Clinical trials: Obstructive Airway Diseases
Asthma, Pulmonary Disease, Chronic Obstructive
Association Between Increased Oxidative Stress, Anti-Inflammatory Fatty Acid Formation, and Airway Infection in People With Asthma and Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) and asthma are common respiratory diseases in which people experience long-term inflammation of the lungs.
- Trial name
- NCT00595114
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea of Adult, Acute Coronary Syndrome
OSA-ACS Project: Association of OSA and CPAP Therapy With Outcomes in ACS Patients
Obstructive sleep apnea (OSA) is an increasingly common chronic disorder in adults that has been strongly associated with various forms of cardiovascular disease.
- Trial name
- NCT03362385
- Testing
- Patients with OSA based on sleep study, Patients without OSA based on sleep study
- Where
- China
- Volunteers
- 2,160 people
- Sponsor
- Beijing Anzhen Hospital
Obstructive Sleep Apnea (OSA) and Obesity
A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study to Evaluate the Efficacy and Safety of HDM1005 Injection in Subjects With Obstructive Sleep Apnea (OSA) and Obesity Receiving Positive Airway Pressure (PAP) Therapy
This is a 56-week randomized, double blinded, parallel-controlled study evaluating the efficacy and safety of the HDM1005 in patients with obstructive sleep apnea (OSA) and obesity receiving positive airway pressure (PAP)…
- Trial name
- NCT07794397
- Testing
- HDM1005
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Acute Respiratory Failure
Continuous Positive Airway Pressure and Oxygen Concentration on Measurement of Rapid Shallow Breathing Index
To compare the rapid shallow breathing index (RSBI) values, the incidence of adverse reactions, and the predictive accuracy measured under 5 different ventilator strategies in the same patient group.
- Trial name
- NCT00632320
- Where
- Taiwan
- Volunteers
- 98 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Obstructive Sleep Apnea
Diagnostic Validation of Drug-Induced Sleep Endoscopy (DISE)
This study aims to validate whether the pattern of airway collapse recorded during Drug-Induced Sleep Endoscopy (DISE) mirrors that of natural sleep, and to develop a model for airway collapse.
- Trial name
- NCT03391141
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Dr. Erica Thaler
Asthma
Novel Method for Removal of Orally Deposited Inhaled Fluticasone Propionate
This study is to find out if an Extra Virgin Olive-Oil-based Water (EVOOW) mix, removes more Fluticasone Propionate (FP) from the mouth than Water alone.
- Trial name
- EVOOW (NCT07664527)
- Testing
- Fluticasone Propionate, Water Mouthwash, EVOOW Mouthwash
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Obstructive Sleep Apnea, Hypoxemia
Mechanisms of Endothelial Cell Dysfunction in Sleep Apnea
Sleep apnea is a common sleep disorder characterized by temporary stops in breathing during sleep and has been associated with the development of cardiovascular disease.
- Trial name
- NCT00859950
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Obstructive Sleep Apnea (OSA)
Palatal Implants in Combination With Continuous Positive Airway Pressure to Treat Obstructive Sleep Apnea
The study will be done for the following purposes: to see if Pillar implants in combination with CPAP therapy can help people with their OSA by decreasing the CPAP pressures to find out if receiving Pillar implants will increase…
- Trial name
- Pillar-CPAP (NCT00730041)
- Testing
- Pillar Palatal Implant System
- Where
- 7 sites in United States
- Volunteers
- 51 people
- Sponsor
- Medtronic Xomed, Inc.
Statin, Airway Disease
Adjunctive Role of Statin Therapy on Airway Inflammation and Clinical Consequences of Chronic Obstructive Pulmonary Disease
This study aimed to evaluate the impact of statin therapy on the clinical consequences, as well as airway inflammation and radiological features, in severe chronic obstructive pulmonary cases.
- Conditions
- Statin, Airway Disease, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT07549932
- Testing
- Statin, placepo intervention
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mohamed Salah El-Sayed
Obstructive Sleep Apnea (OSA)
Mandibular Advancement Device (MAD) and Continuous Positive Airway Pressure (CPAP) for Treatment of Adult Patients Diagnosed With Moderate Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a frequent illness related to sleep and breathing with many symptoms and complications. The primary choices of treatment are continuous positive airway pressure (CPAP) and removable appliance for…
- Trial name
- NCT07677332
- Testing
- Mandibular advancement device (MAD), Continuous positive airway pressure (CPAP)
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- University of Copenhagen
Obstructive Sleep Apnea, Central Sleep Apnea
Long-term Observation of PAP-therapy With Telemonitoring: Telemedicine Registry TelePAP
Telemonitoring for Positive Airway Pressure (PAP) therapy might help to establish and maintain long-term therapy adherence and thus support the beneficial effects of PAP therapy on long-term outcomes.
