Clinical trials: Obstructive Ventilation Disorder
Adenotonsillar Hypertrophy, Obstructive Sleep Apnea
The Effect of Dexmedetomidine on Airway Complications After Deep or Awake Extubation
The investigators aim to investigate the effect of dexmedetomidine on the perioperative respiratory complications in this patient population undergoing both awake and deep tracheal extubation.
- Conditions
- Adenotonsillar Hypertrophy, Obstructive Sleep Apnea, Tonsillitis, Adenoiditis
- Trial name
- NCT02162433
- Testing
- Normal Saline, Dexmedetomidine
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Obstructive Sleep Apnea
Cost Effectiveness of Ambulatory Management for Veterans With Sleep Apnea
This research study is comparing home and in-laboratory testing of veterans with suspected obstructive sleep apnea, a common breathing disorder during sleep.
- Trial name
- VSATT (NCT00880165)
- Testing
- Continuous positive airway pressure apparatus
- Where
- 2 sites in United States
- Volunteers
- 296 people
- Sponsor
- US Department of Veterans Affairs
Obstructive Sleep Apnea
Remote Monitoring in Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) among Veterans is a condition that imparts a great burden to the patient in terms of serious co-morbidities and results in a great cost to the VA Health Care System to treat the co-morbidities, which…
- Trial name
- NCT01678560
- Testing
- Monitoring every 3 months by face-to-face visits, Frequent remote monitoring
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- VA Connecticut Healthcare System
Dyspnea
Aerosol Inhalation Treatment for Dyspnea - Patients
The purpose of this protocol is to develop and test aerosol furosemide, as a treatment that has the potential to significantly improve symptom management and enhance the quality of care for patients with intractable dyspnea.
- Trial name
- NCT02524054
- Testing
- Furosemide, Aerosolized saline
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Beth Israel Deaconess Medical Center
Sleep Apnea, Obstructive
Validation of a Novel Device for Screening Patients With Symptoms of Obstructive Sleep Apnea
The purpose of this study is to evaluate the sensitivity and specificity of the Belun Ring Pulse Oximetry system for screening of obstructive sleep apnea (OSA) in adults during standard polysomnography sleep study conditions.
- Trial name
- NCT04121923
- Testing
- Belun Ring Pulse Oximeter
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Belun Technology Company Limited
Obstructive Sleep Apnea
The Evaluation of the Toffee Mask for the Treatment of Obstructive Sleep Apnea
This investigation is a prospective, non-randomized, non-blinded study. This investigation is designed to evaluate the performance, comfort and ease of use of the F\&P Toffee mask amongst Obstructive Sleep Apnea (OSA) patients.
- Trial name
- NCT03726346
- Testing
- Toffee Full Face Mask
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Fisher and Paykel Healthcare
Sleep Apnea, Obstructive
Comparative Outcomes Management With Electronic Data Technology (COMET) Study
STAGE I of the COMET study was to develop an Electronic Network Informatics Infrastructure that prospectively enabled access to and the sharing of clinical and research data.
- Trial name
- COMET (NCT01461473)
- Testing
- Positive Airway Pressure (PAP), Oral Appliance (OA)
- Where
- 4 sites in United States
- Volunteers
- 131 people
- Sponsor
- Stanford University
Respiratory Disorders
Occurrence of Potential Bacterial and Viral Pathogens in Stable Chronic Obstructive Pulmonary Disease and During Acute Exacerbations of the Disease, in Asia Pacific
Since the infectious aetiology of AECOPD has been suggested to vary according to geographical region, the primary purpose of this study (which will be conducted in several countries in Asia Pacific) is to evaluate the occurrence…
- Trial name
- NCT03151395
- Testing
- Sputum and blood sampling
- Where
- 19 sites in Hong Kong, Philippines and 2 more
- Volunteers
- 197 people
- Sponsor
- GlaxoSmithKline
OSA - Obstructive Sleep Apnea
Parallel Arm Trial of AD109 and AD504 In Patients With OSA
This is a phase 2 randomized double-blind placebo-controlled parallel-arm dose finding study to compare fixed dose combinations of AD109 and AD504 to atomoxetine or placebo in Obstructive Sleep Apnea.
- Trial name
- MARIPOSA (NCT05071612)
- Testing
- AD109, AD504, Atomoxetine Hydrochloride
- Where
- 25 sites in United States
- Volunteers
- 294 people
- Sponsor
- Apnimed
Sleep Apnea, Obstructive
Study of Pain Processing in Subjects Suffering From Obstructive Sleep Apnea
We would like to test the effect of opioid medication on pain sensitivity in subjects who have been diagnosed with a sleep disorder called Obstructive Sleep Apnea (OSA) compared to other subjects without OSA.
