Clinical trials: Obstructive Ventilation Disorder
Sleepiness, SARS-CoV2 Infection
Obstructive Sleep Apnoea Post Covid 19: Role of the Upper Airway Microbiome
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causing coronavirus disease, Covid-19, has spread rapidly across the globe since its emergence in January 2020.
- Conditions
- Sleepiness, SARS-CoV2 Infection, Fatigue Syndrome, Chronic, Snoring
- Trial name
- NCT05116657
- Testing
- Nasal Lavage and Oral Wash
- Volunteers
- 50 people
- Sponsor
- Royal College of Surgeons, Ireland
Chronic Obstructive Pulmonary Disease
Noninvasive Ventilation Weaning Protocol in COPD
Noninvasive ventilation (NIV) has revolutionized the management of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with hypercapnic respiratory failure (HcRF).
- Trial name
- NCT07133711
- Testing
- Noninvasive ventilation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Obstructive Sleep Apnea
High Flow Nasal Cannula for Obstructive Sleep Apnea
This study compare the efficacy of high flow nasal cannula with nasal continuous positive airway pressure. All of participants will be randomized to receive one night high flow nasal cannula therapy and another night for nasal…
- Trial name
- NCT03843372
- Testing
- High flow nasal cannula
- Where
- Taiwan
- Volunteers
- 32 people
- Sponsor
- Chung-Chieh, Yu
Chronic Obstructive Pulmonary Disease (COPD), Heart Failure
Breathlessness Patterns in Patients With Cancer, COPD and Heart Failure: an fMRI Feasibility Study
Dyspnea that persists despite optimal pathophysiological treatment is defined as persistent dyspnea. Currently all brain functional magnetic resonance imaging (fMRI) studies conducted to evaluate breathlessness have done so using…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Heart Failure, Cancer, Volunteers
- Trial name
- BREACH-fMRI (NCT07319039)
- Testing
- Cerebral fMRI, Immersive virtual reality
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Obstructive Sleep Apnea
The Evaluation of a Full Face Mask Seal for the Treatment of Obstructive Sleep Apnea
The investigation is a prospective, randomized, single blinded, crossover study. The investigation is designed to evaluate the performance, comfort and ease of use of the F\&P Trial Full Face Mask Seal amongst Obstructive Sleep…
- Trial name
- NCT03230877
- Testing
- Toffee full face mask with 'Improved Seal', Toffee full face mask with 'Normal Seal'
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea
Sleep Apnea : Diagnosis and Monitoring
This prospective study aims to evaluate a new medical screening method to detect and discriminate sleep apnea-hypopnea events. A new device called ApneaBand will be tested to propose a new screening method facilitating the…
- Trial name
- ApneaBand (NCT03571477)
- Testing
- ApneaBand
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Obstructive Sleep Apnea
Effectiveness of Stellate Ganglion Block for the Treatment of Obstructive Sleep Apnea
The goal of this clinical trial is to test the efficacy of stellate ganglion block in Obstructive Sleep Apnea. The main question it aims to answer are: Can stellate ganglion block improve Obstructive Sleep Apnea? Patients were…
- Trial name
- NCT06319612
- Testing
- routine rehabilitation treatment, Stellate ganglion block, Lidocaine Hydrochloride
- Volunteers
- 80 people
- Sponsor
- Copka Sonpashan
Obstructive Sleep Apnea
Phototherapy for Non-responders to Oral Appliance Therapy for Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a medical condition where a person has great difficulty with breathing, or stops breathing all together, while asleep.
- Trial name
- NCT06960200
- Testing
- Phototherapy
- Where
- Canada
- Volunteers
- 528 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Dyspnea
Trial of a Breathlessness Intervention Service for Intractable Breathlessness
The aim of this study is to evaluate the impact of a Breathlessness Intervention Service (BIS) on the quality of life of patients and families affected by intractable breathlessness.
- Trial name
- NCT00678405
- Testing
- Breathlessness Intervention Service, Best supportive care (Standard Care)
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Obstructive Sleep Apnea
Assessing the Symptoms of Obstructive Sleep Apnea
The purpose of this study is to investigate the correlation between health outcomes associated with the severity of obstructive sleep apnea (OSA) symptomatology, the findings will guide the design of interventional studies.
- Trial name
- OSA (NCT01481636)
- Where
- United Kingdom
- Volunteers
- 66 people
- Sponsor
- Bangor University
COPD, Dyspnea
Ventilation Imbalances in Mild to Moderate Chronic Obstructive Pulmonary Disease
The Investigators plan a single center study to get preliminary data to answer a number of fundamental questions directly related to management of COPD.
