Clinical trials: Obstructive Sleep Apnea, open to volunteers
Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease
The Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome)
Major progress has been made in the area of cardiovascular disease, but we believe that further progress will involve mechanistically addressing underlying respiratory causes including chronic obstructive pulmonary disease (COPD)…
- Conditions
- Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease, Overlap Syndrome
- Trial name
- CRESCENDO-SLP (NCT05237505)
- Testing
- bi-level positive pressure non invasive ventilation, Oxygen gas
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of California, San Diego
Sleep Apnea, Obstructive, Sleep Disorder
Home Apnea Testing in CHildren Trial
This clinical trial will compare home sleep apnea testing with the gold standard in-lab polysomnography in terms of 1) accuracy, 2) therapeutic decision-making, and 3) parent/child acceptability in children referred for…
- Conditions
- Sleep Apnea, Obstructive, Sleep Disorder, Sleep Apnea Syndromes, Sleep Disturbance
- Trial name
- HATCH (NCT05382754)
- Testing
- Home sleep apnea test, In-lab polysomnography
- Where
- United States
- Volunteers
- 317 people
- Sponsor
- Children's Hospital of Philadelphia
Obstructive Sleep Apnea, OSA COPD Overlap Syndrome
Neurocognitive and Health Impact of Sleep Apnea in Elderly Veterans With Comorbid COPD
Cognitive dysfunction in the aging Veteran population is a growing health concern in the Veterans Health System. It is not known whether OSA coexisting with COPD will enhance the risk for cognitive dysfunction.
- Trial name
- NCT02703207
- Testing
- Positive airway pressure, NIPPV and /or oxygen
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- VA Office of Research and Development
Sleep Apnoea, Obesity & Overweight
Tirzepatide Versus Positive Airway Pressure for the Treatment of Obstructive Sleep Apnoea
When used, continuous positive airway pressure (CPAP) is an effective treatment for obstructive sleep apnea (OSA), a condition that is mainly caused by overweight and obesity.
- Conditions
- Sleep Apnoea, Obesity & Overweight, Sleep Apnea Syndrome, Obstructive
- Trial name
- TIRZE-PAP (NCT07846865)
- Testing
- Continuous Positive Airway Pressure, Tirzepatide
- Where
- Australia
- Volunteers
- 256 people
- Sponsor
- Woolcock Institute of Medical Research
Obstructive Sleep Apnea
Optimizing the Management of OSA in Children With Down Syndrome
The objective of this retrospective descriptive study is to assess current practices for the screening and surgical treatment of OSA in children with Down syndrome at the Strasbourg University Hospital and to disseminate a…
- Trial name
- SAOS-21 (NCT07334444)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Sleep Related Breathing Disorder, Snoring
IOA Preventing Occlusal Changes With MAD Use
This study is evaluating two standard-of-care strategies used to prevent bite changes (occlusal changes) in patients treated with a Mandibular Advancement Device (MAD) for sleep-related breathing disorders such as obstructive…
- Conditions
- Sleep Related Breathing Disorder, Snoring, Obstructive Sleep Apnea (OSA), Open Bite
- Trial name
- NCT07103941
- Testing
- AM Aligner, Exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Isabel Moreno Hay
Obstructive Sleep Apnea
Nightly Wearable Monitoring During Home-Based Submental Electrical Stimulation for Obstructive Sleep Apnea
This single-arm pilot study evaluates the feasibility of nightly wearable monitoring with a ring-type sleep monitor during a 4-week home-based program of submental transcutaneous neuromuscular electrical stimulation in adults…
- Trial name
- NCT07921329
- Testing
- Submental transcutaneous neuromuscular electrical stimulation (RS-18), Ring-type sleep monitor (Belun Ring BLS-100)
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- E-DA Hospital
Obstructive Sleep Apnea (OSA) and Obesity
A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study to Evaluate the Efficacy and Safety of HDM1005 Injection in Subjects With Obstructive Sleep Apnea (OSA) and Obesity Receiving Positive Airway Pressure (PAP) Therapy
This is a 56-week randomized, double blinded, parallel-controlled study evaluating the efficacy and safety of the HDM1005 in patients with obstructive sleep apnea (OSA) and obesity receiving positive airway pressure (PAP)…
- Trial name
- NCT07794397
- Testing
- HDM1005
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Obstructive Sleep Apnea
Predicting Cardiometabolic Risk in Mild-to-Moderate Obstructive Sleep Apnea: Inflammation vs. Apnea/Hypopnea Index
The purpose of the study is to compare the relative contribution of systemic inflammation vs. Obstructive Sleep Apnea (OSA) severity (as measured by Apnea Hypopnea Index) in predicting cardiovascular and metabolic aberrations…
- Trial name
- NCT03062748
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- Milton S. Hershey Medical Center
Velopharyngeal Insufficiency, Swallowing
Velopharyngeal Insufficiency After Maxillomandibular Advancement Osteotomy in Obstructive Sleep Apnea Patients
The aim of this study is to gain insight into the development of velopharyngeal insufficiency (VPI) in patients who have undergone maxillomandibular advancement osteotomy (MMA) as a treatment for obstructive sleep apnea syndrome…
- Conditions
- Velopharyngeal Insufficiency, Swallowing, Nasality, Speech
- Trial name
- VPIMMA (NCT07301021)
- Where
- Netherlands
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Obstructive Sleep Apnea Syndromes
Fascial Mobilization Along the Vagus Nerve and Its Effects on Acute Physiological Parameters in Obstructive Sleep Apnea
This randomized controlled trial was designed to investigate the effects of fascial mobilization along the course of the vagus nerve on acute physiological parameters in individuals with obstructive sleep apnea syndrome (OSAS).
- Trial name
- NCT07169058
- Testing
- Vagus Nerve Fascial Mobilization
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Mardin Artuklu University
Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS), Head and Neck Cancers
Innovative OSA Screening in Head and Neck Cancer Patients With the Apneal App
Obstructive sleep apnea syndrome is a common but often underdiagnosed condition, with significant impacts on quality of life, such as fatigue, attention disorders, and an increased risk of heart attack or stroke.
- Trial name
- NCT06896448
- Testing
- Specialized sleep consultation and overnight recording using the APNEAL application
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Obstructive Sleep Apnea (OSA), OSA
Diagnosing Obstructive Sleep Apnea Using Electromyography of the Muscles of the Mouth
The investigators will establish how well a novel, quick, and painless way of measuring muscle activity from the mouth and throat works for detecting sleep apnea.
- Conditions
- Obstructive Sleep Apnea (OSA), OSA, Healthy Volunteers, Electromyography
- Trial name
- NCT06944782
- Testing
- Electromyography (EMG) of the Oropharynx
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego