Clinical trials: Obstructive Sleep Apnoea Hypopnoea Syndrome
OSA
Impact of Intermittent Hypoxia on Neutrophil Extracellular Traps
This prospective observational study will enroll 60 moderate-to-severe OSA patients (AHI≧15/hour, 30 obese [BMI>=27] \& 30 non-obese [BMI<27]) and 40 age-, gender-, BMI-matched controls without OSA.
- Trial name
- NCT05485688
- Testing
- sleep apnea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Asthma, Obstructive Sleep Apnea Syndrome
Factors Issued From Functional Exploration Associated to SAHOS in Asthmatic Children
There is an increase in the prevalence of obstructive apnea-hypopnea syndrome (OSA) in children for which the pathophysiological explanation is unknown.
- Trial name
- SASTHMA (NCT04624815)
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity, Premature Recovery From Anesthesia
Armodafinil (Nuvigil), Postoperative Recovery of OSA (Obstructive Sleep Apnea) and Obese Patients
Obstructive sleep apnea (OSA) and obesity is associated with increased perioperative morbidity and mortality. This group of patients is at risk of perioperative desaturations which can be worsened by perioperative sedatives and…
- Trial name
- NCT02478580
- Testing
- Nuvigil
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- University of Texas Southwestern Medical Center
Obstructive Sleep Apnea
Crossover Trial of AD182 and AD504 in Obstructive Sleep Apnea
This is a randomized, 3-period, placebo-controlled, crossover study to examine the efficacy and safety of AD182 and AD504 versus placebo in patients with obstructive sleep apnea.
- Trial name
- NCT04645524
- Testing
- AD182, AD504, Polysomnography
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Apnimed
Heart Failure, OSA - Obstructive Sleep Apnea
Mandibular Advancement to Reduce Ventricular Load and Improve Quality-of-life in Heart Failure
Heart failure with reduced ejection fraction (HFrEF) is a serious condition that limits daily activities and often leads to hospital stays and early death.
- Trial name
- MARVEL-HF (NCT07460505)
- Testing
- Mandibular advancement device
- Where
- Singapore
- Volunteers
- 328 people
- Sponsor
- National University Hospital, Singapore
Sleep Apnea, Obstructive
HYpopnea and Apnea Detection and Treatment Performance of a New cardiOreSpiratory Holter Monitor
The HYPNOS study is an acute feasibility study to validate a new device for automatic detection and treatment of sleep apnea syndrome.
- Trial name
- HYPNOS (NCT03300037)
- Testing
- Kinesthetic stimulation
- Where
- 5 sites in France
- Volunteers
- 46 people
- Sponsor
- LivaNova
Chronic Obstructive Airway Disease
Cardiac Hemodynamics in Overlap Syndrome (COPD With Obstructive Sleep Apnea)
Patients with both sleep apnea and COPD have overlap syndrome, but their optimal management is not known. We plan to conduct a randomized trial of of bi-level PAP vs.
- Trial name
- NCT01261377
- Testing
- Bi-level positive airway pressure (BPAP), Oxygen, CPAP
- Where
- 2 sites in United States
- Sponsor
- Brigham and Women's Hospital
Sleep Apnea Syndrome, Rapid Maxillary Expansion
Evaluation of the Effects of Different Rapid Maxillary Expansion Appliances on Obstructive Sleep Apnea
Rapid maxillary expansion (RME) is a commonly used orthodontic treatment in patients with maxillary constriction to provide skeletal expansion, correct posterior crossbite and resolve naso-respiratory problems by reducing oral…
- Trial name
- NCT04604392
- Testing
- Rapid Maxillary Expansion Treatment
- Volunteers
- 46 people
- Sponsor
- Izmir Katip Celebi University
Apnea, Sleep
Remifentanil in Adults With OSA
Obstructive Sleep Apnea (OSA) is the most common problem that affects sleep. People with this problem have their airway blocked or minimized, causing snoring or gasping while sleeping.
- Trial name
- AROSA (NCT02898792)
- Testing
- Targeted infusion of remifentanil
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Obstructive Sleep Apnea, Sleep Apnea
The Comfort of Proactive Sleep Apnea Therapy
The goal of this clinical trial is to compare in OSA patients who regularly adhere to CPAP therapy. The main question[s] it aims to answer are: To assess if proactive therapy can effectively treat OSA with lower mean therapy…
- Trial name
- NCT06144892
- Testing
- Proactive Therapy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- NovaResp Technologies Inc
Obesity, Obstructive Sleep Apnea
Obstructive Sleep Apnea-induced Changes in Adipose and Liver Tissue and Effects of Massive Weight Loss on Inflammation
UPDATED May 2016: Originally the study design included investigation of the effects of the bioactive compound resveratrol compared to placebo tablets and to CPAP treatment.
