Clinical trials: Obstructive Apnea
Obstructive Sleep Apnea (OSA)
Direct Referral for Apnea Monitoring
The primary objective of this project is to compare a health care delivery model, Direct Referral for Apnea Monitoring (DREAM), with initial in-person (Traditional) clinic appointments for Veterans at risk for obstructive sleep…
- Trial name
- DREAM (NCT05419323)
- Where
- 3 sites in United States
- Volunteers
- 6,501 people
- Sponsor
- VA Office of Research and Development
Obstructive Sleep Apnea (Moderate to Severe), Obstructive Sleep Apnea
A Mindfulness-Based Intervention to Improve CPAP
The main purpose of this study is to assess the effectiveness of a mindfulness-based intervention in improving CPAP use compared to online peer support
- Trial name
- NCT05499286
- Testing
- Mindfulness Program
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- The Hospital for Sick Children
Obstructive Sleep Apnea
Dexamethasone Treatment for OSA in Children
This is a double-blinded clinical trial of children diagnosed with moderate to severe obstructive sleep apnea (OSA) on a baseline polysomnogram (PSG).
- Trial name
- NCT05638087
- Testing
- Dexamethasone
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- The Hospital for Sick Children
Obstructive Sleep Apnea, Postoperative Pain
Effect of Sleep Apnea on Pain After Dental Treatment
This observational study aims to investigate the effects of sleep quality and systemic health status on pain levels following endodontic treatment in adult patients.
- Conditions
- Obstructive Sleep Apnea, Postoperative Pain, Hypertension Complicated With Type 2 Diabetes
- Trial name
- OSA-EndoPain (NCT07581964)
- Testing
- Standard Endodontic Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Harran University
Multiple Sclerosis, Obstructive Sleep Apnea
Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis
This study will evaluate the influence of sleep apnea on clinical and radiological features of MS. Sleep apnea is associated with hypoxemia during sleep, which is likely detrimental to MS.
- Trial name
- SOMNUS (NCT04603196)
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Beth Israel Deaconess Medical Center
OSA, Sleep Apnea
Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?
Obstructive sleep apnea (OSA) is common in older adults and has recently been implicated in pathogenesis of Alzheimer's disease (AD). Research has shown that sleep disruptions have caused memory impairment.
- Conditions
- OSA, Sleep Apnea, Obstructive Sleep Apnea, Alzheimer Disease
- Trial name
- NCT05094271
- Testing
- Supplemental Oxygen, Continuous Positive Airway Pressure Machine, Room Air
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- University of California, San Diego
Apnea, Obstructive
EFFECT OF A SUBSTANCE P ANTAGONIST ON THE SECRETION OF ALDOSTERONE IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME AND ARTERIAL HYPERTENSION
Obstructive sleep apnea syndrome (OSAS) is associated with hyperaldosteronism with elevated plasma aldosterone/renin ratio, the physiopathological mechanism of which remains uncertain.
- Trial name
- APHOS3 (NCT06462287)
- Testing
- Aprepitant 125 and 80Mg Oral Capsule
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Rouen
Sleep Apnea, Glucose Metabolism Disorders
Obstructive Sleep Apnea and Glucose Metabolism
Many adults who are overweight have obstructive sleep apnea (OSA) which disrupts sleep and makes it difficult to breath during the night. OSA increases the risk for a person to become insulin resistant and diabetic.
- Trial name
- OSAGM (NCT03408613)
- Testing
- Positive Airway Pressure, Supplemental Oxygen
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Obstructive Sleep Apnea
Patient-centered and Neurocognitive Outcomes With Acetazolamide for Sleep Apnea
Obstructive sleep apnea (OSA) is a severe type of snoring causing people to choke in their sleep. It affects millions of Americans, causing many health problems.
- Trial name
- PANACEA (NCT05804084)
- Testing
- Acetazolamide
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Diego
Atrial Fibrillation, Obstructive Sleep Apnea
Structured Testing and Treatment for Obstructive Sleep Apnea in Patients With Atrial Fibrillation
The main goal of this prospective pre-post implementation study is to investigate how a structured testing and treatment program for obstructive sleep apnea using the NOX T3s device and a Fitbit smartwatch with the FibriCheck…
- Trial name
- STAROSA (NCT06263608)
- Testing
- (Cardio)Respiratory polygraphy (NOX T3s), Polysomnography, Devices to deliver Continuous Positive Airway Pressure (CPAP), Bilevel Positive Airway Pressure (BiPAP) or Adaptive support ventilation (ASV)
- Where
- 2 sites in Belgium
- Volunteers
- 209 people
- Sponsor
- University Hospital, Antwerp
Obstructive Sleep Apnea
Exploring the Use of Phototherapy to Improve CPAP Compliance
Photobiomodulation (PBM) is a type of light therapy like lasers and LEDs. PBM was previously known by different terms like "low-level laser therapy" (LLLT) or "photobiostimulation." LLLT, despite its name, can also have effects…
- Trial name
- NCT06960161
- Testing
- Phototherapy
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Hypoxia, OSA
MEA DPA Hypoxic Event Reductions
The goal of the study is to compare deoxygenation events during anesthesia induction and mask ventilation when using standard oral pharyngeal airways or the novel distal pharyngeal airway.
