Clinical trials: Obstructive Sleep Apnoea (OSA)
Obstructive Sleep Apnea Syndrome, Restless Leg Syndrome
Prevalence of OSAS in Chinese Elderly and Its CPAP Compliance
Objective: Obstructive sleep apnoea syndrome (OSAS) is a common form of sleep-disordered breathing (SDB) causing sleep fragmentation, daytime sleepiness, cognitive function impairment, and poor health status in addition to…
- Trial name
- NCT02085720
- Testing
- CPAP therapy
- Where
- Hong Kong
- Volunteers
- 819 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Obstructive Sleep Apnea
Metabolic Impact of Intermittent CPAP
Obstructive sleep apnea is a risk factor for diabetes and cardiovascular disease, by unknown mechanisms. The investigators hypothesize that sleep apnea changes glucose and lipid metabolism during sleep, which over time could lead…
- Trial name
- MIIC (NCT02824263)
- Testing
- CPAP withdrawal
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Johns Hopkins University
Polycystic Ovary Syndrome, Obstructive Sleep Apnea
Metabolic Study of Women With Polycystic Ovary Syndrome and Sleep Apnea
The purpose of this study is to look at the metabolic (use of energy) and hormonal features of sleep problems in women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT00696111
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Chicago
Obstructive Sleep Apnea (OSA)
DAW1033B2 in Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. OSA patients show a marked reduction in upper airway (UA) dilator muscle activity at sleep onset and this phenomenon…
- Trial name
- OsaStimB2 (NCT03426631)
- Testing
- DAW1033B2 oral capsule
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea
The Evaluation of a Mask for the Treatment of Obstructive Sleep Apnea
This investigation is a prospective, non randomized, non blinded study. This investigation is designed to evaluate the performance, comfort and ease of use with the F\&P trial full face and nasal mask amongst Obstructive Sleep…
- Trial name
- NCT03142438
- Testing
- F&P Seal Improvement Project
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea
CPAP vs AutoCPAP for Treatment of Obstructive Sleep Apnea (OSA) in the Postoperative Setting
The purpose of this study is to determine if an Autoadjusting CPAP machine is better than the regular CPAP machine in treatment of Obstructive Sleep Apnea in the postoperative setting.
- Trial name
- NCT00588848
- Testing
- Autoadjusting CPAP (VPAP Auto), CPAP
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- MetroHealth Medical Center
Obstructive Sleep Apnea
Effect of Ketorolac on Post Adenotonsillectomy Pain
This randomized prospective study aims to determine the effect of ketorolac on the total dose of morphine required to achieve postoperative analgesia in children with obstructive sleep apnea (OSA) undergoing adenotonsillectomy.
- Trial name
- NCT03467750
- Testing
- Ketorolac, Standard of Care
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Emory University
Obstructive Sleep Apnea
Mechanisms of Upper Airway Obstruction
The current study is designed to examine underlying mechanisms of action of lingual muscles in the maintenance of airway patency during sleep.
- Trial name
- DISE-CAD (NCT04322097)
- Testing
- Hypoglossal Nerve Stimulation
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Obstructive Sleep Apnea
Study to Assess the Changes in Blood Clotting Factors and Blood Vessel Wall Function in Obstructive Sleep Apnea
Obstructive sleep apnea is a condition in which people have decreased breathing during their sleep. Untreated sleep apnea has been linked to increased risk for cardiovascular diseases.
- Trial name
- NCT00936481
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Obstructive Sleep Apnea
Oxygen Saturation Patterns in Post-Op Patients at Risk for Obstructive Sleep Apnea
This study will include patients who have major surgery and are at risk for or have been diagnosed with sleep apnea. The patients will be monitored the night after surgery for repeating episodes of reduced breathing and oxygen…
- Trial name
- NCT01078207
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Medtronic - MITG
Xerostomia
NeutraSal Treatment for Xerostomia in OSAS Patients Using CPAP Therapy
To assess whether the daily use of NeutraSal will prevent or reduce dry mouth in patients undergoing CPAP therapy for OSAS and improve CPAP compliance
- Trial name
- NCT02107300
- Testing
- NeutraSal
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Medical University of South Carolina
Obstructive Sleep Apnea
Cost Effectiveness of Ambulatory Management for Veterans With Sleep Apnea
This research study is comparing home and in-laboratory testing of veterans with suspected obstructive sleep apnea, a common breathing disorder during sleep.
