Clinical trials: Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS)
Obstructive Sleep Apnea
The Effect of Occlusal Splints on Respiratory Variables in Obstructive Sleep Apnea (OSA) Patients
Rationale: The effect of vertical dimension on sleep apnoea and respiratory variables in obstructive sleep apnoea patients. Objective: To what extend should a possible worsening of the OSA condition, caused by an increase of…
- Trial name
- NCT01004692
- Testing
- Occlusal splints
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Academic Centre for Dentistry in Amsterdam
Obstructive Sleep Apnea
Evaluation of a Mandibular Advancement Device in the Treatment of Obstructive Sleep Apnea Syndrome
The purpose of this study is to determine if the mandibular advancement by Herbst device is effective in the treatment of moderate obstructive sleep apnea patients.
- Trial name
- NCT00213434
- Testing
- Herbst oral appliance
- Where
- France
- Sponsor
- University Hospital, Rouen
Obstructive Sleep Apnea
Inspire® Upper Airway Stimulation (UAS) System German Post-Market Study
The purpose of this study is to obtain additional safety and efficacy data on the use of Inspire® therapy for the treatment of subjects with moderate to severe Obstructive Sleep Apnea.
- Trial name
- NCT02293746
- Testing
- Inspire® Upper Airway Stimulation (UAS) System
- Where
- 3 sites in Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Inspire Medical Systems, Inc.
Sleep Apnea, Obstructive
NPA-OSA Device Tolerability, Usability and Acclimation Clinical Study in Adult Obstructive Sleep Apnea (OSA) Patients
This pilot study is being done to determine if the nasopharyngeal airway obstructive sleep apnea (NPA-OSA) device can be used in the treatment of OSA in adults.
- Trial name
- NCT06677151
- Testing
- nasopharyngeal airway obstructive sleep apnea (NPA-OSA) device
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan
Obstructive Sleep Apnea (OSA)
Metabolic Study of Sleep Apnea in Men and Women
The purpose of this study is to look at the metabolic (use of energy) and hormonal features of sleep problems in men and women.
- Trial name
- NCT00706511
- Testing
- CPAP
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Chicago
Sleep Disordered Breathing, Obstructive Sleep Apnea
Adenotonsillectomy for Obstructive Sleep-Disordered Breathing in Childhood:The Chania Community Oximetry-Based Study
Obstructive sleep-disordered breathing (SDB) in childhood is a disorder of breathing during sleep characterized by intermittent upper airway obstruction.
- Conditions
- Sleep Disordered Breathing, Obstructive Sleep Apnea, Snoring, Obstructive Sleep Disordered Breathing
- Trial name
- NCT01918007
- Testing
- Adenotonsillectomy (AT)
- Where
- 2 sites in Greece
- Volunteers
- 186 people
- Sponsor
- Chania General Hospital "St. George"
Obstructive Sleep Apnea Syndrome in Children
ATT Compared With ATE in OSAS Children
Non-inferiority hypothesis; adenotonsillotomy is equally good as adenotonsillectomy in treating obstructive sleep apnea syndrome (OSAS) in children after one, three and ten years.
- Trial name
- RCT ATE/ATT (NCT01676181)
- Testing
- Adenotonsillectomy, Adenotonsillotomy
- Where
- Sweden
- Volunteers
- 79 people
- Sponsor
- Karolinska University Hospital
Atherothrombosis, Type 2 Diabetes
Aspirin Resistance and Sleep Apnea in Type-2 Diabetic Patients
Type-2 Diabetes and Sleep Apnea Syndrome (SAS) are both related to an increase in platelet activation. Type 2 diabetes is often associated with sleep apnea syndrome with a prevalence up to 60%.
- Conditions
- Atherothrombosis, Type 2 Diabetes, Obstructive Sleep Apnea Syndrome
- Trial name
- AREAS (NCT01788930)
- Testing
- CPAP
- Where
- France
- Volunteers
- 53 people
- Sponsor
- University Hospital, Grenoble
Obstructive Sleep Apnea
Screening for Obstructive Sleep Apnea in Medical Patients
Obstructive sleep apnea (OSA) is highly prevalent in the general population and is associated with multiple adverse cardiovascular consequences.
- Trial name
- NCT05980936
- Testing
- Screening for obstructive sleep apnea
- Where
- 2 sites in Jordan
- Sponsor
- Jordan Collaborating Cardiology Group
Down Syndrome, Obstructive Sleep Apnea Syndrome
Down Syndrome and Continuous Positive Pressure Therapy
The purpose of this study is to evaluate the efficacy and tolerability of Continuous Positive Pressure for SAOS in Down Syndrome patients.
- Trial name
- Morphee (NCT00394290)
- Testing
- Continuous Positive Pressure
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Institut Jerome Lejeune
Laryngopharyngeal Reflux, Obstructive Sleep Apnea
Effect of CPAP Therapy on LPR Among Patients With OSAS
This study will investigate the changes in the reflux symptom index (RSI) and reflux finding score (RFS) among patients with obstructive sleep apnea after regular humidified CPAP therapy.
