Clinical trials: Obstructive Pulmonary Disease
Stroke, Stroke, Chronic
Modulating Interaction of Motor Learning Networks in Rehabilitation of Stroke
This study uses a form on non-invasive brain stimulation called transcranial magnetic stimulation to understand 1) understand how the brain learns post-stroke and 2) assess non-invasive brain stimulation as an addition to current…
- Conditions
- Stroke, Stroke, Chronic, Stroke, Middle Cerebral Artery With Infarction
- Trial name
- NCT03086551
- Testing
- Active continuous theta burst stimulation (cTBS), Motor Practice
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Michigan
Asthma
School-based Asthma Therapy: Stage 2 Effectiveness Study
Asthma is the most common chronic illness of childhood, and hospitalization rates are increasing. In the US, impoverished children and children from minority ethnic and racial backgrounds suffer disproportionately from asthma.
- Trial name
- SBAT (NCT01175369)
- Testing
- School-based Care
- Where
- United States
- Volunteers
- 530 people
- Sponsor
- University of Rochester
Asthma
Problem-Solving Skills Training to Improve Care for Children With Asthma
The purpose of this study is to determine whether Problem-Solving Skills Training is effective in reducing barriers to health care and improving health-related quality of life for children with persistent asthma.
- Trial name
- NCT00250588
- Testing
- Problem solving skills training, Asthma care coordination, Usual Care
- Where
- United States
- Volunteers
- 252 people
- Sponsor
- RAND
Asthma
A Phase III Parallel Group Study, Comparing the Efficacy, Safety and Tolerability of the Fixed Dose Combination (FDC) of Fluticasone Furoate+Umeclidinium Bromide+Vilanterol (FF/UMEC/VI) With the FDC of FF/VI in Subjects With Inadequately Controlled Asthma
A once-daily 'closed' triple FDC therapy of FF/UMEC/VI via a single ELLIPTA® dry powder inhaler (DPI) is being developed by GlaxoSmithKline (GSK) with the aim of providing a new treatment option for the management of asthma by…
- Trial name
- NCT02924688
- Testing
- FF/UMEC/VI (100/31.25/25) mcg, FF/UMEC/VI (100/62.5/25) mcg, FF/UMEC/VI (200/31.25/25) mcg
- Where
- 409 sites in United States, Argentina and 13 more
- Volunteers
- 2,436 people
- Sponsor
- GlaxoSmithKline
Asthma
Vitamin D and Severe Asthma Exacerbations
This study of vitamin D is designed to assess both the safety and efficacy of potential doses (2,000 IU/day and 4,000 IU/day) in raising a vitamin D level to a normal range in a short period of time (e.g.
- Trial name
- SAVED-P (NCT01921894)
- Testing
- Cholecalciferol
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Pittsburgh
Chronic Graft-versus-Host-Disease, Oral Mucosal Disease Due to Graft-versus-host Disease
An Open Label Phase II Trial of Topical Sirolimus for the Treatment of Refractory Oral Chronic Graft-versus-Host-Disease
This research study is evaluating the effectiveness of topical sirolimus combined with topical steroid therapy, as a possible treatment for oral cGVHD.
- Trial name
- NCT02123966
- Testing
- Sirolimus
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Dana-Farber Cancer Institute
Pulmonary Disease, Chronic Obstructive
Effects of Salmeterol on Autonomic Nervous System
This is a 4-week non-randomized, partially blinded, single-arm monocentre study in subjects with Chronic Obstructive Pulmonary Disease (COPD) Global Initiative for Chronic Obstructive Lung Disease (GOLD) class II or III with the…
- Trial name
- ESAN (NCT01536587)
- Testing
- Salmeterol
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- GlaxoSmithKline
Asthma
Comparison of Nebulizers in ED in Pediatric Asthma Patients
The primary objective will be, in an open-label randomized trial, a comparison of emergency department (ED) length of stay (LOS) between children experiencing acute asthma treated with two different nebulizers.
- Trial name
- NCT01951378
- Testing
- Hudson RCI® nebulizer, NebuTech® HDN® nebulizer, Albuterol
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Seton Healthcare Family
Asthma
Trial of Lay-led Individualised Self-management Education for Adults With Asthma
Long term conditions often necessitate long term care. In many cases, giving control of their conditions to the patients themselves produces the best outcomes.
