Clinical trials: Obstructive Ventilation Disorder
Obstructive Sleep Apnea
The Effect of Obstructive Sleep Apnea and Its Treatment on Decision Making
Obstructive sleep apnea (OSA) is an extremely common disease with inadequately explored neurocognitive consequences. The investigators will study OSA patients before and after treatment to understand how OSA changes decision…
- Trial name
- NCT03262519
- Testing
- Computer based neurocognitive testing
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Smoking, Airway Obstruction
Effect of the Salbutamol on Mechanical Properties of Respiratory System
The aim of this study is to assess the bronchodilator response of salbutamol on respiratory mechanics of healthy individuals, smokers and COPD with varying degrees of airway obstruction.
- Trial name
- NCT01521572
- Testing
- Salbutamol sulphate
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Apnea, Obstructive Sleep, Obesity
Association of Body Fluid Distribution With Obstructive Sleep Apnea in Pregnant Women With Body Mass Index ≥ 40 kg/m2
Obstructive Sleep apnea (OSA) is a common and underdiagnosed condition in obese pregnant women with serious and life-threatening complications to the mother and baby.
- Trial name
- NCT04187612
- Testing
- Bioelectrical Impedance Analysis (BIA)
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
COPD (Chronic Obstructive Pulmonary Disease), Non-invasive Ventilation
Effects of Vibrating Mesh Nebulisation in Patients With COPD During Non-invasive Ventilation (VMN-NIV)
Assessment of the effects of vibrating mesh nebulisation versus jet nebulisation on the electrical activity of the muscles involved in breathing (neural respiratory drive), breathing mechanics (respiratory impedance measured by…
- Trial name
- VMN-NIV (NCT06884228)
- Testing
- Vibrating mesh nebulisation, Jet nebuliser
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Chronic Obstructive Pulmonary Disease, Acute Respiratory Failure
Early Rehabilitation of COPD Patients in ICU
Twenty per cent of the intensive care patients mechanically ventilated suffer from chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00628992
- Testing
- No specific intervention, standard therapy serving as a control group, passive mobilization of the legs, Electrical stimulation of the thigh, Cycloergometer training
- Where
- 4 sites in France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Strasbourg, France
Sleep Disordered Breathing
Evaluation of Sleep Disordered Breathing Following Ambulatory Surgery
Obstructive sleep apnea (OSA) is a relatively common medical condition that includes upper-airway obstruction and consequent cessation of breathing during sleep with significant associated other medical problems.
- Trial name
- NCT01851798
- Testing
- Home sleep test administered to all enrolled subjects
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- Walter Reed National Military Medical Center
COPD (Chronic Obstructive Pulmonary Disease), Cardiometry
Cardio-circulatory and Respiratory Monitoring for Prediction of Outcome in Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients
Chronic Obstructive Pulmonary Disease (COPD) remains a leading cause of morbidity and mortality worldwide, often necessitating invasive mechanical ventilation (MV) during acute exacerbations.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Cardiometry, Weaning Invasive Mechanical Ventilation
- Trial name
- NCT07109206
- Where
- Egypt
- Volunteers
- 104 people
- Sponsor
- Assiut University
Chronic Obstructive Pulmonary Disease, Lung Disease Causing Persistent Narrowing of the Airways
AZD2115 Single Ascending Dose Study
AZD2115 Single Ascending Dose Study
- Trial name
- NCT01283984
- Testing
- AZD2115
- Where
- United Kingdom
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Heart Failure, Obstructive Sleep Apnea
Sleep Apnea in Heart Failure With Preserved Ejection Fraction
This is a prospective interventional study to better understand i) the prevalence of Obstructive Sleep Apnea (OSA) in Heart Failure with preserved Ejection Fraction (HFpEF), ii) its hemodynamic correlates, and iii) the impact of…
- Trial name
- NCT05008432
- Testing
- Home sleep apnea testing
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Mayo Clinic
Obstructive Sleep Apnea
TipTraQ Home Sleep Test Validation Study, Duke
A validation study has been designed to assess the performance of a home sleep test device, TipTraQ, for screening sleep apnea. The study involves participants wearing the TipTraQ device on their fingertip during a traditional…
- Trial name
- NCT06351878
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- PranaQ Pte. Ltd.
Chronic Obstructive Pulmonary Disease
Intellivent ASV in Chronic Obstructive Pulmonary Disease Patients in the ICU
This study will evaluate the effect of a fully closed loop ventilation mode (Intellivent ASV) on the duration of ventilation compared to conventional modes in COPD patients.