- Conditions
- Hypoxia, OSA, Obesity
- Trial name
- NCT07572500
- Testing
- DPA, OPA
- Sponsor
- Stanford University
Chronic Rhinosinusitis With Nasal Polyps, Obstructive Sleep Apnea
Polysomnographic Findings in Nasal Polyposis
Nasal polyposis (NP) is a chronic inflammatory disease of the nasal and sinus mucosa leading to protrusion of edematous polyps in the nasal cavity. Prevalence of NP among the chronic rhinosinusitis patients is 25-30 %.
- Trial name
- POLYSOMNO (NCT03725956)
- Testing
- Endoscopic sinus surgery
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Obstructive Sleep Apnea
Increasing the Use of an Anti-snoring Mouth Guard (Mandibular Advancement Appliance) to Prevent Upper Airway Collapse During Sleep in Patients With Obstructive Sleep Apnoea.
Obstructive Sleep Apnoea (OSA) is a sleep-related breathing disorder that is characterized by the repeated collapse of the upper airway during sleep, resulting in sleep deprivation.
- Trial name
- IPOSAT (NCT04092660)
- Testing
- Behaviour change Intervention Based on Health Action Process Approach Model, Mandibular Advancement Appliance (MAA) or Anti-snoring mouth guard
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- Queen Mary University of London
Type 2 Diabetes, Pre Diabetes
Multi-morbidity Screening in People With Type 2 Diabetes and Pre Diabetes
People with type 2 diabetes are at risk of complications linked with high blood sugars and these are monitored for in healthcare appointments.
- Conditions
- Type 2 Diabetes, Pre Diabetes, Obstructive Sleep Apnea, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT06053177
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- University of Liverpool
Obstructive Sleep Apnea
KPAP Adherence Crossover Study
A device able to provide less positive airway pressure (PAP) for the entire duration of inspiration and roughly half the duration of expiration, designated KPAP, is being developed by SleepRes for the treatment of obstructive…
- Trial name
- NCT06413134
- Testing
- KPAP, APAP
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- SleepRes Inc.
Sleep Apnea
Safety and Efficacy Study of Sivopixant, Acetazolamide and SASS-001 in Sleep Apnea
The primary purpose of this study is to evaluate the effectiveness of sivopixant, acetazolamide and SASS-001 in adults with sleep apnea with a central component.
- Trial name
- NCT06776432
- Testing
- Sivopixant, Acetazolamide, SASS-001
- Where
- 9 sites in United States
- Volunteers
- 60 people
- Sponsor
- Shionogi
Obstructive Sleep Apnea Syndrome (OSAS)
Acceptance of Mandibular Advancement Devices
Background: Obstructive sleep apnea syndrome (OSAS) is a prevalent condition with significant comorbidities. Mandibular advancement devices (MADs) are an established alternative for patients intolerant to continuous positive…
- Trial name
- NCT06970171
- Testing
- MAD of the Scheu Dental type with lateral guidance wings (MAD-1), MAD of the Panthera X3 type with lateral guidance wings (MAD-2)
- Where
- Germany
- Volunteers
- 28 people
- Sponsor
- University Medicine Greifswald
Sleep Apnea Syndromes
Effect of Compression Stockings on the Number of Apneas/Hypopneas Per Hour of Sleep in Patients With Syndrome Obstructive Sleep Apnea/Hypopnea as Compared to no Treatment
The sleep apnea-hypopnea syndrome is characterized by the occurrence, during sleep, of abnormally frequent episodes of interruption of ventilation (apnea), or significant reduction in ventilation (hypopnea).
- Trial name
- NCT05477719
- Testing
- Wearing of specific compression stockings
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Sigvaris France
Obstructive Sleep Apnea
Semi-up Right Position Study
Our main objective is to perform an explanatory, first stage proof of concept, randomized controlled trial to determine whether a semi-upright patient position versus a supine position while asleep in the postoperative period…
- Trial name
- NCT02152202
- Testing
- Semi-upright position, Supine position
- Where
- 4 sites in Canada
- Volunteers
- 164 people
- Sponsor
- University Health Network, Toronto