- Trial name
- NCT00672737
- Testing
- Remifentanil, Cold pain threshold and tolerance, Heat pain threshold and tolerance
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Stanford University
COPD, COPD Exacerbation
Roflumilast in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Fixed Dose Combinations of Long-acting β2-agonist (LABA) and Inhaled Corticosteroid (ICS)
To demonstrate the additional benefit of roflumilast when added on to fixed-dose combination (FDC) LABA/ICS in the reduction of exacerbations in subjects with severe to very severe COPD.
- Conditions
- COPD, COPD Exacerbation, Lung Diseases, Respiratory Disorders
- Trial name
- NCT01443845
- Testing
- Roflumilast
- Where
- 338 sites in United States, Argentina and 15 more
- Volunteers
- 2,354 people
- Sponsor
- AstraZeneca
Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease
Right Ventricular Hemodynamics Using Cardiac MRI in Patients COPD and OSA
The coexistence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) in the same patient has been termed overlap syndrome, affecting 1% of the U.S.
- Conditions
- Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease, Overlap Syndrome
- Trial name
- NCT02244957
- Testing
- Bi-level positive airway pressure (BPAP), Nocturnal oxygen
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of California, San Diego
Stroke, Sleep Apnea, Obstructive
Stroke and CPAP Outcome Study: A Sham-controlled Trial of CPAP Among Stroke Rehabilitation Patients
The purpose of this study is to assess the effect of continuous positive airway pressure (CPAP) on functional outcome in patients with acute stroke, the investigators conducted a sham-controlled, double-blind pilot trial during…
- Trial name
- SCOUTS (NCT02551757)
- Testing
- Auto-titrating CPAP
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Washington
Chronic Cough, Eosinophilic Bronchitis
Mepolizumab for the Treatment of Chronic Cough With Eosinophilic Airways Diseases
Cough is the most common presenting symptom to family physician. Chronic Cough affects approximately 10-12% of the general population and is one of the commonest reasons for referral to secondary care.
- Conditions
- Chronic Cough, Eosinophilic Bronchitis, Asthma
- Trial name
- MUCOSA (NCT04765722)
- Testing
- Mepolizumab, Normal Saline
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- McMaster University
Asthma, COPD
Can we Reduce Hospital Attendance Without Compromising Care by the Use of Telephone Consultation
Consultation time in busy respiratory clinics is inevitably limited and attendance is often disruptive to patients' lives; involves time, expense, travel, and waiting; and can have effects upon occupation.
- Conditions
- Asthma, COPD, Sleep Apnea Syndromes, Interstitial Lung Diseases
- Trial name
- NCT00129701
- Testing
- Telephone consultation
- Where
- United Kingdom
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Imperial College London
COPD, Chronic Musculoskeletal Pain
BRAIN, Symptoms, and Physical Activity in COPD
Persons with COPD have both chronic musculoskeletal pain and dyspnea that require accurate diagnosis and treatment, ultimately to optimize functional status.
- Trial name
- BRAIN-SPA (NCT04291131)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- VA Office of Research and Development
Obstructive Sleep Apnea Syndrome
The Use of Heliox in Obstructive Sleep Apnea Syndrome
The goals of the project is to evaluate the effects of Heliox therapy on obstructive sleep apnea syndrome (OSAS).
- Trial name
- HOSA (NCT02135900)
- Testing
- Heliox
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Northwell Health
Sleep Apnea, Obstructive
Sleep Apnea Treatment With Expiratory Resistance(Provent™)
Continuous positive airway pressure (CPAP) continues to be the primary therapy prescribed for the treatment of obstructive sleep apnea (OSA).
- Trial name
- SATER (NCT01061476)
- Testing
- Treatment sleep study (Provent™ device used), Baseline sleep study (No device), Physiology sleep study (Provent™ on/off)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
Sleep Apnea
Effects of Suvorexant in Participants With Obstructive Sleep Apnea (MK-4305-036)
This study will evaluate the safety, tolerability, and effect of multiple doses of suvorexant (MK-4305) on respiratory function in participants with mild to moderate obstructive sleep apnea (OSA) compared to administration of…
- Trial name
- NCT01300455
- Testing
- Suvorexant
- Volunteers
- 26 people
- Sponsor
- Merck Sharp & Dohme LLC
Emphysema, Chronic Obstructive Pulmonary Disease (COPD)
Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability
The purpose of this research study is to learn about the safety of transplanting lungs obtained from non-heart-beating donors (NHBDs) that have been ventilated (attached to a breathing machine or ventilator to deliver oxygen) and…
- Conditions
- Emphysema, Chronic Obstructive Pulmonary Disease (COPD), Cystic Fibrosis, Pulmonary Fibrosis
- Trial name
- NCT01615484
- Testing
- Transplantation of lungs obtained from Non-Heart-Beating Donors (NHBDs) after ex-vivo perfusion w/ STEEN Solution™, STEEN Solution™
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of North Carolina, Chapel Hill