Clinical trials: Obstructive Ventilation Disorder
Obstructive Sleep Apnea, Healthy
Renal Hemodynamics and Tubular Function in Patients With Obstructive Sleep Apnea and Healthy Controls
Nitrogen-oxide (NO) plays an important role for blood pressure regulation, renal hemodynamics, and the renal excretion of sodium.
- Trial name
- NCT00410085
- Testing
- L-NMMA (N-mono.methyl-L-arginine)
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
Obstructive Sleep Apnea (OSA)
The Effects of Hypoxic Burden on Executive Function (EF) in Preschool Children With Obstructive Sleep Apnea
The goal of this observational study is to study the effect of hypoxic burden on executive function in preschool children aged 2-6 years who have OSA.
- Trial name
- NCT07023458
- Testing
- Brief-P
- Where
- Thailand
- Volunteers
- 72 people
- Sponsor
- Mahidol University
Sickle Cell Disease, Anemia, Sickle Cell
Daily Vitamin D for Sickle-cell Respiratory Complications
This study aims to answer the question whether daily oral vitamin D supplementation can reduce the risk of respiratory or lung complications in children and adolescents with sickle cell disease.
- Conditions
- Sickle Cell Disease, Anemia, Sickle Cell, Anemia, Hemolytic, Congenital, Respiratory Tract Diseases
- Trial name
- ViDAS-2 (NCT04170348)
- Testing
- Daily oral vitamin D3, 3,333 IU, Monthly oral vitamin D3, 100,000 IU
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Columbia University
Chronic Obstructive Pulmonary Disease
Physiological Study of Minimally Invasive ECCO2R in Exacerbations of COPD Requiring Invasive Mechanical Ventilation
Morbidity and mortality in COPD result largely of acute exacerbations.The optimization of the respiratory management represents a fundamental challenge for improving prognosis and reducing mortality.
- Trial name
- EPHEBE (NCT02586948)
- Testing
- extracorporeal CO2 removal (Hemolung device)
- Where
- 3 sites in France
- Volunteers
- 12 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy, Obstructive Sleep Apnea
Vasoactive Hormones During the Night in Patients With Obstructive Sleep Apnea and Healthy Controls.
Obstructive sleep apnea syndrome is complicated by considerable cardiovascular morbidity and mortality, at least partly due to hypertension.
- Trial name
- NCT00291993
- Where
- 3 sites in Denmark
- Volunteers
- healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
Chronic Obstructive Pulmonary Disease Mild, Chronic Obstructive Pulmonary Disease Moderate
Effect Of Ketamine Infusion In Patients With COPD Applied One Lung Ventilation
Chronic obstructive pulmonary disease (COPD) patients often undergo thoracic surgery due to lung cancer and emphysematous changes.
- Conditions
- Chronic Obstructive Pulmonary Disease Mild, Chronic Obstructive Pulmonary Disease Moderate, Chronic Obstructive Pulmonary Disease Severe, Lungcancer
- Trial name
- NCT02962999
- Testing
- Ketamine, Saline
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Obstructive Sleep Apnea, Overhydration
Effect of Intermittent Hemodialysis on Sleep Apnea Syndrome in End Stage Renal Disease Patients
The purpose of this study is to investigate the effect of decreasing fluid overload by hemodialysis on the severity of obstructive sleep apnea, in patients with end stage chronic kidney disease on intermittent hemodialysis.
- Conditions
- Obstructive Sleep Apnea, Overhydration, End Stage Renal Disease
- Trial name
- SASinHD (NCT01860209)
- Testing
- Hemodialysis
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Snoring, OSA - Obstructive Sleep Apnea
Serene Sleep Palatal Implant System Clinical Confirmatory Trial in Participants Who Snore or Are Diagnosed With Mild-to-moderate Obstructive Sleep Apnea (OSA).
This clinical investigation is a prospective, non-randomized, parallel-group clinical investigation conducted at two (2) investigative sites.
- Trial name
- NCT07613281
- Testing
- Palatal Implant System
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Serene Sleep, Inc.
Dyspnea
Vibration Response Imaging (VRI) in Dyspnea Patients Presenting to the ED
For the patient with acute dyspnea in the ED, early differentiation between CHF and non-CHF causes is essential for proper management.
