Clinical trials: Obstructive Apnea
Schizoaffective Disorder, Schizophrenia
Obstructive Sleep Apnea Treatment in Serious Mental Illness
Serious mental illnesses (SMI) like schizophrenia and bipolar disorder are two of the most disabling and costly chronic illnesses worldwide.
- Conditions
- Schizoaffective Disorder, Schizophrenia, Bipolar Disorder, Obstructive Sleep Apnea of Adult
- Trial name
- NCT05457127
- Testing
- Automatic Positive Airway Pressure (APAP)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Obstructive Sleep Apnea, Cardiovascular Disease
Cardiovascular Effects After CPAP Withdrawal for Obstructive Sleep Apnea
Background: Patients with obstructive sleep apnea run an increased risk of cardiovascular disease including hypertension. Continuous positive airway pressure (CPAP) is the first line of treatment.
- Trial name
- NCT02329470
- Testing
- Withdrawal of continuous positive airway pressure treatment
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Umeå University
Obstructive Sleep Apnea Syndrome
Safety and Efficacy of Eszopiclone With Mild to Moderate Obstructive Sleep Apnea Syndrome (OSAS)
The purpose of this study is to evaluate the hypnotic efficacy of ezopiclone in subjects with mild to moderate OSAS.
- Trial name
- NCT00685269
- Testing
- Eszopiclone
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Sumitomo Pharma America, Inc.
Obstructive Sleep Apnea, Hypertension
Isometric Hand Grip Training in Obstructive Sleep Apnea (OSA)
Obstructive sleep apnea (OSA) is a common clinical condition, involving the development of arterial hypertension. A Meta analysis study have shown that isometric hand grip training promotes blood pressure reduction.
- Trial name
- OSA (NCT03757169)
- Testing
- Hand grip isometric contraction, Control
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- University of Pernambuco
Ischemic Stroke, Sleep Apnea Syndrome
Screening and Treatment of SAHS in Patients With Acute Ischemic Stroke
Ischemic stroke is a kind of common disease with great harm. In acute stage of stroke there is sharply increasing morbidity of sleep apnea hypopnea syndrome.
- Trial name
- SAHS (NCT02029183)
- Testing
- Bi level positive pressure ventilation, bi-level positive airway pressure
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University
Sleep Apnea Syndromes, Sleep Apnea, Obstructive
How Does the Clinical and Paraclinical Efficacy of an Oral Appliance Evolved According to Propulsion: Control With Each mm of Advancement
The OAMMM study is a mono-centrer , non interventional, prospective study, carried out in CH Valence Oral Appliance is indicated for first line moderate sleep Apnea Syndrome or severe sleep Apnea Syndrome after failure of…
- Conditions
- Sleep Apnea Syndromes, Sleep Apnea, Obstructive, Respiratory Tract Diseases
- Trial name
- OAMMM (NCT05056766)
- Testing
- questionnaires: Epworth Sleepiness Scale; Pichot fatigue questionnaire.
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier de Valence
Type 1 Diabetes, Obstructive Sleep Apnoea
Obstructive Sleep Apnoea in Patients With Type 1 Diabetes
The primary aim of this study is to assess the relationship between obstructive sleep apnoea (OSA) and cardiac autonomic neuropathy (CAN) in patients with T1D.
- Trial name
- NCT03481361
- Where
- United Kingdom
- Volunteers
- 47 people
- Sponsor
- University of Birmingham
Obstructive Sleep Apnea
Efficacy, Safety and Tolerability of Sulthiame in Patients With Obstructive Sleep Apnea (OSA)
multi-center, randomized, double-blind, placebo-controlled, dose-finding, 4-arm, parallel assignment study to evaluate the efficacy of three different doses of sulthiame (STM) compared to placebo on sleep apnea activity in adult…
- Trial name
- NCT05236842
- Testing
- Sulthiame
- Where
- Belgium
- Volunteers
- 298 people
- Sponsor
- Desitin Arzneimittel GmbH
Obstructive Sleep Apnea, Sleep Apnea
Continuation Protocol for Study Using Negative Pressure to Reduce Apnea Trial
The goal of this study is to allow continued access to the aerSleep II System for subjects that have completed the SOM-029 study until the device is commercially available.
- Trial name
- CO-STAR (NCT05608486)
- Testing
- aerSleep II
- Sponsor
- Sommetrics, Inc.
Obstructive Sleep Apnea
Self-Management of Continuous Positive Airway Pressure Settings
Obstructive sleep apnea (OSA) is a major chronic condition affecting the quality of life of millions of Americans. Per the Institute of Medicine new treatment adherence strategies are needed to help improve the quality of care…
- Trial name
- ImPRESS (NCT03536572)
- Testing
- Sleep Apnea Self-Management Program
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- VA Office of Research and Development
Obstructive Sleep Apnea
TipTraQ Home Sleep Test Validation Study, VGH
A validation study has been designed to assess the performance of a home sleep test device, TipTraQ, for screening sleep apnea. The study involves participants wearing the TipTraQ device on their fingertip during a traditional…
- Trial name
- NCT06474390
- Where
- Taiwan
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- PranaQ Pte. Ltd.
