Clinical trials: Obstructive Sleep Apnoea Hypopnoea Syndrome
Ischemic Stroke, Obstructive Sleep Apnea
Nasal EPAP for Stroke Patients With Sleep Apnea: a Pilot Trial.
Specific aim: To test the effects of nasal expiratory positive airway pressure (EPAP) therapy on sleep apnea severity among patients with recent ischemic stroke.
- Trial name
- NCT01703663
- Testing
- EPAP
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Obstructive Sleep Apnea
Mask Study: One-handed vs. Two Handed Technique in Children
During induction of anesthesia in children, the investigators have observed significant variability in mask holding technique at our institution among different anesthesia practitioners.
- Trial name
- NCT03215121
- Testing
- One handed mask airway, switch to two hands, Two handed mask airway + jaw thrust, Two handed mask airway, switch to one hand
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Obstructive Sleep Apnea, Adherence, Patient
Increasing Adherence to Oral Appliance Therapy for Obstructive Sleep Apnea
Obstructive sleep apnea is a chronic condition that has serious health consequences including increased risk of hypertension, type-2 diabetes, heart disease, stroke and reduced life expectancy.
- Trial name
- NCT05038215
- Testing
- adherence promotion techniques, Routine Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ohio State University
Pulmonary Hypertension
CPAP Therapy in Obstructive Sleep Apnea Patients With Pulmonary Hypertension
All patients are newly diagnosed Obstructive Sleep Apnea patients performing full night polysmnographic sleep study, whose echocardiographic findings elucidate presence of pulmonary hypertension(PH).
- Trial name
- NCT04769635
- Testing
- CPAP therapy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Zagazig University
Atrial Fibrillation, Obstructive Sleep Apnea
OSA Prevalence in Atrial Fibrillation Patients: Jordanian Study
Current Knowledge: Countless studies have been conducted to study the relationship between OSA and AF, and a significant association has been established between both diseases, owing to the numerous shared risk factors and a wide…
- Trial name
- NCT05990010
- Testing
- Berlin Questionnaire
- Where
- Jordan
- Volunteers
- 545 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Obstructive Sleep Apnea, Type 2 Diabetes
Sleep Apnea in Look AHEAD (Action for Health in Diabetes)
This study will assess the effects of weight loss on sleep-disordered breathing (SDB) in 120 obese, type 2 diabetics with obstructive sleep apnea (OSA) from four Look AHEAD sites.
- Trial name
- NCT00194259
- Where
- 4 sites in United States
- Volunteers
- 320 people
- Sponsor
- Temple University
Obstructive Sleep Apnea
The Evaluation of a New Nasal Mask for the Treatment of Obstructive Sleep Apnea
This investigation is designed to evaluate the comfort, ease of use and performance of a trial nasal mask for the treatment of Obstructive Sleep Apnea (OSA) in the home environment.
- Trial name
- NCT04011826
- Testing
- Device: Trial nasal mask (F&P)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Fisher and Paykel Healthcare
Sleep Apnea, Obstructive
Statins and CPAP in Adipose Tissue of OSA
This study is aimed at examining the alterations in adipose tissue in obstructive sleep apnea (OSA) patients in response to treatment with atorvastatin in continuation with standard treatment with continuous positive airway…
- Trial name
- SCAT-OSA (NCT03308578)
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Pediatric Obstructive Sleep Apnea
Oral Corticosteroids' Role in Pediatric Obstructive Sleep Apnea
This prospective interventional clinical trial (non-randomized) aims to evaluate oral corticosteroids' role as an alternative to surgery (gold-standard) in the treatment of obstructive sleep apnea in children.
- Trial name
- NCT06917768
- Testing
- Adenotonsillectomy, Prednisolone
- Where
- Lebanon
- Volunteers
- 87 people
- Sponsor
- Hotel Dieu de France Hospital
Obstructive Sleep Apnea Syndrome
Multimodal Remote Monitoring and Integrated Educational Program in OSA Patients Initiating Continuous Positive Airway Pressure (CPAP): (SLEEPCONNECT)
Continuous positive airway pressure (CPAP) is the first line therapy for Obstructive Sleep Apnea Syndrome (OSAS) but has limited impact for reducing cardio-metabolic risk.
- Trial name
- SLEEPCONNECT (NCT04054180)
- Testing
- CPAP associated with connected devices: blood pressure monitor , scales and activity monitor
- Where
- France
- Volunteers
- 41 people
- Sponsor
- University Hospital, Grenoble
Sleep Apnea, Obstructive
Characterizing Upper Airway Collapse to Guide Patient Selection for Oral Appliance Therapy for Obstructive Sleep Apnea
Obstructive Sleep Apnea (OSA) is characterized by collapse of one or more pharyngeal structures during sleep (velum, tongue base, lateral walls, epiglottis).
