Clinical trials: Obstructive Ventilation Disorder
Sleep Apnea, Obstructive, Hypertension, Pulmonary
Auto-PAP for Pulmonary Hypertension Treatment in Decompensated HF Patients With Sleep Apnea.
The objective of the study is to evaluate the effect of continuous positive airway pressure (PAP) therapy on pulmonary arterial (PA) pressures in acute decompensated heart failure (HF) patients with obstructive sleep apnea (OSA).
- Conditions
- Sleep Apnea, Obstructive, Hypertension, Pulmonary, Heart Failure
- Trial name
- ASAP-HF (NCT02963597)
- Testing
- AirSense™ 10 AutoSet, Standard Medical Therapy
- Where
- 2 sites in United States, Germany
- Volunteers
- 21 people
- Sponsor
- Albert Einstein Healthcare Network
COPD
Effects of Bevespi on Ventilation and Gas Exchange Abnormalities in COPD Assessed by 129Xe MRI
The purpose of this study is to determine whether the new inhaler, Bevespi improves lung function. Magnetic resonance imaging (MRI) using inhaled hyperpolarized 129Xe gas, that can provide useful images of the functioning of the…
- Trial name
- COPD (NCT03324607)
- Testing
- hyperpolarized 129Xe gas MRI, Bevespi Aerosphere
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Bastiaan Driehuys
Obstructive Sleep Apnea
A Development Study to Evaluate a Full-Face Mask for the Treatment of Obstructive Sleep Apnea
This investigation is designed to evaluate the comfort, ease of use and performance of a trial nasal mask for the treatment of Obstructive Sleep Apnea (OSA) in the home environment.
- Trial name
- NCT03272763
- Testing
- F&P Toffee mask
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea
Montelukast and Inhaled Nasal Steroid Tx in Adult Obstructive Sleep Apnea (OSA)
In children with mild apnea combined therapy with an inhaled nasal steroid and a medication that decreased nasal congestion (montelukast) was shown to be effective.
- Trial name
- NCT01089647
- Testing
- budesonide and montelukast
- Where
- 2 sites in United States
- Volunteers
- 34 people
- Sponsor
- Romaker & Associates
Scientific Terminology Chronic Obstructive Pulmonary Disease (COPD), Laymen Terminology Chronic Bronchitis and Emphysema
A 4 Week Study to Investigate the Safety and Tolerability of AZD5069 in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is the evaluate the safety and tolerability of AZD5069 in patients with Chronic Obstructive Pulmonary Disease
- Trial name
- CIRRUS (NCT01233232)
- Testing
- AZD5069 50mg, AZD5069 80mg
- Where
- 8 sites in Bulgaria, Germany and 2 more
- Volunteers
- 109 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease (COPD)
Aides in Respiration Health Coaching for COPD
This study examined whether health coaches can improve the management of chronic obstructive pulmonary disease (COPD) in a population of vulnerable patients cared for in 'safety-net' clinics.
- Trial name
- AIR (NCT02234284)
- Testing
- Health Coaching
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- University of California, San Francisco
Sleep Apnea, Obstructive
Metabolic Effects of Metformin Therapy in Obstructive Sleep Apnea
The purpose of the study is to see if metformin improves metabolism in patients with obstructive sleep apnea (OSA) using positive airway pressure (PAP) therapy.
- Trial name
- MET-OSA (NCT04530747)
- Testing
- Metformin + PAP
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Pennington Biomedical Research Center
Bronchiolitis, Respiratory Disease
Nasal Suction in Infants With Bronchiolitis Using a NoseFrida vs. Bulb Syringe
This research study will evaluate the difference in effectiveness of nasal suction between two different suction devices (NoseFrida and bulb syringe) in infants that have bronchiolitis.
- Trial name
- NCT04599101
- Testing
- Nose Frida nasal suction device, Bulb syringe nasal suction device
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Corewell Health East
OSA, Sleep Apnea
Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?
Obstructive sleep apnea (OSA) is common in older adults and has recently been implicated in pathogenesis of Alzheimer's disease (AD). Research has shown that sleep disruptions have caused memory impairment.
- Conditions
- OSA, Sleep Apnea, Obstructive Sleep Apnea, Alzheimer Disease
- Trial name
- NCT05094271
- Testing
- Supplemental Oxygen, Continuous Positive Airway Pressure Machine, Room Air
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- University of California, San Diego
Sleep Apnea, Obstructive, Hypotonia
Pilot Study of a Self-Supporting Nasopharyngeal Airway in Hypotonia
Children with hypotonic upper airway obstruction have a high prevalence of severe obstructive sleep apnea, which if not treated has significant clinical consequence.
