Clinical trials: Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS)
Osa Syndrome
Nasal Versus Oronasal Mask in Continuous Positive Airway Pressure (CPAP) Treatment of Patients Affected by Obstructive Sleep Apnea Syndrome (OSAS).
Continuous positive airway pressure (CPAP) is considered the gold standard treatment for patients with moderate to severe obstructive sleep apnea (OSA).
- Trial name
- NCT04681196
- Testing
- patients shifted to nasal mask after persistent OSA with oronasal mask
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Obstructive Sleep Apnea
Clinical Evaluation of a Wearable Sleep Diagnosis Technology
The primary endpoint is to evaluate the sensitivities and specificities for diagnosis of sleep apnoea of a wearable sleep diagnosis technology vs. existing gold standard.
- Trial name
- NCT03544086
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Acurable Ltd.
Obstructive Sleep Apnea, Sleep Disordered Breathing
Nasal High Flow Therapy in Surgical Patients with Unrecognized Obstructive Sleep Apnea
In this study the investigators will determine whether using high flow oxygen in moderate-to-severe Obstructive Sleep Apnea patients following a major non cardiac surgery is more efficacious than usual care in preventing decrease…
- Trial name
- POSAII (NCT03964376)
- Testing
- Nasal High Flow, Usual Care
- Where
- 8 sites in Canada, Hong Kong and 2 more
- Volunteers
- 22 people
- Sponsor
- University Health Network, Toronto
Obstructive Sleep Apnea
Obstructive Sleep Apnea Syndrome and Attention Executive Function Disturbances
Studies demonstrate that sleep disturbances are associated with cognitive dysfunction and attention deficit. However the correlation between the severity of obstructive sleep apnea and the degree of cognitive dysfunction was not…
- Trial name
- NCT00757796
- Volunteers
- 80 people
- Sponsor
- Assaf-Harofeh Medical Center
Coronary Artery Disease
Evaluation of Association Between Obstructive Sleep Apnea and the Severity of Coronary Artery Disease
It is widely accepted that coronary artery disease (CAD) is related to a high mortality. It is predicted that an increase of approximately 21.3 million cardiovascular events and 7.7 million cardiovascular deaths over 2010 to 2030…
- Trial name
- NCT03066141
- Where
- China
- Volunteers
- 255 people
- Sponsor
- Chinese Pulmonary Vascular Disease Research Group
Obesity, Overweight
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight
The purpose of this study is to evaluate the efficacy and safety of retatrutide in participants who have obesity or overweight (J1I-MC-GZBJ master protocol) including subsets of participants who have knee osteoarthritis (OA)…
- Conditions
- Obesity, Overweight, Osteoarthritis, Knee, Obstructive Sleep Apnea
- Trial name
- TRIUMPH-1 (NCT05929066)
- Testing
- Retatrutide
- Where
- 134 sites in United States, Australia and 10 more
- Volunteers
- 2,335 people
- Sponsor
- Eli Lilly and Company
Obstructive Sleep Apnea
Spinal Morphine for Patients With Obstructive Sleep Apnea
Patients with Obstructive Sleep Apnea (OSA) appear to be especially vulnerable to medications that suppress pharyngeal muscle activity such as general anesthetics and opioids.
- Trial name
- NCT01790971
- Testing
- Intrathecal Morphine, No Intrathecal Morphine
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Obstructive Sleep Apnea, Diagnostic Imaging
The Role of Sub-mental Ultrasonography in Diagnosing Obstructive Sleep Apnea and Its Correlation With Subjective Scales
The investigators hypothesize that sub-mental ultrasonography measures are strongly correlated with the severity of Obstructive Sleep Apnea Syndrome and the related specific subjective scales.
- Conditions
- Obstructive Sleep Apnea, Diagnostic Imaging, Ultrasound
- Trial name
- NCT03832244
- Testing
- Sub-mental ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Bartin State Hospital
Sleep Disordered Breathing, Obstructive Sleep Apnea
Adenotonsillectomy for Obstructive Sleep-Disordered Breathing in Childhood:The Chania Community Oximetry-Based Study
Obstructive sleep-disordered breathing (SDB) in childhood is a disorder of breathing during sleep characterized by intermittent upper airway obstruction.