- Trial name
- NCT02489591
- Testing
- Oral appliance, BluePro oral appliance
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea
Device-Assisted Oropharyngeal Rehabilitation in Obstructive Sleep Apnea Patients Using Continuous Positive Airway Pressure
The goal of this clinical trial is to evaluate the effectiveness of device-assisted oropharyngeal rehabilitation (OPR) in improving upper airway muscle function and reducing obstructive sleep apnea (OSA) severity in adult…
- Trial name
- NCT06999746
- Testing
- Control, Oropharyngeal Exercise, Continuous positive airway pressure
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Cheng-Kung University Hospital
Apnea, Obstructive
EFFECT OF A SUBSTANCE P ANTAGONIST ON THE SECRETION OF ALDOSTERONE IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME AND ARTERIAL HYPERTENSION
Obstructive sleep apnea syndrome (OSAS) is associated with hyperaldosteronism with elevated plasma aldosterone/renin ratio, the physiopathological mechanism of which remains uncertain.
- Trial name
- APHOS3 (NCT06462287)
- Testing
- Aprepitant 125 and 80Mg Oral Capsule
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Rouen
Renal Failure Chronic Requiring Dialysis, Obstructive Sleep Apnea
Effects of Compression Stockings on Obstructive Sleep Apnea in Patients Under Hemodialysis
To study the effects of compression stockings on sleep apnea in hemodialysis patients with diagnosed obstructive sleep apnea. The rationale of this study consists in the fluid shift theory, which consists in the nocturnal rostral…
- Trial name
- EComStockOSA (NCT02503215)
- Testing
- Compression Stockings
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- University of Sao Paulo
Obstructive Sleep Apnea
Adherence and Outcome of Upper Airway Stimulation (UAS) for OSA International Registry
Inspire intends to conduct this registry to: 1) collect Inspire therapy clinical evidence in the clinical practice setting; 2) collect additional information on the effectiveness, use and safety in the commercial setting; and 3)…
- Trial name
- NCT02907398
- Testing
- Inspire therapy, No intervention
- Where
- 64 sites in United States, Belgium and 3 more
- Volunteers
- 5,000 people
- Sponsor
- Inspire Medical Systems, Inc.
Obstructive Sleep Apnea, Gastroesophageal Reflux
Proton Pump Inhibitor Therapy for Mild to Moderate Obstructive Sleep Apnea
Obstructive Sleep Apnea (OSA) is common in modern society, affecting up to 5% of working middle-aged adults in the United States. Obesity is the number one risk factor for the development of OSA.
- Trial name
- NCT00211614
- Testing
- Lansoprazole
- Where
- United States
- Sponsor
- MetroHealth Medical Center
Coronary Artery Disease, Obstructive Sleep Apnea
Relationship Between Obstructive Sleep Apnea and Coronary Atherosclerosis
Obstructive sleep apnea (OSA) is a respiratory disorder of sleep characterized by recurrent episodes of complete or partial upper airway obstruction, leading to intermittent oxygen deprivation.
- Trial name
- IDEAS-OSA (NCT01306526)
- Where
- Singapore
- Volunteers
- 118 people
- Sponsor
- National University of Singapore
Obstructive Sleep Apnea
Atomoxetine and DAW2022 on OSA Severity
Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. In previous research atomoxetine and oxybutynin showed promising effect at reducing OSA severity, however they reduced…
- Trial name
- NCT05350215
- Testing
- Atomoxetine Oral Capsule [Strattera]
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Brigham and Women's Hospital
Positional Obstructive Sleep Apnea
Comparison of 2 Different Positional Therapies for Positional Obstructive Sleep Apnea Syndrome
The proposed study is a randomized cross over trial assessing the efficacy of two different positional therapies for positional obstructive sleep apnea (POSA).
- Trial name
- NCT04425408
- Testing
- Consecutive trial of two different devices for the treatment of positional sleep apnoea, for 3 nights with each device (positional pillow and vibrating belt).
- Where
- Belgium
- Volunteers
- 19 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Obstructive Sleep Apnea of Adult
Does Race Make a Difference in Obstructive Sleep Apnea?
Obstructive sleep apnea (OSA) is a sleep-related breathing disorder, often associated with a compromised upper airway space and an increase in upper airway collapsibility.
- Trial name
- NCT03463785
- Testing
- cone beam computed tomography
- Where
- 2 sites in China, Netherlands
- Volunteers
- 58 people
- Sponsor
- Academic Centre for Dentistry in Amsterdam
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