Clinical trials: Obstructive Airway Diseases
Chronic Obstructive Pulmonary Disease
Efficacy, Safety and Tolerability of Aclidinium Bromide/Formoterol Fumarate Compared With Aclidinium Bromide and Formoterol Fumarate in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this Phase III study is to assess the maintenance bronchodilator effects of the fixed dose combination versus monotherapies.
- Trial name
- NCT01437397
- Testing
- Aclidinium Bromide/Formoterol Fumarate, Aclidinium Bromide, Formoterol Fumarate
- Where
- 222 sites in United States, Australia and 2 more
- Volunteers
- 1,692 people
- Sponsor
- AstraZeneca
Bronchiolitis Acute
Bronchiolitis Clearance Airways With Seaserum
The objective of this study is to show that the use of electrodialyzed seawater reduces the duration (in days) of symptoms in acute infant bronchiolitis compared with the use of saline solution in infants aged 1 month to less…
- Trial name
- B-CLASS (NCT06177197)
- Testing
- Physiomer, Saline solution
- Where
- 8 sites in France
- Volunteers
- 458 people
- Sponsor
- University Hospital, Brest
Obstructive Sleep Apnea
KPAP vs EPR for Efficacy
The KPAP EPR is a randomized, crossover study in which treatment efficacy will be compared between SleepRes CPAP + KPAP and ResMed CPAP + EPR.
- Trial name
- NCT07530523
- Testing
- APAP + KPAP, APAP + EPR
- Volunteers
- 24 people
- Sponsor
- SleepRes Inc.
Obstructive Sleep Apnea, High Flow Nasal Canula
Long-term Effect of High Flow Nasal Canula Therapy on Obstructive Sleep Apnea
Patients meeting the criteria of obstructive sleep apnea were included, and all patients signed informed consent, which met the requirements of the ethics Committee of our unit. All subjects were hospitalized patients.
- Conditions
- Obstructive Sleep Apnea, High Flow Nasal Canula, Continuous Positive Airway Pressure Ventilation
- Trial name
- HFNC (NCT05549310)
- Testing
- CPAP, high-flow nasal canula oxygen therapy
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Qilu Hospital of Shandong University
Obstructive Sleep Apnea, Excessive Daytime Sleepiness
BF2.649 in Patients With OSA and Treated by CPAP But Still Complaining of EDS
Multicenter randomized double blind study versus placebo during 12 weeks with at first, an escalating dose period followed by stable dose period at the selected dose.
- Trial name
- HAROSA1 (NCT01071876)
- Testing
- BF2.649
- Where
- France
- Volunteers
- 244 people
- Sponsor
- Bioprojet
Cardiopulmonary Disease
SGA for TEE: Safe Alternative to Deep Sedation for Patients With High-risk Cardiopulmonary Disease.
Increasingly, transesophageal echos (TEEs) are being done on high risk patients. A TEE is a short procedure done with deep sedation, but poses an increased risk of apnea/ hypoxemia in those with pulmonary disease.
- Trial name
- SGA-TEE (NCT04939220)
- Testing
- TEE with SGA, TEE with Deep Sedation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Obstructive Sleep Apnea Syndrome, Obesity
Influence of nCPAP on Metabolic Consequences Associated With OSAS
Context: Obstructive sleep apnea syndrome (OSAS) is associated with cardiovascular morbidity. Recurrent episodes of occlusion of upper airways during sleep result in hormonal changes that may predispose to high cardiovascular…
- Trial name
- NCT00435643
- Testing
- nasal continuous positive airway pressure
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Asthma in Children
Exhaled Nitric Oxide and Airway Caliber in Children With Asthma
The purpose of this study is to assess if in steroid naïve asthmatic children with elevated baseline exhaled nitric oxide, treatment with inhaled steroid and normalization of exhaled nitric oxide level results in restoration of…
- Trial name
- NCT01645397
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Atlantic Health System
Obstructive Sleep Apnea, Sleep Apnea
The Comfort of Proactive Sleep Apnea Therapy
The goal of this clinical trial is to compare in OSA patients who regularly adhere to CPAP therapy. The main question[s] it aims to answer are: To assess if proactive therapy can effectively treat OSA with lower mean therapy…
- Trial name
- NCT06144892
- Testing
- Proactive Therapy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- NovaResp Technologies Inc
Asthma, Copd
Effects of Smoking on Bronchial Epithelium
Asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory airway diseases affecting millions of people worldwide.
- Trial name
- NCT00849433
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- University Medical Center Groningen
Eosinophilic Asthma, Chronic Sinusitis
Eosinophils Endotypes in Chronic Airway Inflammatory Diseases
Asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) are frequently described as unified airway inflammatory diseases. Both heavily impacts quality of life with substantial productivity loss.
