Clinical trials: Obstructive Chronic Pulmonary Disease
Chronic Obstructive Pulmonary Disease
Pathophysiological Mechanisms of Dyspnea and Activity-limitation in Mild Chronic Obstructive Pulmonary Disease (COPD)
Chronic obstructive pulmonary disease (COPD) is a growing cause of death, disability and health care costs in Canada. Nevertheless, COPD remains largely under-diagnosed and under-treated, particularly in its early stages.
- Trial name
- NCT00975403
- Testing
- Dead space breathing, Room air breathing
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Queen's University
Pulmonary Disease, Chronic Obstructive
An Exercise Endurance Study to Evaluate the Effects of Treatment of Chronic Obstructive Pulmonary Disease (COPD) Patients With a Dual Bronchodilator: GSK573719/GW642444.Study B
This is a phase III multicenter, randomized, double-blind, placebo-controlled, combination and component, two-period, incomplete block design cross-over study using GSK573719/GW642444.
- Trial name
- COPD (NCT01323660)
- Testing
- GSK573719/GW642444 125/25, GSK573719/GW642444 62.5/25, GSK573719 125
- Where
- 53 sites in United States, Canada and 5 more
- Volunteers
- 307 people
- Sponsor
- GlaxoSmithKline
Acute-graft-versus-host Disease, Chronic Graft-versus-host-disease
Study of Ruxolitinib for Acute and Chronic Graft Versus Host Disease
While hematopoietic stem cell transplant (HSCT) is an effective therapy, graft versus host disease (GVHD) is the most significant complication after HSCT.
- Conditions
- Acute-graft-versus-host Disease, Chronic Graft-versus-host-disease, Solid Organ Transplant
- Trial name
- NCT05121142
- Testing
- Ruxolitinib
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Pulmonary Disease, Chronic Obstructive
24-week Trial Comparing GSK573719/GW642444 With GSK573719 and With Tiotropium in Chronic Obstructive Pulmonary Disease
This is a Phase III multicenter, randomized, double-blind, double-dummy, parallel-group study to evaluate the efficacy and safety of two doses of GSK573719/GW642444 Inhalation Powder, GSK573719 Inhalation Powder via a Novel Dry…
- Trial name
- NCT01316913
- Testing
- GSK573719/GW642444 125/25, GSK573719/GW642444 62.5/25, GSK573719
- Where
- 100 sites in United States, Argentina and 8 more
- Volunteers
- 872 people
- Sponsor
- GlaxoSmithKline
COPD
Music and Perceived Rate of Exertion
The aim of this study was to evaluate the effect of listening to ambient music on the perceived exertion rate during pulmonary rehabilitation for chronic obstructive pulmonary disease patients.
- Trial name
- NCT01833260
- Testing
- Music
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Chronic Obstructive Pulmonary Disease (COPD)
Intermittent Intrapulmonary Deflation and Dyspnea Following Exercise in People With Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease is a long-term lung condition that causes breathing difficulties. People living with this disease often feel short of breath, especially during physical activity, which can make daily tasks…
- Trial name
- DEFLA-DYSPNEA (NCT06956742)
- Testing
- Active intermittent intrapulmonary deflation.
- Where
- France
- Volunteers
- 33 people
- Sponsor
- ADIR Association
Chronic Obstructive Pulmonary Disease
Long-term Maintenance Benefits of a Pulmonary Rehabilitation Program Using a Mobile Digital Solution: a Prospective, Randomized, Controlled, Multicenter Study in a Population of COPD Patients
Chronic obstructive pulmonary disease (COPD) is a public health problem: high prevalence; increasing morbidity and mortality; impact on health costs.
- Trial name
- m-Rehab COPD (NCT04550741)
- Testing
- telerehabilitation
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Chronic Obstructive Pulmonary Disease
Advanced eHealth for Chronic Obstructive Pulmonary Disease (COPD) in Colorado
Chronic obstructive pulmonary disease (COPD) is the 4th leading cause of death in the United States, affects 24 million people and is responsible for up to $32 billion annually in direct and indirect health care costs.
- Trial name
- NCT01044927
- Testing
- Integrated Care, Standard Therapy
- Where
- 2 sites in United States
- Volunteers
- 511 people
- Sponsor
- University of Colorado, Denver
Chronic Obstructive Pulmonary Disease
Effects of Temazepam in Patients With Chronic Pulmonary Obstructive Disease
The purpose of this study is to evaluate the effects of temazepam during sleep and in daytime on dyspnea, gas exchange and sleep quality in patients with chronic obstructive pulmonary disease.
- Trial name
- NCT00245661
- Testing
- Temazepam
- Where
- Netherlands
- Volunteers
- 14 people
- Sponsor
- Rijnstate Hospital
Hypertension, Diabetes
Development and Testing of a Sub-district Specific Model of 'Whole-of-government', and 'Whole-of-society' Approaches for the Prevention and Control of Non-communicable Diseases in a Sub-district of Bangladesh
Globally, non-communicable diseases (NCDs) are the leading cause of both mortality and morbidity. This intervention study aims to prevent and manage NCDs by adopting the World Health Organization's (WHO) comprehensive…
- Conditions
- Hypertension, Diabetes, Asthma, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT06453382
- Testing
- Behavioural change modification, Screening, NCD related knowledge practice and attitude
- Where
- Bangladesh
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- BRAC University
Main Heading (Descriptor) Terms
Impact of Kolcaba Comfort Theory Training on Dyspnea, Function, and Comfort in COPD Patients
Chronic Obstructive Pulmonary Disease (COPD) is the third most fatal chronic disease worldwide, following cardiovascular diseases and cancer.