- Conditions
- Obstructive Sleep Apnea, Central Sleep Apnea, Mixed Sleep Apnea
- Trial name
- TelePAP (NCT03043716)
- Testing
- PAP therapy with telemonitoring
- Where
- 6 sites in Germany
- Volunteers
- 14,147 people
- Sponsor
- ResMed
Obstructive Sleep Apnea
Telemedici ne Management of Veterans With Newly Diagnosed Obstructiv e Sleep Apnea (OSA)
Automatically titrating continuous positive airway pressure (APAP) and continuous positive airway pressure (CPAP) are considered first-line treatments for obstructive sleep apnea.
- Trial name
- NCT02159885
- Testing
- Telemonitoring
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Corporal Michael J. Crescenz VA Medical Center
Obstructive Sleep Apnea Syndrome
Continuous Positive Airway Pressure and Acetazolamide to Treat Sleep Apnea Syndrome Patients at Altitude
The purpose of the study is to investigate the effect of nasal continuous positive airway pressure in combination with acetazolamide as a treatment for sleep related breathing disturbances in patients with the obstructive sleep…
- Trial name
- NCT00928655
- Testing
- acetazolamide, nocturnal continuous positive airway pressure
- Where
- Switzerland
- Volunteers
- 51 people
- Sponsor
- University of Zurich
Pulmonary Disease, Chronic Obstructive
Airway Limitation Study: Study In Primary Care Centers Of Chronic Bronchitis In Long-Term Cigarette Smokers Of At Least 40 Years Of Age With Symptoms Of Cough And Shortness Of Breath
The study does not involve testing of a drug (no treatment intervention). The study will will use spirometry (breathing tests) in subjects of 40 years of age and older with a history of cigarette smoking with chronic bronchitis…
- Trial name
- NCT00442468
- Testing
- Non-interventional study.
- Where
- 47 sites in United States
- Volunteers
- 1,283 people
- Sponsor
- GlaxoSmithKline
COPD
Effects of Exhalation Valve on the Lack of Air and Exercise Tolerance in Patients With COPD
The purpose of this study is to evaluate the effects of the application of Expiratory Positive Airway Pressure (EPAP) on Dynamic Hyperinflation, dyspnea and exercise tolerance in patients with Chronic Obstructive Pulmonary…
- Trial name
- NCT02566915
- Testing
- CPET submaximal with EPAP
- Where
- Brazil
- Volunteers
- 19 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Asthma
Acute Airway Vascular Smooth Muscle Effects of Inhaled Budesonide
Glucocorticosteroids recently have been shown to have non-genomic actions that are plasma membrane-mediated and do not require gene transcription and translation.
- Trial name
- NCT01219738
- Testing
- Budesonide 360ug, Budesonide 720ug, Budesonide 1440ug
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Miami
COPD, Chronic Obstructive Pulmonary Disease
A Study to Assess the Effects of PT001 and PT005 MDI on Specific Image Based Parameters in Subjects With Moderate to Severe COPD
To assess the effect of treatment with Glycopyronnium (GP) MDI administered twice daily (BID) and Formoterol Fumarate (FF) MDI administered BID on specific image-based airway volumes and resistance in subjects with moderate to…
- Trial name
- NCT02937584
- Testing
- GP MDI (PT001) 14.4 μg, FF MDI (PT005) 9.6 μg
- Where
- 2 sites in Belgium
- Volunteers
- 23 people
- Sponsor
- Pearl Therapeutics, Inc.
Chronic Obstructive Pulmonary Disease (COPD)
Patients With Chronic Obstructive Pulmonary Disease at Altitude - Effect of Nocturnal Oxygen on Breathing and Sleep
The purpose of this study is to investigate the effect of nocturnal oxygen therapy during a stay at moderate altitude on breathing and sleep of patients with chronic obstructive lung disease.
- Trial name
- NCT02150590
- Testing
- Oxygen
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- University of Zurich
Obstructive Sleep Apnea, Difficult Intubation
STOP-BANG and Cephalometry in Prediction of Difficult Airway in Patients at Risk of OSA
Incidence of difficult laryngoscopy and difficult intubation are higher among patients with obstructive sleep apnoea (OSA). Precision in making the diagnosis and predicting difficult laryngoscopy preoperatively may help to reduce…
- Trial name
- NCT03105388
- Where
- Malaysia
- Volunteers
- 41 people
- Sponsor
- Universiti Sains Malaysia
Pulmonary Disease, Chronic Obstructive
A Study to Evaluate the Anti-inflammatory Effects of Solithromycin in Chronic Obstructive Pulmonary Disease
This study examines the potential benefit of a new antibiotic, Solithromycin, for the long-term treatment of Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT02628769
- Testing
- Solithromycin
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Imperial College London
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