- Trial name
- NCT01206621
- Where
- 8 sites in United States, Israel
- Volunteers
- 530 people
- Sponsor
- Deep Breeze
Obstructive Sleep Apnoea
Effect of Continuous Positive Airway Pressure (CPAP) on Systemic Blood Pressure, Coagulability and Carotid Intima-media Thickness in Patients With Sleep Apnea
Sleep-disordered breathing (SDB) briefly means cessation of breathing during sleep at least 5 times per hour. Sleep-disordered breathing affects 9 to 24% of the middle-aged and overall 4% of the middle-aged males suffers from…
- Trial name
- NCT00300599
- Testing
- Continuous Positive Airway pressure
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Obstructive Sleep Apnea
Chronic Care Management With Wearable Devices in Patients Prescribed Positive Airway Pressure Therapy (mPAP) Trial
The goal of this clinical trial in adults with obstructive sleep apnea prescribed positive airway pressure therapy is to test the effects of a new patient-facing consumer wearable-based program (that involves provision of a…
- Trial name
- mPAP (NCT06039865)
- Testing
- Immediate Intervention, Waitlist control
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Greater Los Angeles Healthcare System
Obstructive Sleep Apnea (OSA)
DAW1033D in Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. OSA patients show a marked reduction in upper airway (UA) dilator muscle activity at sleep onset and this phenomenon…
- Trial name
- OSAstimD (NCT03383887)
- Testing
- DAW1033D oral capsule
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea, Morbid Obesity
Epigenetics Modifications in Morbid Obesity and Obstructive Sleep Apnea Patients: The EPIMOOSA Study
This study evaluates epigenetics in morbid obese patients who are waiting for bariatric surgery. A home cardiopulmonary polygraphy is performed to evaluate for the presence of sleep-disordered breathing.
- Conditions
- Obstructive Sleep Apnea, Morbid Obesity, Epigenetic Disorder
- Trial name
- EPIMOOSA (NCT03995836)
- Testing
- CPAP, Bariatric Surgery
- Volunteers
- 70 people
- Sponsor
- Aragon Institute of Health Sciences
Disease, Pulmonary
Study to Evaluate the Safety and Pharmacokinetics of Inhaled Ciprofloxacin in Patients With Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD)
Objectives of the study are to investigate the safety, tolerability and levels of ciprofloxacin in the lung after single and multiple inhalative administration to patients with mild to moderate COPD (stage I-II according to GOLD…
- Trial name
- NCT01052298
- Testing
- Ciprofloxacin (Cipro inhale, BAYQ3939)
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Bayer
Hypertension, Obstructive Sleep Apnea
Impact of Sleep-Disordered Breathing Management in Systemic Hypertension Control: METASLEEP Project
Hypertension is a frequent condition affecting 11M Spanish citizens and is the leading modifiable contributor to cardiovascular disease and death.
- Trial name
- NCT05986487
- Testing
- CPAP or usual practice, Monitoring and intervention in follow-up
- Where
- Spain
- Volunteers
- 1,523 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Obstructive Sleep Apnea
Outcome of Laser or Debrider Tonsillotomy Versus Tonsillectomy in Obstructive Sleep Apnea
Tonsil surgery for children suffering from obstructive sleep apnea have significant post operative morbidity including pain and occasionally bleeding. This morbidity is partly caused by post surgical inflammation.
- Trial name
- TVLOD (NCT01319058)
- Testing
- Tonsillectomy, laser tonsillotomy, debrider tonsillotomy
- Where
- Israel
- Volunteers
- 88 people
- Sponsor
- Soroka University Medical Center
COPD, Pulmonary Rehabilitation
Effects of Respiratory Rehabilitation by Gender in COPD Patients
Without calling into question the effectiveness of pulmonary rehabilitation in women, the difference in outcome by gender was not established due to insufficient evidence .
- Trial name
- REHABGENRE (NCT04297514)
- Where
- France
- Volunteers
- 504 people
- Sponsor
- University Hospital, Brest
COPD
Minimal Clinically Significant Difference (MCID) of Multidimensional Dyspnea Profile (MDP) in COPD Patients Undergoing Respiratory Rehabilitation
This study is designed to determine the individual threshold of minimal clinical change (MCID) for each component of the Multidimensional Dyspnea Profile (MDP) questionnaire in COPD patients undergoing pulmonary rehabilitation.
- Trial name
- DYSCO (NCT06012006)
- Testing
- constant work-rate cycling exercise test
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obstructive Sleep Apnea
Bi-lateral HGN Therapy in Real-World Patients -Post Approval Research Investigation
The objective of the BREATHE study is to demonstrate the continued safety and effectiveness of the Genio® System in treating subjects diagnosed with moderate to severe obstructive sleep apnea (OSA) who are intolerant to or…
- Trial name
- BREATHE (NCT07331285)
- Testing
- This is a single arm study, all consented and eligible subjects will be implanted with the Genio® System 2.1
- Where
- 2 sites in United States
- Volunteers
- 229 people
- Sponsor
- Nyxoah Inc.
Sleep Apnea, Obstructive
Novel Auto-continuous Positive Airway Pressure (CPAP) Validation
This single-blind randomised crossover trial aims to compare the efficacy of a novel Auto-CPAP algorithm (SPAP) to conventional CPAP. Up to 50 patients will be recruited from an OSA population, aged over 18.
- Trial name
- NCT01943708
- Testing
- SPAP, CPAP
- Where
- New Zealand
- Volunteers
- 74 people
- Sponsor
- Fisher and Paykel Healthcare
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