Clinical trials: Obstructive Airway Diseases
Healthy, Smokers
Effect of Whole Body Periodic Acceleration on Airway Endothelial Function
In the present proposal the investigators wish to assess the effect of a single session with the device known as Exer-Rest® which applies Whole Body Periodic Acceleration (WBPA) on baseline airway blood flow (Qaw) and in Qaw…
- Conditions
- Healthy, Smokers, Asthma
- Trial name
- NCT01213706
- Testing
- Whole Body Periodic Acceleration (WBPA)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Miami
Asthma Childhood, Exercise
Active Airways for Children and Young People With Asthma
What is this study about? The investigators want to see if exercise and education sessions can help children and young people (aged 10-17) with asthma, manage the participants asthma better.
- Conditions
- Asthma Childhood, Exercise, Children
- Trial name
- NCT07643753
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION, education
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Leicester
Asthma, Allergic Rhinitis
Assessment of Oxidative Stress Markers in the Upper and Lower Airways of Atopic Children Treated With Nebulized Beclomethasone
Although it is well known that the presence of uncontrolled inflammation in upper airways may compromise the control of asthma and may favor the progression of asthma toward more severe grades of disease, few studies addressed…
- Trial name
- NCT01113489
- Testing
- beclomethasone dipropionate
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy
Obstructive Sleep Apnea (OSA)
Educational Motivational Program on Sleep Apnea
The study aims to introduce a motivational intervention for patients with Obstructive Sleep Apnea (OSA) starting CPAP therapy to improve sleep quality and treatment adherence.
- Trial name
- ME-CA (NCT06668597)
- Testing
- Motivational educational program to improve sleep quality in OSA patients through adherence to CPAP
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Obstructive Sleep Apnea
Stimulation Therapy for Apnea: Reporting Thoughts
Upper airway stimulation (UAS) via unilateral implantation of a phasic hypoglossal nerve stimulation device is a safe and effective alternative treatment for patients with moderate to severe obstructive sleep apnea (OSA) who are…
- Trial name
- START (NCT04768543)
- Testing
- Upper airway stimulation (Inspire Medical Systems, Inc.)
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Pittsburgh
Excessive Daytime Sleepiness, Obstructive Sleep Apnea
Pitolisant (BF2.649) in the Treatment of EDS in Patients With OSA
The first objective of this study is to demonstrate the efficacy and safety of pitolisant given at 10, 20, or 40 mg per day versus placebo during 12 weeks of the Double Blind period, to treat the Excessive Daytime Sleepiness…
- Trial name
- HAROSA3 (NCT02739568)
- Testing
- Pitolisant (BF2.649)
- Where
- 6 sites in Bulgaria, North Macedonia
- Volunteers
- 389 people
- Sponsor
- Bioprojet
Sleep Apnea, Obstructive, Respiration Disorders
Treatment of Children With Obstructive Sleep Apnea and Laryngomalacia: the Role of Laser Supraglottoplasty
This is a research study of the effect of treating laryngomalacia (floppiness of tissue on top of the voice box that can possibly block breathing) found in association with obstructive sleep apnea (blockage of breathing while…
- Trial name
- NCT00394550
- Testing
- supraglottoplasty with laser
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Indiana University
Obstructive Sleep Apnea, Spinal Cord Injuries
Overnight Upper Airway Infiltration in Spinal Cord Injury
Obstructive Sleep Apnea (OSA), a common disorder resulting from repetitive pharyngeal collapse during sleep, is multifactorial. Usually, OSA is considered primarily a problem of upper airway anatomy, with the craniofacial…
- Trial name
- OUI-SCI (NCT05391308)
- Testing
- Pre-polysomnography mesurement, Polysomnography measure, Post-polysomnography measurements
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension, Obstructive Sleep Apnea
Renal Denervation in Patients With Resistant Hypertension and Obstructive Sleep Apnea
The purpose of this study is to investigate the clinical utility of renal denervation for the treatment of resistant hypertension coexisting with obstructive sleep apnea.
- Trial name
- NCT01366625
- Testing
- Renal denervation with a catheter-based procedure (Symplicity® Catheter System)
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Asthma Bronchiale, COPD
Bronchodilator Response in COPD and Asthma: Correlation Between Spirometry, IOS Indices, and Dyspnea Relief
A bronchodilator reversibility test is widely used in the diagnosis and management of obstructive lung diseases. Bronchodilators relieve symptoms in asthma and COPD.
- Conditions
- Asthma Bronchiale, COPD, Bronchodilation, Spirometry
- Trial name
- NCT07364188
- Testing
- Bronchodilator
- Volunteers
- 120 people
- Sponsor
- Allergi- og Lungeklinikken, Elsinore
Radionuclide Imaging (MIBG Scintigraphy), Exercise Test
The Effects of Continuous Positive Airway Pressure (CPAP) on Sympathetic Activity in Different Sites of Activation
Recent evidences suggest that obstructive sleep apnea (OSA) can contribute to cardiovascular disease even in the absence of hypertension.
