Clinical trials: Obstructive Sleep Apnea-Hypopnea Syndrome
Obstructive Sleep Apnea (OSA), Positional Obstructive Sleep Apnea
Effectiveness of Audio Cues to Achieve Positional Therapy in Patients With Positional Obstructive Sleep Apnea
Patients with obstructive sleep apnea (OSA) often experience more frequent and severe breathing disturbances when sleeping in the supine (back-sleeping) position compared with non-supine positions.
- Trial name
- NCT07714330
- Testing
- Investigational Positional Therapy Device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- SleepDev, Inc
Obstructive Sleep Apnea, Preoperative Evaluation
Systematic Screening for Obstructive Sleep Apnea During Preoperative Consultation Using AI-preoperative Agents
The goal of this observational study is to evaluate the feasibility of a systematic screening protocol for Obstructive Sleep Apnea (OSA) during preoperative anesthesia consultations in adults aged 50 and older undergoing elective…
- Trial name
- DASCA (NCT06779682)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Intelligence Anesthesia
Obstructive Sleep Apnea, Snoring
LinguaFlex Tongue Retractor (LTR) for the Treatment of OSA and Snoring in Adults
The LinguaFlex™ Tongue Retractor (LTR) is an investigational medical device that is inserted into the tongue to lessen its backward movement during sleep.
- Trial name
- NCT04129229
- Testing
- LinguaFlex Tongue Retractor (LTR)
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Linguaflex, Inc.
Sleep Apnea, Obstructive
Oxygen Saturation Monitoring During Surgery
Patients with Obstructive Sleep Apnea (OSA) have cyclical patterns of lower blood oxygen during sleep because of repeated episodes of upper airway obstruction that cause their breathing to stop.
- Trial name
- NCT01098851
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Medtronic - MITG
Sleep Apnea
A Study of Danavorexton (TAK-925) in Adults With Obstructive Sleep Apnea
The main aim of the study is to check the side effects from overnight treatment with danavorexton and assess the tolerability of varying doses of danavorexton administered intravenously.
- Trial name
- NCT05180890
- Testing
- Danavorexton
- Where
- Australia
- Volunteers
- 13 people
- Sponsor
- Takeda
Obstructive Sleep Apnea
Performance of the Salt Lake Mask System
Assessment of the performance of the Salt Lake mask system acting as a patient interface in the provision of PAP therapy. This study will assess the suitability of this mask system in its current form for use.
- Trial name
- NCT01395693
- Testing
- Salt Lake mask system
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- ResMed
Osa Syndrome
Evaluation of Prophylactic Heated Humidification on Obstructive Sleep Apnea (OSA) Patient Short Term Compliance to CPAP Therapy
To compare two different clinical strategies in order to evaluate the impact of prophylactic heated humidification on OSA patients' compliance to CPAP therapy.
- Trial name
- Humidifier (NCT04391699)
- Testing
- heated humidification
- Where
- France
- Sponsor
- ResMed
Obstructive Sleep Apnea
Assessment of the Effect of PAP on Energy and Vitality in Mild OSA Patients: The Merge Study
The investigators wish to prospectively determine the response to CPAP in patients presenting with mild OSA. In many healthcare systems, patients with mild OSA (AHI 5-15) are not reimbursed for treatment.
- Trial name
- NCT02699463
- Testing
- Continous Positive Airway Pressure, Control Group
- Where
- 11 sites in United Kingdom
- Volunteers
- 301 people
- Sponsor
- ResMed
Obstructive Sleep Apnea
LTR for Treatment of Obstructive Sleep Apnea
Study of tongue implant for treatment of obstructive sleep apnea
- Trial name
- NCT03066765
- Testing
- Linguaflex Tongue Retractor
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Linguaflex, Inc.
Sleep Disordered Breathing, Obstructive Sleep Apnea
The Evaluation of an Interface for the Treatment of Obstructive Sleep Apnea (OSA)
This investigation is designed to evaluate the performance as well as the patients overall acceptance of the interface.
- Trial name
- NCT03725839
- Testing
- F&P Interface
- Where
- 3 sites in New Zealand
- Volunteers
- 33 people
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea
The Evaluation of the Toffee Mask for the Treatment of Obstructive Sleep Apnea
This investigation is a prospective, non-randomized, non-blinded study. This investigation is designed to evaluate the performance, comfort and ease of use of the F\&P Toffee mask amongst Obstructive Sleep Apnea (OSA) patients.
- Trial name
- NCT03726346
- Testing
- Toffee Full Face Mask
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea
Apnex Clinical Study of the Hypoglossal Nerve Stimulation (HGNS®) System to Treat Obstructive Sleep Apnea
The purpose of this study is to evaluate the benefits and risks of hypoglossal nerve stimulation with the Apnex Medical Hypoglossal Nerve Stimulation (HGNS) System as a potential therapeutic option for individuals with moderate…
- Trial name
- NCT01446601
- Testing
- Hypoglossal Nerve Stimulation (HGNS) System (Apnex Medical )
- Where
- 14 sites in United States, Australia
- Volunteers
- 132 people
- Sponsor
- Apnex Medical, Inc.
