Clinical trials: Obstructive Sleep Apnoea Hypopnoea Syndrome
Obstructive Sleep Apnea, Ischaemic Heart Desease
Impact of Continuous Positive Airway Pressure (CPAP) Therapy on Outcomes in Patients Undergoing Coronary Revascularization
Investigators assume that continuous positive airway pressure (CPAP) therapy can reduce the mortality, stroke rate and secondary coronary surgery in CAD with obstructive sleep apnea (OSA) patients after percutaneous coronary…
- Trial name
- NCT02080156
- Testing
- CPAP
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Beijing Anzhen Hospital
Sleep Apnea Syndrome, Obstructive, Bruxism, Sleep-Related
Bruxism Induced by Obstructive Sleep Apnoea.
The relationship between obstructive sleep apnea (OSA), sleep bruxism, and temporomandibular disorders is becoming clearer, but data on how upper airway volume affects bruxism due to OSA is limited.
- Conditions
- Sleep Apnea Syndrome, Obstructive, Bruxism, Sleep-Related, Upper Respiratory Tract Illness
- Trial name
- OSA Bruxism (NCT07511946)
- Testing
- Upper airway volume assessment using Cone-Beam Computed Tomography (CBCT) and Polysomnography, Upper airway volume assessment using Cone-Beam Computed Tomography (CBCT)
- Where
- Poland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Obstructive Sleep Apnea
Trial on Oral Appliance Design for Improving Upper Airway Function and Sleep Quality
This study will compare the effectiveness of the two leading oral appliances (OAs) designs for the treatment of severe obstructive sleep apnea in overweight adults.
- Trial name
- NCT03219034
- Testing
- oral appliance - A ; washout; oral appliance B, oral appliance - B; washout; oral appliance A
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Texas A&M University
Schizoaffective Disorder, Schizophrenia
Obstructive Sleep Apnea Treatment in Serious Mental Illness
Serious mental illnesses (SMI) like schizophrenia and bipolar disorder are two of the most disabling and costly chronic illnesses worldwide.
- Conditions
- Schizoaffective Disorder, Schizophrenia, Bipolar Disorder, Obstructive Sleep Apnea of Adult
- Trial name
- NCT05457127
- Testing
- Automatic Positive Airway Pressure (APAP)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Obstructive Sleep Apnea Syndrome, Hypertension
Cardiovascular Phenotype Study in Patients With Obstructive Sleep Apnea Syndrome
Patients with obstructive sleep apnea syndrome have permanent variations of their hemodynamic parameters during the night : heart rate, arterial blood pressure, cardiac output.
- Trial name
- SAS-HTA (NCT00764218)
- Testing
- Positive airway pressure treatment, No positive airway pressure treatment
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Snoring, Mouth Breathing
OA Therapy for Mouth-breathers Who Snore
Breathing is one of the body's vital functions that occur under normal conditions using the nose. When humans breathe primarily through the mouth instead of the nose, this is referred to as mouth breathing.
- Conditions
- Snoring, Mouth Breathing, Obstructive Sleep Apnea
- Trial name
- OATMB (NCT04876625)
- Testing
- myTAP oral appliance plus mouth shield, myTAP oral appliance alone for first 4 weeks
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Obstructive Sleep Apnea
Abdominal Breathing for Depression, Anxiety, Heart Rate Variability in Obstructive Sleep Apnea Patients
The research topic is to explore the effectiveness of abdominal breathing on improving of depression, anxiety, and heart rate variability in obstructive sleep apnea patients with depressive symptoms.
- Trial name
- NCT05594212
- Testing
- Abdominal breathing training
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Sleep Apnea
A Novel Pharmacological Therapy for Obstructive Sleep Apnea
A pharmacological, non-mechanical therapy for OSA that is efficacious and tolerable remains elusive. Here the investigators study the effect on sleep apnea severity of a combination of pharmacological agents (atomoxetine and…
- Trial name
- NCT03919955
- Testing
- Atomoxetine, Oxybutynin
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Brigham and Women's Hospital
Obesity, Childhood, Behavior, Eating
Pediatric Obesity Management Study
Childhood obesity is a critical public health issue. Obesity in childhood is associated with many complications, including high blood pressure, type II diabetes mellitus, abnormal blood lipid values, obstructive sleep apnea…
- Trial name
- NCT05622981
- Testing
- Age-specific educational materials and monitoring
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Corewell Health East
Chronic Respiratory Conditions, Obstructive Sleep Apnea (OSA)
Evaluation of F&P Mask, US, 2026
This clinical investigation is designed to validate and confirm the overall performance, safety, usability, reliability, and acceptability of the F\&P mask in a home environment.