- Conditions
- Sleep Apnea, Obstructive, Hypotonia, Child, Only
- Trial name
- ssNPA (NCT04846400)
- Testing
- ssNPA
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Michigan
Sleep Apnea, Obstructive
Effect of Desipramine on Genioglossus Muscle Activity in Healthy Adults Study A
Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. OSA patients show a marked reduction in upper airway (UA) dilator muscle activity at sleep onset and this phenomenon…
- Trial name
- DESOSA (NCT02428478)
- Testing
- Desipramine
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Respiratory Disorders
A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of GlaxoSmithkline (GSK) Biologicals' Investigational Vaccine GSK2838504A When Administered to Chronic Obstructive Pulmonary Disease (COPD) Patients With Persistent Airflow Obstruction.
The purpose of this Phase II study is to assess the safety, reactogenicity and immunogenicity of the investigational Non-typeable Haemophilus influenzae (NTHi) vaccine in patients with moderate and severe persistent airflow…
- Trial name
- NCT02075541
- Testing
- NTHi-10-AS01E
- Where
- 14 sites in Sweden, United Kingdom
- Volunteers
- 145 people
- Sponsor
- GlaxoSmithKline
Obstructive Sleep Apnea
The Evaluation of the Toffee Mask for the Treatment of Obstructive Sleep Apnea
This investigation is a prospective, non-randomized, non-blinded study. This investigation is designed to evaluate the performance, comfort and ease of use of the F\&P Toffee mask amongst Obstructive Sleep Apnea (OSA) patients.
- Trial name
- NCT03726346
- Testing
- Toffee Full Face Mask
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Fisher and Paykel Healthcare
Sleep Apnea, Obstructive
Effect of Desipramine on Upper Airway Collapsibility and Genioglossus Muscle Activity in Patients With Obstructive Sleep Apnea - Study B
Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. OSA patients show a marked reduction in upper airway (UA) dilator muscle activity at sleep onset and this phenomenon…
- Trial name
- DESOSA (NCT02436031)
- Testing
- Desipramine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea
Comparison of High Flow Nasal Cannula Therapy to Nasal Oxygen as a Treatment for Obstructive Sleep Apnea in Infants
This is a small pilot study that will compare High Flow Nasal Cannula (HFNC) therapy to oxygen nasal cannula therapy on infants who have obstructive sleep apnea (OSA) and are scheduled for a clinically ordered sleep study called…
- Trial name
- NCT02858154
- Testing
- HFNC, Low flow oxygen by nasal cannula
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Chronic Obstructive Pulmonary Disease
Mindfulness Mediation Intervention in Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to assess the feasibility and potential impact of an eight week program of meditation on expiratory time, anxiety and dyspnea in people with COPD.
- Trial name
- NCT01577329
- Testing
- Mindfulness meditation
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Michigan
Pulmonary Disease, Chronic Obstructive, Bronchospasm
Prophylactic Efficacy of Relenza Against Influenza A and B
In response to the European regulatory authorities, GSK is conducting a post-marketing observational study to assess the efficacy of Relenza when used as prophylaxis against influenza. SPECIFIC AIMS 1.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Bronchospasm, Influenza, Human, Asthma
- Trial name
- NCT01156701
- Testing
- Receiving a prescription of Relenza for prophylaxis, No prophylaxis with Relenza
- Volunteers
- 171,705 people
- Sponsor
- GlaxoSmithKline
Obstructive Sleep Apnea
"Six-week Study of the Safety and Efficacy of JZP-110 in the Treatment of Excessive Sleepiness in OSA"
This trial is a 6-week, double-blind, placebo-controlled, randomized-withdrawal, multicenter study of safety and efficacy of JZP-110 in the treatment of excessive sleepiness in adult subjects with OSA.
- Trial name
- OSA (NCT02348619)
- Testing
- JZP-110
- Where
- 30 sites in United States, Finland and 3 more
- Volunteers
- 174 people
- Sponsor
- Jazz Pharmaceuticals
Chronic Obstructive Pulmonary Disease
Functional Respiratory Imaging Study (DARWiIN)
The objective of this clinical study was to evaluate the tolerability, safety, and efficacy of stepping up from fluticasone propionate (FP)/salmeterol (SLM) dry-powder inhaler (DPI) (SERETIDE™ DISKUS™) to extrafine beclometasone…
- Trial name
- DARWiIN (NCT04876677)
- Testing
- Beclomethasone dipropionate/Formoterol Fumarate/Glycopyrronium (BDP/FF/GB)
- Where
- 8 sites in Belgium, Hungary
- Volunteers
- 25 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Obstructive Sleep Apnea
TPAP for Comfort in OSA
TheraPAP is a prototype device (with full documented electrical and isolation safety) being developed by SleepRes for the treatment of obstructive sleep apnea (OSA) that can deliver either standard CPAP at a set pressure or what…
- Trial name
- NCT06264128
- Testing
- TPAP, CPAP
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- SleepRes Inc.