Clinical trials: Obstructive Ventilation Disorder
Acute Respiratory Failure, Delirium in Old Age
Exploring the Correlations of Lung Ultrasound with Delirium and Outcomes in Acute GEriatrics World: a Multicenter, Prospective, Observational Study from the GRETA Group of the Italian Society of Gerontology and Geriatrics
The purpose of this observational study is to investigate the prognostic relevance of lung ultrasound (LUS) performed on older patients (aged 65 and above) admitted to the hospital with acute respiratory symptoms.
- Conditions
- Acute Respiratory Failure, Delirium in Old Age, Pneumonia, Acute Heart Failure (AHF)
- Trial name
- ECO-AGE (NCT06670118)
- Where
- Italy
- Volunteers
- 480 people
- Sponsor
- University of Milano Bicocca
Acute Respiratory Distress Syndrome
Impact of Tissue Plasminogen Activator (tPA) Treatment for an Atypical Acute Respiratory Distress Syndrome (COVID-19)
At the beginning COVID-associated lung injury was considered as typical ARDS, hence respiratory and nonrespiratory treatments were delivered according to general principles for this kind of illness.
- Trial name
- AtTAC (NCT04453371)
- Testing
- Tissue plasminogen activator, Ringer solution
- Sponsor
- Negovsky Reanimatology Research Institute
Obstructive Sleep Apnea
Impact of Sugammadex vs. Neostigmine Reversal on Post-Operative Recovery and Complications
Sugammadex or neostigmine are given at the end of the surgery to reverse neuro muscular blocking drugs (NMBD). This study will evaluate whether reversal of NMBD with sugammadex is associated with faster recovery than neostigmine…
- Trial name
- Sugammadex (NCT03679611)
- Testing
- Sugammadex Sodium, Neostigmine
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Sleep Apnea Syndrome, Obstructive Sleep Apnea
Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)
Obstructive sleep apnea (OSA) and Chronic Obstructive Pulmonary Disease (COPD) are highly prevalent chronic respiratory diseases in the Veteran population.
- Conditions
- Sleep Apnea Syndrome, Obstructive Sleep Apnea, COPD, Overlap Syndrome
- Trial name
- NCT04179981
- Testing
- Positive airway pressure, Conservative care (control arm)
- Where
- United States
- Volunteers
- 668 people
- Sponsor
- VA Office of Research and Development
Respiratory Disease
REspiratory reHABilitation and PSYchiatric Comorbidities
Patients with respiratory insufficiency, chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, asthma, bronchiectasis, and, to a lesser extent, other pathologies that result in respiratory insufficiency and require…
- Trial name
- REHABPSY (NCT06229600)
- Testing
- Standard rehabilitation
- Where
- 6 sites in Italy
- Volunteers
- 994 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Obstructive Sleep Apnea
Magnetic Apnea Prevention(MAGNAP) Device to Treat Obstructive Sleep Apnea:First-In-Human Study of Feasibility and Safety
The purpose of this study is to determine the safety and feasibility of the Magnap magnetic device in the treatment of obstructive sleep apnea (OSA).
- Trial name
- MAGNAP (NCT02431507)
- Testing
- Magnap
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Michael Harrison
Sleep Apnea, Obstructive
Effect of Modified Fujita Technique Uvulopalatoplasty on Oxidative DNA Damage Levels in Patients With Obstructive Sleep Apnea SyndromE (OSAS)
The purpose of this study is to determine the possible effects of uvulopalatopharngoplasty (UPPP) -which is a a therapy used on patients with Obstructive sleep apnea syndrome (OSAS- on oxidative damage.
- Trial name
- NCT01635699
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people
- Sponsor
- Erzurum Regional Training & Research Hospital
Chronic Obstructive Pulmonary Disease
Bronchodilator Test in Mechanical Ventilated Chronic Obstructive Pulmonary Disease Patients
Investigators developed a test to assess the bronchodilator effects in mechanically ventilated chronic obstructive pulmonary disease patients by comparing the change of airway resistance.
- Trial name
- NCT02218398
- Testing
- Albuterol
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Beijing Chao Yang Hospital
Hypertension, Metabolic Disorder
The Effects of Obstructive Sleep Apnea and Its Intervention on Coronary Heart Disease
Obstructive sleep apnea(OSA) is an important identifiable cause of hypertension. Previous study has suggested that OSA significantly increases cardiovascular morbidity and mortality, especially in patients with pre-existing…
- Trial name
- NCT02059993
- Testing
- continuous positive airway pressure
- Volunteers
- 83 people
- Sponsor
- Chinese Pulmonary Vascular Disease Research Group
Polycystic Ovary Syndrome, Obstructive Sleep Apnea
The Impact of Obstructive Sleep Apnoea in Women With Polycystic Ovary Syndrome.
