Fluticasone Effects on Upper Airway Patency in Obstructive Lung Disease
The Chairman of the Veterans' Disability Benefits Commission reported at a recent US Senate hearing that asthma, chronic obstructive pulmonary disease (COPD), and sleep apnea are among the top 13 most frequent diagnoses leading…
- Conditions
- Asthma, Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnea
- Trial name
- InFLOW (NCT01554488)
- Testing
- Inhaled Fluticasone Propionate
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- VA Office of Research and Development
Chronic Rhinosinusitis (Diagnosis), Asthma
Unified Airway Model
Chronic rhinosinusitis (CRS) impacts approximately 5% of Canadians. CRS patients suffer from a combination of symptoms that include facial pain, nasal obstruction, hyposmia and mucopurulence discharge.
- Trial name
- NCT03937427
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University of British Columbia
Sleep Apnea, Obstructive Sleep Apnea
Continuous Positive Airway Pressure, Arousability and Links to Mechanisms in Obstructive Sleep Apnea
The study design is a randomized, controlled clinical trial to test the hypothesis that arousal threshold (ArTH) will affect how individuals with obstructive sleep apnea (OSA, Apnea-Hypopnea Index (AHI) of 10/hour of higher)…
- Trial name
- CALM-OSA (NCT07332442)
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Yale University
Tracheobronchomalacia
Pressure Dependent Tracheal Obstruction in Copd Patients
Background. Do pressure dependent tracheal obstructions (PDTO) often seen during bronchoscopy in COPD patients affect pulmonary function tests and breathing symptoms? Method. Model study.
- Trial name
- PDTO (NCT01679808)
- Where
- Norway
- Volunteers
- 104 people
- Sponsor
- LHL Helse
Asthma
Tezepelumab Treatment in Korean Severe Asthma Patients
There is no study that systematically evaluated the effect of Tezepelumab on cough, and based on this background, the present researchers aimed to evaluate the effect of Tezepelumab treatment in patients with severe asthma who…
- Trial name
- NCT06438913
- Testing
- Tezepelumab
- Volunteers
- 100 people
- Sponsor
- Asan Medical Center
Early Adult Lung Function, Small Airway Disease
Factors Affecting Early Adult Lung Function
Attainment of peak healthy lung function during the 18-26 yr window is a strong determinant of the rate of lung function decline during the later years of life.
- Conditions
- Early Adult Lung Function, Small Airway Disease, Metabolic Syndrome
- Trial name
- FEAL (NCT03187158)
- Testing
- Forced Oscillation Technique
- Where
- India
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Council of Scientific and Industrial Research, India
Chronic Obstructive Pulmonary Disease
Efficacy and Safety of Aclidinium Bromide for Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) (LAS-MD-33)
The purpose of this study is to assess the efficacy (effectiveness) and safety of aclidinium bromide doses as compared to placebo in the treatment of moderate to severe chronic obstructive pulmonary disease.
- Trial name
- NCT00891462
- Testing
- Aclidinium bromide
- Where
- 112 sites in United States, Canada
- Volunteers
- 561 people
- Sponsor
- AstraZeneca
Asthma
Effect of Inhaled Ciclesonide in Adult Patients With Asthma (BY9010/M1-125)
Ciclesonide is a novel inhaled corticosteroid for the treatment of asthma. In this study the effect of ciclesonide on airway hyperresponsiveness (AHR), exhaled nitric oxide (NO), and induced sputum inflammatory biomarkers will be…
- Trial name
- NCT00546520
- Testing
- Ciclesonide
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease (COPD)
Altitude Related Illness In Patients With Respiratory Disease
Randomized, placebo controlled trial evaluating efficacy of dexamethasone in preventing acute mountain sickness in lowlanders with chronic obstructive lung disease travelling from 700 m to 3200 m.
- Trial name
- NCT02450968
- Testing
- Dexamethasone
- Where
- Kyrgyzstan
- Volunteers
- 124 people
- Sponsor
- University of Zurich
COPD
A 1-year Multi-center, Prospective, Cohort Study in Patients With Chronic Obstructive Pulmonary Disease Treated With Long-acting Bronchodilator
This multi-center study is designed to describe natural history of disease, treatment and health care products in physician-diagnosed COPD patients who require adding daily maintenance therapy in real world.
- Trial name
- NCT01794780
- Testing
- LABA based treatment: indacaterol, LAMA based treatment: tiotropium, LABA/ICS based treatment: salmeterol/fluticasone
- Where
- 2 sites in China
- Volunteers
- 2,229 people
- Sponsor
- Novartis Pharmaceuticals
Obstructive Sleep Apnea
PAP Therapy Sleep Apnea and Exercise
Positive airway pressure (PAP) therapy is generally offered to patients with obstructive sleep apnea. The investigators suggest that beneficial effects of PAP therapy is by preventing apneas and therefore reducing cardiac and…
- Trial name
- NCT01786291
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- University of Gaziantep
Innate Immunity, Mucosal Immunity
Lung Immune Challenge Study: Controlled Exposure to Inhaled Resiquimod (R848)
Respiratory viral infections can be a cause of significant illness, particularly in vulnerable individuals as seen in the COVID-19 pandemic.
- Conditions
- Innate Immunity, Mucosal Immunity, Asthma, Viral Infection
- Trial name
- NCT06488118
- Testing
- R848, Saline
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Akhilesh Jha
Obstructive Sleep Apnea Syndrome, Gut Microbiota
Intestinal Dysbiosis During Obstructive Sleep Apnea Syndrome
Obstructive Sleep Apnea Syndrome (OSA) is one of the most common chronic diseases and is associated with prognostic cardiovascular and metabolic co-morbidities.
- Trial name
- DYNAMIC (NCT04947410)
- Testing
- CPAP or nasal dilators
- Sponsor
- University Hospital, Grenoble
Obstructive Sleep Apnea, Diabetes Mellitus
Obstructive Sleep Apnea and Diabetes Mellitus
The investigators hypothesize that obstructive sleep apnea (OSA) contributes to impaired glucose homeostasis and associated vasculopathy, and nCPAP treatment of OSA should improve glycemic control and vascular function in OSA…
- Trial name
- NCT00876980
- Testing
- nasal Continuous Positive Airway Pressure
- Where
- Hong Kong
- Volunteers
- 64 people
- Sponsor
- The University of Hong Kong
Smoke-related Lung Diseases, Chronic Obstructive Pulmonary Disease
Impact of Fluticasone and Salmeterol on Airway Dendritic Cells (DCs) in Smokers
Airway dendritic cells (DCs) play a key role in smoke-related lung diseases. In this study, the researchers investigate the effects of fluticasone and salmeterol on human airway DCs in smokers.
- Trial name
- NCT00908362
- Testing
- fluticasone, fluticasone/salmeterol
- Where
- Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Rostock
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