- Trial name
- NCT02419092
- Where
- Denmark
- Volunteers
- 27 people
- Sponsor
- University of Aarhus
Obstructive Sleep Apnea (OSA)
Validation of HC250 and HC240 Series.
This study is designed to determine the effectiveness of two different CPAP devices. One a standard CPAP which has the ability to store comprehensive compliance and efficacy data and the second a auto adjusting CPAP which uses…
- Trial name
- NCT00739011
- Testing
- SleepStyle 254/244 CPAP series CPAP humidifier
- Where
- 2 sites in New Zealand
- Volunteers
- 40 people
- Sponsor
- Fisher and Paykel Healthcare
OSA - Obstructive Sleep Apnea, Coronary Microvascular Dysfunction (CMD)
The Correlation Between Obstructive Sleep Apnea-Related Nocturnal Hypoxemia Parameters and Coronary Microvascular Dysfunction: A Prospective Cohort Study (SLEEP-CMD)
In a cohort of patients with suspected myocardial ischemia undergoing sleep studies, the objectives of this study were: 1. To determine the association between various obstructive sleep apnea (OSA)-related nocturnal hypoxemia…
- Conditions
- OSA - Obstructive Sleep Apnea, Coronary Microvascular Dysfunction (CMD), Coronary Artery Disease (CAD)
- Trial name
- SLEEP-CMD (NCT07315399)
- Testing
- Polysomnography
- Where
- China
- Volunteers
- 560 people
- Sponsor
- Beijing Anzhen Hospital
Obstructive Sleep Apnea
Prevalence of Sleep Apnoea in Adolescents
Obstructive sleep apnoea (OSA) is associated with a variety of important complications, namely cardiovascular, neurocognitive and metabolic disturbances. The prevalence of OSA is well studied in children and adults.
- Trial name
- NCT03895775
- Where
- Hong Kong
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Obstructive Sleep Apnea
Continuous Positive Airway Pressure (CPAP) Promotion And Prognosis - the Army Sleep Apnea Program (ASAP)
The purpose of this study is to assess the efficacy of Eszopiclone in improving short and intermediate-term compliance with continuous positive airway pressure (CPAP) in patients newly diagnosed with obstructive sleep apnea (OSA).
- Trial name
- CPAPASAP (NCT00612157)
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Walter Reed Army Medical Center
Obstructive Sleep Apnea (OSA)
Safety and Tolerability of Gefapixant (MK-7264) in Participants With Obstructive Sleep Apnea (MK-7264-039)
The purpose of this study is to assess the safety and tolerability of multiple dose administration of gefapixant (MK-7264) in participants with moderate to severe obstructive sleep apnea (OSA).
- Trial name
- NCT03882801
- Testing
- Gefapixant
- Where
- 5 sites in United States, Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Sleep Apnea, Obstructive
Right Ventricular Function in Obstructive Sleep Apnea
The purpose of this study is to determine the structural and functional cardiac alterations in obstructive sleep apne (OSA) independent from systemic and pulmonary arterial hypertension and their correlation to the severity of…
- Trial name
- NCT00640536
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Florence Nightingale Hospital, Istanbul
Obstructive Sleep Apnea (OSA), Oral Applliance Therapy
Application of the Patient-reported Longitudinal Assessment Tool for OSA (PLATO) Questionnaire in Oral Appliance Therapy for Obstructive Sleep Apnea
Prospective, real-world observational study in a dental sleep practice to assess the feasibility of incorporating the PLATO into a dental sleep practice and applicability for patients who are undergoing oral appliance therapy for…
- Trial name
- APQ-OAT (NCT07789834)
- Testing
- The study will assess the feasibility of incorporating the PLATO questionnaire into a dental sleep practice. The PLATO questionnaire was developed as a patient reported outcome measure
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Nevada Dental Sleep
Coronary Artery Disease
Influence of Obstructive Sleep Apnea on the Severity of Coronary Artery Disease
It is widely accepted that coronary artery disease (CAD) is related to a high mortality. It is predicted that an increase of approximately 21.3 million cardiovascular events and 7.7 million cardiovascular deaths over 2010 to 2030…
- Trial name
- NCT04741022
- Where
- China
- Volunteers
- 255 people
- Sponsor
- Chinese Pulmonary Vascular Disease Research Group
Osa Syndrome
Nasal Versus Oronasal Mask in Continuous Positive Airway Pressure (CPAP) Treatment of Patients Affected by Obstructive Sleep Apnea Syndrome (OSAS).
Continuous positive airway pressure (CPAP) is considered the gold standard treatment for patients with moderate to severe obstructive sleep apnea (OSA).
- Trial name
- NCT04681196
- Testing
- patients shifted to nasal mask after persistent OSA with oronasal mask
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
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