Clinical trials: Obstructive Lung Disease, open to volunteers
Chronic Graft-versus-host-disease
A Study of Axatilimab at 3 Different Doses in Participants With Chronic Graft Versus Host Disease (cGVHD)
This is a Phase 2 study to evaluate the efficacy, safety, and tolerability of axatilimab at 3 different dose levels in participants with recurrent or refractory active chronic graft versus host disease (cGVHD) who have received…
- Trial name
- AGAVE-201 (NCT04710576)
- Testing
- Axatilimab
- Where
- 121 sites in United States, Australia and 14 more
- Volunteers
- 296 people
- Sponsor
- Syndax Pharmaceuticals
Asthma, Atherosclerosis
Study of the Effect of Innate on the Inflammatory Response to Endotoxin
Background: Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation.
- Conditions
- Asthma, Atherosclerosis, Metabolic Syndrome, Insulin Resistance
- Trial name
- NCT01143480
- Where
- United States
- Volunteers
- 725 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Obesity, Asthma
Intragastric Balloon in Obese Patients With Uncontrolled Asthma
The aim of this project is to study the effect of an intragastric balloon (IGB) on asthma control in obese patients. Obese patients with uncontrolled asthma will be recruited and randomly assigned to two intervention arms : an…
- Trial name
- BOA (NCT05364957)
- Testing
- Intragastric balloon device, Dietary, Exercise intervention
- Where
- France
- Volunteers
- 84 people
- Sponsor
- University Hospital, Toulouse
Asthma Acute, Exacerbation of Allergic Asthma
Nebulized Ketamine for Severe Asthma Attacks in Children
This is a double-blinded, randomised, placebo-controlled trial enrolling 60 children aged 1 to 13 years with severe asthma exacerbation. All participants will receive standard therapy.
- Trial name
- NCT07728851
- Testing
- Ketamine (1 mg/kg)
- Where
- Oman
- Volunteers
- 60 people
- Sponsor
- Sultan Qaboos University
Pulmonary Disease, Chronic Obstructive, Exacerbation Copd
Monitoring of the End-tidal Carbon Dioxide (EtCO2) as a Severity Criterion in COPD Exacerbations
Although we know that these numbers are underestimated, Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease that affects between 8 and 12% of adults.
- Trial name
- CO2PD (NCT05704881)
- Testing
- End-Tidal CO2 measurement during COPD exacerbation
- Where
- 2 sites in France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Grenoble
Chronic Interstitial Cystitis, Bladder Pain Syndrome
Pain Type and Interstitial Cystitis/Bladder Pain Syndrome Treatment
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a severe pain condition affecting 3-8 million people in the United States lacking treatments that work.
- Conditions
- Chronic Interstitial Cystitis, Bladder Pain Syndrome, Painful Bladder Syndrome, Cystitis, Interstitial
- Trial name
- NCT06299683
- Testing
- Psychosocial Treatment, Pelvic Floor Physical Therapy
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Vanderbilt University Medical Center
Severe Asthma, Asthma in Children
Severe Eosinophilic Asthma Phenotypes During Childhood Have Various Origins
Study of the clinical evolution at 10 years of children from the SAMP cohort (severe asthma, eosinophilic or not, allergic or not) in order to understand the different possible evolutions of these phenotypes at different ages.
- Trial name
- SAMP 2 (NCT05762627)
- Where
- France
- Volunteers
- 360 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COPD
The Efficacy of Fluticasone Furoate/Vilanterol/Umeclidinium Compared With Vilanterol/Umeclidinium in Reducing Air Trapping and Airway and Blood Cytokine Levels in COPD
This study aims to demonstrate the effects of triple therapy (ICS/LABA/LAMA) and dual bronchodilators (LAMA/LABA) on air trapping in the lungs' COPD patients and inflammatory mediators
- Trial name
- NCT06474039
- Testing
- Trelegy or Anoro
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- Mahidol University
Asthma, Asthma Chronic
Metformin IN Asthma for Overweight and Obese Individuals (MINA)
This is a randomized clinical trial of metformin among overweight or obese adults with not well-controlled asthma despite maintenance inhaler therapy.
- Conditions
- Asthma, Asthma Chronic, Overweight and Obesity
- Trial name
- NCT06273072
- Testing
- Metformin hydrochloride extended-release tablets
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins University
Chronic Obstructive Pulmonary Disease, Takotsubo Cardiomyopathy
Cardiac Assessment and Takotsubo-stunning Among COPD-exacerbations In-Hospital
The goal of this prospective observational study is to investigate to what extent acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) triggers Takotsubo-stunning, and how this affects the outcome for these…
- Conditions
- Chronic Obstructive Pulmonary Disease, Takotsubo Cardiomyopathy, Acute Heart Failure
- Trial name
- CATCH (NCT06597331)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Sahlgrenska University Hospital
Pulmonary Disease (COPD), Chronic Obstructive
Comparison of Arterial and Capillary Blood Gas Analyses in Patients With Respiratory Distress Due to COPD or APE
The assessment of gas exchange is crucial for the management of patients suffering from respiratory distress due to an exacerbation of chronic obstructive pulmonary disease (COPD) or cardiogenic acute pulmonary edema (APE).