- Trial name
- VSATT (NCT00880165)
- Testing
- Continuous positive airway pressure apparatus
- Where
- 2 sites in United States
- Volunteers
- 296 people
- Sponsor
- US Department of Veterans Affairs
Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS)
Prospective Study to Evaluate Outcomes From Transoral BOT Resection for OSAHS
This is a prospective observational study that will collect outcome data for patients who choose to undergo transoral tongue base operations for Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS)as part of their standard of care…
- Trial name
- NCT01107795
- Testing
- Transoral Robotic Surgery
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Alabama at Birmingham
Desaturation of Blood, Colonoscopy
The Use of High Flow Nasal Cannula, Standard Face Mask and Standard Nasal Cannula in Morbidly Obese Patients
It is standard practice in the United States and many parts of world to perform Gastrointestinal endoscopy with the patient under deep intravenous sedation.
- Trial name
- NCT03479905
- Testing
- Salter nasal cannula, Face mask, High Flow Nasal Cannula
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- University of Texas Southwestern Medical Center
Obstructive Sleep Apnea (OSA)
Differences in Efficacy Between Nasal and Oronasal Masks in the Treatment of OSA With CPAP
Our group previously conducted a study looking at the performance of three styles of positive airway pressure masks during laboratory treatment studies for obstructive sleep apnea, and we found that patients using a full-mask…
- Trial name
- NCT01909674
- Testing
- Switch CPAP mask type
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Excessive Daytime Sleepiness, Narcolepsy
Study to Assess Patient Reported Outcomes With Armodafinil Treatment for Excessive Sleepiness in Adults With Narcolepsy or Obstructive Sleep Apnea/Hypopnea Syndrome
The purpose of this study is to assess patient reported outcomes with armodafinil treatment in terms of improvement in sleepiness, satisfaction with treatment, impact on ability to engage in life activities (ie, daily or work and…
- Conditions
- Excessive Daytime Sleepiness, Narcolepsy, Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS)
- Trial name
- NCT00228566
- Testing
- Armodafinil
- Where
- 43 sites in United States
- Volunteers
- 247 people
- Sponsor
- Cephalon
Obstructive Sleep Apnea
Pediatric Nasal Mask Usability Study
The purpose of the study is to demonstrate the effectiveness of a pediatric mask in treating obstructive sleep apnea (OSA) in a pediatric population.
- Trial name
- NCT01154322
- Testing
- Pixi pediatric mask
- Where
- 3 sites in United States
- Volunteers
- 16 people
- Sponsor
- ResMed
Acute Decompensated Heart Failure, Sleep Disordered Breathing
Cardiovascular Improvements With MV ASV Therapy in Heart Failure
The aim of the study is to compare the effects of MV targeted ASV in addition to optimized medical therapy versus optimized medical therapy alone at 6 months in patients with acute decompensated HF.
- Trial name
- CAT-HF (NCT01953874)
- Testing
- MV ASV, Optimized Medical Treatment
- Where
- 15 sites in United States, Germany
- Volunteers
- 126 people
- Sponsor
- ResMed
Sleep-disordered Breathing, Obstructive Sleep Apnea
Comparison of Sleep Study Results After Partial Intracapsular Tonsillectomy Versus Total Tonsillectomy
The purpose of this study is to demonstrate similar improvements in sleep-disordered breathing as determined by sleep study with microdebrider-assisted partial intracapsular tonsillectomy and adenoidectomy versus total Bovie…
- Trial name
- NCT00887471
- Testing
- PITA or T&A
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- State University of New York - Downstate Medical Center
Human Immunodeficiency Virus, Obstructive Sleep Apnea
Obstructive Sleep Apnea Endotypes and Impact on Phenotypes of People Living With HIV
The investigators seek to understand how the different underlying causes of OSA affect the way people living with HIV (PLWH) experience OSA.
- Trial name
- PLWH/OSA (NCT03575143)
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- University of California, San Diego