- Conditions
- Eosinophilic Asthma, Chronic Sinusitis, Eosinophilic Rhinitis
- Trial name
- PLEIAD (NCT04187976)
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Lille
Obstructive Sleep Apnea, Atherosclerosis
Early Signs of Atherosclerosis in Obstructive Sleep Apnea: Effects of Treatment
Obstructive sleep apnea (OSA) is associated with adverse cardiovascular outcomes, including acute myocardial infarction and stroke. Atherosclerosis is an important step for these events.
- Trial name
- NCT00400543
- Testing
- Continuous positive airway pressure (CPAP)
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- University of Sao Paulo
Chronic Obstructive Pulmonary Disease (COPD)
Effect of Dexamethasone on Sleep Related Breathing Disturbances in Patients With COPD at Altitude
Randomized, placebo controlled trial evaluating efficacy of dexamethasone in preventing sleep related breathing disturbances in lowlanders with chronic obstructive lung disease travelling from 700 m to 3200 m.
- Trial name
- NCT02450994
- Testing
- Dexamethasone
- Where
- Kyrgyzstan
- Volunteers
- 124 people
- Sponsor
- University of Zurich
Lung Cancer, Emphysema
CryoSpray Ablation(tm)Thoracic Patient Registry
The purpose of this study is to create a patient registry to collect and analyze information on subjects treated with the CryoSpray Ablation™ System post-510K approval.
- Conditions
- Lung Cancer, Emphysema, Chronic Bronchitis, COPD
- Trial name
- NCT00785239
- Sponsor
- CSA Medical, Inc.
Down Syndrome, Obstructive Sleep Apnea
Computer Models of Airways in Children and Young Adults With Sleep Apnea and Down Syndrome
The purpose of this research study is to develop a way of predicting with computers how surgery on the airway will affect night time breathing called Obstructive Sleep Apnea (OSA) in children with Down Syndrome.
- Trial name
- DYMOSA (NCT01902407)
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Asthma, Allergies and Obesity
The Relation Between Obesity, Adipose Tissue Content of Fatty Acids and Systemic and Airway Inflammation
Obesity has been recognized as a risk factors for developing asthma. In a cohort of 5384 children aged 15-17, we aim to: 1. To investigate the association of asthma prevalence at age 15-17 with body mass index (BMI) at age 15-17…
- Trial name
- NCT01229787
- Where
- Cyprus
- Volunteers
- 5,384 people, healthy volunteers welcome
- Sponsor
- Cyprus International Institute for Environment and Public Health
Chronic Obstructive Pulmonary Disease (COPD)
Assessment of Risk in Chronic Airways Disease Evaluation
Patients with chronic obstructive pulmonary disease (COPD) have an increased risk of cardiovascular disease,osteoporosis, muscle wasting and diabetes mellitus.
- Trial name
- ARCADE (NCT01656421)
- Where
- United Kingdom
- Volunteers
- 767 people, healthy volunteers welcome
- Sponsor
- Cardiff University
Obstructive Sleep Apnea, Fatty Acid Metabolism
Fatty Acid Metabolism in Obstructive Sleep Apnea (FAMOSA)
Obstructive sleep apnea syndrome (OSA) is a disease affecting 5-15% of population and 50-80% of type 2 diabetes mellitus (T2DM) and obese subjects. OSA causally contributes to the development of glucose intolerance and T2DM.
- Conditions
- Obstructive Sleep Apnea, Fatty Acid Metabolism, Continuous Positive Airway Pressure
- Trial name
- FAMOSA (NCT02683616)
- Testing
- CPAP
- Where
- Czechia
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Obstructive Sleep Apnea Syndrome
Continuous Positive Airway Pressure (CPAP) Mode Impact on Clinical Blood Arterial Pressure
Background: Continuous positive airway pressure (CPAP) is the first line therapy for obstructive sleep apnea syndrome (OSAS). Two positive airway pressure (PAP) modalities can be used: Fixed pressure, in which the effective…
- Trial name
- AgirSASadom (NCT01090297)
- Testing
- S8 Spirit 2, Somnosmart 2, Remstar Auto
- Where
- France
- Volunteers
- 322 people
- Sponsor
- AGIR à Dom
Obstructive Sleep Apnea
Study to Predict the Benefits of First-line Humidification Use and Comparison of the Effect of ThermoSmart™ and no Humidification on Adherence
This study aims to investigate the benefits of using first line heated humidification. The primary objective of this research is to determine the effect of high levels of humidification delivered by ThermoSmart™ on CPAP…
- Trial name
- NCT01742949
- Testing
- Heated humidification (ThermoSmart), No Humidification
- Where
- 4 sites in France
- Volunteers
- 40 people
- Sponsor
- Fisher and Paykel Healthcare
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