Clinical trials: Obstructive Sleep Apnea-hypopnea Syndrome
Obstructive Sleep Apnea, Sleep Hypopnea
Armodafinil (CEP-10953) in Treatment of Excessive Sleepiness Associated With Obstructive Sleep Apnea/Hypopnea (OSA/H) Syndrome
The primary objective of this study is to determine whether treatment with Armodafinil (CEP-10953) is more effective than placebo treatment for patients with residual excessive sleepiness associated with obstructive sleep…
- Trial name
- NCT00079677
- Testing
- Armodafinil 150 mg/day
- Volunteers
- 263 people
- Sponsor
- Cephalon
Obstructive Sleep Apnea
Trial of AD036 in Obstructive Sleep Apnea
This is a randomized, double blind, placebo-controlled, repeat-dose, parallel arm, outpatient and inpatient phase 2 clinical study to examine the efficacy and safety of three dose levels of AD036 versus placebo in patients with…
- Trial name
- NCT03845023
- Testing
- AD036 Dose 1, AD036 Dose 2, AD036 Dose 3
- Where
- 12 sites in United States
- Volunteers
- 140 people
- Sponsor
- Apnimed
Sleep Apnea, Obstructive
eXciteOSA for Treatment of Mild Obstructive Sleep Apnea
The objective of this study is to assess the efficacy of the eXciteOSA device amongst a sample of patients with mild OSA. The study is a multi-center, prospective, open-label, randomized, parallel-arm trial of eXciteOSA versus…
- Trial name
- OREM (NCT05183009)
- Testing
- eXciteOSA
- Where
- 7 sites in United States
- Volunteers
- 102 people
- Sponsor
- Signifier Medical Technologies
Obstructive Sleep Apnea
The Evaluation of a New Nasal Mask for the Treatment of Obstructive Sleep Apnea
This investigation is designed to evaluate the comfort, ease of use and performance of a trial nasal mask for the treatment of Obstructive Sleep Apnea (OSA) in the home environment.
- Trial name
- NCT04011826
- Testing
- Device: Trial nasal mask (F&P)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea
Inspire® Upper Airway Stimulation System
The purpose of this post-market study is to assess safety and effectiveness of Inspire Upper Airway System (UAS) in a commercial setting.
- Trial name
- RCT (NCT02675816)
- Testing
- Inspire® Upper Airway Stimulation (UAS) System
- Where
- 4 sites in Belgium, Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Inspire Medical Systems, Inc.
Subjects With Moderate-to-severe OSA and Obesity Who Are on PAP Therapy
A Multicenter, Randomized, Double-blind, Placebo-controlled Phase III Clinical Study to Evaluate the Efficacy and Safety of HRS9531 Injection in Subjects With Obstructive Sleep Apnea (OSA) and Obesity Who Are on Positive Airway Pressure Ventilation (PAP) Therapy
This study is a phase 3 clinical trial, aiming to evaluate the efficacy and safety of HRS-9531 injection in obese subjects with obstructive sleep apnea (OSA) who are on positive airway pressure ventilation (PAP) therapy.
- Trial name
- NCT06994650
- Testing
- HRS9531
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Obstructive Sleep Apnea
REV 002 Observational Study of the ReVENT Sleep Apnea System: Minimally Invasive Treatment for Obstructive Sleep Apnea
The purpose of this post-market observational study is to assess the effectiveness and patient perception of benefit of the ReVENT Sleep Apnea System in patients diagnosed with Obstructive Sleep Apnea due to primary tongue base…
- Trial name
- NCT02180815
- Testing
- ReVENT Sleep Apnea System
- Where
- 14 sites in Belgium, Czechia and 3 more
- Volunteers
- 50 people
- Sponsor
- Revent Medical International B.V.
Narcolepsy, Sleep Apnea, Obstructive
PROVIGIL® (Modafinil) Treatment in Children and Adolescents With Excessive Sleepiness Associated With Narcolepsy or Obstructive Sleep Apnea/Hypopnea Syndrome
The primary objective of the study is to evaluate the safety and tolerability of treatment with PROVIGIL in children and adolescents with excessive sleepiness (ES) associated with narcolepsy or OSAHS (obstructive sleep…
- Trial name
- NCT00107848
- Testing
- Modafinil
- Where
- 61 sites in United States, Canada
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Cephalon
Obstructive Sleep Apnea, Atrial Fibrillation
Effective Conversion of Individuals at Risk
This study aims to guide participants in recognizing their OSA (obstructive sleep apnea) and AFib (atrial fibrillation) symptoms, realizing what medical conditions can cause these symptoms (if any) and inform the participants on…
- Trial name
- NCT05112757
- Testing
- Smartphone application use
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Philips Clinical & Medical Affairs Global
Obstructive Sleep Apnea
Transcutaneous Electrical Stimulation in Obstructive Sleep Apnea
The aim of this study is to assess the efficacy of transcutaneous electrical stimulation of the upper airway muscles in patients with obstructive sleep apnea.
