Clinical trials: Obstructive Chronic Pulmonary Disease
Chronic Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Domiciliary Nasal High Flow and Patient Outcomes in Chronic Hypercapnic Respiratory Failure in the United Kingdom
Chronic hypercapnic respiratory failure (CHRF) in the context of Chronic Obstructive Pulmonary Disease (COPD) and Obesity Hypoventilation Syndrome (OHS) is associated with increased mortality.
- Conditions
- Chronic Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease, Obesity Hypoventilation Syndrome (OHS), Nasal High Flow
- Trial name
- NCT05167201
- Testing
- Nasal High Flow
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Copd, Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The Individualized Accurate Diagnosis and Treatment of Chronic Objective Pulmonary Disease(COPD) Patients Based on Multidimensional Data
Chronic obstructive pulmonary disease (COPD) is known as progressive lung disease and the fourth leading cause of death worldwide.
- Trial name
- COPD (NCT04183530)
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Pulmonary Disease, Chronic Obstructive
A Psychological Intervention to Promote Acceptance and Adherence to NIV in People With COPD
This study aims to analyze the impact of a brief psychological support intervention in the promotion of the adherence to Non Invasive Ventilation (NIV) among people with Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT02499653
- Testing
- Psychological Intervention, Videos
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Asthma Bronchiale, COPD
Investigation of the Respiratory Profile of Patients With Obstructive Pulmonary Disease (ASTHMA, COPD)
The primary aim of the OPTIPULM study is the evaluation of recorded pulmonary function curves and, based on them, the computer modelling of lung deposition for the individually used or potentially applicable inhalation drugs.
- Trial name
- OPTIPULM (NCT06966271)
- Where
- 7 sites in Hungary
- Volunteers
- 150 people
- Sponsor
- Tradeflex Ltd
Chronic Obstructive Pulmonary Disease (COPD)
Effects of Mud Bath Therapy in Chronic Obstructive Pulmonary Disease
Rehabilitation and physical therapy strategies targeting extra pulmonary manifestations of Chronic Obstructive Pulmonary Disease (COPD)are far from being well defined.
- Trial name
- NCT01253941
- Testing
- Mud bath Therapy
- Where
- 2 sites in Italy
- Volunteers
- 42 people
- Sponsor
- Fondazione Salvatore Maugeri
Chronic Obstructive Pulmonary Disease, Type 2 Diabetes Mellitus
The Early Predictors for Developing Type 2 Diabetes Mellitus in Patients With Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease(COPD), characterized by persistent airflow limitation, associated with an progressive chronic inflammatory response of the lung to noxious particles or gases, can lead to dyspnea and limited…
- Trial name
- NCT03152994
- Testing
- Checking fasting blood glucose(FBG)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Zhujiang Hospital
COPD, HEAD&NECK CANCER,SCREENING
Prevalence of Malignant and Premalignant Lesions in the Head & Neck in Patients With Chronic Obstructive Pulmonary Disease
Head and neck cancers usually occur in patients who have a history of long tobacco use. Chronic obstructive pulmonary disease (COPD) is a chronic progressive disease of the airways and lung parenchyma that is also associated with…
- Trial name
- NCT02333812
- Testing
- Stroboscopic nasopharyngeal laryngoscopy
- Volunteers
- 250 people
- Sponsor
- Hadassah Medical Organization
Chronic Obstructive Pulmonary Disease
Compliance of Long-term Home Non-invasive Ventilation for Patients With Chronic Obstructive Pulmonary Disease
Background : Long-term home non-invasive ventilation (NIV) can be proposed as treatment for acute respiratory failure with severe alveolar hypoventilation.
- Trial name
- NCT04333901
- Where
- 8 sites in France
- Volunteers
- 25 people
- Sponsor
- Vivisol
Pulmonary Disease, Chronic Obstructive, Respiratory Insufficiency
Сohort Study to Evaluate Exacerbations, Respiratory Symptoms, Physical Exercise Intolerance and Lung Functions Among Participants Who Use IQOS With Heatsticks Compared to Smokers of Conventional Cigarettes
This study evaluates frequency of exacerbations, respiratory symptoms, physical exercise intolerance and abnormal lung functions among participants who use IQOS with heatsticks compared to smokers of conventional cigarettes
- Conditions
- Pulmonary Disease, Chronic Obstructive, Respiratory Insufficiency, Physical Disability, Respiratory Disease
- Trial name
- NCT03383601
- Testing
- Heated Tobacco product IQOS/heatstick, Smoking combustible cigarettes
- Where
- Kazakhstan
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Kazakhstan Academy of Preventive Medicine
Chronic Obstructive Pulmonary Disease, Urinary Incontinence
Urinary Incontinence Amongst Women With Chronic Obstructive Pulmonary Disease
The primary aim of the study is to investigate whether pelvic floor muscle training or cough-suppression therapy reduces symptoms of urinary incontinence amongst women with chronic obstructive pulmonary disease grade 1-4 (mild to…
- Trial name
- UriCO (NCT02614105)
- Testing
- Pelvic floor muscle training, Cough-suppression therapy, Control
- Where
- 2 sites in Norway
- Volunteers
- 35 people
- Sponsor
- Ostfold Hospital Trust
Heart Failure, Copd
The DIVERT-CARE (Collaboration Action Research & Evaluation) Trial
Rationale: In Canada, home care clients are a large and expanding subgroup of medically complex older adults with relatively poor access to effective chronic disease management.