- Conditions
- Sleep Disordered Breathing, Obstructive Sleep Apnea, Snoring, Obstructive Sleep Disordered Breathing
- Trial name
- NCT01918007
- Testing
- Adenotonsillectomy (AT)
- Where
- 2 sites in Greece
- Volunteers
- 186 people
- Sponsor
- Chania General Hospital "St. George"
Obstructive Sleep Apnea Syndrome
Follow-up Studies of Primary Snoring(PS) and Obstructive Sleep Apnea Hypopnea Syndrome(OSAHS) in Chinese Children
The study is designed to investigate the natural course of Primary snoring in 1-2 years or more and the different effect of drug and surgical treatment applied in children with obstructive sleep apnea (OSAS) by comparing the…
- Trial name
- NCT02447614
- Testing
- Adenotonsillectomy, Conservative treatment, no treatment
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Children's Hospital
Obstructive Sleep Apnea
Quantitative Genioglossal Muscle Strength in Obstructive Sleep Apnea (OSAS)
Quantitative Genioglossal muscle strength in Obstructive Sleep Apnea (OSAS) defined in the clinical spectrum of subjects with Snoring Disturbance, Oral Appliance Therapy Responsive, and CPAP Responsive
- Trial name
- EatonOSAS (NCT02695667)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Obstructive Sleep Apnea, Insomnia
Effect of Eszopiclone on Adherence to CPAP and Severity of Insomnia in Patients With COMISA
The comorbidity between obstructive sleep apnea (OSA) and insomnia (COMISA) is common, and associated with poorer sleep quality. CPAP adherence among COMISA patients is worst than among those with OSA only.
- Trial name
- NCT06017921
- Testing
- Eszopiclone 3 mg
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Obstructive Sleep Apnea, Diabetes Mellitus
The Effect of Lifestyle Intervention Versus Gastric Bypass on Various Comorbidities in Morbidly Obese Subjects
This follow up study (>1 year) aims to compare the effects of lifestyle intervention and gastric by pass surgery on various comorbidities associated with morbid obesity.
- Conditions
- Obstructive Sleep Apnea, Diabetes Mellitus, Hypertension
- Trial name
- NCT00273104
- Testing
- Bariatric surgery, Intensive lifestyle intervention
- Where
- Norway
- Volunteers
- 180 people
- Sponsor
- The Hospital of Vestfold
Obstructive Sleep Apnea
Sodium-Restricted Diet and Diuretic in the Treatment of Severe Sleep Apnea
This study evaluates the intervention of the 1) sodium-restricted diet, or 2) diuretic, or 3) placebo pill in the treatment of obstructive sleep apnea in adults.
- Trial name
- DESALT (NCT01945801)
- Testing
- Lasilactone, Sodium-Restricted Diet
- Where
- Brazil
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Pulmonary Disease, Cardiac Disease
World Trade Center (WTC) CHEST
This project will evaluate the effects of World Trade Center (WTC) exposure in WTC responders 10-13 years following the events of 9/11.
- Conditions
- Pulmonary Disease, Cardiac Disease, Cardiopulmonary Disease, Obstructive Sleep Apnea
- Trial name
- NCT01466218
- Where
- United States
- Volunteers
- 1,012 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Obstructive Sleep Apnea, Snoring
A Trial to Evaluate a Device for the Treatment of OSA and Snoring
To evaluate the safety and efficacy of the Tongue Advancement Retainer Device in treating subjects with Obstructive Sleep Apnea (OSA) and snoring.
- Trial name
- OPEN (NCT01772017)
- Testing
- Tongue Advancement Retainer Device
- Where
- 3 sites in United States, Australia
- Volunteers
- 15 people
- Sponsor
- Sleepy, Inc
Ischemic Stroke, Acute Coronary Syndrome
Comparative Study of Arterial Properties After an Ischaemic Stroke or an Acute Coronary Syndrome
A pilot, prospective, comparative study. To include both male and female patients who have presented an ischaemic stroke (full stroke or TIA) or an ACS, 5 to 30 days prior to inclusion.
- Conditions
- Ischemic Stroke, Acute Coronary Syndrome, Obstructive Sleep Apnea Syndrome
- Trial name
- AVC/SCA (NCT00926874)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Grenoble
OSAHS, Craniofacial Abnormalities
Upper-airway Changes After Bimaxillary Advancement in OSAHS
One of the most effective surgical treatments for obstructive sleep apnoea / hypopnoea syndrome (SAHS) with global impact on the upper-airway (UA) is the maxilla-mandibular advancement (MMA).
- Trial name
- OSAHS (NCT04301635)
- Testing
- Maxillo-mandibular Advancement + Counterclockwise rotation
- Where
- Spain
- Volunteers
- 38 people
- Sponsor
- Hospital de Cruces
Lung Cancer
Early Diagnosis and Treatment of Sleep Disordered Breathing in Lung Cancer
Sleep-disordered breathing at night is a common medical problem. It leads to daytime fatigue, impairment in concentration and daily activities, and a higher risk of cardiovascular disease and life-threatening events.
- Trial name
- NCT03443908
- Testing
- CPAP
- Where
- United States
- Sponsor
- Mark M. Fuster, MD
Obstructive Sleep Apnea of Adult
Imaging Predictors of Cryolysis Efficacy for Treatment of Obstructive Sleep Apnea
The goal of this observational study is to further evaluate the efficacy and mechanism of action of the Cryosa Procedure, a novel procedure intended to treat obstructive sleep apnea (OSA).
- Trial name
- ICE-OSA (NCT06434558)
- Testing
- Cryosa Procedure
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania
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