Sleep Apnea, Obstructive, Pulmonary Disease, Chronic Obstructive
A Study to Evaluate the Respiratory Safety of Lemborexant in Adult and Elderly Participants With Moderate to Severe Obstructive Sleep Apnea, and in Adult and Elderly Participants With Moderate to Severe Chronic Obstructive Pulmonary Disease
The primary purpose of the study is to determine whether lemborexant increases the apnea hypopnea index (AHI) on Day 8 of treatment in adult and elderly participants (adults greater than or equal to [>=] 45 to less than [<] 65…
- Conditions
- Sleep Apnea, Obstructive, Pulmonary Disease, Chronic Obstructive, Respiration Disorders
- Trial name
- NCT04647383
- Testing
- Lemborexant 10 mg
- Where
- 11 sites in United States
- Volunteers
- 63 people
- Sponsor
- Eisai Inc.
Metabolism and Nutrition Disorder, Obesity
Effect of Liraglutide in Obese Subjects With Moderate or Severe Obstructive Sleep Apnoea: SCALE™ - Sleep Apnoea
This trial is conducted in North America. The aim of the trial is to investigate the effect of liraglutide in obese subjects with sleep apnoea.
- Conditions
- Metabolism and Nutrition Disorder, Obesity, Obstructive Sleep Apnoea
- Trial name
- NCT01557166
- Testing
- liraglutide
- Where
- 42 sites in United States, Canada
- Volunteers
- 359 people
- Sponsor
- Novo Nordisk A/S
Bstructive Sleep Apnea (OSA) and Obesity
A Phase III Study Evaluating the Efficacy and Safety of HRS9531 Injection in Subjects With Obstructive Sleep Apnea (OSA) and Obesity
A Phase III Study Evaluating the Efficacy and Safety of HRS9531 Injection in Subjects with Obstructive Sleep Apnea (OSA) and Obesity
- Trial name
- NCT06974851
- Testing
- HRS9531
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Obstructive Sleep Apnea
Severe Label Expansion for EVO Products Trial
Title: Severe Label Expansion for EVO Positioner (SLEEP) Study Description: Single-arm study to determine the safety and effectiveness of treating severe obstructive sleep apnea using the EVO Sleep and Snore Device (ProSomnus…
- Trial name
- SLEEP (NCT07090395)
- Testing
- EVO Sleep and Snore Device
- Where
- 2 sites in United States
- Volunteers
- 49 people
- Sponsor
- ProSomnus Sleep Technologies
Obstructive Sleep Apnea
Revised Algorithm for Next Generation DeVilbiss Healthcare AutoAdjust Continuous Positive Airway Pressure (CPAP)
The purpose of this protocol is to improve the current FDA-approved continuous positive pressure auto-titration algorithm, including treatment precision, residual disease detection characteristics and phenotyping with the…
- Trial name
- NCT01797705
- Testing
- DeVilbiss AutoAdjust CPAP with revised algorithm
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- DeVilbiss Healthcare LLC
Sleep Apnea, Obstructive
Assessment of PPG & PAT to Detect Upper Airway Obstruction in Patients With Obstructive Sleep Apnea
The goal of this study is to collect raw waveform data for two separate noninvasive methods, both of which may be useful for the assessment of upper airway obstruction.
- Trial name
- NCT01831583
- Testing
- Measurement of PPG waveforms, Measurement of Pulse Arrival Time (PAT)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Sotera Wireless, Inc.
Obstructive Sleep Apnea
Use of Blood Biomarkers and Biomarker Index to Aid in the Diagnosis of Obstructive Sleep Apnea (OSA)
This multicenter prospective trial will evaluate the association between obstructive sleep apnea (OSA) and blood biomarkers in a representative population of consecutively enrolled symptomatic patients with a clinical suspicion…
- Trial name
- NCT03122483
- Testing
- blood biomarker
- Where
- 3 sites in United States
- Volunteers
- 250 people
- Sponsor
- Beckman Coulter, Inc.
Obstructive Sleep Apnea, Hypertension
A Study to Assess the Efficacy and Safety of Lorundrostat in Participants With Obstructive Sleep Apnea and Hypertension
The primary purpose of the study is to assess the effect of lorundrostat taken orally (po) once a day on the Apnea-Hypopnea Index (AHI) in participants with moderate to severe obstructive sleep apnea (OSA) and hypertension.
- Trial name
- NCT06785454
- Testing
- Lorundrostat
- Where
- 27 sites in United States
- Volunteers
- 48 people
- Sponsor
- Mineralys Therapeutics Inc.