Clinical trials: Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS)
Multiple Sclerosis, Obstructive Sleep Apnea
Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis
This study will evaluate the influence of sleep apnea on clinical and radiological features of MS. Sleep apnea is associated with hypoxemia during sleep, which is likely detrimental to MS.
- Trial name
- SOMNUS (NCT04603196)
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Beth Israel Deaconess Medical Center
Obstructive Sleep Apnea Syndrome
Acoustic Pharyngometry in Obstructive Sleep Apnea Syndrome Patients, With Indication of Continuous Positive Air Pressure
Acoustic Pharyngometry (AP) is a method of measurement of Transversal Sectional Areas (TSA) and Volumes of oral cavity and pharynx, based on acoustic waves.
- Trial name
- APOSAS (NCT01210703)
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo General Hospital
Pediatric Obstructive Sleep Apnea Syndrome
Investigating the Safety of Post-surgical Analgesics in Children With Obstructive Sleep Apnea
Every year thousands of young children with obstructive sleep apnea undergo surgery which requires them to be prescribed pain medication.
- Trial name
- NCT01680939
- Testing
- Morphine, Ibuprofen
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Obstructive Sleep Apnea
Design and Usability Testing of a Tailored Intervention About Sleep and Sleep Disorders Among Transportation Workers
The objective of this protocol is to conduct a focus group to identify OSA beliefs, attitudes, and knowledge among employees in the transportation industry on shift schedules.
- Trial name
- NCT05039528
- Testing
- Personalized OSA messages, Control
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea
Efficacy, Safety and Tolerability of Sulthiame in Patients With Obstructive Sleep Apnea (OSA)
multi-center, randomized, double-blind, placebo-controlled, dose-finding, 4-arm, parallel assignment study to evaluate the efficacy of three different doses of sulthiame (STM) compared to placebo on sleep apnea activity in adult…
- Trial name
- NCT05236842
- Testing
- Sulthiame
- Where
- Belgium
- Volunteers
- 298 people
- Sponsor
- Desitin Arzneimittel GmbH
Polycystic Ovary Syndrome, Obstructive Sleep Apnea
Metabolic Study of Women With Polycystic Ovary Syndrome and Sleep Apnea
The purpose of this study is to look at the metabolic (use of energy) and hormonal features of sleep problems in women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT00696111
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Chicago
Obstructive Sleep Apnea (OSA)
Evaluation of the Diagnostic Capacity of a Smart Mattress Versus Conventional Polysomnography
This project aims to develop and evaluate an innovative, non-invasive diagnostic system based on a smart mattress for detecting obstructive sleep apnea (OSA), as well as assessing overall sleep quality and identifying periodic…
- Trial name
- NCT07432919
- Testing
- Integrated polysomnographic assessment with smart mattress.
- Where
- 2 sites in Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Hospital San Pedro de Logroño
Hypertension, OSA - Obstructive Sleep Apnea
Primary Prevention Long-term Registry Study in OSA and Hypertension. Survival Analysis 2010-2022
Hypertension and obstructive sleep apnea (OSA) are both common conditions that independently increase the risk cardiovascular disease including atrial fibrillation, ischemic heart disease, heart failure and stroke.
- Conditions
- Hypertension, OSA - Obstructive Sleep Apnea, MACE, Survival Analysis
- Trial name
- DISCOVERY-HT (NCT06930989)
- Testing
- Positive airway pressure (PAP)
- Where
- Sweden
- Volunteers
- 148,467 people
- Sponsor
- Vastra Gotaland Region
Obstructive Sleep Apnea
The Effects of Nasal Airflow on Upper Airway Dilator Muscles During Sleep
Obstructive sleep apnea (OSA) is an increasingly prevalent disorder characterized by repeated upper airway collapse during sleep, resulting in oxygen desaturation and frequent arousals. The etiology of OSA remains unclear.
- Trial name
- NCT03506178
- Testing
- Oxymetazoline Nasal Spray, Menthol Nasal Spray, Normal saline Nasal Spray
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Sleep Apnea, Obstructive
Effects of Quetiapine on Sleep and Next Day Alertness in People With Obstructive Sleep Apnea
Quetiapine is medication used to treat schizophrenia and bipolar disorder. Increasingly, low doses of quetiapine are prescribed "off-label" for insomnia.