- Trial name
- GAZOCAP (NCT07835945)
- Testing
- Capillary blood gas analysis
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Obesity, Interstitial Lung Disease
Feasibility of Semaglutide in Advanced Lung Disease
The goal of this clinical trial is to learn whether semaglutide, an FDA-approved treatment for diabetes and obesity, is feasible and tolerable in patients with advanced lung disease. The main question[s] it aims to answer are: 1.
- Conditions
- Obesity, Interstitial Lung Disease, Chronic Obstructive Pulmonary Disease, Sarcoidosis, Pulmonary
- Trial name
- NCT05746039
- Testing
- Semaglutide Pen Injector
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pennsylvania
Chronic Obstructive Pulmonary Disease (COPD)
Smartphone-based Self-Management Support Program to Enhance Quality of Life in Patients With COPD
The goal of this study is to find out if a smartphone-based program (called 3S-C) can help people with COPD live better, healthier lives. It will also look at how the program affects their knowledge, habits, and overall health.
- Trial name
- NCT06888557
- Testing
- Smartphone-based self-management support program ( 3S-C)
- Where
- 3 sites in Hong Kong
- Volunteers
- 130 people
- Sponsor
- Hong Kong Metropolitan University
Bronchial Asthma
Study on the Safety and Efficacy of PA9159 Inhalation Aerosol for the Treatment of Adult Bronchial Asthma
PA9159 is a highly potent novel corticosteroid. The purpose of this study is to evaluate the safety, efficacy and characteristics of population pharmacokinetics of multiple dosing of PA9159 Inhaler in patients with bronchial…
- Trial name
- NCT07324707
- Testing
- PA9159 Metered-Dose Inhaler, 120 μg per day for 28 days, Fluticasone Propionate Inhaled Aerosol 200 μg per day for 28 days
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Anhui Palo Alto Pharmaceuticals, Inc.
Asthma
A Trial Evaluating Novel Technologies for the Diagnosis of Asthma The LUNG-TECH Trial
This trial aims to evaluate novel diagnostic technologies for asthma in 3 different pathways providing the necessary evidence-base to allow adoption into clinical practice: Pathway 1 evaluates whether the technology can…
- Trial name
- LUNG-Tech (NCT05819944)
- Where
- United Kingdom
- Volunteers
- 356 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Asthma Management, Asthma
eAMS-Eco: Implementation of a Tool for Climate Conscious Inhaler Prescribing
The goal of this study is to determine whether an 'eco' version of the Electronic Asthma Management System (eAMS) can reduce inhaler carbon emissions in primary care, in patients with asthma.
- Conditions
- Asthma Management, Asthma, Computerized Decision Support System, Primary Care
- Trial name
- NCT07638735
- Testing
- Climate-Conscious Clinical Decision Support System for Asthma Management
- Where
- 2 sites in Canada
- Volunteers
- 95 people
- Sponsor
- University of Toronto
COPD (Chronic Obstructive Pulmonary Disease), Airway Disease
Comparing Advanced Technologies to Standard Testing for the Diagnosis of Airway Disease in Hospital and Community Settings
Airway disease, such as chronic obstructive pulmonary disease (COPD), is usually diagnosed through breathing tests like spirometry.
- Trial name
- BREATHE (NCT07798596)
- Testing
- Capnography, Oscillometry, FENO
- Where
- 2 sites in United Kingdom
- Volunteers
- 300 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
COPD Exacerbation (AECOPD), Pulmonary Hypertension
Dynamic Changes in Right Ventricle and Pulmonary Artery Coupling Among COPD Patients With Acute Exacerbation
Chronic obstructive pulmonary disease (COPD) is a common, preventable, and manageable disease characterized by persistent respiratory symptoms and airflow limitation.
- Trial name
- NCT07694713
- Testing
- Echocardiography assessment
- Where
- Egypt
- Volunteers
- 115 people
- Sponsor
- Assiut University
Chronic Obstructive Pulmonary Disease (COPD), Traditional Chinese Medicine Syndrome
Multi-Omics Study of COPD Stages and Traditional Chinese Medicine Syndromes
This is a multicenter, prospective, observational cohort study of patients with chronic obstructive pulmonary disease (COPD), individuals with pre-COPD, and healthy participants.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Traditional Chinese Medicine Syndrome, Multi-omics
- Trial name
- NCT07873489
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Asthma (Diagnosis)
Pediatric Asthma Trial of Corticosteroid Heterogeneity (PATCH): Trial of Dexamethasone Versus Methylprednisolone for Pediatric Critical Asthma
Acute asthma exacerbation is caused by dysregulated pulmonary inflammatory pathways such that standard treatment includes prompt administration of exogenous systemic corticosteroids (SCs), but there remains an ongoing dialogue…
- Trial name
- PATCH (NCT07455396)
- Testing
- Dexamethasone (0.6mg/kg; Max 16mg) Once Daily, Dexamethasone (0.25 mg/kg/dose, Max dose 16mg) every 6-hours, Methylprednisolone
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Johns Hopkins All Children's Hospital