- Trial name
- NCT06588361
- Testing
- Training Based on Kolcoba Comfort Theory
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Atelectasis, Pulmonary Infection
Bi-PAP vs Sham Bi-PAP on Pulmonary Function in Morbidly Obese Patients After Bariatric Surgery
The effect of biphasic positive airway pressure (Bi-PAP) at individualized pressures on the postoperative pulmonary recovery of morbidly obese patients (MOP) undergoing open bariatric surgery (OBS) and possible placebo…
- Conditions
- Atelectasis, Pulmonary Infection, Chronic Obstructive Pulmonary Disease (COPD), Pulmonary Disease
- Trial name
- NCT03438383
- Testing
- Bi-PAP
- Volunteers
- 48 people
- Sponsor
- Evangelismos Hospital
Cholelithiasis, Cholecystitis, Acute
Evaluation of Risk Factors Leading to Conversion From Laparoscopic Cholecystectomy to Open Surgery
This retrospective controlled study aims to evaluate risk factors that affect open conversion in laparoscopic cholecystectomy. Patient characteristics, medical history, biochemical and radiological studies of the patient will…
- Conditions
- Cholelithiasis, Cholecystitis, Acute, Cholecystitis, Chronic, Gallbladder Diseases
- Trial name
- NCT06244589
- Testing
- Laparoscopic cholecystectomy, Open-conversion cholecystectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 1,695 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Diabetic Foot Ulcers, Venous Ulcers
Registry Trial of the Effectiveness of Platelet Rich Plasma for Chronic Non-Healing Wounds
This study will examine differences in the process of wound-healing in patients treated with platelet rich plasma (a concentration of proteins derived from a patients own blood) applied to the wound as a gel; injected into the…
- Conditions
- Diabetic Foot Ulcers, Venous Ulcers, Pressure Ulcers
- Trial name
- CMS (NCT02071979)
- Testing
- Autologous PRP Gel, Autologous PRP Injections, Autologous PRP Gel plus PRP Injections
- Where
- 6 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Arteriocyte, Inc.
Chronic Obstructive Pulmonary Disease, Patient Education
An Educational Intervention to Improve Disease Management Knowledge of Hospitalized Patients With COPD
The objective of this study is to determine if inpatient COPD education would result in improved patient knowledge of COPD.
- Conditions
- Chronic Obstructive Pulmonary Disease, Patient Education, Inpatients
- Trial name
- NCT03323190
- Testing
- Inpatient COPD education
- Where
- United States
- Sponsor
- Rush University Medical Center
COPD
Investigation on the Role of Corticosteroids and Beta-Agonists on Cytokine Production in COPD Patients
Research on the synergistic effect of corticosteroids and beta-agonists on the cytokine production in COPD patients. Blood will be obtained from healthy volunteers and COPD patients and blood monocytes will be stimulated to…
- Trial name
- NCT00263380
- Where
- 2 sites in Netherlands
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- St. Antonius Hospital
COPD
A COPD Data Registry for Participants With Frequent Exacerbations
This registry will collect data on COPD, including the course of disease, treatment patterns, and potential new therapies. The registry will also track the experience of participants and caregivers in clinical practice.
- Trial name
- AIREIC (NCT07059273)
- Sponsor
- Hoffmann-La Roche
COPD, Heterogeneous Emphysema
To Improve Lung Function and Symptoms for Emphysema Patients Using Zephyr Valves
To compare the clinical outcomes of Endoscopic Lung Volume Reduction (ELVR) using Pulmonx Zephyr Valves vs. Standard of Care (SoC) in the treatment of heterogeneous emphysema subjects in a controlled trial design setting.
- Trial name
- TRANSFORM (NCT02022683)
- Testing
- ELVR (Endoscopic Lung Volume Reduction) with Zephyr Valves
- Where
- 17 sites in Belgium, France and 4 more
- Volunteers
- 97 people
- Sponsor
- Pulmonx Corporation
Chronic Bronchitis
RejuvenAir® System Trial for COPD With Chronic Bronchitis
Chronic Obstructive Pulmonary Disease (COPD) is defined as an impaired ability to move air within the lungs and is a major public health problem that is projected to rank fifth worldwide in terms of disease burden and third in…
- Trial name
- SPRAY-CB (NCT03893370)
- Testing
- RejuvenAir System
- Where
- 27 sites in United States, United Kingdom
- Volunteers
- 210 people
- Sponsor
- CSA Medical, Inc.
Chronic Obstructive Pulmonary Disease
Evaluation of Symbicort® Turbuhaler® (Budesonide/Formoterol) in Chronic Obstructive Pulmonary Disease (COPD)
This non-interventional study is to analyse the therapeutic effectiveness in patients with severe COPD following a generally accepted 12-week treatment period with Symbicort Turbuhaler, which could anyhow be shortened or extended…
- Trial name
- NCT00837629
- Volunteers
- 743 people
- Sponsor
- AstraZeneca
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