Clinical trials: Obstructive Sleep Apnoea Hypopnoea Syndrome
Obstructive Sleep Apnea
High Flow Nasal Cannula Therapy for Childhood OSA
The main objective of this study is to evaluate the efficacy of high-flow nasal cannula (HFNC) therapy in children with OSA. Children and adolescents aged 6 to 18 years old with a diagnosis of moderate-to-severe OSA requiring…
- Trial name
- NCT03933800
- Testing
- High flow nasal cannula, Continuous positive airway pressure
- Where
- Hong Kong
- Volunteers
- 32 people
- Sponsor
- Chinese University of Hong Kong
Childhood Obstructive Sleep Apnea Syndrome (OSAS)
Mechanism of Action of Fluticasone Furoate in Childhood Obstructive Sleep Apnea Syndrome
The purpose of this research is to find out how a nasal spray (fluticasone furoate), sometimes given to children with obstructive sleep apnea syndrome (OSAS), works on certain cells within a child's adenoids.
- Trial name
- NCT00603044
- Testing
- fluticasone furoate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Chicago
Lung Transplant, Lung Resection
Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders
The goal of this research is to optimize the MRI system to obtain ideal lung images using Hyperpolarized (HP) Noble and Inert Fluorinated Gases as contrast agents. Lung coils tuned to the frequencies of these gases will be used.
- Conditions
- Lung Transplant, Lung Resection, Lung Cancer, Asthma
- Trial name
- NCT02748798
- Testing
- HP 3He, HP 129Xe, PFP
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Thunder Bay Regional Health Research Institute
OSA, Obstructive Sleep Apnea
AD816 Crossover Study
The VicTor Study is a randomized, double blind, placebo-controlled, 3-period, multiple-dose crossover study in participants with OSA.
- Trial name
- VicTor (NCT05793684)
- Testing
- Period A, Period B, Period C
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Apnimed
Obstructive Sleep Apnea
We-PAP: A Couples-based Intervention for Sleep Apnea
The purpose of this study is to develop, refine and evaluate the feasibility of a novel couples-based intervention to improve adherence for patients with obstructive sleep apnea (OSA).
- Trial name
- We-PAP (NCT04759157)
- Testing
- Couples-based treatment, Standardized education
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of Utah
Fatigue, Multiple Sclerosis
Continuous Positive Airway Pressure (CPAP) for Fatigue in Patients With Multiple Sclerosis (MS) and Obstructive Sleep Apnea (OSA)
Fatigue is a symptom present in 76 to 92% of people with multiple sclerosis (MS). Fatigue is usually described as an overwhelming sense of tiredness, lack of energy, and feeling of exhaustion which is different from sleepiness.
- Conditions
- Fatigue, Multiple Sclerosis, Sleep Apnea
- Trial name
- NCT01563900
- Testing
- Auto-titration CPAP
- Where
- United States
- Sponsor
- Northwestern University
Obstructive Sleep Apnea Syndrome
Physical Status of OSA Patients
To investigate the differences in postural stability, anxiety/depression, and quality of life of the patients according to the severity of Obstructive Sleep Apnea Syndrome.
- Trial name
- OSASRehab (NCT05051514)
- Testing
- Evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Okan University
Sleep Apnea, Glaucoma
Long-term Observation of Ophthalmic Changes in Patients With Obstructive Sleep Apnea
The ophthalmic changes during long-lasting sleep apnea are lacking in description and assessment. The investigators intend to observe patients for a long time and observe if the changes in eye tissues are progressing over the…
- Conditions
- Sleep Apnea, Glaucoma, Ocular Hypertension
- Trial name
- NCT03928665
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- Wroclaw Medical University
Morbid Obesity, Obstructive Sleep Apnea Syndrome
LAGB as a Treatment for Morbid Obesity in Adolescents
Laparoscopic adjustable gastric banding (LAGB) has been used worldwide to help selected morbidly obese adults to lose weight. The FDA has approved LAGB only for patients 18 years or older.
- Conditions
- Morbid Obesity, Obstructive Sleep Apnea Syndrome, Metabolic Syndrome, Insulin Resistance
- Trial name
- NCT01045499
- Testing
- Laparoscopic adjustable gastric banding (Allergan Lap Band)
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Jeffrey L Zitsman, MD
Obstructive Sleep Apnea (OSA), Oral Applliance Therapy
Application of the Patient-reported Longitudinal Assessment Tool for OSA (PLATO) Questionnaire in Oral Appliance Therapy for Obstructive Sleep Apnea
Prospective, real-world observational study in a dental sleep practice to assess the feasibility of incorporating the PLATO into a dental sleep practice and applicability for patients who are undergoing oral appliance therapy for…
- Trial name
- APQ-OAT (NCT07789834)
- Testing
- The study will assess the feasibility of incorporating the PLATO questionnaire into a dental sleep practice. The PLATO questionnaire was developed as a patient reported outcome measure
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Nevada Dental Sleep
Hypertension,Essential, Obstructive Sleep Apnea
Reduction of Left Ventricular Hypertrophy After Eplerenone Therapy
Obstructive sleep apnea syndrome (OSA) is the most frequent sleep disorder characterized by excessive decrease in muscle tone of the soft palate, the tongue and the posterior pharyngeal wall. It leads to airway collapse.