- Trial name
- NCT07847814
- Testing
- F&P Mask
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Fisher and Paykel Healthcare
Sleep Apnoea, Cerebral Palsy
Ischaemic Stroke and Sleep Apnea in Northern Part of Finland
Obstructive sleep apnoea is a risk factor for ischaemic stroke. study hypothesis: In prospective study the investigators want to know how many ischaemic stroke patients have sleep apnoea and does thrombolysis play a role in…
- Trial name
- NCT01861275
- Testing
- Nasal CPAP
- Where
- Finland
- Volunteers
- 256 people
- Sponsor
- University of Oulu
Obstructive Apnea, Sleep Apnea Syndrome, Obstructive
Pilot Study of Negative Pressure Neck Therapy (NPNT)
Obstructive sleep apnea (OSA) is a serious, chronic sleep-related breathing disease in which the upper airway repeatedly collapses during sleep, leading to intermittent oxygen deprivation.
- Conditions
- Obstructive Apnea, Sleep Apnea Syndrome, Obstructive, Sleep Disorder (Disorder)
- Trial name
- NCT07301567
- Testing
- Negative Pressure Neck Therapy (NPNT)
- Where
- 2 sites in Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Obstructive Sleep Apnea
Trazodone on OSA Endotypes
Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. Some OSA patients with low arousal threshold wake up prematurely during an obstructive event and do not have time for…
- Trial name
- NCT06286189
- Testing
- Trazodone Hydrochloride
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea
Cardiovascular Impact of Obstructive Sleep Apnea Treatment in Normotensive Patients
Recent evidences suggest that obstructive sleep apnea (OSA) can contribute to cardiovascular disease even in the absence of hypertension.
- Trial name
- OSA-NORMO (NCT00741520)
- Testing
- CPAP
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Ehler's Danlos Syndrome, Obstructive Sleep Apnea
Obstructive Sleep Apnoea in Children and Adolescents With Ehlers-Danlos Syndrome
Ehlers-Danlos Syndrome (EDS) is a clinically and genetically heterogeneous group of inherited connective tissue disorders characterized by joint hypermobility, skin hyperextensibility, and tissue fragility.
- Trial name
- NCT02712060
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Obstructive Sleep Apnea of Adult
A Pilot Study of Antioxidant Therapy in Obstructive Sleep Apnea Patients
Sleep apnea is a common under-diagnosed medical disorder, and moderate to severe disease is found in approximately 9% of men and 4% of women.
- Trial name
- NCT05009901
- Testing
- Alpha Lipoic Acid 600 MG Oral Tablet
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of British Columbia
Obstructive Sleep Apnea (Moderate to Severe), Obstructive Sleep Apnea
A Mindfulness-Based Intervention to Improve CPAP
The main purpose of this study is to assess the effectiveness of a mindfulness-based intervention in improving CPAP use compared to online peer support
- Trial name
- NCT05499286
- Testing
- Mindfulness Program
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- The Hospital for Sick Children
Positive-Pressure Respiration, Communication
Determining the Benefits of Improving Communication in BPAP/CPAP Users
The purpose of this study is to determine the effectiveness of a non-invasive communication aid for BPAP/CPAP masks. This study also looks to determine the potential impact of the device on patients with obstructive sleep apnea…
- Trial name
- NCT03795753
- Testing
- F2S Communicator, Non-functioning Communicator
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Emory University
Obstructive Sleep Apnea (OSA)
Level 3 Validation Study
This study will compare the output of a new Level 3 polysomnography system against in-laboratory polysomnography.
- Trial name
- NCT07688603
- Testing
- Comparison 1: Level 1 Polysomnography: Cadwell/Alice, Comparison 2: Level 3 Test: Berry Sleep Apnea Screening Monitor
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Windsor Sleep Disorders Clinic
Obstructive Sleep Apnoea Syndrome
Identification of Biomarkers for Obstructive Sleep Apnoea Syndrome
Untreated Obstructive Sleep Apnea Syndrome (OSAS) has long-term complications, namely metabolic imbalances (obesity, dislipidemia, type 2 diabetes mellitus).
- Trial name
- NCT02043483
- Where
- Portugal
- Volunteers
- 120 people
- Sponsor
- Universidade Nova de Lisboa
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