Clinical trials: Occlusion
Muscle Relaxation
Effect of Deep Neuromuscular Block (NMB), Inhalation or TIVA on Pneumoperitoneum.
The objective of this study is to compare the value of deep neuromuscular block (NMB) (using rocuronium) in laparoscopy versus high dose opioids (using remifentanil) or 1 minimum alveolar concentration (MAC) inhalation (using…
- Trial name
- TIVA (NCT01930747)
- Testing
- rocuronium, Sevoflurane, remifentanyl
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- AZ Sint-Jan AV
Venous Occlusion
Venous Occlusion and Limb Swelling
Problems affecting the veins in the legs can cause discomfort and swelling. We want to see how artificially and reversibly blocking the leg veins affects swelling in the lower limb.
- Trial name
- NCT02241343
- Testing
- Venous occlusion (leg tourniquet, made in-house)
- Where
- United Kingdom
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Dental Caries
Conventional Bite Wing Radiography Versus Stationary Intraoral Tomosynthesis, a Comparison Study
A comparison of caries detection rates between conventional intraoral bitewing radiography and a stationary intraoral digital tomosynthesis (s-IOT) using a carbon nanotube X-ray source array.
- Trial name
- NCT02873585
- Testing
- Stationary intraoral tomosynthesis, Standard conventional bitewing radiography
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Coronary Artery Disease (CAD)
Evaluation of a Web-based Intervention to Promote Physical Activity in Patients With Heart Disease.
A randomized control trial (RCT) is planned to evaluate a web-based intervention (CardioFit) against usual care in increasing physical activity levels in patients with Coronary Artery Disease (CAD).
- Trial name
- NCT00265525
- Testing
- CardioFit
- Where
- 2 sites in Canada
- Volunteers
- 223 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Depression, Depressive Symptoms
Beating the Blues for Your Heart
The objective of this clinical trial is to evaluate whether a computerized depression treatment, delivered before the onset of heart disease, reduces the risk of heart disease in the future.
- Conditions
- Depression, Depressive Symptoms, Cardiovascular Disease (CVD), Coronary Artery Disease (CAD)
- Trial name
- BtB-Heart (NCT01605552)
- Testing
- Beating the Blues (BtB), Usual Care
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Indiana University
Coronary Artery Disease, Myocardial Infarction
PRIDE. Assessment of the Efficacy, Adherence and Tolerability of the Single Pill Combination Bisoprolol/Perindopril
This non-interventional, ambispective study was aimed at evaluating the effectiveness, safety, and tolerability of bisoprolol and perindopril SPC in previous myocardial infarction patients with HTN and CAD treated with the drug…
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Arterial Hypertension
- Trial name
- PRIDE (NCT04656847)
- Testing
- in daily everyday routine practice
- Where
- Russia
- Volunteers
- 504 people, healthy volunteers welcome
- Sponsor
- Servier Russia
Nasal Obstruction
A New Treatment for Mechanical Nasal Obstruction
The research team has developed a prototype for an investigational mechanical nasal dilator and the investigators aim to evaluate its efficacy.
- Trial name
- NCT03456115
- Testing
- Mechanical nasal dilator
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Carotid Artery Diseases, Atherosclerosis
Effect of Valsartan on Carotid Artery Disease
The EFFERVESCENT trial is designed to evaluate the effects of a specific ARB, called valsartan, on atherosclerosis. The investigators want to know if treatment with valsartan will increase the blood levels of markers responsible…
- Trial name
- NCT00208767
- Testing
- Valsartan
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Emory University
Angioplasty, Transluminal, Percutaneous Coronary, Coronary Arteriosclerosis
Safety and Effectiveness Study of the Ensure Medical Vascular Closure Device
The purpose of this study is to determine whether the Ensure Medical Vascular Closure Device is more effective than standard manual compression at sealing the puncture made in the femoral artery following a cardiac or peripheral…
- Conditions
- Angioplasty, Transluminal, Percutaneous Coronary, Coronary Arteriosclerosis, Peripheral Arteriosclerosis
- Trial name
- NCT00345631
- Testing
- Manual Compression, Vascular Closure Device
- Where
- 17 sites in United States
- Volunteers
- 488 people
- Sponsor
- Cordis US Corp.
Coronary Artery Disease, Peripheral Vascular Disease
Vorapaxar on Thrombin Generation and Coagulability
This investigation will be conducted in patients 18-75 years of age with multiple coronary artery disease risk factors (antiplatelet naïve patients) and patients with prior MI or PVD on antiplatelet therapy.
