Clinical trials: Occlusion, Cerebrovascular
Permeable Foramen Ovale, Cerebrovascular Accident
Interest of Occlusion of Permeable Foramen Ovale After a Cryptogenic Cerebrovascular Accident (CVA)
Facing the lack of recommandations of Neurology and cardiology societies, the investigators decided in 2002 some Good Medical Practices to define a specific and precise population for whom the closure of permeable oval formaen…
- Trial name
- FOPasa (NCT00872443)
- Testing
- Data collection
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Nantes University Hospital
Stroke, TIA
A New Oxygen Mask for Carotid Endarterectomy Under Local Anaesthesia
The purpose of this study is to determine the effectiveness of oxygenation and patient-acceptability of a novel oxygen face mask in patients undergoing carotid endarterectomies (CEAs).
- Conditions
- Stroke, TIA, Surgery, Anaesthesia
- Trial name
- NCT01064908
- Testing
- OxyMask
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Brighton and Sussex University Hospitals NHS Trust
AIS, Stroke
Endovascular Treatment for Acute Large Vessel Occlusion With Ultra-Large Ischemic Core
an investigator initiated, prospective, multicenter, randomized, open-label, blinded endpoint trial (PROBE)
- Trial name
- LARGE CORE-MT (NCT07791810)
- Testing
- Patients assigned to the EVT group should undergo EVT as soon as possible, followed by BMM according to the current EVT guidelines., The medical group receives BMM alone. EVT is not performed in the medical group.
- Where
- China
- Volunteers
- 450 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Carotid Stenosis, Atherosclerosis
Revacept in Symptomatic Carotid Stenosis
Patients suffering from symptomatic carotid artery stenosis, transient ischemic attacks (TIAs), amaurosis fugax or stroke receive either Revacept (single dose) plus antiplatelet monotherapy or monotherapy alone.
- Conditions
- Carotid Stenosis, Atherosclerosis, Stroke, Transient-ischaemic Attack
- Trial name
- RevaceptCS02 (NCT01645306)
- Testing
- Revacept
- Where
- 12 sites in Germany, United Kingdom
- Volunteers
- 158 people
- Sponsor
- AdvanceCor GmbH
Coronary Artery Disease
Assessment of Coronary Artery Disease in Stroke Patients
This study is to evaluate the prevalence, plaque characteristics (plaque types, stenosis degree, remodeling) and predictors of coronary atherosclerosis in stroke patients with coronary CT angiography.
- Trial name
- ACADIS (NCT01850693)
- Where
- South Korea
- Volunteers
- 1,657 people
- Sponsor
- Seoul National University Hospital
Choroid Disease, Carotid Stenosis
Ophthalmologic Outcomes in Patients With Carotid Artery Stenosis
The retinal vessels have been shown to reflect vascular changes inherent to systemic pathologies, even when no ocular disease is identified.
- Conditions
- Choroid Disease, Carotid Stenosis, Carotid Atherosclerosis, Retinal Disease
- Trial name
- NCT05623293
- Testing
- eye - Optcial coherence tomography
- Where
- Portugal
- Volunteers
- 40 people
- Sponsor
- Universidade do Porto
Acute Stroke, Ischemic Stroke, Acute
Emergent Stenting In Acute Vertebrobasilar Occlusions
In the acute posterior circulation strokes, the vertebrobasilar occlusions frequently related to worse outcomes than the anterior ones.
- Conditions
- Acute Stroke, Ischemic Stroke, Acute, Vertebro Basilar Ischemia
- Trial name
- ESVO (NCT06129721)
- Testing
- Emergent Stenting
- Where
- Vietnam
- Volunteers
- 38 people
- Sponsor
- Can Tho Stroke International Services Hospital
Carotid Artery Occlusion, Middle Cerebral Artery Occlusion
The Carotid and Middle Cerebral Artery Occlusion Surgery Study
The recently published Carotid Occlusion Surgery Study (COSS) failed to show a benefit of extracranial-intracranial (EC-IC) bypass surgery over medical therapy in patients with symptomatic hemodynamically significant carotid…
- Conditions
- Carotid Artery Occlusion, Middle Cerebral Artery Occlusion, Stroke
- Trial name
- CMOSS (NCT01758614)
- Testing
- bypass surgery, Aspirin, Clopidogrel
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Xuanwu Hospital, Beijing
Atherosclerosis, Inflammation
Atherosclerosis and Acute Ischemic Stroke Study
A significant proportion of strokes are thromboembolic in nature, arising from atherosclerotic plaque at the carotid bifurcation. It is now wellknown that inflammation plays a key role in atherogenesis and plaque destabilization.