- Trial name
- QOSA (NCT05303935)
- Testing
- Quetiapine 50 MG
- Where
- Australia
- Volunteers
- 15 people
- Sponsor
- Flinders University
OSA, Heart Failure
Impact of Early Diagnosis and Treatment of OSA on Hospital Readmission in Hospitalized Cardiac Patients
The purpose of this study is to determine whether early diagnosis of obstructive sleep apnea and initiation of and adherence to CPAP therapy in hospitalized cardiac patients would impact 30-day hospital readmission rates.
- Conditions
- OSA, Heart Failure, Myocardial Infarction, Arrhythmia, Cardiac
- Trial name
- CV Readmit (NCT03647891)
- Testing
- Continuous Positive Airway Pressure
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Airway Inflammation, Chronic Obstructive Pulmonary Disease (COPD)
Immune Status and Disease Control of Inflammatory Airway Diseases
The goal of this study is to learn how the body's immune system affects disease control in people with different airway inflammatory diseases.We want to understand: 1.Whether specific immune cell patterns in the blood are linked…
- Conditions
- Airway Inflammation, Chronic Obstructive Pulmonary Disease (COPD), Asthma (Diagnosis), Bronchiectasis
- Trial name
- ISDC-IAD (NCT07493629)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Ningbo University
Apnea of Prematurity, Desaturation of Blood
Arterial Oxygen Saturation on Ventilatory Stability in Extremely Premature Infants
This is a prospective crossover study to compare the within-subject effect of the two target ranges of arterial oxygen saturation (SpO2), both within the clinically recommended range of 90- 95%.
- Conditions
- Apnea of Prematurity, Desaturation of Blood, Central Apnea, Periodic Breathing
- Trial name
- NCT03695900
- Testing
- Targeting SpO2 at 93-95%, Targeting SpO2 at 90-92%
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Miami
Sleep Apnea, Obstructive
Study of PROVIGIL ® (Modafinil) Treatment in Children and Adolescents With Excessive Sleepiness Associated With Obstructive Sleep Apnea/Hypopnea Syndrome
The primary objectives of the study are to determine the effectiveness of PROVIGIL treatment, compared to placebo treatment, in children and adolescents with excessive sleepiness (ES) associated with obstructive sleep…
- Trial name
- NCT00107809
- Testing
- Modafinil
- Where
- 64 sites in United States, Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Cephalon
Snoring, Sleep Apnea, Obstructive
Genioglossus Muscle Training for Snoring and Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) carries serious health consequences for patients. Evidence exists that some behavioral (e.g. exercise based) therapies may assist in lessening the severity of this disorder.
- Trial name
- NCT02834767
- Testing
- Genioglossis Strength Trainer
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Florida
Obstructive Sleep Apnea
Correlation Between CPAP Compliance and Food Intake Timing
Despite widespread agreement that continuous positive airway pressure is effective therapy for obstructive sleep apnea, it is estimated that 50% of patients recommended for therapy are noncompliant 1 year later.
- Trial name
- TLMECC (NCT01851811)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Hackensack Meridian Health
Obstructive Sleep Apnea
Efficacy of Shitali Respiratory Rehabilitation Program in Obstructive Sleep Apnea
obstructive sleep apnea has a negative impact on blood pressure of patients, sleeping quality, and respiration
- Trial name
- NCT06715228
- Testing
- shitali pranayama respiratory rehabilitation training
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Sleep Apnea
Obstructive Sleep Apneas in Elderly:Neuroimaging Changes and Neurocognitive Function Before and After Treatment
In the near future more than 20% of the European population will be over 65 years old and the prevalence of obstructive sleep apnea (OSA) in this aged population is known to be higher than 50%.
- Trial name
- NCT01826032
- Testing
- CPAP, Standard care for OSA
- Where
- Spain
- Volunteers
- 33 people
- Sponsor
- Hospital Clinic of Barcelona
Obstructive Sleep Apnea, Adherence
Effort-based Decision-making and CPAP Adherence
Obstructive sleep apnoea is the most common sleep disorder in general population, and is often associated with cognitive deficit, mood disorders, hypertension, diabetes mellitus, excessive daytime somnolence, nicturia and an…
- Trial name
- NCT04557293
- Testing
- Continuous Positive Airway Pressure (CPAP) treatment
- Where
- Italy
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Obstructive Sleep Apnea, Nasal Obstruction
Assessment of Adenoidal Obstruction in Children : Clinical Signs Versus Flexible Nasal Endoscopy and Roentgenographic Findings
The term adenoids describes lymphoid tissue on the superior and posterior walls of the nasopharynx, and their hypertrophy is a common condition of childhood.
- Trial name
- NCT01965457
- Where
- Israel
- Volunteers
- 36 people
- Sponsor
- Carmel Medical Center
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