- Conditions
- Coronary Artery Disease, Peripheral Vascular Disease, Myocardial Infarction
- Trial name
- NCT03207451
- Testing
- Vorapaxar, Vorapaxar and Aspirin, Vorapaxar and Clopidogrel
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Inova Health Care Services
Macular Edema, Retinal Vein Occlusion
Study of Ozurdex® Treatment Practice in Patients With Macular Oedema Due to Retinal Vein Occlusion
Epidemiological study of Ozurdex® in sites treating patients with retinal vein occlusion.
- Trial name
- NCT01618266
- Testing
- dexamethasone intravitreal implant
- Where
- France
- Volunteers
- 375 people
- Sponsor
- Allergan
Heart Diseases
Developing and Testing a Personalized Evidence-based Shared Decision-making Tool for Stent Selection
The goal of this study is to gather input from patients who have undergone PCI, their family and/or caregivers, and clinicians to develop a patient decision aid.
- Trial name
- DECIDE-PCI (NCT02046902)
- Where
- 2 sites in United States
- Volunteers
- 586 people, healthy volunteers welcome
- Sponsor
- University of Missouri, Kansas City
Incomplete Reversal of Neuromuscular Block
Quality of Recovery After Reversal With Neostigmine or Sugammadex.
This study will compare patient recovery measures after reversal of neuromuscular blockade with neostigmine or sugammadex after surgery.
- Trial name
- NCT02909439
- Testing
- Sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Stony Brook University
Coronary Artery Disease, Pain
Study of Ranexa in Patients With Coronary Artery Disease and Painful Polyneuropathy
This study was to determine whether ranolazine was effective in the treatment of neuropathic pain in patients with coronary artery disease.
- Conditions
- Coronary Artery Disease, Pain, Peripheral Nervous System Diseases, Polyneuropathy
- Trial name
- NCT00832572
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Gilead Sciences
Internal Carotid Artery Stenosis
Ultrasound-guided Intermediate Cervical Plexus Block
The investigators test with the present study design, whether an ultrasound-guided blockade of the cervical plexus in combination with an additional application of local anesthetic to the superficial cervical ansa (facial nerve…
- Trial name
- NCT02794974
- Testing
- cervical plexus block, facial nerve block, perivascular block
- Where
- Germany
- Volunteers
- 29 people
- Sponsor
- Helios Research Center
Peripheral Arterial Disease, Type II Diabetes Mellitus
Dietary Nitrate and Exercise to Augment Exercise Training Benefits in Subjects With DM+PAD
The hypothesis of this proposal is that in subjects with Type II diabetes mellitus (T2D) and peripheral arterial disease (PAD) with intermittent claudication (IC), regular consumption of a high nitrate supplement which raises…
- Trial name
- DM+PAD (NCT01785524)
- Testing
- Beetroot Juice (Beet-It Stamina Shot) and Exercise Training
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Duke University
Symptomatic Aortic Stenosis
The REFLECT Trial: Cerebral Protection to Reduce Cerebral Embolic Lesions After Transcatheter Aortic Valve Implantation
The Keystone Heart TriGuard™ HDH is an aortic embolism deflection device intended to reduce the amount of embolic material that may enter the carotid, subclavian, and vertebral arteries during transcatheter heart valve…
- Trial name
- NCT02536196
- Testing
- Embolic Protection Device, Transcatheter aortic valve implantation (TAVI)
- Where
- 30 sites in United States, Germany and 2 more
- Volunteers
- 478 people
- Sponsor
- Keystone Heart
Pain, Surgical Abortion
Paracervical Block in First Trimester Surgical Abortions
The investigators primary objective is to study the analgesic effects of combined ketorolac and lidocaine in a paracervical block compared to preoperative ibuprofen followed by intra-operative paracervical block with lidocaine…
- Trial name
- NCT00617097
- Testing
- lidocaine, ketorolac and lidocaine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Peripheral Artery Disease
Improving Walking in Peripheral Artery Disease
Peripheral artery disease (PAD) is a cardiovascular disease manifesting from systemic atherosclerosis that blocks the leg arteries and results in insufficient blood flow to the lower extremities.
- Trial name
- PAD (NCT05103280)
- Testing
- Assistive tennis shoes
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
Diaphragmatic Hernia, Lung Disease
Fetal Tracheal Balloon Study in Diaphragmatic Hernia
The purpose of this phase 2 limited study is to examine whether prenatal intervention correct the lung underdevelopment associated with severe diaphragmatic hernia.
- Trial name
- NCT00966823
- Testing
- Fetal tracheal obstruction with detachable balloon (device)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Rhode Island Hospital
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