- Conditions
- Hypertension,Essential, Obstructive Sleep Apnea, Left Ventricular Hypertrophy
- Trial name
- NCT03186742
- Testing
- Eplerenone 50 mg Tab
- Volunteers
- 125 people
- Sponsor
- Poznan University of Medical Sciences
Obstructive Sleep Apnea
Oximetry in Children for Sleep Apnea Diagnosis
Video-polygraphy or video-polysomnography (vP(S)G) is the reference exam for the diagnosis of obstructive sleep apnea syndrome (OSAS) in children as it allows the detection of the respiratory events presented by the child during…
- Trial name
- NCT05634096
- Testing
- Oximetry
- Where
- France
- Volunteers
- 950 people
- Sponsor
- Central Hospital, Nancy, France
Obstructive Sleep Apnea, Overhydration
Effect of Renal Transplantation on Obstructive Sleep Apnea in End Stage Renal Disease Patients (SASinTx)
The purpose of this study is to investigate the effect of renal transplantation on fluid overload and its consequence on the severity of obstructive sleep apnea, in patients with end stage chronic kidney disease.
- Conditions
- Obstructive Sleep Apnea, Overhydration, End Stage Renal Disease, Renal Transplantation
- Trial name
- SASinTx (NCT02020642)
- Testing
- Renal transplantation
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Apnea
A Study of Breathing Sound-based Classification of Patients With Breathing Disorders
Sleep-disordered breathing can damage the cardiovascular system, and may also lead to dysregulation of the autonomic nervous system, endocrine disorders, and hemodynamic changes, causing multi-system and multi-organ damage.
- Trial name
- NCT05868694
- Testing
- polysomnography
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Huai'an No.1 People's Hospital
Obstructive Sleep Apnea, Obesity
UBT251 Injection Phase Ⅲ Study (OSA-NPAP)
The objective of this clinical trial is to evaluate the efficacy of investigational drug UBT251 in the treatment of moderate-to-severe obstructive sleep apnea (OSA) with obesity, as well as to assess its safety.
- Trial name
- UNISHAPE-OSA-1 (NCT07767942)
- Testing
- UBT251
- Volunteers
- 150 people
- Sponsor
- The United Bio-Technology (Hengqin) Co., Ltd.
Mild Obstructive Sleep Apnea, Snoring
Study to Examine the Effect of Silicone Mouth Tape on Snoring and Mild Sleep Apnea.
Snoring is a common problem caused by vibration of tissues in the throat region during sleep. Although snoring is sometimes dismissed as a minor nuisance rather than a medical disorder, several studies indicate that snoring can…
- Trial name
- MTASSA (NCT06587256)
- Testing
- Mouth Tape
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins University
Sleep-Disordered Breathing, Obstructive Sleep Apnea
A Multi-Center Study to Assess the Performance of Saturation Patterns.
A multi-center, prospective, single-visit study designed to acquire physiologic pulse oximeter waveform data during standard polysomnography (PSG) studies performed at multiple different Sleep Lab Centers.
- Conditions
- Sleep-Disordered Breathing, Obstructive Sleep Apnea, Sleep Apnea, Central Sleep Apnea
- Trial name
- NCT00775346
- Where
- 3 sites in United States
- Volunteers
- 92 people
- Sponsor
- Medtronic - MITG
Obstructive Sleep Apnea, Sleep Apnea
North West London Pebble Pathway: Automated OSA Diagnosis
Patients with obstructive sleep apnoea (OSA) wait up to two years for a diagnostic test. Early diagnosis enables optimal treatment, mitigating risks including heart failure, lung disease, and stroke.
- Trial name
- PEBBLE (NCT06507228)
- Testing
- NWL PEBBLE STT
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Patrik Bachtiger
Obstructive Sleep Apnea
The Effect of Occlusal Splints on Respiratory Variables in Obstructive Sleep Apnea (OSA) Patients
Rationale: The effect of vertical dimension on sleep apnoea and respiratory variables in obstructive sleep apnoea patients. Objective: To what extend should a possible worsening of the OSA condition, caused by an increase of…
- Trial name
- NCT01004692
- Testing
- Occlusal splints
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Academic Centre for Dentistry in Amsterdam
Obstructive Sleep Apnea
Evaluation of a Mandibular Advancement Device in the Treatment of Obstructive Sleep Apnea Syndrome
The purpose of this study is to determine if the mandibular advancement by Herbst device is effective in the treatment of moderate obstructive sleep apnea patients.
- Trial name
- NCT00213434
- Testing
- Herbst oral appliance
- Where
- France
- Sponsor
- University Hospital, Rouen
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