- Conditions
- Atherosclerosis, Inflammation, Ischemic Stroke
- Trial name
- NCT03685006
- Where
- Norway
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Hyperlipidemia
Implementation of an Algorithm- and Multi-professional Team-supported Strategy to Improve Lipid Management of Patients With Atherosclerotic Cardiovascular Disease
This is a randomized, controlled, collaborative, multicenter, pilot implementation science study evaluating the hypothesis that algorithm- and multi-professional team-supported lipid management reduces low density…
- Trial name
- OPTIMIZE ASCVD (NCT07334834)
- Testing
- Algorithm- and multi-professional team-supported lipid management, Guideline-directed lipid management by usual care provider
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Colorado Prevention Center
Acute Ischemic Stroke
Cerebrolysin After Reperfusion in Extended-window EndoVascular Thrombectomy
Acute ischemic stroke caused by blockage of a large brain artery can lead to severe disability. Endovascular thrombectomy is a catheter-based procedure used to remove the blood clot and restore blood flow.
- Trial name
- CARE-EVT (NCT06339411)
- Testing
- Cerebrolysin
- Volunteers
- 100 people
- Sponsor
- Chang Gung Memorial Hospital
Stroke, Dementia
Neuro-Prävention im Rahmen Des Interventionsprojektes INVADE-2 (Follow-up Studie)
"Silent" strokes are more frequent than clinical apparent strokes and can be detected noninvasively by MRI-investigations of the brain.
- Trial name
- NCT01126775
- Where
- 2 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- INVADE gGmbH
Carotid Artery Plaque, Carotid Stenosis
Carotid Artery Stent Implantation in the Treatment of Vulnerable Plaque
To investigate the efficacy and safety of carotid stenting for vulnerable carotid plaques. All patients with carotid artery stenosis underwent carotid arterial contrast-enhanced ultrasonography before operation.
- Conditions
- Carotid Artery Plaque, Carotid Stenosis, Stent Embolisation
- Trial name
- CASTLE (NCT05524207)
- Testing
- carotid artery stenting
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Carotid Artery Plaque, Mannose-Binding Lectin Complement Pathway
Lectine Pathway in Unstable Carotid Plaque
The study is aimed to investigate the possible role of lectin pathway - an alternative pathway of complement activation - in affecting stability of carotid atherosclerotic plaques and the possible correlations with clinical…
- Trial name
- NCT03822195
- Testing
- Carotid endoarterectomy
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Carotid Artery Stenoses
A Multi-Center Study to Evaluate Acute Safety and Clinical Performance of Paladin® Carotid Post-Dilation Balloon System With Integrated Embolic Protection
The purpose of this study is to assess the safety and clinical performance of Paladin System in patients with carotid artery stenosis.
- Trial name
- NCT02501148
- Testing
- carotid artery stenting
- Where
- 5 sites in Germany
- Volunteers
- 106 people
- Sponsor
- Contego Medical, Inc.
Stroke, Atherosclerosis
ParisK: Validation of Imaging Techniques
The possibility of the identification of the risk of rupture of a carotid plaque will have tremendous impact in clinical decision making.
- Trial name
- ParisK (NCT01208025)
- Testing
- Magnetic Resonance Imaging (MRI), Multidetector Computed Tomography (MDCT), Ultrasonography (US), Transcranial Doppler (TCD)
- Where
- 4 sites in Netherlands
- Volunteers
- 244 people
- Sponsor
- Maastricht University Medical Center
Cardiovascular Disease, Peripheral Artery Disease
Personalized Cardiovascular Risk Information to Initiate and Maintain Health Behavior Changes
The investigators propose an evaluation that will assess three important components of risk communication: 1. provide patients with personalized risk communication using the risk calculator developed by FIMDM and health…
- Conditions
- Cardiovascular Disease, Peripheral Artery Disease, Ischemic Stroke, Diabetes
- Trial name
- FIMDM_CVD (NCT01134458)
- Testing
- Web-Based Intervention
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Duke University
Microcirculation, Coronary Artery Disease
The Cerebral Microcirculation Diseases and Coronary Microcirculation Disease Study
Ischaemic heart disease (IHD) and degenerative brain disease are two major sources of death and disability affecting all countries.
- Conditions
- Microcirculation, Coronary Artery Disease, Cerebrovascular Circulation
- Trial name
- CCMD (NCT06368635)
- Testing
- Coronary angiography
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Weijing Wang
Carotid Artery Stenosis Without Infarction (Disorder), Ischemic Stroke
Brachial Versus Femoral Access for Carotid Artery Stenting
Study purpose: A multicenter, prospective and randomized study is planned to compare the clinical outcomes of carotid artery stenting via brachial artery access and femoral artery access.
- Trial name
- BEFIT (NCT06557135)
- Testing
- Carotid Artery Stenting (CAS)
- Where
- China
- Volunteers
- 235 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Ischemic Stroke, Intracranial Atherosclerosis
Combination Antithrombotic Treatment for Prevention of Recurrent Ischemic Stroke in IntraCranial Atherosclerotic diseaSe (CATIS- ICAS)
CATIS-ICAS is a double-blind, randomized, placebo-controlled (RCT), phase III study seeking to demonstrate that oral rivaroxaban 2.5 mg twice daily plus aspirin daily is superior to clopidogrel 75 mg daily plus aspirin daily for…
- Trial name
- CATIS-ICAS (NCT07468448)
- Testing
- Rivaroxaban, ASA
- Volunteers
- 1,172 people
- Sponsor
- Population Health Research Institute
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