- Conditions
- COPD, Dyspnea, Respiratory Disease, Lung Diseases
- Trial name
- VAPOR (NCT04880551)
- Testing
- Fluoroscopy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Oregon Health and Science University
Excessive Daytime Sleepiness, Narcolepsy
Extension Study of the Safety and Efficacy of Armodafinil in the Treatment of Patients With Excessive Sleepiness
A 12 Month, Open-Label, Flexible Dosage Extension Study of the Safety and Efficacy of Armodafinil (CEP-10953) in the Treatment of Patients with Excessive Sleepiness Associated with Narcolepsy, Obstructive Sleep Apnea/Hypopnea…
- Conditions
- Excessive Daytime Sleepiness, Narcolepsy, Obstructive Sleep Apnea/Hypopnea Syndrome, Chronic Shift Work Sleep Disorder
- Trial name
- NCT00228553
- Testing
- Armodafinil 100 to 250 mg/day
- Where
- 100 sites in United States, Australia and 5 more
- Volunteers
- 743 people
- Sponsor
- Cephalon
Asthma
NHFT Effects on Symptatheic Drive of Asthma Patients
The project will be pursued in our respiratory, autonomic nervous system physiology laboratory (Respiratory, autonomic nervous system physiology laboratory, Department of Pneumology and Intensive Care Medicine, RWTH Aachen…
- Trial name
- MSNA in Asthma (NCT05704101)
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
COPD (Chronic Obstructive Pulmonary Disease)
RESP-FIT: A Respiratory Muscle Strength Training Intervention for COPD
Individuals with chronic obstructive pulmonary disease (COPD) often experience dyspnea, low physical activity, and reduced quality of life.
- Trial name
- NCT07811219
- Testing
- RESPFIT Intervention
- Volunteers
- 288 people
- Sponsor
- Medical University of South Carolina
Obstructive Sleep Apnea
Measuring Effectiveness in Sleep Apnea Surgery
The goal of this research is to improve our understanding of the effectiveness of surgical OSA treatment by evaluating its impact on these health-related and functional outcomes and comparing these effects to the changes in…
- Trial name
- NCT00518128
- Testing
- Surgical OSA treatment, Positive Airway Pressure Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco
COPD (Chronic Obstructive Pulmonary Disease), Non-invasive Ventilation
Effects of Vibrating Mesh Nebulisation in Patients With COPD During Non-invasive Ventilation (VMN-NIV)
Assessment of the effects of vibrating mesh nebulisation versus jet nebulisation on the electrical activity of the muscles involved in breathing (neural respiratory drive), breathing mechanics (respiratory impedance measured by…
- Trial name
- VMN-NIV (NCT06884228)
- Testing
- Vibrating mesh nebulisation, Jet nebuliser
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Sleep Apnea
A Study of VI-0521 for the Treatment of Obstructive Sleep Apnea / Hypopnea Syndrome in Obese Adults
The primary objectives of this study are to evaluate the safety and efficacy of VI-0521 compared to placebo in the treatment of obese adults with obstructive sleep apnea (OSA) and to assess the relative contributions of weight…
- Trial name
- NCT00745251
- Testing
- VI-0521
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- VIVUS LLC
Obstructive Pulmonary Disease, Mechanical Ventilation Pressure High
FCV vs VCV in Obstructive and Asthmatic Patients
The goal of this physiological pilot study with a randomized crossover design is to study the effect of Flow-controlled ventilation (FCV) on the minute volume compared to Volume-controlled ventilation (VCV) in intubated patients…
- Conditions
- Obstructive Pulmonary Disease, Mechanical Ventilation Pressure High, Asthma COPD
- Trial name
- NCT06563544
- Testing
- FCV
- Where
- 2 sites in Netherlands
- Volunteers
- 10 people
- Sponsor
- Erasmus Medical Center
Asthma, Chronic Obstructive Pulmonary Disease
Evaluation of the Efficacy of Respicure® (Resveratrol / Quercetin) in the Management of Respiratory Conditions Including Asthma,COPD and Long COVID.
Interventional, Prospective, National, Multicentre, Randomised, Open-label, Controlled Clinical Study Comparing Two Parallel Groups, One Control Arm (Standard Treatment) Versus Intervention Arm (Standard Treatment + Study…
- Conditions
- Asthma, Chronic Obstructive Pulmonary Disease, Long COVID
- Trial name
- NCT05601180
- Testing
- Respicure®, Standard of care
- Where
- 8 sites in Algeria
- Volunteers
- 402 people
- Sponsor
- Beker Laboratories
COPD, Chronic Obstructive Pulmonary Disease
The PALP™-COPD Trial (Low-Flow CO2-Removal (ECCO2-R) in Exacerbated COPD)
A Multicenter, Randomized, Controlled Trial to Determine Safety and Efficacy of Pump Assisted Lung Protection (PALP™) for Low Flow Carbon Dioxide (CO2) Removal in Conjunction with Liberation from Mechanical Ventilation Compared…
- Trial name
- PALP-COPD (NCT02107222)
- Testing
- CO2-Removal (PALP-Device/MaquetCP)
- Where
- Germany
- Sponsor
- Maquet Cardiopulmonary GmbH
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