Sleep Apnea, Obstructive
The Advance Trial. Tongue Advancement for Obstructive Sleep Apnea: An Evaluation of the Aspire Medical Advance System
The objective of the study is to assess the effectiveness of the Aspire Medical Advance System in obstructive sleep apnea by demonstrating a statistically significant mean reduction in the apnea-hypopnea index (AHI) from baseline…
- Trial name
- NCT00467324
- Testing
- Aspire Medical Advance System
- Where
- 4 sites in United States
- Volunteers
- 42 people
- Sponsor
- Aspire Medical
Sleep Apnea, Obstructive, Hypopnea Syndrome
Treatment of Refractory Excessive Daytime Sleepiness in Patients With Obstructive Sleep Apnea/Hypopnea Syndrome (OSA/HS) Using Nasal Continuous Positive Airway Pressure (nCPAP) Therapy (0249-015)
The purpose of this study is to determine the safety and efficacy of MK0249 in treating refractory excessive daytime sleepiness (EDS) in patients with Obstructive Sleep Apnea/Hypopnea Syndrome (OSA/HS) using nasal continuous…
- Conditions
- Sleep Apnea, Obstructive, Hypopnea Syndrome, Excessive Daytime Sleepiness
- Trial name
- NCT00620659
- Testing
- Comparator: MK0249, Comparator: modafinil
- Volunteers
- 125 people
- Sponsor
- Merck Sharp & Dohme LLC
Sleep Apnea, Obstructive
Evaluating Accuracy of Breath Sound Recordings and STOP-Bang Screening For Obstructive Sleep Apnea While Awake
The investigators will perform a diagnostic accuracy study comparing tracheal breath sound recordings in awake individuals to the STOP-Bang screening questionnaire, using the apnea-hypopnea index (AHI) score determined by…
- Trial name
- NCT02987283
- Where
- Canada
- Volunteers
- 439 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Coronary Artery Disease
Influence of Obstructive Sleep Apnea on the Severity of Coronary Artery Disease
It is widely accepted that coronary artery disease (CAD) is related to a high mortality. It is predicted that an increase of approximately 21.3 million cardiovascular events and 7.7 million cardiovascular deaths over 2010 to 2030…
- Trial name
- NCT04741022
- Where
- China
- Volunteers
- 255 people
- Sponsor
- Chinese Pulmonary Vascular Disease Research Group
Lung Transplant, Lung Resection
Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders
The goal of this research is to optimize the MRI system to obtain ideal lung images using Hyperpolarized (HP) Noble and Inert Fluorinated Gases as contrast agents. Lung coils tuned to the frequencies of these gases will be used.
- Conditions
- Lung Transplant, Lung Resection, Lung Cancer, Asthma
- Trial name
- NCT02748798
- Testing
- HP 3He, HP 129Xe, PFP
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Thunder Bay Regional Health Research Institute
Sleep Apnea, Obstructive
Maxillomandibular Advancement Surgery for Treatment of Obstructive Sleep Apnoea Syndrome
This study looks at how jaw surgery called maxillomandibular advancement with counterclockwise rotation affects breathing during sleep in people with moderate to severe obstructive sleep apnea who cannot tolerate standard…
- Trial name
- OSAS (NCT07446634)
- Testing
- Maxillomandibular advancement surgery with counterclockwise rotation
- Where
- Sweden
- Volunteers
- 48 people
- Sponsor
- Jani Talvilahti
Sleep Apnea
Sideward Turning Beds for Sleep Apnea
The aim of this feasibility study is to compare different settings of a custom-made automated bed with respect to their ability to induce a change in the sleeping position of the user.
- Trial name
- NCT04265118
- Testing
- Sidewards Tilting Bed
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Sleep Apnea, Cardiovascular Diseases
Oxidative Stress and Cardiovascular Morbidity in Sleep Apnea-Hypopnea Syndrome (SAHS)
The purpose of this study is to compare the levels of 8-isoprostane and other oxidative stress biomarkers in plasma and condensed exhaled air between patients with SAHS and cardiovascular complications, patients with SAHS without…
- Trial name
- OSCAMSA (NCT00487929)
- Testing
- nasal CPAP
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario La Paz
Obstructive Sleep Apnea, Hypertension
The Effect of Sleep Apnea and Hypertension on Gut Microbiome
Obstructive sleep apnea (OSA) and hypertension are closely associated diseases. Here we characterized the differences in the gut microbiome which is affected by the two diseases, when the two diseases coexist or are present…
- Conditions
- Obstructive Sleep Apnea, Hypertension, Gut Microbiome
- Trial name
- NCT05266131
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Peking University First Hospital
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