- Trial name
- NCT02651935
- Testing
- Intellivent ASV
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
Snoring, Obstructive Sleep Apnea
Prospective Evaluation of a Palato-Pharyngeal Implant System (PPIS) Obstructive Sleep Apnea Syndrome (OSAS)
Prospective Evaluation of a Palato-Pharyngeal Implant System (PPIS) for the Treatment of Snoring and Obstructive Sleep Apnea Syndrome (OSAS): A Pilot Study.
- Trial name
- NCT03640793
- Testing
- Implantation
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- Medartis AG
Chronic Obstructive Pulmonary Disease, Dyspnea
Abdominal Binding in Chronic Obstructive Pulmonary Disease
Conventional approaches to relieve dyspnea (respiratory discomfort) in chronic obstructive pulmonary disease (COPD) have focused on improving respiratory motor drive (e.g., hyperoxia) and/or dynamic respiratory mechanics (e.g.…
- Trial name
- NCT01852006
- Testing
- Abdominal Binder
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McGill University
Obstructive Sleep Apnea
Ezopiclone Improves the Quality of Overnight Polysomnography
Patients often have difficulty sleeping during overnight sleep testing in a lab environment. The purpose of this study is to determine if taking a sleep aid will improve sleep and therefore the quality of the sleep study.
- Trial name
- NCT00507117
- Testing
- Lunesta
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Pulmonary Disease, Chronic Obstructive
Effects of Acute Long-acting Bronchodilation on Oxygenation and Peripheral Ventilation in COPD
The goal of this clinical trial was to compare the action of long-acting ß2-agonists (LABA-olodaterol) and muscarinic antagonists (LAMA-tiotropium) on tissue oxygenation in COPD considering their impact on proximal and peripheral…
- Trial name
- NCT05927155
- Testing
- LABA, LAMA
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Erasme University Hospital
Pulmonary Disease, Chronic Obstructive, Obesity Hypoventilation Syndrome
Treatment of Metabolic Alkalosis With Acetazolamide. Effect on the Length of Mechanical Ventilation.
The purpose of this study is to analyze whether the treatment of metabolic alkalosis with acetazolamide in intubated patients with chronic obstructive pulmonary disease (COPD) or with obesity hypoventilation syndrome (OHS)…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Obesity Hypoventilation Syndrome, Metabolic Alkalosis
- Trial name
- TRAMA (NCT01499485)
- Testing
- Acetazolamide
- Where
- 8 sites in Spain
- Volunteers
- 140 people
- Sponsor
- Hospital Son Llatzer
Sleep Apnea, Obstructive; Post-Traumatic Stress Disorders
Obstructive Sleep Apnea and Arousal Threshold in Patients With Post-traumatic Stress Disorder
Obstructive sleep apnea (OSA) has traditionally been attributed only to a collapsible upper airway. However, it is increasingly recognized that multiple additional non-anatomical mechanisms contribute to the disease.
- Trial name
- NCT02699138
- Testing
- Trazodone, Epiglottic catheter
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Diego
COPD, Emphysema or COPD
Steroid Resistance During COPD Exacerbations With Respiratory Failure
Chronic obstructive pulmonary disease (COPD) is a lung disease caused by cigarette smoke that affects millions of people. In the United States, COPD is the 3rd leading cause of death making it one of our most important public…
- Conditions
- COPD, Emphysema or COPD, COPD Exacerbation, COPD Exacerbation Acute
- Trial name
- NCT03680495
- Testing
- Methylprednisolone
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Colorado, Denver
Obstructive Sleep Apnea Syndrome
Systemic Steroids Plus Antibiotics in Sleep Apnea Syndrome in Children
The purpose of this study is to investigate the effect of treatment with a steroid and antibiotic on the size of the tonsils and symptoms of children with OSAS.
- Trial name
- NCT00456339
- Testing
- Prednisolone and amoxicillin/clavulanate
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Chicago
Video-assisted Thoracoscopic Surgery, Chronic Obstructive Pulmonary Disease
Effects of Iloprost on Pulmonary Hemodynamics and Oxygenation in Patients of Chronic Obstructive Pulmonary Disease During One-lung Ventilation
The inhaled Iloprost, approved for pulmonary hypertension, caused increase in oxygenation, and increase exercise tolerance in ARDS or chronic obstructive pulmonary disease.
- Trial name
- NCT02490657
- Testing
- Inhaled iloprost, normal saline (Saline 0.9%)
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Yonsei University
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