Clinical trials: Obstructive Apnea
Non-alcoholic Fatty Liver Disease, Sleep Apnea, Obstructive
Obstructive Sleep Apnea and Non-alcoholic Fatty Liver Disease
Obstructive sleep apnea (OSA) and nonalcoholic fatty liver disease (NAFLD) are frequently encountered in patients with metabolic syndrome (MS). Several data suggest that OSA per se could be a risk factor of liver injury.
- Trial name
- NASHSAS (NCT03373643)
- Testing
- OSA screening
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Angers
Obstructive Sleep Apnea
The Effects of Oral Appliance Therapy on Masseter Muscle Activity in Obstructive Sleep Apnea
Previous studies have shown that contractions of the jaw-closing masseter muscle (MAS) often occur shortly after respiratory events during sleep in obstructive sleep apnea (OSA) patients.
- Trial name
- NCT02011425
- Testing
- mandibular advancement appliance
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Université de Montréal
Obstructive Sleep Apnea
Vasoactive Hormones During the Night in Patients With Obstructive Sleep Apnea Before and After Treatment With CPAP.
We wanted to test the hypothesis that treatment with continuous positive airway pressure reduces nocturnal hypoxia and thereby affecting levels of vasoactive hormones leading to a fall in blood pressure patients with obstructive…
- Trial name
- NCT00360659
- Testing
- Continuous Positive Airway Pressure
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Regional Hospital Holstebro
Chronic Respiratory Failure With Hypercapnia, Chronic Obstructive Pulmonary Disease (COPD)
Study Evaluating Telemonitoring and Experimentation in Telemedicine for the Improvement of Healthcare Pathways (ETAPES Program) Compared to Standard of Care in Patients With Chronic Respiratory Failure Receiving Non-invasive Home Ventilation
The ETAPES Program, a French national Experimentation in Telemedicine for the Improvement of Healthcare Pathways, was launched in 2018 for 4 years.
- Conditions
- Chronic Respiratory Failure With Hypercapnia, Chronic Obstructive Pulmonary Disease (COPD), Obesity Hypoventilation Syndrome (OHS)
- Trial name
- e-VENT (NCT04615078)
- Testing
- ETAPES Program
- Where
- 11 sites in France
- Volunteers
- 56 people
- Sponsor
- Air Liquide Santé International
Obstructive Sleep Apnea of Adult
Acute and Long-term Effects of CPAP in OSA
Two-phase interventional non-inferiority trial (phase 1: at least 8 weeks of CPAP; phase 2: 2 weeks of CPAP withdrawal) including 32 patients with moderate to severe OSA to compare the physiological consequences of a short-term…
- Trial name
- NCT06277115
- Testing
- Continuous positive airway pressure (CPAP)
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- University of Zurich
Obstructive Sleep Apnea Syndrome, Nasal Obstruction
Heated Humidified Continuous Positive Airway Pressure and Nasal Physiology
Nasal continuous positive airway pressure can cause nasal side effects which can compromise compliance to therapy. Humidifiers can attenuate this effect.
- Trial name
- NCT00850876
- Where
- Greece
- Volunteers
- 20 people
- Sponsor
- University of Athens
Sarcoidosis, Obstructive Sleep Apnea
Obstructive Sleep Apnoea in Sarcoidosis
Sarcoidosis is a multisystemic granulomatous disease of unknown origin. Fatigue is a common problem in sarcoidosis affecting between 50% and 80% of patients, and thus represents a major impairment of their quality of life.
- Conditions
- Sarcoidosis, Obstructive Sleep Apnea, Fatigue, Sleepiness
- Trial name
- OSASA (NCT04156789)
- Testing
- Home sleep apnea testing
- Where
- Switzerland
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Malcolm Kohler
Sleep Apnea Syndrome (OSAS)
Semaglutide Effects on Sleep Apnea in Patients With Type 2 Diabetes/Obesity and Comorbid Obstructive Sleep Apnea
Semaglutide (a GLP-1RA) is approved for type 2 diabetes mellitus T2DM and obesity, but its effect on obstructive sleep apnea OSA remains unclear.
- Trial name
- NCT07281196
- Testing
- Semaglutide Subcutaneous Injection
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Shanghai Fengxian District Central Hospital
Obstructive Sleep Apnea, Patent Foramen Ovale
Close Obstructive Sleep Apnea (OSA) Trial
The aim of this study is to evaluate the benefits of patent foramen ovale (PFO) closure on patients with obstructive sleep apnea (OSA) and persistent hypoxia despite optimal therapy.