- Conditions
- Radionuclide Imaging (MIBG Scintigraphy), Exercise Test, Blood Pressure Monitoring, Ambulatory, Sympathetic Nerve Activity
- Trial name
- NCT01336335
- Testing
- CPAP
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo
Sleep Apnea, Obstructive, Acute Myocardial Infarction
Obstructive Sleep Apnea and Acute Myocardial Infarction and the Role of Continuous Positive Airway Pressure (CPAP)Treatment
Specific Aim 1. To determine the prevalence of OSA in patients of first-time AMI in acute phase By screening patients of first-time, single-vessel disease, Killip I AMI, and successful revascularization 2.
- Trial name
- NCT00821210
- Testing
- CPAP of optimal pressure
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Ischemic Stroke, Intra Cerebral Hemorrhage
Stroke and CPAP Outcome Study 3
A problem with breathing during sleep, called obstructive sleep apnea (OSA), likely increases the risk of stroke and is common in people who have had a stroke, present in about 2/3 of stroke survivors.
- Conditions
- Ischemic Stroke, Intra Cerebral Hemorrhage, Obstructive Sleep Apnea, Adherence, Treatment
- Trial name
- SCOUTS3 (NCT06029959)
- Testing
- Continuous positive airway pressure (CPAP), CPAP technical support intervention, Motivational Enhancement Therapy (MET)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Washington
Mounier-Kuhn Syndrome
Airway Collapse in Patients With Mounier-Kuhn Syndrome: Titration With Positive Pressure to Reduce Collapse
Mounier-Kuhn syndrome (MKS), or congenital tracheobronchiomegaly, is an entity characterized by dilation of the trachea and bronchi, associated with respiratory infections.The main signs and symptoms are cough, bulging and…
- Trial name
- NCT03101059
- Testing
- Non invasive ventilation - Continuous Positive Airway Pressure
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- University of Sao Paulo General Hospital
Heart Failure, Pulmonary Disease, Chronic Obstructive
Pulmonary Function, Chronic Obstructive Pulmonary Disease (COPD) Prevalence, and Systemic Inflammation in Chronic Heart Failure With or Without COPD
The aim of the present study is: 1. To investigate pulmonary function abnormalities (restriction, obstruction, diffusion impairment, mixed pulmonary defects) in patients with chronic heart failure (CHF) and to determine which of…
- Conditions
- Heart Failure, Pulmonary Disease, Chronic Obstructive, Inflammation
- Trial name
- NCT01429376
- Testing
- Pulmonary function tests, Blood tests, Questionnaires
- Where
- 2 sites in Netherlands
- Volunteers
- 234 people
- Sponsor
- Rijnstate Hospital
Severe, Refractory Asthma, Airway Inflammation
A Randomized, Placebo-Controlled, Double-Blind Pilot Study of Pioglitazone Hydrochloride in Severe, Refractory Asthma
Background: Individuals who have severe asthma that is not easily controlled by current treatments are in need of new treatments to prevent potentially life-threatening asthma attacks.
- Conditions
- Severe, Refractory Asthma, Airway Inflammation, Airflow Obstruction
- Trial name
- NCT00994175
- Testing
- Pioglitazone
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Copd
Searching Clinical Chronic Obstructive Pulmonary Disease Onset
The aim of this study is to determine if presence of dyspnea identifies differences in the 6-min walk test performance among smokers with normal or mild spirometric obstruction, accounting for the confounding effect of heart…
- Trial name
- SOON (NCT03026439)
- Where
- Chile
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Chronic Obstructive Pulmonary Disease, Emphysema
BROnchoalveolar Investigations of Never-smokers With Chronic Obstruction From the Swedish CardioPulmonary bioImage Study
Obstructive lung disease is an increasing global health problem of pandemic proportions, with COPD alone affecting >10% of the population. Smoking is the main and most well studies risk factor for developing COPD.
- Conditions
- Chronic Obstructive Pulmonary Disease, Emphysema, Chronic Bronchitis, Airway Obstruction
- Trial name
- BRONCOSCAPIS (NCT03049202)
- Where
- 6 sites in Sweden
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Sleep Apnea, Obstructive
Effect of CPAP Treatment in Elderly: Randomized Clinical Trial
Rationale: Almost all the information the investigators have about the effect of continuous positive airway pressure (CPAP) in patients with obstructive sleep apnea (OSA) comes from randomized clinical trials including only…
- Trial name
- NCT02069600
- Testing
- Continuous Positive Airway Pressure
- Where
- Spain
- Volunteers
- 224 people
- Sponsor
- Hospital Universitario La Fe
Asthma, Small Airway Disease
The Prevalence Of Small Airways Dysfunction In Asthma Patients And The Impact On The Asthma Control
Asthma, which are one of the most important causes of morbidity and mortality both in the world and in our country, constitute a very serious social and economic burden.
- Trial name
- NCT04375995
- Testing
- Impulse oscillometry, Spirometric pulmonary function test, Fractional exhaled nitric oxide (FENO) test
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Sibel Naycı
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