Women with PCOS and OSA, compared to women with PCOS only, have more severe clinical and biochemical features of PCOS and impaired QoL.
- Trial name
- NCT03065322
- Testing
- To assess risk of OSA
- Where
- United Kingdom
- Volunteers
- 38 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Laryngomalacia, Sleep Apnea, Obstructive
Laryngomalacia, Examinations and Quality of Life in Children Before and After Treatment With Follow-up After 1 Year
Laryngomalacia is the most frequent cause of stridor in children under 1 year. The airway obstruction generates turbulent airway flow and creates the characteristic high-frequency stridor sound.
- Conditions
- Laryngomalacia, Sleep Apnea, Obstructive, Sleep Apnea, Ear, Nose and Throat Disorder
- Trial name
- NCT06464757
- Where
- 2 sites in Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Obstructive Sleep Apnea
Effect of ALA on Retrolingual Collapse in Patients With Multilevel Obstructive OSA
To determine the effect of Anterolateral advancement pharyngoplasty on retrolingual collapse in patients with multilevel OSA, and thus if multistage surgery is required.
- Trial name
- NCT06538701
- Testing
- Anterolateral advancement pharyngoplasty
- Volunteers
- 28 people
- Sponsor
- Assiut University
COPD, Ventilator Lung
Best End-Expiratory and Driving-pressure for Individualized Flow Controlled Ventilation in Patients With COPD
Patients with chronic obstructive pulmonary disease (COPD) have a significantly increased risk of postoperative pulmonary complications (PPC).
- Conditions
- COPD, Ventilator Lung, Anesthesia
- Trial name
- NCT05812365
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Non-alcoholic Fatty Liver Disease
Evaluating the Efficacy of CPAP Therapy for the Treatment of Fatty Liver
We are doing this research study to evaluate whether continuous positive airway pressure (CPAP), a treatment for sleep apnea, will also help treat fatty liver disease.
- Trial name
- NCT01849081
- Testing
- CPAP, LIfestyle
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Obstructive Sleep Apnea, Spinal Cord Injuries
Obstructive Sleep Apnea Management in People With Spinal Cord Injury
The prevalence of obstructive sleep apnea (OSA) is a significantly higher in people after spinal cord injury (SCI) than in the general population.
- Trial name
- NCT04962165
- Testing
- Mandibular Advancement Device
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- University Hospital, Motol
Obstructive Sleep Apnea
Post Market Clinical Follow up of ResMed Mask Systems
Post Market follow up study to systematically and proactively collect supplementary real world data to confirm the usability and performance of the new generation mask systems. .
- Trial name
- NCT05262439
- Testing
- New generation CPAP mask
- Where
- Australia
- Volunteers
- 500 people
- Sponsor
- ResMed
Obstructive Sleep Apnea
KPAP Adherence Crossover Study
A device able to provide less positive airway pressure (PAP) for the entire duration of inspiration and roughly half the duration of expiration, designated KPAP, is being developed by SleepRes for the treatment of obstructive…
- Trial name
- NCT06413134
- Testing
- KPAP, APAP
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- SleepRes Inc.
Obesity Hypoventilation Syndrome, Chronic Respiratory Failure
Cost Effectiveness of Outpatient Set-up of Automated NIV in Obese Patients With Chronic Respiratory Failure
Obesity is an escalating issue, with an accompanying increase in referrals of patients with obesity-related respiratory failure.
- Trial name
- OPIP (NCT02342899)
- Testing
- Outpatient NIV Set Up using AVAPS AE (Manufactured by Philips-Respironics), Inpatient NIV Set Up using spontaneous/timed (S/T) mode pressure support ventilation (Manufactured by Philips-Respironics)
- Where
- 6 sites in France, United Kingdom
- Volunteers
- 82 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Bariatric Surgery Candidate, Sleep Apnea, Obstructive
Using Digitalized Incentive Spirometers to Assist Postoperative Rehabilitation of Abdominal Surgery Patients
The purpose of this clinical trial is to use a digital recording device integrated with an incentive spirometer to record a patient's deep breathing lung training following abdominal surgery.
- Trial name
- NCT06132100
- Testing
- digitalized incentive spirometry, traditional incentive spirometry
- Volunteers
- 200 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Obstructive Sleep Apnea
Derivation and Validation of a Combination of BOSTON Score and DES-OSA Score for Selection of OSA Patients.
Derivation and Validation of a combination of BOSTON score and DES-OSA score to exclude OSA or to confirm OSA in patients.
- Trial name
- NCT03983564
- Testing
- Cutoff Validation
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Astes
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