- Trial name
- NCT06113562
- Testing
- PFO closure
- Sponsor
- University of Miami
Obstructive Sleep Apnea, Obesity
Novel Inhibitors of Lipolysis in the Treatment of Lipid a Glucose Metabolism in Obstructive Sleep Apnea Syndrome
Obstructive sleep apnea syndrome (OSA) represents highly prevalent (typically overlooked, undiagnosed and untreated) disorder significantly increasing cardiovascular, cancer and overall mortality as well as increasing the risk of…
- Trial name
- NORRIS (NCT05245240)
- Testing
- Dietary and physical intervention
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Obstructive Sleep Apnea, Hypoxemia
Mechanisms of Endothelial Cell Dysfunction in Sleep Apnea
Sleep apnea is a common sleep disorder characterized by temporary stops in breathing during sleep and has been associated with the development of cardiovascular disease.
- Trial name
- NCT00859950
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Sleep Apnea, Mixed Central and Obstructive
Prevention of Airway Obstruction Events
The standard for treatment for people suffering from obstructive sleep apnea (OSA) syndrome involves the use of Continuous, or Automatic Positive Airway Pressure (CPAP, APAP) machines, which work by delivering air via tubing and…
- Trial name
- NCT04873024
- Testing
- cMAP Flow V 2.0
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- NovaResp Technologies Inc
Obstructive Sleep Apnea, Snoring
A Trial to Evaluate a Device for the Treatment of OSA and Snoring
To evaluate the safety and efficacy of the Tongue Advancement Retainer Device in treating subjects with Obstructive Sleep Apnea (OSA) and snoring.
- Trial name
- OPEN (NCT01772017)
- Testing
- Tongue Advancement Retainer Device
- Where
- 3 sites in United States, Australia
- Volunteers
- 15 people
- Sponsor
- Sleepy, Inc
Obstructive Sleep Apnea
Sleepiness and Tiredness Among Doctors Working in A Tertiary Hospital
Sleep disorders are important health issues that can reduced ones quality of life by affecting their performance and productivity in a negative way.
- Trial name
- NCT04020991
- Testing
- Sleep Study
- Where
- Malaysia
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Obstructive Sleep Apnea
Effect of a Very Low Calorie and Low Calorie Diet on Moderate to Severe Obstructive Sleep Apnea in Obese Adults
The purpose of this study is to test the effectiveness of two different weight loss diets on obstructive sleep apnea (OSA) severity.
- Trial name
- NCT02251574
- Testing
- Low Calorie Diet, Very Low Calorie Diet, Standard Care
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Pulmonary Disease, Cardiac Disease
World Trade Center (WTC) CHEST
This project will evaluate the effects of World Trade Center (WTC) exposure in WTC responders 10-13 years following the events of 9/11.
- Conditions
- Pulmonary Disease, Cardiac Disease, Cardiopulmonary Disease, Obstructive Sleep Apnea
- Trial name
- NCT01466218
- Where
- United States
- Volunteers
- 1,012 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Type 2 Diabetes, Obesity
A Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or Overweight
The purpose of this study is to is to evaluate the efficacy and safety of retatrutide in participants with type 2 diabetes in participants who have obesity or overweight (J1I-MC-GZBK master protocol) including a subset of…
- Conditions
- Type 2 Diabetes, Obesity, Overweight, Obstructive Sleep Apnea
- Trial name
- TRIUMPH-2 (NCT05929079)
- Testing
- Retatrutide
- Where
- 98 sites in United States, Argentina and 6 more
- Volunteers
- 1,152 people
- Sponsor
- Eli Lilly and Company
Obstructive Sleep Apnea, Coronary Heart Disease
Long-term Effects of CPAP on Lipidemia and Hs-CRP Levels in OSA Patients
The increased risk of atherosclerotic morbidity and mortality in patients with obstructive sleep apnea (OSA) has been linked to hypertension, insulin resistance, dyslipidemia, and systemic inflammation.
- Trial name
- NCT02127177
- Testing
- Continuous Positive Airway Pressure Ventilator
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Chinese Pulmonary Vascular Disease Research Group
Obstructive Sleep Apnea (OSA)
Dim Light at Night in Patients With Obstructive Sleep Apnea
With the advent of electricity, light at night has become a ubiquitous part of our society. The main purpose of this study is to determine whether sleeping with dim light (40 lux), the brightness of a night light) in your bedroom…
- Trial name
- NCT01853891
- Testing
- dim light at night
- Where
- United States
- Sponsor
- Ulysses Magalang MD
Obstructive Sleep Apnea (OSA)
Telemonitoring With CPAP in Severe Obstructive Sleep Apnea in Primary Health Care
Obstructive sleep apnea (OSA) is a prevalent sleep disorder associated with cardiovascular, metabolic, cognitive, and psychological complications.
- Trial name
- CPAP-APS (NCT07464262)
- Testing
- CPAP Telemonitoring, CPAP Therapy
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Federal University of São Paulo
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