Clinical trials: Obstructive Chronic Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD)
Efficacy and Tolerability of Symbicort as an add-on Treatment to Spiriva Compare With Spiriva Alone in Patients With Severe Chronic Obstructive Pulmonary Disease (COPD)
This is a multicentre study with a randomised, parallel group, open-label, 3-month phase IV design to assess the efficacy and tolerability of Symbicort as an add-on treatment to Spiriva compare with Spiriva alone in patients with…
- Trial name
- SECURE 1 (NCT01397890)
- Testing
- Budesonide/formoterol (Symbicort® Turbuhaler®), Tiotropium (SpirivaTM)
- Where
- 31 sites in China, Hong Kong and 3 more
- Volunteers
- 793 people
- Sponsor
- AstraZeneca
Emphysema, COPD
Distribution of Regional Lung Function by Vibration Response Imaging
Assessment of regional contribution of different areas of the lung to its integrated function is often required, such as prior to lung resection in the presence of tumor or emphysema.
- Trial name
- NCT01229020
- Testing
- Observational study - no intervention
- Where
- Israel
- Volunteers
- 25 people
- Sponsor
- Deep Breeze
COPD
Exercise Training in Chronic Obstructive Pulmonary Disease (COPD)
Exercise training is the key component of respiratory rehabilitation.The success of long-term program resides in the integration between exercise prescription and patients'compliance with home training.
- Trial name
- NCT01218282
- Testing
- Home exercise training, NO Exercise Training
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Università degli Studi di Ferrara
Chronic Obstructive Pulmonary Disease
The Influence of an Acute Exacerbation During Pulmonary Rehabilitation in COPD Patients Awaiting Lung Transplantation
Data from chronic obstructive pulmonary disease patients awaiting lung transplantation which performed a pulmonary rehabilitation program will be analyzed retrospectively.
- Trial name
- NCT04363723
- Testing
- Pulmonary Rehabilitation
- Where
- Germany
- Volunteers
- 559 people
- Sponsor
- Klaus Kenn
Lung Diseases, Obstructive, Asbestosis
Specialized Center of Research in Occupational and Immunologic Lung Disease
The overall objective of the Center was to develop a scientific data base for the control and prevention of acute and chronic lung injury caused by the inhalation of a variety of agents in the workplace and in the environment.
- Conditions
- Lung Diseases, Obstructive, Asbestosis, Silicosis, Pneumoconiosis
- Trial name
- NCT00005280
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Obstructive Pulmonary Disease
Study to Evaluate Safety and Efficacy of Inhaled Bimosiamose for the Treatment of Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to determine whether inhalation of Bimosiamose is safe and effective in the treatment of patients with moderate to severe Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT01108913
- Testing
- Bimosiamose
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Revotar Biopharmaceuticals AG
Chronic Obstructive Pulmonary Disease (COPD)
Identifying REsponders and Exploring Mechanisms of ACTION of the Endobronchial Coil Treatment for Emphysema
Rationale: The PneumRx RePneu Lung Volume Reduction Coil (RePneu LVR-coil) is a bronchoscopic lung volume reduction treatment designed to compress the areas of lung parenchyma most damaged by emphysema.
- Trial name
- REACTION (NCT02179125)
- Testing
- RePneu Lung Volume Reduction Coil System
- Where
- 2 sites in Netherlands, United Kingdom
- Volunteers
- 48 people
- Sponsor
- University Medical Center Groningen
Chronic Obstructive Pulmonary Disease
Pilot Study of Tetomilast in Chronic Obstructive Pulmonary Disease (COPD) Associated With Emphysema
Phase 2a multicenter, randomized, double-blind, placebo-controlled study to assess the pharmacodynamics, efficacy, and safety of tetomilast in patients with emphysema.
- Trial name
- EMPHASIS (NCT00874497)
- Testing
- tetomilast
- Where
- 15 sites in United States
- Volunteers
- 84 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Chronic Obstructive Pulmonary Disease (COPD)
A Trial to Evaluate the Safety and Efficacy of HL231 Solution for Inhalation in Patients with COPD
To evaluate the efficacy and safety of HL231 Solution for Inhalation vs Ultibro in Chinese patients with moderate to severe COPD.
- Trial name
- NCT06619210
- Testing
- HL231 Dose 1/2/3/4
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Chronic Obstructive Pulmonary Disease
Acute Effect of Aclidinium on Hyperinflation and Ventilation Inhomogeneity in Severe COPD Patients
Chronic Obstructive Pulmonary Disease (COPD) is characterized by lung hyperinflation and flow limitation. These physiopathological modifications are secondary to loss of elastic recoil and bronchial obstruction due to emphysema.