- Trial name
- NCT04932486
- Testing
- Transcutaneous electrical stimulation
- Where
- Belgium
- Volunteers
- 42 people
- Sponsor
- Sunrise
OSAS (Obstructive Sleep Apneas Syndrome)
ISIS 1 Therapeutic Effectiveness
The study is a prospective field evaluation to assess the therapeutic value of the CPAP/autoCPAP Sandman in 24 new diagnosed Obstructive Sleep Apneic patients.
- Trial name
- NCT00646477
- Testing
- titration night
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Tyco Healthcare Group
Obstructive Sleep Apnea, Obstructive Sleep Apnea (OSA)
EURO-STIM Registry
The registry is to measure longitudinal outcomes and adherence of the Inspire System. The goal of the registry is to capture the life cycle of the patient's use of the Inspire System through routine clinical care visits.
- Trial name
- EURO-STIM (NCT06971796)
- Testing
- Inspire UAS System
- Where
- 21 sites in Austria, Belgium and 5 more
- Volunteers
- 1,000 people
- Sponsor
- Inspire Medical Systems, Inc.
Obstructive Sleep Apnea
Pilairo Lab Market Research
The purpose of the study is to observe the Pilairo mask in a lab setting.
- Trial name
- NCT01824979
- Testing
- CPAP mask ( Pilairo), Other CPAP mask
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Fisher and Paykel Healthcare
Sleep Apnea, Obstructive
New Versus Existing Auto-titrating CPAP Device to Treat Obstructive Sleep Apnea in Adults
Obstructive sleep apnea (OSA) is a condition of disordered breathing characterised by intermittent partial and/or complete upper airway obstruction during sleep.
- Trial name
- APAP (NCT01210261)
- Testing
- Compumedics Somnilink SPAP - Auto-titrating CPAP, Resmed Autoset S8 - Auto-titrating CPAP
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Compumedics Limited
OSA, Obstructive Sleep Apnea
AD816 Crossover Study
The VicTor Study is a randomized, double blind, placebo-controlled, 3-period, multiple-dose crossover study in participants with OSA.
- Trial name
- VicTor (NCT05793684)
- Testing
- Period A, Period B, Period C
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Apnimed
Obstructive Sleep Apnea
Registry Study on Prescription, Patient Pathways, Therapy Efficacy and Usage of Mandibular Advancement Devices in Obstructive Sleep Apnea - PATT-OSA Registry
During sleep, the muscle tonus in the oropharyngeal space is lost, the tongue might fall back andthe volume of the pharynx decreases. Air cannot pass through as it would in the awake state and thus airflow limitations occur.
- Trial name
- PATT-OSA (NCT03924817)
- Where
- 4 sites in Germany
- Volunteers
- 500 people
- Sponsor
- ResMed
Obstructive Sleep Apnea
Oran Park Mask External Clinical Study (3) Marketing Claims Study
The goal of this prospective, randomized, open label, cross over study to assess the seal, comfort, usability, and performance of the prototype Oran Park mask system (referred to as Mask A in this study protocol) in the home…
- Trial name
- NCT06079866
- Testing
- Mask A (Oran Park Mask) then Mask B (Evora Mask), Mask B (Evora Mask) then Mask A (Oran Park Mask)
- Where
- 2 sites in United States
- Volunteers
- 58 people
- Sponsor
- ResMed
Chronic Respiratory Conditions, Obstructive Sleep Apnea (OSA)
Evaluation of the F&P Mask, US, 2026
This clinical investigation is designed to validate and confirm the overall performance, safety, usability, reliability, and acceptability of the F\&P PAP mask in a home environment.
- Trial name
- NCT07826429
- Testing
- F&P Licorice Mask
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea (OSA)
Evaluate the Efficacy and Safety of GZR18 Injection in Obese Subjects With Obstructive Sleep Apnea Not Treated With Positive Airway Pressure (PAP) Therapy
This study is a multicenter, randomized, double-blind, parallel, placebo-controlled Phase III clinical trial evaluating the efficacy and safety of GZR18 injection in obese subjects with moderate to severe obstructive sleep apnea…
- Trial name
- NCT07493057
- Testing
- GZR18 injection
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Gan & Lee Pharmaceuticals.
Obstructive Sleep Apnea
SleepFlexTM Treatment of Obstructive Sleep Apnea
The purpose of this study is to evaluate the safety and effectiveness of the SleepFlex program for treatment of mild to moderate OSA
- Trial name
- NCT04726514
- Testing
- SleepFlex
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Berendo Scientific, LLC