- Trial name
- DIVERT-CARE (NCT03012256)
- Testing
- Cardio-respiratory management model
- Where
- 3 sites in Canada
- Volunteers
- 896 people
- Sponsor
- McMaster University
COPD
HFNC During Bronchoscopy in COPD Patients
Bronchoscopy diagnosis and treatment is highly irritating, and the effect of local topical anesthesia is poor; the airway is shared; and COPD patients have low oxygen reserves due to impaired lung function.
- Trial name
- HFNC COPD (NCT07850856)
- Testing
- group N used traditional nasal cannula for oxygen inhalation, Group HFNC used nasal high-flow oxygen inhalation.
- Volunteers
- 1,000 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
COPD, Aging
D Vitamine and Whole Body Vibration in Functional Outcomes
Older with Chronic obstructive Pulmonary Disease (COPD) were submitted to chronic whole body vibration training during 03 months, receiving a vitamine D dose for each week or placebo vitamine.
- Trial name
- NCT03684837
- Testing
- Vitamine D supplementation, chronic exercise in whole body vibration (WBV)
- Where
- Brazil
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Maíra F Pessoa
Depression in Patients With Chronic Obstructive Pulmonary Disease
Evaluation of Depression In Chronic Obstructive Pulmonary Disease
Background: Several clinical studies show high rates of anxiety and depressive disorders in Chronic Obstructive Pulmonary Disease (COPD), that suggest common underlying pathogenetic mechanisms of COPD and depressive disorders.
- Trial name
- EDIC (NCT02147912)
- Testing
- Aerobic Exercise
- Volunteers
- 154 people
- Sponsor
- University Hospital, Catania
Pulmonary Disease, Chronic Obstructive
Adaptive Support Ventilation in the Weaning of COPD
Adaptive support ventilation (ASV) is a closed loop ventilation mode that can act both as pressure support (PSV) and pressure controlled (PCV) ventilation.
- Trial name
- NCT00969605
- Testing
- Comparison of two different modes for weaning from mechanical ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 97 people
- Sponsor
- Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
COPD
A Multicenter, Prospective Cohort Study of Preserved Ratio Impaired Spirometry(PRISm) in a Population
Chronic obstructive pulmonary disease (COPD) is the most common chronic tract disease and the third leading cause of death worldwide.
- Trial name
- NCT06340295
- Where
- 6 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Peking University First Hospital
Chronic Graft-versus-host Disease (cGVHD)
A Study to Evaluate the Safety, Tolerability, Immunogenicity, Pharmacokinetics, and Pharmacodynamics of AMG 592 in Healthy Participants
The primary objective of this study is to evaluate the safety, tolerability and immunogenicity profile of single and multiple dose administrations of AMG 592 in healthy participants.
- Trial name
- NCT05873907
- Testing
- AMG 592
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Amgen
COPD, Chronic Bronchitis
The Effectiveness of Roflumilast in Improving Mucociliary Clearance in Patients With COPD and Chronic Bronchitis
Specific Aim: To determine the effectiveness of Roflumilast in improving i) whole right lung and ii) peripheral right lung mucociliary clearance (MCC) in patients with COPD and chronic bronchitis.
- Conditions
- COPD, Chronic Bronchitis, Emphysema
- Trial name
- NCT03073798
- Testing
- Roflumilast
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
Vulvovaginal Candidiasis
Effect of a Multi-strain Probiotic on Recurrent Vulvovaginal Candidiasis
This study evaluates the effect of a multi-strain probiotic on the risk of recurrence and severity of symptoms in females with recurrent vulvovaginal candidiasis (R-VVC).
- Trial name
- PROVELIA (NCT06480604)
- Testing
- Probiotic
- Where
- 6 sites in India
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- The Archer-Daniels-Midland Company
Pulmonary Disease, Chronic Obstructive
Cardiovascular Events in Chronic Obstructive Pulmonary Disease Patients Initiating Olodaterol or Other Long-acting beta2 Agonists
Examine the risk of cardiovascular events (cardiac arrhythmia or myocardial ischemia) or all-cause mortality in Chronic Obstructive Pulmonary Disease (COPD) patients who are new users of Olodaterol or other LABAs available for…
- Trial name
- NCT03405363
- Where
- Denmark
- Volunteers
- 65,406 people
- Sponsor
- Boehringer Ingelheim
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