- Trial name
- NCT02181023
- Testing
- Aclidinium Bromide, Glycopyrronium Bromide
- Where
- Italy
- Volunteers
- 37 people
- Sponsor
- University of Milan
Chronic Obstructive Pulmonary Disease
Respiratory Disease Management
The aim of this study is to reduce the number of subsequent hospital admissions and/or emergency department (ED) visits for hospitalized patients with chronic obstructive pulmonary disease (COPD) by utilizing a respiratory care…
- Trial name
- NCT01543217
- Testing
- RT management, Ususal care
- Where
- United States
- Volunteers
- 428 people
- Sponsor
- Barnes-Jewish Hospital
COPD
Time-based Register and Analysis of COPD Endpoints
The Time-based Register and Analysis of COPD Endpoints (TRACE) study is prospective cohort study aiming at evaluating COPD patients using simple basic tools normally used in the clinic at hand of any physician.
- Trial name
- TRACE (NCT03485690)
- Where
- Spain
- Volunteers
- 1,440 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
COPD
Protein Supplementation to Enhance Exercise Capacity in COPD
Chronic obstructive pulmonary disease (COPD) is a common smoking-related lung disease. Pulmonary Rehabilitation (PR) is a six-week supervised group exercise and education class.
- Trial name
- NCT04027413
- Testing
- fortisip compact protein, preOp
- Where
- United Kingdom
- Volunteers
- 68 people
- Sponsor
- University College, London
Chronic Obstructive Pulmonary Disease
Muscle Energy Techniques in COPD Patients
Patients diagnosed with COPD as a result of hyperinflation adapt to the increased workload through shortening and overactivation of other muscles because of their dual function as muscles of the upper limb and neck motion which…
- Trial name
- NCT04773860
- Testing
- Muscle Energy Techniques
- Volunteers
- 110 people
- Sponsor
- University of Malta
Chronic Obstructive Pulmonary Disease, Balance
Investigation of Impairments in Body Functions and Structures, Activities and Participation Restrictions in COPD
This cross-sectional study aims to investigate to the impairments in body functions and structures, activities and participation restrictions according to the International Classification of Functioning, Disability and Health…
- Conditions
- Chronic Obstructive Pulmonary Disease, Balance, Activity, Motor, Participation, Patient
- Trial name
- NCT05632120
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University - Cerrahpasa
Chronic Obstructive Pulmonary Disease
Treatment in Patients Hospitalized With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease has become a serious global health care and public health problems due to its high prevalence, high morbidity and heavy economic burden.
- Trial name
- TripAE (NCT02219360)
- Volunteers
- 400 people
- Sponsor
- Beijing Chao Yang Hospital
COPD
Proteoglycan 4 Mechanism the Effectiveness of Pulmaonry Recovery in COPD Patients
The investigators previous research has demonstrated that proteoglycan 4 (PRG4) may be a biomarker for identification of severity in COPD.
- Trial name
- NCT02764658
- Testing
- Pulmonary recovery on the AECOPD, Routine care on the AECOPD, Routine care on the stable COPD
- Volunteers
- 90 people
- Sponsor
- Taipei Medical University
Asthma
Efficacy and Safety Study of Benralizumab to Reduce OCS Use in Patients With Uncontrolled Asthma on High Dose Inhaled Corticosteroid Plus LABA and Chronic OCS Therapy
The purpose of this trial is to confirm if benralizumab can reduce the use of maintenance OCS in systemic corticosteroid dependent patients with severe refractory asthma with elevated eosinophils.
- Trial name
- NCT02075255
- Testing
- Benralizumab
- Where
- 87 sites in United States, Argentina and 10 more
- Volunteers
- 220 people
- Sponsor
- AstraZeneca
Smoking Cessation, COPD
Effectiveness of Spirometry as a Motivational Tool to Quit Smoking
The aim of the study is to asses the efficacy of the spirometry and a minimal smoking cessation counselling intervention to quit smoking after a year in patients older than 40 years, smokers of more than 10 packs-year and without…
- Trial name
- ESPIMOAT (NCT01821885)
- Testing
- Spirometry and a brief advice to quit smoking, Brief advice to quit smoking
- Where
- Spain
- Volunteers
- 335 people
- Sponsor
- Basque Health Service
Dyspnea, Heart Failure
Registry of Patients With Acute Dyspnea in the Emergency Department
This is a prospective registry of patients presenting with acute dyspnea to the emergency department of the city hospital in Nuremberg.
- Conditions
- Dyspnea, Heart Failure, COPD
- Trial name
- NCT01910233
- Where
- Germany
- Volunteers
- 947 people
- Sponsor
- Klinikum Nürnberg
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