- Trial name
- NCT03455803
- Testing
- CPAP
- Volunteers
- 30 people
- Sponsor
- Assiut University
Hypoxia, Sleep Apnea
Intermittent Hypoxia 2: Cardiovascular and Metabolism
The purpose of this study is to compare cardiovascular physiological adaptation to intermittent hypoxia (IH) of nonobese healthy subjects. The exposure will be two periods of two weeks (IH versus exposure "placebo hypoxia").
- Conditions
- Hypoxia, Sleep Apnea, Obstructive Sleep Apnea
- Trial name
- IH2 (NCT02058823)
- Testing
- Valsartan, Amlodipine
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Obstructive Sleep Apnea
Efficacy and Compliance of the Mandibular Advancement Devices ONIRIS® vs. Custom Made Devices
To evaluate the efficacy (non-inferiority) in terms of response between patients using custom fitted mandibular advancement devices ONIRIS® and patient using laboratory custom made devices TALI, after 2 months of use.
- Trial name
- IRIS (NCT02348970)
- Testing
- ONIRIS®, TALI
- Where
- 10 sites in France
- Volunteers
- 211 people
- Sponsor
- ONIRIS
Sleep Related Breathing Disorder, Snoring
IOA Preventing Occlusal Changes With MAD Use
This study is evaluating two standard-of-care strategies used to prevent bite changes (occlusal changes) in patients treated with a Mandibular Advancement Device (MAD) for sleep-related breathing disorders such as obstructive…
- Conditions
- Sleep Related Breathing Disorder, Snoring, Obstructive Sleep Apnea (OSA), Open Bite
- Trial name
- NCT07103941
- Testing
- AM Aligner, Exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Isabel Moreno Hay
Obstructive Sleep Apnea
Endotype-Targeted Therapy to Rescue OSA Patients Struggling With CPAP Adherence (TOP-CPAP)
More than 10% of the US population have obstructive sleep apnea (OSA). Standard of care is therapy with CPAP (continuous positive airway pressure) which virtually eliminates OSA.
- Trial name
- TOP-CPAP (NCT05951023)
- Testing
- Eszopiclone 2 mg
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of California, San Diego
Obstructive Sleep Apnea, Lung Cancer
Impact of Risk for OSA in Lung Cancer
Background: Previous studies have reported that intermittent hypoxia in obstructive sleep apnea (OSA) is associated with tumor progression, metastasis and treatment outcomes.
- Trial name
- NCT04003961
- Testing
- STOP- BANG Questionnaire and Epworth sleepiness scale
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
OSAS (Obstructive Sleep Apneas Syndrome), DISE
The Use of Remimazolam Versus Dexmedetomidine for Patients Receiving Drug-Induced Sleep Endoscopy
This study seeks to compare the clinical efficacy and safety of the novel sedative Remimazolam with Dexmedetomidine in Drug-Induced Sleep Endoscopy (DISE), evaluating their performance in sedation depth stability, incidence of…
- Conditions
- OSAS (Obstructive Sleep Apneas Syndrome), DISE, Sedation
- Trial name
- NCT07459322
- Testing
- Remimazolam, Dexmedetomidine
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Fu Jen Catholic University Hospital
Stroke, Transient Ischemic Attack
DOC Utility: Screening of Depression, Obstructive Sleep Apnea and Cognitive Impairment
The primary objective of this study is to determine whether baseline DOC screening can add to clinical and demographic data to predict the occurrence of a composite negative outcome (any of: recurrent stroke, myocardial…
- Conditions
- Stroke, Transient Ischemic Attack, Depression, Obstructive Sleep Apnea
- Trial name
- NCT02363114
- Where
- Canada
- Volunteers
- 6,500 people
- Sponsor
- Dr. Richard H. Swartz
Obstructive Sleep Apnoea, Open Angle Glaucoma
Prevalence of Obstructive Sleep Apnoea in Glaucoma
This study aims to investigate a potential link between Obstructive Sleep Apnoea (OSA) and Open Angle Glaucoma (OAG); initially by determining whether the prevalence of OSA is higher in patients with OAG in comparison to people…
- Trial name
- POSAG (NCT02713152)
- Where
- United Kingdom
- Volunteers
- 403 people, healthy volunteers welcome
- Sponsor
- Papworth Hospital NHS Foundation Trust
Rheumatic Valvular Heart Disease, Obstructive Sleep Apnea
CPAP Treatment and Postoperative Outcomes in Patients With Rheumatic Valvular Heart Disease
The prevalence of OSA (Obstructive sleep apnea，OSA) is 2%-4% in general population and 16%-47% in surgical-heart failure patients.
- Trial name
- CPAP (NCT03398733)
- Testing
- continuous positive airway pressure
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Nanjing Medical University
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