- Trial name
- NCT00129987
- Testing
- Self management education
- Where
- United Kingdom
- Volunteers
- 567 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Insomnia
Effects of Suvorexant in Patients With Chronic Obstructive Pulmonary Disease (MK-4305-032)
This study will evaluate the safety, tolerability, and effect of multiple doses of suvorexant (MK-4305) on respiratory function in participants with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT01293006
- Testing
- suvorexant
- Volunteers
- 25 people
- Sponsor
- Merck Sharp & Dohme LLC
Asthma
Teva Asthma Predictive Analytics Study
This trial is being completed to determine baseline inhalation parameters and patterns of use in patients receiving treatment with TEVA digital inhalers, to develop predictive models for asthma exacerbations and response to…
- Trial name
- NCT04997304
- Testing
- AirDuo Digihaler, ProAir Digihaler
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Michigan
Pulmonary Disease, Chronic Obstructive
Pharmacokinetics, Safety and Tolerability of Twice-Daily Aclidinium Bromide/Formoterol Fumarate Fixed Dose Combination in Chinese Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease
A Phase IIa, open-label, repeat-dose trial to investigate the pharmacokinetics (PK), safety and tolerability of single and multiple twice daily doses of inhaled Aclidinium Bromide/Formoterol Fumarate 400/12 μg in 20 Chinese male…
- Trial name
- NCT03276078
- Testing
- Aclidinium Bromide/Formoterol Fumarate 400/12μg BID
- Where
- China
- Volunteers
- 20 people
- Sponsor
- AstraZeneca
Chronic Graft Versus Host Disease
Extracorporeal Photopheresis (ECP) With Methoxsalen for Chronic Graft Versus Host Disease (cGVHD)
Chronic graft-versus-host disease (cGVHD) is a long-lasting complication that can occur after transplants. The transplanted cells seem to fight with the patient's own cells.
- Trial name
- NCT01380535
- Testing
- ECP Methoxsalen, Standard of Care
- Where
- 32 sites in United States, Austria and 6 more
- Volunteers
- 60 people
- Sponsor
- Mallinckrodt
Chronic Obstructive Pulmonary Disease
Study to Determine the Onset of Action of Indacaterol in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
This study will evaluate the onset of action of indacaterol (150 and 300 µg) as compared to placebo, salbutamol 200 µg and salmeterol/fluticasone 50/500 µg
- Trial name
- NCT00669617
- Testing
- Indacaterol, Salmeterol/fluticasone (50/500 μg), Salbutamol (200 µg)
- Where
- 17 sites in United States, Belgium and 2 more
- Volunteers
- 89 people
- Sponsor
- Novartis
Asthma
First Time in Human (FTIH) Study to Evaluate Safety, Tolerability, Immunogenicity, Pharmacokinetics (PK) and Pharmacodynamics (PD) of GSK3511294 Administered Subcutaneously (SC) in Subjects With Mild to Moderate Asthma
GSK3511294 is a humanized monoclonal antibody antagonist of Interleukin (IL)-5 which is known to block binding of IL-5 to the IL-5 receptor complex, causing a reduction in the circulating population of eosinophils.
- Trial name
- NCT03287310
- Testing
- GSK3511294, Salbutamol/albuterol
- Where
- 5 sites in Germany, United Kingdom
- Volunteers
- 50 people
- Sponsor
- GlaxoSmithKline
Wheezing, Asthma
Allergy Immunotherapy for the Reduction of Asthma
In this clinical study we aim to determine the effect of allergy immunotherapy in decreasing asthma and allergy related disease in children who had multiple episodes of wheezing and who are at high risk for developing persisting…
- Conditions
- Wheezing, Asthma, Allergy
- Trial name
- AIR (NCT01028560)
- Testing
- Allergen extracts (subcutaneous injections), Standard of care
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Albert Einstein College of Medicine
Asthma
A Pilot and Feasibility Study of Mobile-Based Asthma Action Plans
Investigators from University of Arkansas for Medical Sciences Department of Pediatrics and University of Arkansas for Medical Sciences Center for Distance Health will collaborate to develop a mobile-based Asthma Action Plan…
- Trial name
- NCT01514760
- Testing
- Mobile-based Asthma Action Plan
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Asthma
A Study to Evaluate the Effect of Dupilumab on Exercise Capacity in Adult Patients With Asthma
The primary objective of the study is to demonstrate that dupilumab treatment improves exercise capacity in patients with moderate-to-severe asthma.
- Trial name
- NCT04203797
- Testing
- dupilumab
- Where
- 30 sites in United States, France and 3 more
- Volunteers
- 40 people
- Sponsor
- Regeneron Pharmaceuticals
Chronic Obstructive Pulmonary Disease
An Evaluation of Post Discharge Utilization Among Patients With an Acute Exacerbation of COPD
Patients who are hospitalized at select Carolinas Healthcare System (CHS) sites with Chronic Obstructive Pulmonary Disorder (COPD) acute exacerbation symptoms will be treated per the CHS COPD Clinical Pathway.
- Trial name
- NCT03207776
- Testing
- Usual Care, COPD Clinical Pathway
- Where
- 8 sites in United States
- Volunteers
- 4,832 people
- Sponsor
- Wake Forest University Health Sciences
CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ASTHMA
Inhaler Lung Deposition in Chronic Obstructive Pulmonary Disease (COPD)
Patients with chronic obstructive pulmonary disease (COPD) experience breathing difficulties because the airways deep in their lungs become narrowed. COPD patients use inhaler drugs to provide relief from breathlessness.
- Conditions
- CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ASTHMA, HEALTHY SUBJECTS
- Trial name
- NCT01721291
- Testing
- SALBUTAMOL
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Imperial College London
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